H-RN, a novel antiangiogenic peptide derived from hepatocyte growth factor inhibits inflammation in vitro and in vivo through PI3K/AKT/IKK/NF-κB signal pathway

Biochemical Pharmacology

Volumn 89, Issue 2, 2014, Pages 255-265

  Wang, Lili ^a,b   Xu, Yan ^a,b   Yu, Qi ^a,b   Sun, Qiao ^a,b   Xu, Yi ^a,b   Gu, Qing ^a,b   Xu, Xun ^a,b  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b Shanghai Key Laboratory of Fundus Disease   (China)

Author keywords

Anti inflammation; Endotoxin induced uveitis (EIU); Experimental autoimmune uveitis (EAU); Keywords; Nuclear factor (NF) B; Peptide

Indexed keywords

ANGIOGENESIS INHIBITOR; ANTIINFLAMMATORY AGENT; CELL ADHESION MOLECULE; DEXAMETHASONE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; GAMMA INTERFERON; H GP; H RN; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; OCULAR ANTIINFLAMMATORY AGENT; PADGEM PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P85; SCATTER FACTOR; SYNAPTOTAGMIN I; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL MIGRATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENDOTHELIUM CELL; ENDOTOXIN-INDUCED UVEITIS; ENZYME ACTIVATION; ENZYME DEGRADATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; EXPERIMENTAL AUTOIMMUNE UVEITIS; EXPERIMENTAL UVEITIS; IMMUNOFLUORESCENCE; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANTI-INFLAMMATION; DEXAMETHASOME SODIUM PHOSPHATE (PUBCHEM CID: 16961); ENDOTOXIN-INDUCED UVEITIS (EIU); EXPERIMENTAL AUTOIMMUNE UVEITIS (EAU); LIPOPOLYSACCHARIDE (PUBCHEM CID: 53481793); NUCLEAR FACTOR (NF)-ΚB; PEPTIDE;

AMINO ACID SEQUENCE; ANGIOGENESIS INHIBITORS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; COCULTURE TECHNIQUES; FEMALE; HEPATOCYTE GROWTH FACTOR; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MALE; MICE; NF-KAPPA B; PEPTIDE FRAGMENTS; PHOSPHATIDYLINOSITOL 3-KINASE; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, INBRED LEW; RATS, WISTAR; SIGNAL TRANSDUCTION;

EID: 84899445444     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2014.02.026     Document Type: Article

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