-
3
-
-
84922178425
-
The genetics of familial hypercholesterolemia and emerging therapies
-
A. Vogt The genetics of familial hypercholesterolemia and emerging therapies Appl Clin Genet 8 2015 27 36
-
(2015)
Appl Clin Genet
, vol.8
, pp. 27-36
-
-
Vogt, A.1
-
4
-
-
84887905912
-
Alkaptonuria: leading to the treasure in exceptions
-
T.M. Cox Alkaptonuria: leading to the treasure in exceptions JIMD Rep 5 2012 49 57
-
(2012)
JIMD Rep
, vol.5
, pp. 49-57
-
-
Cox, T.M.1
-
5
-
-
77950665927
-
Physiological role of alkaline phosphatase explored in hypophosphatasia
-
M.P. Whyte Physiological role of alkaline phosphatase explored in hypophosphatasia Ann N Y Acad Sci 1192 2010 190 220
-
(2010)
Ann N Y Acad Sci
, vol.1192
, pp. 190-220
-
-
Whyte, M.P.1
-
6
-
-
49749205640
-
Excretion of inorganic pyrophosphate in hypophosphatasia
-
R.G. Russell Excretion of inorganic pyrophosphate in hypophosphatasia Lancet 2 1965 461 464
-
(1965)
Lancet
, vol.2
, pp. 461-464
-
-
Russell, R.G.1
-
7
-
-
0013916391
-
Effect of pyrophosphate on dissolution of hydroxyapatite and its possible importance in calcium homeostasis
-
H. Fleisch, J. Maerki, and R.G. Russell Effect of pyrophosphate on dissolution of hydroxyapatite and its possible importance in calcium homeostasis Proc Soc Exp Biol Med 122 1966 317 320
-
(1966)
Proc Soc Exp Biol Med
, vol.122
, pp. 317-320
-
-
Fleisch, H.1
Maerki, J.2
Russell, R.G.3
-
8
-
-
79958695940
-
Bisphosphonates: the first 40 years
-
R.G. Russell Bisphosphonates: the first 40 years Bone 49 2011 2 19
-
(2011)
Bone
, vol.49
, pp. 2-19
-
-
Russell, R.G.1
-
9
-
-
84927740769
-
Bisphosphonates for the prevention of fractures in osteogenesis imperfecta: meta-analysis of placebo-controlled trials
-
J.D. Hald, E. Evangelou, B.L. Langdahl, and S.H. Ralston Bisphosphonates for the prevention of fractures in osteogenesis imperfecta: meta-analysis of placebo-controlled trials J Bone Miner Res 30 2015 929 933
-
(2015)
J Bone Miner Res
, vol.30
, pp. 929-933
-
-
Hald, J.D.1
Evangelou, E.2
Langdahl, B.L.3
Ralston, S.H.4
-
10
-
-
84891747397
-
The coupling of bone and cartilage turnover in osteoarthritis: opportunities for bone antiresorptives and anabolics as potential treatments?
-
M.A. Karsdal, A.C. Bay-Jensen, R.J. Lories, S. Abramson, T. Spector, P. Pastoureau, C. Christiansen, M. Attur, K. Henriksen, S.R. Goldring, and V. Kraus The coupling of bone and cartilage turnover in osteoarthritis: opportunities for bone antiresorptives and anabolics as potential treatments? Ann Rheum Dis 73 2014 336 348
-
(2014)
Ann Rheum Dis
, vol.73
, pp. 336-348
-
-
Karsdal, M.A.1
Bay-Jensen, A.C.2
Lories, R.J.3
Abramson, S.4
Spector, T.5
Pastoureau, P.6
Christiansen, C.7
Attur, M.8
Henriksen, K.9
Goldring, S.R.10
Kraus, V.11
-
11
-
-
0028123480
-
Molecular cloning of a possible cysteine proteinase predominantly expressed in osteoclasts
-
K. Tezuka, Y. Tezuka, A. Maejima, T. Sato, K. Nemoto, H. Kamioka, Y. Hakeda, and M. Kumegawa Molecular cloning of a possible cysteine proteinase predominantly expressed in osteoclasts J Biol Chem 269 1994 1106 1109
-
(1994)
J Biol Chem
, vol.269
, pp. 1106-1109
-
-
Tezuka, K.1
Tezuka, Y.2
Maejima, A.3
Sato, T.4
Nemoto, K.5
Kamioka, H.6
Hakeda, Y.7
Kumegawa, M.8
-
12
-
-
0028831635
-
Molecular cloning of human cDNA for cathepsin K: novel cysteine proteinase predominantly expressed in bone
-
T. Inaoka, G. Bilbe, O. Ishibashi, K. Tezuka, M. Kumegawa, and T. Kokubo Molecular cloning of human cDNA for cathepsin K: novel cysteine proteinase predominantly expressed in bone Biochem Biophys Res Commun 206 1995 89 96
-
(1995)
Biochem Biophys Res Commun
, vol.206
, pp. 89-96
-
-
Inaoka, T.1
Bilbe, G.2
Ishibashi, O.3
Tezuka, K.4
Kumegawa, M.5
Kokubo, T.6
-
13
-
-
0029809357
-
Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency
-
B.D. Gelb, G.P. Shi, H.A. Chapman, and R.J. Desnick Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency Science 273 1996 1236 1238
-
(1996)
Science
, vol.273
, pp. 1236-1238
-
-
Gelb, B.D.1
Shi, G.P.2
Chapman, H.A.3
Desnick, R.J.4
-
14
-
-
0031081303
-
Localization of cathepsin K in human osteoclasts by in situ hybridization and immunohistochemistry
-
A. Littlewood-Evans, T. Kokubo, O. Ishibashi, T. Inaoka, B. Wlodarski, J.A. Gallagher, and G. Bilbe Localization of cathepsin K in human osteoclasts by in situ hybridization and immunohistochemistry Bone 20 1997 81 86
-
(1997)
Bone
, vol.20
, pp. 81-86
-
-
Littlewood-Evans, A.1
Kokubo, T.2
Ishibashi, O.3
Inaoka, T.4
Wlodarski, B.5
Gallagher, J.A.6
Bilbe, G.7
-
15
-
-
15144356711
-
The osteoclast-associated protease cathepsin K is expressed in human breast carcinoma
-
A.J. Littlewood-Evans, G. Bilbe, W.B. Bowler, D. Farley, B. Wlodarski, T. Kokubo, T. Inaoka, J. Sloane, D.B. Evans, and J.A. Gallagher The osteoclast-associated protease cathepsin K is expressed in human breast carcinoma Cancer Res 57 1997 5386 5390
-
(1997)
Cancer Res
, vol.57
, pp. 5386-5390
-
-
Littlewood-Evans, A.J.1
Bilbe, G.2
Bowler, W.B.3
Farley, D.4
Wlodarski, B.5
Kokubo, T.6
Inaoka, T.7
Sloane, J.8
Evans, D.B.9
Gallagher, J.A.10
-
16
-
-
84925493847
-
Odanacatib for the treatment of postmenopausal osteoporosis: development history and design and participant characteristics of LOFT, the Long-term Odanacatib Fracture Trial
-
H.G. Bone, D.W. Dempster, J.A. Eisman, S.L. Greenspan, M.R. McClung, T. Nakamura, S. Papapoulos, W.J. Shih, A. Rybak-Feiglin, A.C. Santora, N. Verbruggen, A.T. Leung, and A. Lombardi Odanacatib for the treatment of postmenopausal osteoporosis: development history and design and participant characteristics of LOFT, the Long-term Odanacatib Fracture Trial Osteoporos Int 26 2015 699 712
-
(2015)
Osteoporos Int
, vol.26
, pp. 699-712
-
-
Bone, H.G.1
Dempster, D.W.2
Eisman, J.A.3
Greenspan, S.L.4
McClung, M.R.5
Nakamura, T.6
Papapoulos, S.7
Shih, W.J.8
Rybak-Feiglin, A.9
Santora, A.C.10
Verbruggen, N.11
Leung, A.T.12
Lombardi, A.13
-
17
-
-
84887441062
-
Are cathepsin k inhibitors just another class of anti-resorptives?
-
T.J. Chambers, and J.H. Tobias Are cathepsin k inhibitors just another class of anti-resorptives? J Clin Endocrinol Metab 98 2013 4329 4331
-
(2013)
J Clin Endocrinol Metab
, vol.98
, pp. 4329-4331
-
-
Chambers, T.J.1
Tobias, J.H.2
-
18
-
-
0035282968
-
Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)
-
W. Balemans, M. Ebeling, N. Patel, E. Van Hul, P. Olson, M. Dioszegi, C. Lacza, W. Wuyts, J. Van Den Ende, P. Willems, A.F. Paes-Alves, S. Hill, M. Bueno, F.J. Ramos, P. Tacconi, F.G. Dikkers, C. Stratakis, K. Lindpaintner, B. Vickery, D. Foernzler, and W. Van Hul Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST) Hum Mol Genet 10 2001 537 543
-
(2001)
Hum Mol Genet
, vol.10
, pp. 537-543
-
-
Balemans, W.1
Ebeling, M.2
Patel, N.3
Van Hul, E.4
Olson, P.5
Dioszegi, M.6
Lacza, C.7
Wuyts, W.8
Van Den Ende, J.9
Willems, P.10
Paes-Alves, A.F.11
Hill, S.12
Bueno, M.13
Ramos, F.J.14
Tacconi, P.15
Dikkers, F.G.16
Stratakis, C.17
Lindpaintner, K.18
Vickery, B.19
Foernzler, D.20
Van Hul, W.21
more..
-
19
-
-
18244403197
-
Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease
-
W. Balemans, N. Patel, M. Ebeling, E. Van Hul, W. Wuyts, C. Lacza, M. Dioszegi, F.G. Dikkers, P. Hildering, and P.J. Willems Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease J Med Genet 39 2002 91 97
-
(2002)
J Med Genet
, vol.39
, pp. 91-97
-
-
Balemans, W.1
Patel, N.2
Ebeling, M.3
Van Hul, E.4
Wuyts, W.5
Lacza, C.6
Dioszegi, M.7
Dikkers, F.G.8
Hildering, P.9
Willems, P.J.10
-
20
-
-
22244474640
-
Genomic deletion of a long-range bone enhancer misregulates sclerostin in Van Buchem disease
-
G.G. Loots, M. Kneissel, H. Keller, M. Baptist, J. Chang, N.M. Collette, D. Ovcharenko, I. Plajzer-Frick, and E.M. Rubin Genomic deletion of a long-range bone enhancer misregulates sclerostin in Van Buchem disease Genome Res 15 2005 928 935
-
(2005)
Genome Res
, vol.15
, pp. 928-935
-
-
Loots, G.G.1
Kneissel, M.2
Keller, H.3
Baptist, M.4
Chang, J.5
Collette, N.M.6
Ovcharenko, D.7
Plajzer-Frick, I.8
Rubin, E.M.9
-
21
-
-
27744461726
-
Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation
-
K.E. Poole, R.L. van Bezooijen, N. Loveridge, H. Hamersma, S.E. Papapoulos, C.W. Lowik, and J. Reeve Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation FASEB J 19 2005 1842 1844
-
(2005)
FASEB J
, vol.19
, pp. 1842-1844
-
-
Poole, K.E.1
Van Bezooijen, R.L.2
Loveridge, N.3
Hamersma, H.4
Papapoulos, S.E.5
Lowik, C.W.6
Reeve, J.7
-
22
-
-
21844467220
-
SOST is a target gene for PTH in bone
-
H. Keller, and M. Kneissel SOST is a target gene for PTH in bone Bone 37 2005 148 158
-
(2005)
Bone
, vol.37
, pp. 148-158
-
-
Keller, H.1
Kneissel, M.2
-
23
-
-
78650958526
-
Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody
-
D. Padhi, G. Jang, B. Stouch, L. Fang, and E. Posvar Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody J Bone Miner Res 26 2011 19 26
-
(2011)
J Bone Miner Res
, vol.26
, pp. 19-26
-
-
Padhi, D.1
Jang, G.2
Stouch, B.3
Fang, L.4
Posvar, E.5
-
24
-
-
84897586287
-
Single- and multiple-dose randomized studies of blosozumab, a monoclonal antibody against sclerostin, in healthy postmenopausal women
-
J. McColm, L. Hu, T. Womack, C.C. Tang, and A.Y. Chiang Single- and multiple-dose randomized studies of blosozumab, a monoclonal antibody against sclerostin, in healthy postmenopausal women J Bone Miner Res 29 2013 935 943
-
(2013)
J Bone Miner Res
, vol.29
, pp. 935-943
-
-
McColm, J.1
Hu, L.2
Womack, T.3
Tang, C.C.4
Chiang, A.Y.5
-
25
-
-
84893044528
-
Romosozumab in postmenopausal women with low bone mineral density
-
M.R. McClung, A. Grauer, S. Boonen, M.A. Bolognese, J.P. Brown, A. Diez-Perez, B.L. Langdahl, J.Y. Reginster, J.R. Zanchetta, and S.M. Wasserman Romosozumab in postmenopausal women with low bone mineral density N Engl J Med 370 2014 412 420
-
(2014)
N Engl J Med
, vol.370
, pp. 412-420
-
-
McClung, M.R.1
Grauer, A.2
Boonen, S.3
Bolognese, M.A.4
Brown, J.P.5
Diez-Perez, A.6
Langdahl, B.L.7
Reginster, J.Y.8
Zanchetta, J.R.9
Wasserman, S.M.10
-
26
-
-
22844445934
-
SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor
-
M. Semenov, K. Tamai, and X. He SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor J Biol Chem 280 2005 26770 26775
-
(2005)
J Biol Chem
, vol.280
, pp. 26770-26775
-
-
Semenov, M.1
Tamai, K.2
He, X.3
-
27
-
-
21244480924
-
Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling
-
X. Li, Y. Zhang, H. Kang, W. Liu, P. Liu, J. Zhang, S.E. Harris, and D. Wu Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling J Biol Chem 280 2005 19883 19887
-
(2005)
J Biol Chem
, vol.280
, pp. 19883-19887
-
-
Li, X.1
Zhang, Y.2
Kang, H.3
Liu, W.4
Liu, P.5
Zhang, J.6
Harris, S.E.7
Wu, D.8
-
28
-
-
55249101949
-
The binding between sclerostin and LRP5 is altered by DKK1 and by high-bone mass LRP5 mutations
-
W. Balemans, E. Piters, E. Cleiren, M. Ai, L. Van Wesenbeeck, M.L. Warman, and W. Van Hul The binding between sclerostin and LRP5 is altered by DKK1 and by high-bone mass LRP5 mutations Calcif Tissue Int 82 2008 445 455
-
(2008)
Calcif Tissue Int
, vol.82
, pp. 445-455
-
-
Balemans, W.1
Piters, E.2
Cleiren, E.3
Ai, M.4
Van Wesenbeeck, L.5
Warman, M.L.6
Van Hul, W.7
-
29
-
-
79959936613
-
Increased chondrocyte sclerostin may protect against cartilage degradation in osteoarthritis
-
B.Y. Chan, E.S. Fuller, A.K. Russell, S.M. Smith, M.M. Smith, M.T. Jackson, M.A. Cake, R.A. Read, J.F. Bateman, P.N. Sambrook, and C.B. Little Increased chondrocyte sclerostin may protect against cartilage degradation in osteoarthritis Osteoarthritis Cartilage 19 2011 874 885
-
(2011)
Osteoarthritis Cartilage
, vol.19
, pp. 874-885
-
-
Chan, B.Y.1
Fuller, E.S.2
Russell, A.K.3
Smith, S.M.4
Smith, M.M.5
Jackson, M.T.6
Cake, M.A.7
Read, R.A.8
Bateman, J.F.9
Sambrook, P.N.10
Little, C.B.11
-
30
-
-
84928817487
-
Loss of sclerostin promotes osteoarthritis in mice via β-catenin-dependent and -independent Wnt pathways
-
Epub ahead of print
-
W. Bouaziz, T. Funck-Brentano, H. Lin, C. Marty, H.K. Ea, E. Hay, and M. Cohen-Solal Loss of sclerostin promotes osteoarthritis in mice via β-catenin-dependent and -independent Wnt pathways Arthritis Res Ther 17 2015 24 (Epub ahead of print)
-
(2015)
Arthritis Res Ther
, vol.17
, pp. 24
-
-
Bouaziz, W.1
Funck-Brentano, T.2
Lin, H.3
Marty, C.4
Ea, H.K.5
Hay, E.6
Cohen-Solal, M.7
-
31
-
-
84874412598
-
Sclerostin is expressed in articular cartilage but loss or inhibition does not affect cartilage remodeling during aging or following mechanical injury
-
M. Roudier, X. Li, Q.T. Niu, E. Pacheco, J.K. Pretorius, K. Graham, B.R. Yoon, J. Gong, K. Warmington, H.Z. Ke, R.A. Black, J. Hulme, and P. Babij Sclerostin is expressed in articular cartilage but loss or inhibition does not affect cartilage remodeling during aging or following mechanical injury Arthritis Rheum 65 2013 721 731
-
(2013)
Arthritis Rheum
, vol.65
, pp. 721-731
-
-
Roudier, M.1
Li, X.2
Niu, Q.T.3
Pacheco, E.4
Pretorius, J.K.5
Graham, K.6
Yoon, B.R.7
Gong, J.8
Warmington, K.9
Ke, H.Z.10
Black, R.A.11
Hulme, J.12
Babij, P.13
-
32
-
-
84908309743
-
Parathyroid hormone (1-34) prevents cartilage degradation and preserves subchondral bone micro-architecture in guinea pigs with spontaneous osteoarthritis
-
J.Y. Yan, F.M. Tian, W.Y. Wang, Y. Cheng, H.P. Song, Y.Z. Zhang, and L. Zhang Parathyroid hormone (1-34) prevents cartilage degradation and preserves subchondral bone micro-architecture in guinea pigs with spontaneous osteoarthritis Osteoarthritis Cartilage 22 2014 1869 1877
-
(2014)
Osteoarthritis Cartilage
, vol.22
, pp. 1869-1877
-
-
Yan, J.Y.1
Tian, F.M.2
Wang, W.Y.3
Cheng, Y.4
Song, H.P.5
Zhang, Y.Z.6
Zhang, L.7
-
33
-
-
59649092384
-
Employing molecular genetics of chondrodysplasias to inform the study of osteoarthritis
-
P. Kannu, J.F. Bateman, D. Belluoccio, A.J. Fosang, and R. Savarirayan Employing molecular genetics of chondrodysplasias to inform the study of osteoarthritis Arthritis Rheum 60 2009 325 334
-
(2009)
Arthritis Rheum
, vol.60
, pp. 325-334
-
-
Kannu, P.1
Bateman, J.F.2
Belluoccio, D.3
Fosang, A.J.4
Savarirayan, R.5
-
34
-
-
0028232724
-
Limb alterations in brachypodism mice due to mutations in a new member of the TGF beta-superfamily
-
E.E. Storm, T.V. Huynh, N.G. Copeland, N.A. Jenkins, D.M. Kingsley, and S.J. Lee Limb alterations in brachypodism mice due to mutations in a new member of the TGF beta-superfamily Nature 368 1994 639 643
-
(1994)
Nature
, vol.368
, pp. 639-643
-
-
Storm, E.E.1
Huynh, T.V.2
Copeland, N.G.3
Jenkins, N.A.4
Kingsley, D.M.5
Lee, S.J.6
-
35
-
-
84901004922
-
Homozygous missense and nonsense mutations in BMPR1B cause acromesomelic chondrodysplasia-type Grebe
-
L.M. Graul-Neumann, A. Deichsel, U. Wille, N. Kakar, R. Koll, C. Bassir, J. Ahmad, V. Cormier-Daire, S. Mundlos, C. Kubisch, G. Borck, E. Klopocki, T.D. Mueller, S.C. Doelken, and P. Seemann Homozygous missense and nonsense mutations in BMPR1B cause acromesomelic chondrodysplasia-type Grebe Eur J Hum Genet 22 2014 726 733
-
(2014)
Eur J Hum Genet
, vol.22
, pp. 726-733
-
-
Graul-Neumann, L.M.1
Deichsel, A.2
Wille, U.3
Kakar, N.4
Koll, R.5
Bassir, C.6
Ahmad, J.7
Cormier-Daire, V.8
Mundlos, S.9
Kubisch, C.10
Borck, G.11
Klopocki, E.12
Mueller, T.D.13
Doelken, S.C.14
Seemann, P.15
-
36
-
-
0029936784
-
A human chondrodysplasia due to a mutation in a TGF-beta superfamily member
-
J.T. Thomas, K. Lin, M. Nandedkar, M. Camargo, J. Cervenka, and F.P. Luyten A human chondrodysplasia due to a mutation in a TGF-beta superfamily member Nat Genet 12 1996 315
-
(1996)
Nat Genet
, vol.12
, pp. 315
-
-
Thomas, J.T.1
Lin, K.2
Nandedkar, M.3
Camargo, M.4
Cervenka, J.5
Luyten, F.P.6
-
37
-
-
84907029403
-
Human chondrocytes respond discordantly to the protein encoded by the osteoarthritis susceptibility gene GDF5
-
M. Ratnayake, F. Plöger, M. Santibanez-Koref, and J. Loughlin Human chondrocytes respond discordantly to the protein encoded by the osteoarthritis susceptibility gene GDF5 PLoS One 9 2014 e86590
-
(2014)
PLoS One
, vol.9
-
-
Ratnayake, M.1
Plöger, F.2
Santibanez-Koref, M.3
Loughlin, J.4
-
38
-
-
66449089103
-
Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and hand
-
E. Evangelou, K. Chapman, I. Meulenbelt, F.B. Karassa, J. Loughlin, A. Carr, M. Doherty, S. Doherty, J.J. Gómez-Reino, and A. Gonzalez Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and hand Arthritis Rheum 60 2009 1710 1721
-
(2009)
Arthritis Rheum
, vol.60
, pp. 1710-1721
-
-
Evangelou, E.1
Chapman, K.2
Meulenbelt, I.3
Karassa, F.B.4
Loughlin, J.5
Carr, A.6
Doherty, M.7
Doherty, S.8
Gómez-Reino, J.J.9
Gonzalez, A.10
-
39
-
-
84874041956
-
The genetics and functional analysis of primary osteoarthritis susceptibility
-
L.N. Reynard, and J. Loughlin The genetics and functional analysis of primary osteoarthritis susceptibility Expert Rev Mol Med 15 2013 e2
-
(2013)
Expert Rev Mol Med
, vol.15
, pp. e2
-
-
Reynard, L.N.1
Loughlin, J.2
-
40
-
-
84923340852
-
Increased classical endoplasmic reticulum stress is sufficient to reduce chondrocyte proliferation rate in the growthplate and decrease bone growth
-
L.H.W. Kung, M.H. Rajpar, R. Preziosi, M.D. Briggs, and R.P. Boot-Handford Increased classical endoplasmic reticulum stress is sufficient to reduce chondrocyte proliferation rate in the growthplate and decrease bone growth PLoS One 10 2015 e0117016
-
(2015)
PLoS One
, vol.10
-
-
Kung, L.H.W.1
Rajpar, M.H.2
Preziosi, R.3
Briggs, M.D.4
Boot-Handford, R.P.5
-
41
-
-
84924855824
-
Cartilage-specific ablation of XBP1 signaling in mouse results in a chondrodysplasia characterized by reduced chondrocyte proliferation and delayed cartilage maturation and mineralization
-
T.L. Cameron, I.L. Gresshoff, K.M. Bell, K.A. Piróg, L. Sampurno, C.L. Hartley, E.M. Sanford, R. Wilson, J. Ermann, R.P. Boot-Handford, L.H. Glimcher, M.D. Briggs, and J.F. Bateman Cartilage-specific ablation of XBP1 signaling in mouse results in a chondrodysplasia characterized by reduced chondrocyte proliferation and delayed cartilage maturation and mineralization Osteoarthritis Cartilage 23 2015 661 670
-
(2015)
Osteoarthritis Cartilage
, vol.23
, pp. 661-670
-
-
Cameron, T.L.1
Gresshoff, I.L.2
Bell, K.M.3
Piróg, K.A.4
Sampurno, L.5
Hartley, C.L.6
Sanford, E.M.7
Wilson, R.8
Ermann, J.9
Boot-Handford, R.P.10
Glimcher, L.H.11
Briggs, M.D.12
Bateman, J.F.13
-
42
-
-
0032699840
-
CACP, encoding a secreted proteoglycan, is mutated in camptodactyly-arthropathy-coxa vara-pericarditis syndrome
-
J. Marcelino, J.D. Carpten, W.M. Suwairi, O.M. Gutierrez, S. Schwartz, C. Robbins, R. Sood, I. Makalowska, A. Baxevanis, B. Johnstone, R.M. Laxer, L. Zemel, C.A. Kim, J.K. Herd, J. Ihle, C. Williams, M. Johnson, V. Raman, L.G. Alonso, D. Brunoni, A. Gerstein, N. Papadopoulos, S.A. Bahabri, J.M. Trent, and M.L. Warman CACP, encoding a secreted proteoglycan, is mutated in camptodactyly-arthropathy-coxa vara-pericarditis syndrome Nat Genet 23 1999 319 322
-
(1999)
Nat Genet
, vol.23
, pp. 319-322
-
-
Marcelino, J.1
Carpten, J.D.2
Suwairi, W.M.3
Gutierrez, O.M.4
Schwartz, S.5
Robbins, C.6
Sood, R.7
Makalowska, I.8
Baxevanis, A.9
Johnstone, B.10
Laxer, R.M.11
Zemel, L.12
Kim, C.A.13
Herd, J.K.14
Ihle, J.15
Williams, C.16
Johnson, M.17
Raman, V.18
Alonso, L.G.19
Brunoni, D.20
Gerstein, A.21
Papadopoulos, N.22
Bahabri, S.A.23
Trent, J.M.24
Warman, M.L.25
more..
-
43
-
-
24744467785
-
Consequences of disease-causing mutations on lubricin protein synthesis, secretion, and post-translational processing
-
D.K.1. Rhee, J. Marcelino, S. Al-Mayouf, D.K. Schelling, C.F. Bartels, Y. Cui, R. Laxer, R. Goldbach-Mansky, and M.L. Warman Consequences of disease-causing mutations on lubricin protein synthesis, secretion, and post-translational processing J Biol Chem 280 2005 31325 31332
-
(2005)
J Biol Chem
, vol.280
, pp. 31325-31332
-
-
Rhee, D.K.1
Marcelino, J.2
Al-Mayouf, S.3
Schelling, D.K.4
Bartels, C.F.5
Cui, Y.6
Laxer, R.7
Goldbach-Mansky, R.8
Warman, M.L.9
-
44
-
-
84922308933
-
Anti-lubricin monoclonal antibodies created using lubricin-knockout mice immunodetect lubricin in several species and in patients with healthy and diseased joints
-
M. Ai, Y. Cui, M.S. Sy, D.M. Lee, L.X. Zhang, K.M. Larson, K.C. Kurek, G.D. Jay, and M.L. Warman Anti-lubricin monoclonal antibodies created using lubricin-knockout mice immunodetect lubricin in several species and in patients with healthy and diseased joints PLoS One 10 2015 e0116237
-
(2015)
PLoS One
, vol.10
-
-
Ai, M.1
Cui, Y.2
Sy, M.S.3
Lee, D.M.4
Zhang, L.X.5
Larson, K.M.6
Kurek, K.C.7
Jay, G.D.8
Warman, M.L.9
-
45
-
-
84875183983
-
Proteoglycan 4 expression protects against the development of osteoarthritis
-
M.Z. Ruan, A. Erez, K. Guse, B. Dawson, T. Bertin, Y. Chen, M.M. Jiang, J. Yustein, F. Gannon, and B.H. Lee Proteoglycan 4 expression protects against the development of osteoarthritis Sci Transl Med 5 2013 176ra134
-
(2013)
Sci Transl Med
, vol.5
, pp. 176ra134
-
-
Ruan, M.Z.1
Erez, A.2
Guse, K.3
Dawson, B.4
Bertin, T.5
Chen, Y.6
Jiang, M.M.7
Yustein, J.8
Gannon, F.9
Lee, B.H.10
-
46
-
-
0019426077
-
Progressive ankylosis, a new skeletal mutation in the mouse
-
H.O. Sweet, and M.C. Green Progressive ankylosis, a new skeletal mutation in the mouse J Hered 72 1981 87 931
-
(1981)
J Hered
, vol.72
, pp. 87-931
-
-
Sweet, H.O.1
Green, M.C.2
-
47
-
-
79651469613
-
Pathophysiology of articular chondrocalcinosis - role of ANKH
-
A. Abhishek, and M. Doherty Pathophysiology of articular chondrocalcinosis - role of ANKH Nat Rev Rheumatol 7 2011 96 104
-
(2011)
Nat Rev Rheumatol
, vol.7
, pp. 96-104
-
-
Abhishek, A.1
Doherty, M.2
-
48
-
-
84862566402
-
Decreased levels of nucleotide pyrophosphatase phosphodiesterase 1 are associated with cartilage calcification in osteoarthritis and trigger osteoarthritic changes in mice
-
J. Bertrand, Y. Nitschke, M. Fuerst, S. Hermann, M. Schäfers, J. Sherwood, G. Nalesso, W. Ruether, F. Rutsch, F. Dell'Accio, and T. Pap Decreased levels of nucleotide pyrophosphatase phosphodiesterase 1 are associated with cartilage calcification in osteoarthritis and trigger osteoarthritic changes in mice Ann Rheum Dis 71 2012 1249 1253
-
(2012)
Ann Rheum Dis
, vol.71
, pp. 1249-1253
-
-
Bertrand, J.1
Nitschke, Y.2
Fuerst, M.3
Hermann, S.4
Schäfers, M.5
Sherwood, J.6
Nalesso, G.7
Ruether, W.8
Rutsch, F.9
Dell'accio, F.10
Pap, T.11
-
49
-
-
84885537495
-
The progressive ankylosis gene product ANK regulates extracellular ATP levels in primary articular chondrocytes
-
A.K. Rosenthal, C.M. Gohr, E. Mitton-Fitzgerald, M.K. Lutz, G.R. Dubyak, and L.M. Ryan The progressive ankylosis gene product ANK regulates extracellular ATP levels in primary articular chondrocytes Arthritis Res Ther 15 2013 R154
-
(2013)
Arthritis Res Ther
, vol.15
, pp. R154
-
-
Rosenthal, A.K.1
Gohr, C.M.2
Mitton-Fitzgerald, E.3
Lutz, M.K.4
Dubyak, G.R.5
Ryan, L.M.6
-
50
-
-
84908237450
-
Recent advances in the research of an endemic osteochondropathy in China: Kashin-Beck disease
-
X. Guo, W.J. Ma, F. Zhang, F.L. Ren, C.J. Qu, and M.J. Lammi Recent advances in the research of an endemic osteochondropathy in China: Kashin-Beck disease Osteoarthritis Cartilage 22 2014 1774 1778
-
(2014)
Osteoarthritis Cartilage
, vol.22
, pp. 1774-1778
-
-
Guo, X.1
Ma, W.J.2
Zhang, F.3
Ren, F.L.4
Qu, C.J.5
Lammi, M.J.6
-
51
-
-
84908334923
-
Alkaptonuria
-
edn 2 S. Maloy, K. Hughes, Academic Press San Diego
-
J.A. Gallagher, L.R. Ranganath, and A. Zatkova Alkaptonuria edn 2 S. Maloy, K. Hughes, Brenner's Encyclopedia of Genetics vol 1 2013 Academic Press San Diego 71 75
-
(2013)
Brenner's Encyclopedia of Genetics
, vol.1
, pp. 71-75
-
-
Gallagher, J.A.1
Ranganath, L.R.2
Zatkova, A.3
-
53
-
-
54949145369
-
Alkaptonuria - a review of surgical and autopsy pathology
-
T.R. Helliwell, J.A. Gallagher, and L. Ranganath Alkaptonuria - a review of surgical and autopsy pathology Histopathology 53 2008 503 512
-
(2008)
Histopathology
, vol.53
, pp. 503-512
-
-
Helliwell, T.R.1
Gallagher, J.A.2
Ranganath, L.3
-
54
-
-
78751699292
-
Development of an in vitro model to investigate joint ochronosis in alkaptonuria
-
L. Tinti, A.M. Taylor, A. Santucci, B. Wlodarski, P.J. Wilson, J.C. Jarvis, W.D. Fraser, J.S. Davidson, L.R. Ranganath, and J.A. Gallagher Development of an in vitro model to investigate joint ochronosis in alkaptonuria Rheumatology (Oxford) 50 2011 271 277
-
(2011)
Rheumatology (Oxford)
, vol.50
, pp. 271-277
-
-
Tinti, L.1
Taylor, A.M.2
Santucci, A.3
Wlodarski, B.4
Wilson, P.J.5
Jarvis, J.C.6
Fraser, W.D.7
Davidson, J.S.8
Ranganath, L.R.9
Gallagher, J.A.10
-
55
-
-
77954196185
-
Ultrastructural examination of tissue in a patient with alkaptonuric arthropathy reveals a distinct pattern of binding of ochronotic pigment
-
A.M. Taylor, B. Wlodarski, I.A. Prior, P.J. Wilson, J.C. Jarvis, L.R. Ranganath, and J.A. Gallagher Ultrastructural examination of tissue in a patient with alkaptonuric arthropathy reveals a distinct pattern of binding of ochronotic pigment Rheumatology 49 2010 1412 1414
-
(2010)
Rheumatology
, vol.49
, pp. 1412-1414
-
-
Taylor, A.M.1
Wlodarski, B.2
Prior, I.A.3
Wilson, P.J.4
Jarvis, J.C.5
Ranganath, L.R.6
Gallagher, J.A.7
-
56
-
-
82455210470
-
The role of calcified cartilage and subchondral bone in the initiation and progression of ochronotic arthropathy in alkaptonuria
-
A.M. Taylor, A. Boyde, P.J. Wilson, J.C. Jarvis, J.S. Davidson, J.A. Hunt, L.R. Ranganath, and J.A. Gallagher The role of calcified cartilage and subchondral bone in the initiation and progression of ochronotic arthropathy in alkaptonuria Arthritis Rheum 63 2011 3887 3896
-
(2011)
Arthritis Rheum
, vol.63
, pp. 3887-3896
-
-
Taylor, A.M.1
Boyde, A.2
Wilson, P.J.3
Jarvis, J.C.4
Davidson, J.S.5
Hunt, J.A.6
Ranganath, L.R.7
Gallagher, J.A.8
-
57
-
-
84863003048
-
Ochronosis in a murine model of alkaptonuria is synonymous to that in the human condition
-
A.M. Taylor, A.J. Preston, N.K. Paulk, H. Sutherland, C.M. Keenan, P.J. Wilson, B. Wlodarski, M. Grompe, L.R. Ranganath, J.A. Gallagher, and J.C. Jarvis Ochronosis in a murine model of alkaptonuria is synonymous to that in the human condition Osteoarthritis Cartilage 20 2012 880 886
-
(2012)
Osteoarthritis Cartilage
, vol.20
, pp. 880-886
-
-
Taylor, A.M.1
Preston, A.J.2
Paulk, N.K.3
Sutherland, H.4
Keenan, C.M.5
Wilson, P.J.6
Wlodarski, B.7
Grompe, M.8
Ranganath, L.R.9
Gallagher, J.A.10
Jarvis, J.C.11
-
58
-
-
84889672004
-
Ochronotic osteoarthropathy in a mouse model of alkaptonuria, and itsinhibition by nitisinone
-
A.J. Preston, C.M. Keenan, H. Sutherland, P.J. Wilson, B. Wlodarski, A.M. Taylor, D.P. Williams, L.R. Ranganath, J.A. Gallagher, and J.C. Jarvis Ochronotic osteoarthropathy in a mouse model of alkaptonuria, and itsinhibition by nitisinone Ann Rheum Dis 73 2014 284 289
-
(2014)
Ann Rheum Dis
, vol.73
, pp. 284-289
-
-
Preston, A.J.1
Keenan, C.M.2
Sutherland, H.3
Wilson, P.J.4
Wlodarski, B.5
Taylor, A.M.6
Williams, D.P.7
Ranganath, L.R.8
Gallagher, J.A.9
Jarvis, J.C.10
-
59
-
-
0036164004
-
Crosslinking by advanced glycation end products increases the stiffness of the collagen network in human articular cartilage: a possible mechanism through which age is a risk factor for osteoarthritis
-
N. Verzijl, J. DeGroot, Z.C. Ben, O. Brau-Benjamin, A. Maroudas, R.A. Bank, J. Mizrahi, C.G. Schalkwijk, S.R. Thorpe, J.W. Baynes, J.W. Bijlsma, F.P. Lafeber, and J.M. TeKoppele Crosslinking by advanced glycation end products increases the stiffness of the collagen network in human articular cartilage: a possible mechanism through which age is a risk factor for osteoarthritis Arthritis Rheum 46 2002 114 123
-
(2002)
Arthritis Rheum
, vol.46
, pp. 114-123
-
-
Verzijl, N.1
Degroot, J.2
Ben, Z.C.3
Brau-Benjamin, O.4
Maroudas, A.5
Bank, R.A.6
Mizrahi, J.7
Schalkwijk, C.G.8
Thorpe, S.R.9
Baynes, J.W.10
Bijlsma, J.W.11
Lafeber, F.P.12
Tekoppele, J.M.13
-
60
-
-
79959807956
-
Diabetes-induced osteoarthritis: from a new paradigm to a new phenotype
-
F. Berenbaum Diabetes-induced osteoarthritis: from a new paradigm to a new phenotype Ann Rheum Dis 70 2011 1354 1356 10.1136/ard.2010.146399
-
(2011)
Ann Rheum Dis
, vol.70
, pp. 1354-1356
-
-
Berenbaum, F.1
-
61
-
-
79957917510
-
Immunohistochemical distribution of advanced glycation end products (AGEs) in human osteoarthritic cartilage
-
J. Hirose, S. Yamabe, K. Takada, N. Okamoto, R. Nagai, and H. Mizuta Immunohistochemical distribution of advanced glycation end products (AGEs) in human osteoarthritic cartilage Acta Histochem 113 2011 613 618
-
(2011)
Acta Histochem
, vol.113
, pp. 613-618
-
-
Hirose, J.1
Yamabe, S.2
Takada, K.3
Okamoto, N.4
Nagai, R.5
Mizuta, H.6
-
62
-
-
84908335859
-
On fragmenting, densely mineralised acellular protrusions into articular cartilage and their possible role in osteoarthritis
-
A. Boyde, G.R. Davis, D. Mills, T. Zikmund, T.M. Cox, V.L. Adams, A. Niker, P.J. Wilson, J.P. Dillon, L.R. Ranganath, N. Jeffery, J.C. Jarvis, and J.A. Gallagher On fragmenting, densely mineralised acellular protrusions into articular cartilage and their possible role in osteoarthritis J Anat 225 2014 436 446
-
(2014)
J Anat
, vol.225
, pp. 436-446
-
-
Boyde, A.1
Davis, G.R.2
Mills, D.3
Zikmund, T.4
Cox, T.M.5
Adams, V.L.6
Niker, A.7
Wilson, P.J.8
Dillon, J.P.9
Ranganath, L.R.10
Jeffery, N.11
Jarvis, J.C.12
Gallagher, J.A.13
-
63
-
-
0027463842
-
Microcracks in articular calcified cartilage of human femoral heads
-
S. Mori, R. Harruff, and D.B. Burr Microcracks in articular calcified cartilage of human femoral heads Arch Pathol Lab Med 117 1993 196 198
-
(1993)
Arch Pathol Lab Med
, vol.117
, pp. 196-198
-
-
Mori, S.1
Harruff, R.2
Burr, D.B.3
-
64
-
-
0027458771
-
Microcracks in the calcified layer of articularcartilage
-
L. Sokoloff Microcracks in the calcified layer of articularcartilage Arch Pathol Lab Med 117 1993 191 195
-
(1993)
Arch Pathol Lab Med
, vol.117
, pp. 191-195
-
-
Sokoloff, L.1
-
65
-
-
0042066398
-
The real response of bone to exercise
-
A. Boyde The real response of bone to exercise J Anat 203 2003 173 189
-
(2003)
J Anat
, vol.203
, pp. 173-189
-
-
Boyde, A.1
-
66
-
-
80053095490
-
Cartilage damage involving extrusion of mineralisable matrix from the articular calcified cartilage and subchondral bone
-
A. Boyde, C.M. Riggs, A.J. Bushby, B. McDermott, G.L. Pinchbeck, and P.D. Clegg Cartilage damage involving extrusion of mineralisable matrix from the articular calcified cartilage and subchondral bone Eur Cell Mater 21 2011 470 478
-
(2011)
Eur Cell Mater
, vol.21
, pp. 470-478
-
-
Boyde, A.1
Riggs, C.M.2
Bushby, A.J.3
McDermott, B.4
Pinchbeck, G.L.5
Clegg, P.D.6
-
67
-
-
84865561363
-
Identification of trabecular excrescences, novel microanatomical structures, present in bone in osteoarthropathies
-
A.M. Taylor, A. Boyde, J.S. Davidson, J.C. Jarvis, L.R. Ranganath, and J.A. Gallagher Identification of trabecular excrescences, novel microanatomical structures, present in bone in osteoarthropathies Eur Cell Mater 23 2012 300 308
-
(2012)
Eur Cell Mater
, vol.23
, pp. 300-308
-
-
Taylor, A.M.1
Boyde, A.2
Davidson, J.S.3
Jarvis, J.C.4
Ranganath, L.R.5
Gallagher, J.A.6
-
68
-
-
80053983922
-
Bisphosphonates for osteoarthritis
-
D.A. Walsh, and V. Chapman Bisphosphonates for osteoarthritis Arthritis Res Ther 13 2011 128
-
(2011)
Arthritis Res Ther
, vol.13
, pp. 128
-
-
Walsh, D.A.1
Chapman, V.2
-
69
-
-
84872091677
-
Efficacy and safety of strontium ranelate in the treatment of knee osteoarthritis: results of a double-blind, randomised placebo-controlled trial
-
J.Y. Reginster, J. Badurski, N. Bellamy, W. Bensen, R. Chapurlat, X. Chevalier, C. Christiansen, H. Genant, F. Navarro, E. Nasonov, P.N. Sambrook, T.D. Spector, and C. Cooper Efficacy and safety of strontium ranelate in the treatment of knee osteoarthritis: results of a double-blind, randomised placebo-controlled trial Ann Rheum Dis 72 2013 179 186
-
(2013)
Ann Rheum Dis
, vol.72
, pp. 179-186
-
-
Reginster, J.Y.1
Badurski, J.2
Bellamy, N.3
Bensen, W.4
Chapurlat, R.5
Chevalier, X.6
Christiansen, C.7
Genant, H.8
Navarro, F.9
Nasonov, E.10
Sambrook, P.N.11
Spector, T.D.12
Cooper, C.13
-
70
-
-
84868236593
-
Staining plastic blocks with triiodide to image cells and soft tissues in backscattered electron SEM of skeletal and dental tissues
-
A. Boyde Staining plastic blocks with triiodide to image cells and soft tissues in backscattered electron SEM of skeletal and dental tissues Eur Cell Mater 24 2012 154 160
-
(2012)
Eur Cell Mater
, vol.24
, pp. 154-160
-
-
Boyde, A.1
|