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Volumn 7, Issue 2, 2011, Pages 458-470

An Inhibitor of Arachidonate 5-Lipoxygenase, Nordy, Induces Differentiation and Inhibits Self-Renewal of Glioma Stem-Like Cells

Author keywords

Cancer stem cells; Cell differentiation; Glioma; Lipoxygenase inhibitor; Nordihydroguaiaretic acid

Indexed keywords

ARACHIDONATE 5 LIPOXYGENASE; CD133 ANTIGEN; DRUG DERIVATIVE; GLIAL FIBRILLARY ACIDIC PROTEIN; GLYCOPROTEIN; HOMEODOMAIN PROTEIN; INTERMEDIATE FILAMENT PROTEIN; KI 67 ANTIGEN; LEUKOCYTE ANTIGEN; LEUKOTRIENE B4; LIPOXYGENASE INHIBITOR; MELK PROTEIN, HUMAN; NANOG PROTEIN, HUMAN; NERVE PROTEIN; NESTIN; NORDIHYDROGUAIARETIC ACID; NORDY; OCTAMER TRANSCRIPTION FACTOR 4; PEPTIDE; POU5F1 PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE; SOX2 PROTEIN, HUMAN; TRANSCRIPTION FACTOR SOX;

EID: 79955015036     PISSN: 15508943     EISSN: 15586804     Source Type: Journal    
DOI: 10.1007/s12015-010-9175-9     Document Type: Article
Times cited : (37)

References (45)
  • 1
    • 52549087785 scopus 로고    scopus 로고
    • Cancer stem cells in solid tumours: accumulating evidence and unresolved questions
    • Visvader, J. E., & Lindeman, G. J. (2008). Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat Rev Cancer, 8, 755-68.
    • (2008) Nat Rev Cancer , vol.8 , pp. 755-768
    • Visvader, J.E.1    Lindeman, G.J.2
  • 2
    • 33750313208 scopus 로고    scopus 로고
    • Cancer stem cells-perspectives on current status and future directions: AACR Workshop on cancer stem cells
    • Clarke, M. F., Dick, J. E., Dirks, P. B., et al. (2006). Cancer stem cells-perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res, 66, 9339-44.
    • (2006) Cancer Res , vol.66 , pp. 9339-9344
    • Clarke, M.F.1    Dick, J.E.2    Dirks, P.B.3
  • 3
    • 37349067098 scopus 로고    scopus 로고
    • Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells
    • Lee, J., Son, M. J., Woolard, K., et al. (2008). Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells. Cancer Cell, 13, 69-80.
    • (2008) Cancer Cell , vol.13 , pp. 69-80
    • Lee, J.1    Son, M.J.2    Woolard, K.3
  • 4
    • 38349075007 scopus 로고    scopus 로고
    • CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells
    • Wang, J., Sakariassen, P. O., Tsinkalovsky, O., et al. (2008). CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells. Int J Cancer, 122, 761-8.
    • (2008) Int J Cancer , vol.122 , pp. 761-768
    • Wang, J.1    Sakariassen, P.O.2    Tsinkalovsky, O.3
  • 5
    • 34249332411 scopus 로고    scopus 로고
    • CD133(+) and CD133(-) glioblastoma-derived cancer stem cells show differential growth characteristics and molecular profiles
    • Beier, D., Hau, P., Proescholdt, M., et al. (2007). CD133(+) and CD133(-) glioblastoma-derived cancer stem cells show differential growth characteristics and molecular profiles. Cancer Res, 67, 4010-5.
    • (2007) Cancer Res , vol.67 , pp. 4010-4015
    • Beier, D.1    Hau, P.2    Proescholdt, M.3
  • 6
    • 33644913145 scopus 로고    scopus 로고
    • Nordy, a synthetic lipoxygenase inhibitor, inhibits the expression of formylpeptide receptor and induces differentiation of malignant glioma cells
    • Chen, J. H., Bian, X. W., Yao, X. H., et al. (2006). Nordy, a synthetic lipoxygenase inhibitor, inhibits the expression of formylpeptide receptor and induces differentiation of malignant glioma cells. Biochem Biophys Res Commun, 342, 1368-74.
    • (2006) Biochem Biophys Res Commun , vol.342 , pp. 1368-1374
    • Chen, J.H.1    Bian, X.W.2    Yao, X.H.3
  • 7
    • 39149144060 scopus 로고    scopus 로고
    • Unique proteomic features induced by a potential antiglioma agent, Nordy (dl-nordihydroguaiaretic acid), in glioma cells
    • Bian, X. W., Xu, J. P., Ping, Y. F., et al. (2008). Unique proteomic features induced by a potential antiglioma agent, Nordy (dl-nordihydroguaiaretic acid), in glioma cells. Proteomics, 8, 484-94.
    • (2008) Proteomics , vol.8 , pp. 484-494
    • Bian, X.W.1    Xu, J.P.2    Ping, Y.F.3
  • 8
    • 67649861052 scopus 로고    scopus 로고
    • Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia
    • Chen, Y., Hu, Y., Zhang, H., Peng, C., & Li, S. (2009). Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia. Nat Genet, 41, 783-92.
    • (2009) Nat Genet , vol.41 , pp. 783-792
    • Chen, Y.1    Hu, Y.2    Zhang, H.3    Peng, C.4    Li, S.5
  • 9
    • 0141842674 scopus 로고    scopus 로고
    • Identification of a cancer stem cell in human brain tumors
    • Singh, S. K., Clarke, I. D., Terasaki, M., et al. (2003). Identification of a cancer stem cell in human brain tumors. Cancer Res, 63, 5821-8.
    • (2003) Cancer Res , vol.63 , pp. 5821-5828
    • Singh, S.K.1    Clarke, I.D.2    Terasaki, M.3
  • 10
    • 33748051406 scopus 로고    scopus 로고
    • Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor
    • Bao, S. D., Wu, Q. L., Sathornsumetee, S., et al. (2006). Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor. Cancer Res, 66, 7843-8.
    • (2006) Cancer Res , vol.66 , pp. 7843-7848
    • Bao, S.D.1    Wu, Q.L.2    Sathornsumetee, S.3
  • 11
    • 43649086456 scopus 로고    scopus 로고
    • Isolation and characterization of cancer stem cells from a human glioblastoma cell line U87
    • Yu, S. C., Ping, Y. F., Yi, L., et al. (2008). Isolation and characterization of cancer stem cells from a human glioblastoma cell line U87. Cancer Lett, 265, 124-34.
    • (2008) Cancer Lett , vol.265 , pp. 124-134
    • Yu, S.C.1    Ping, Y.F.2    Yi, L.3
  • 12
    • 34548792934 scopus 로고    scopus 로고
    • Isolation and characterization of stem cell-like precursor cells from primary human anaplastic oligoastrocytoma
    • Yi, L., Zhou, Z. H., Ping, Y. F., et al. (2007). Isolation and characterization of stem cell-like precursor cells from primary human anaplastic oligoastrocytoma. Mod Pathol, 20, 1061-8.
    • (2007) Mod Pathol , vol.20 , pp. 1061-1068
    • Yi, L.1    Zhou, Z.H.2    Ping, Y.F.3
  • 13
    • 32244440850 scopus 로고    scopus 로고
    • Increased expression of 5-lipoxygenase in high-grade astrocytomas
    • Nathoo, N., Prayson, R. A., Bondar, J., et al. (2006). Increased expression of 5-lipoxygenase in high-grade astrocytomas. Neurosurgery, 58, 347-54.
    • (2006) Neurosurgery , vol.58 , pp. 347-354
    • Nathoo, N.1    Prayson, R.A.2    Bondar, J.3
  • 14
    • 79955048268 scopus 로고    scopus 로고
    • MK886-induced apoptosis depends on the 5-LO expression level in human malignant glioma cells
    • Lim JY, Oh JH, Jung JR, et al. MK886-induced apoptosis depends on the 5-LO expression level in human malignant glioma cells. J Neurooncol 2009.
    • (2009) J Neurooncol
    • Lim, J.Y.1    Oh, J.H.2    Jung, J.R.3
  • 15
    • 70549103224 scopus 로고    scopus 로고
    • 5-lipoxygenase pathway promotes cell proliferation in human glioma cell lines
    • Ishii, K., Zaitsu, M., Yonemitsu, N., Kan, Y., Hamasaki, Y., & Matsuo, M. (2009). 5-lipoxygenase pathway promotes cell proliferation in human glioma cell lines. Clin Neuropathol, 28, 445-52.
    • (2009) Clin Neuropathol , vol.28 , pp. 445-452
    • Ishii, K.1    Zaitsu, M.2    Yonemitsu, N.3    Kan, Y.4    Hamasaki, Y.5    Matsuo, M.6
  • 16
    • 33645509496 scopus 로고    scopus 로고
    • Expression patterns of 5-lipoxygenase in human brain with traumatic injury and astrocytoma
    • Zhang, L., Zhang, W. P., Hu, H., et al. (2006). Expression patterns of 5-lipoxygenase in human brain with traumatic injury and astrocytoma. Neuropathology, 26, 99-106.
    • (2006) Neuropathology , vol.26 , pp. 99-106
    • Zhang, L.1    Zhang, W.P.2    Hu, H.3
  • 17
    • 66549099464 scopus 로고    scopus 로고
    • Common variation in genes related to innate immunity and risk of adult glioma
    • Rajaraman, P., Brenner, A. V., Butler, M. A., et al. (2009). Common variation in genes related to innate immunity and risk of adult glioma. Cancer Epidemiol Biomark Prev, 18, 1651-8.
    • (2009) Cancer Epidemiol Biomark Prev , vol.18 , pp. 1651-1658
    • Rajaraman, P.1    Brenner, A.V.2    Butler, M.A.3
  • 18
    • 34250323489 scopus 로고    scopus 로고
    • Cannabinoids induce glioma stem-like cell differentiation and inhibit gliomagenesis
    • Aguado, T., Carracedo, A., Julien, B., et al. (2007). Cannabinoids induce glioma stem-like cell differentiation and inhibit gliomagenesis. J Biol Chem, 282, 6854-62.
    • (2007) J Biol Chem , vol.282 , pp. 6854-6862
    • Aguado, T.1    Carracedo, A.2    Julien, B.3
  • 19
    • 42649112047 scopus 로고    scopus 로고
    • An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors
    • Ben-Porath, I., Thomson, M. W., Carey, V. J., et al. (2008). An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat Genet, 40, 499-507.
    • (2008) Nat Genet , vol.40 , pp. 499-507
    • Ben-Porath, I.1    Thomson, M.W.2    Carey, V.J.3
  • 20
    • 58949102947 scopus 로고    scopus 로고
    • Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells
    • Somervaille, T. C. P., Matheny, C. J., Spencer, G. J., et al. (2009). Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells. Cell Stem Cell, 4, 129-40.
    • (2009) Cell Stem Cell , vol.4 , pp. 129-140
    • Somervaille, T.C.P.1    Matheny, C.J.2    Spencer, G.J.3
  • 21
    • 41449118521 scopus 로고    scopus 로고
    • Module map of stem cell genes guides creation of epithelial cancer stem cells
    • Wong, D. J., Liu, H., Ridky, T. W., Cassarino, D., Segal, E., & Chang, H. Y. (2008). Module map of stem cell genes guides creation of epithelial cancer stem cells. Cell Stem Cell, 2, 333-44.
    • (2008) Cell Stem Cell , vol.2 , pp. 333-344
    • Wong, D.J.1    Liu, H.2    Ridky, T.W.3    Cassarino, D.4    Segal, E.5    Chang, H.Y.6
  • 22
    • 44349166602 scopus 로고    scopus 로고
    • PML targeting eradicates quiescent leukaemia-initiating cells
    • Ito, K., Bernardi, R., Morotti, A., et al. (2008). PML targeting eradicates quiescent leukaemia-initiating cells. Nature, 453, 1072-8.
    • (2008) Nature , vol.453 , pp. 1072-1078
    • Ito, K.1    Bernardi, R.2    Morotti, A.3
  • 23
    • 33749612562 scopus 로고    scopus 로고
    • What are cyclooxygenases and lipoxygenases doing in the driver's seat of carcinogenesis?
    • Furstenberger, G., Krieg, P., Muller-Decker, K., & Habenicht, A. J. (2006). What are cyclooxygenases and lipoxygenases doing in the driver's seat of carcinogenesis? Int J Cancer, 119, 2247-54.
    • (2006) Int J Cancer , vol.119 , pp. 2247-2254
    • Furstenberger, G.1    Krieg, P.2    Muller-Decker, K.3    Habenicht, A.J.4
  • 24
    • 67349091428 scopus 로고    scopus 로고
    • Inhibition of arachidonic acid metabolism and its implication on cell proliferation and tumour-angiogenesis
    • Hyde, C. A., & Missailidis, S. (2009). Inhibition of arachidonic acid metabolism and its implication on cell proliferation and tumour-angiogenesis. Int Immunopharmacol, 9, 701-15.
    • (2009) Int Immunopharmacol , vol.9 , pp. 701-715
    • Hyde, C.A.1    Missailidis, S.2
  • 26
    • 36149000163 scopus 로고    scopus 로고
    • Lipoxygenase metabolism: roles in tumor progression and survival
    • Pidgeon, G. P., Lysaght, J., Krishnamoorthy, S., et al. (2007). Lipoxygenase metabolism: roles in tumor progression and survival. Cancer Metastasis Rev, 26, 503-24.
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 503-524
    • Pidgeon, G.P.1    Lysaght, J.2    Krishnamoorthy, S.3
  • 27
    • 0037207863 scopus 로고    scopus 로고
    • Expression of the leukotriene D4 receptor CysLT1, COX-2, and other cell survival factors in colorectal adenocarcinomas
    • Öhd, J. F., Nielsen, C. K., Campbell, J., Landberg, G., Löfberg, H., & Sjölander, A. (2003). Expression of the leukotriene D4 receptor CysLT1, COX-2, and other cell survival factors in colorectal adenocarcinomas. Gastroenterology, 124, 57-70.
    • (2003) Gastroenterology , vol.124 , pp. 57-70
    • Öhd, J.F.1    Nielsen, C.K.2    Campbell, J.3    Landberg, G.4    Löfberg, H.5    Sjölander, A.6
  • 28
    • 33747875667 scopus 로고    scopus 로고
    • Involvement of the 5-lipoxygenase/leukotriene A4 hydrolase pathway in 7, 12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamster cheek pouch, and inhibition of carcinogenesis by its inhibitors
    • Sun, Z., Sood, S., Li, N., et al. (2006). Involvement of the 5-lipoxygenase/leukotriene A4 hydrolase pathway in 7, 12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamster cheek pouch, and inhibition of carcinogenesis by its inhibitors. Carcinogenesis, 27, 1902-8.
    • (2006) Carcinogenesis , vol.27 , pp. 1902-1908
    • Sun, Z.1    Sood, S.2    Li, N.3
  • 29
    • 58149187464 scopus 로고    scopus 로고
    • Overexpression of 5-lipoxygenase in colon polyps and cancer and the effect of 5-LOX inhibitors in vitro and in a murine model
    • Melstrom, L. G., Bentrem, D. J., Salabat, M. R., et al. (2008). Overexpression of 5-lipoxygenase in colon polyps and cancer and the effect of 5-LOX inhibitors in vitro and in a murine model. Clin Cancer Res, 14, 6525-30.
    • (2008) Clin Cancer Res , vol.14 , pp. 6525-6530
    • Melstrom, L.G.1    Bentrem, D.J.2    Salabat, M.R.3
  • 30
    • 33845199658 scopus 로고    scopus 로고
    • Inhibition of 5-lipoxygenase by MK886 augments the antitumor activity of celecoxib in human colon cancer cells
    • Cianchi, F., Cortesini, C., Magnelli, L., et al. (2006). Inhibition of 5-lipoxygenase by MK886 augments the antitumor activity of celecoxib in human colon cancer cells. Mol Cancer Ther, 5, 2716-26.
    • (2006) Mol Cancer Ther , vol.5 , pp. 2716-2726
    • Cianchi, F.1    Cortesini, C.2    Magnelli, L.3
  • 31
    • 34547843495 scopus 로고    scopus 로고
    • Control of the growth of human breast cancer cells in culture by manipulation of arachidonate metabolism
    • Hammamieh, R., Sumaida, D., Zhang, X., Das, R., & Jett, M. (2007). Control of the growth of human breast cancer cells in culture by manipulation of arachidonate metabolism. BMC Cancer, 7, 138.
    • (2007) BMC Cancer , vol.7 , pp. 138
    • Hammamieh, R.1    Sumaida, D.2    Zhang, X.3    Das, R.4    Jett, M.5
  • 32
    • 36248961179 scopus 로고    scopus 로고
    • Tumorigenesis of chemotherapeutic drug-resistant cancer stem-like cells in brain glioma
    • Kang, M. K., & Kang, S. K. (2007). Tumorigenesis of chemotherapeutic drug-resistant cancer stem-like cells in brain glioma. Stem Cells Dev, 16, 837-47.
    • (2007) Stem Cells Dev , vol.16 , pp. 837-847
    • Kang, M.K.1    Kang, S.K.2
  • 33
    • 49949111381 scopus 로고    scopus 로고
    • Oct-4 expression maintained cancer stem-like properties in lung cancer-derived CD133-positive cells
    • Chen, Y. C., Hsu, H. S., Chen, Y. W., et al. (2008). Oct-4 expression maintained cancer stem-like properties in lung cancer-derived CD133-positive cells. PLoS ONE, 3, e2637.
    • (2008) PLoS ONE , vol.3
    • Chen, Y.C.1    Hsu, H.S.2    Chen, Y.W.3
  • 34
    • 59849125142 scopus 로고    scopus 로고
    • SOX2 silencing in glioblastoma tumor-initiating cells causes stop of proliferation and loss of tumorigenicity
    • Gangemi, R. M., Griffero, F., Marubbi, D., et al. (2009). SOX2 silencing in glioblastoma tumor-initiating cells causes stop of proliferation and loss of tumorigenicity. Stem Cells, 27, 40-8.
    • (2009) Stem Cells , vol.27 , pp. 40-48
    • Gangemi, R.M.1    Griffero, F.2    Marubbi, D.3
  • 35
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi, K., & Yamanaka, S. (2006). Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell, 126, 663-76.
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 36
    • 58149487199 scopus 로고    scopus 로고
    • Human Dicer C-terminus functions as a 5-lipoxygenase binding domain
    • Dincbas-Renqvist, V., Pepin, G., Rakonjac, M., et al. (2009). Human Dicer C-terminus functions as a 5-lipoxygenase binding domain. Biochim Biophys Acta, 1789, 99-108.
    • (2009) Biochim Biophys Acta , vol.1789 , pp. 99-108
    • Dincbas-Renqvist, V.1    Pepin, G.2    Rakonjac, M.3
  • 37
    • 56449126945 scopus 로고    scopus 로고
    • Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal
    • Godlewski, J., Nowicki, M. O., Bronisz, A., et al. (2008). Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal. Cancer Res, 68, 9125-30.
    • (2008) Cancer Res , vol.68 , pp. 9125-9130
    • Godlewski, J.1    Nowicki, M.O.2    Bronisz, A.3
  • 38
    • 73049110243 scopus 로고    scopus 로고
    • The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs
    • Wellner, U., Schubert, J., Burk, U. C., et al. (2009). The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs. Nat Cell Biol, 11, 1487-95.
    • (2009) Nat Cell Biol , vol.11 , pp. 1487-1495
    • Wellner, U.1    Schubert, J.2    Burk, U.C.3
  • 39
    • 67649881121 scopus 로고    scopus 로고
    • Lin28 promotes transformation and is associated with advanced human malignancies
    • Viswanathan, S. R., Powers, J. T., Einhorn, W., et al. (2009). Lin28 promotes transformation and is associated with advanced human malignancies. Nat Genet, 41, 843-8.
    • (2009) Nat Genet , vol.41 , pp. 843-848
    • Viswanathan, S.R.1    Powers, J.T.2    Einhorn, W.3
  • 40
    • 39449135834 scopus 로고    scopus 로고
    • PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo
    • Hambardzumyan, D., Becher, O. J., Rosenblum, M. K., Pandolfi, P. P., Manova-Todorova, K., & Holland, E. C. (2008). PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo. Genes Dev, 22, 436-48.
    • (2008) Genes Dev , vol.22 , pp. 436-448
    • Hambardzumyan, D.1    Becher, O.J.2    Rosenblum, M.K.3    Pandolfi, P.P.4    Manova-Todorova, K.5    Holland, E.C.6
  • 41
    • 33845317573 scopus 로고    scopus 로고
    • Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
    • Bao, S., Wu, Q., McLendon, R. E., et al. (2006). Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature, 444, 756-60.
    • (2006) Nature , vol.444 , pp. 756-760
    • Bao, S.1    Wu, Q.2    McLendon, R.E.3
  • 42
    • 60849117508 scopus 로고    scopus 로고
    • PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells
    • Bleau, A. M., Hambardzumyan, D., Ozawa, T., et al. (2009). PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells. Cell Stem Cell, 4, 226-35.
    • (2009) Cell Stem Cell , vol.4 , pp. 226-235
    • Bleau, A.M.1    Hambardzumyan, D.2    Ozawa, T.3
  • 43
    • 33646106342 scopus 로고    scopus 로고
    • Cancer stem cells and differentiation therapy
    • Sell, S. (2006). Cancer stem cells and differentiation therapy. Tumour Biol, 27, 59-70.
    • (2006) Tumour Biol , vol.27 , pp. 59-70
    • Sell, S.1
  • 44
    • 33750584024 scopus 로고    scopus 로고
    • Tumour stem cell-targeted treatment: elimination or differentiation
    • Massard, C., Deutsch, E., & Soria, J. C. (2006). Tumour stem cell-targeted treatment: elimination or differentiation. Ann Oncol, 17, 1620-4.
    • (2006) Ann Oncol , vol.17 , pp. 1620-1624
    • Massard, C.1    Deutsch, E.2    Soria, J.C.3
  • 45
    • 68749099671 scopus 로고    scopus 로고
    • Identification of selective inhibitors of cancer stem cells by high-throughput screening
    • Gupta, P. B., Onder, T. T., Jiang, G., et al. (2009). Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell, 138, 645-59.
    • (2009) Cell , vol.138 , pp. 645-659
    • Gupta, P.B.1    Onder, T.T.2    Jiang, G.3


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