Lysine-specific demethylase 1 promotes the stemness and chemoresistance of Lgr5 + liver cancer initiating cells by suppressing negative regulators of β-catenin signaling

Oncogene

Volumn 34, Issue 24, 2015, Pages 3188-3198

  Lei, Z J ^a   Wang, J ^a   Xiao, H L ^a   Guo, Y ^a   Wang, T ^a   Li, Q ^a   Liu, L ^a   Luo, X ^a   Fan, L L ^a   Lin, L ^a   Mao, C Y ^a   Wang, S N ^b   Wei, Y L ^a   Lan, C H ^a   Jiang, J ^a   Yang, X J ^c   Liu, P D ^d   Chen, D F ^a   Wang, B ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b THIRD MILITARY MEDICAL UNIVERSITY   (China)

^c SHANTOU UNIVERSITY   (China)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; BETA CATENIN; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 5; HISTONE H3; LYSINE DERIVATIVE; LYSINE SPECIFIC DEMETHYLASE 1; PRICKLE1; PROTEIN DERIVATIVE; UNCLASSIFIED DRUG; HISTONE DEMETHYLASES; KDM1A PROTEIN, HUMAN; LGR5 PROTEIN, HUMAN; RECEPTORS, G-PROTEIN-COUPLED;

ARTICLE; CANCER GROWTH; CANCER RESISTANCE; CANCER SURVIVAL; CELL RENEWAL; CONTROLLED STUDY; HISTONE DEMETHYLATION; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ANIMALS; CARCINOMA, HEPATOCELLULAR; DOWN-REGULATION; DRUG RESISTANCE, NEOPLASM; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETICS; HUMANS; LIVER NEOPLASMS; MALE; METABOLISM; MICE; MICE, NUDE; NEOPLASTIC STEM CELLS; PATHOLOGY; PHYSIOLOGY; TUMOR CELLS, CULTURED; WNT SIGNALING PATHWAY;

ANIMALS; BETA CATENIN; CARCINOMA, HEPATOCELLULAR; DOWN-REGULATION; DRUG RESISTANCE, NEOPLASM; GENE EXPRESSION REGULATION, NEOPLASTIC; HISTONE DEMETHYLASES; HUMANS; LIVER NEOPLASMS; MALE; MICE; MICE, NUDE; NEOPLASTIC STEM CELLS; RECEPTORS, G-PROTEIN-COUPLED; TUMOR CELLS, CULTURED; WNT SIGNALING PATHWAY;

EID: 84930821809     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2015.129     Document Type: Article

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