Increased classical endoplasmic reticulum stress is sufficient to reduce chondrocyte proliferation rate in the growth plate and decrease bone growth

PLoS ONE

Volumn 10, Issue 2, 2015, Pages

  Kung, Louise H W ^a   Rajpar, M Helen ^a   Preziosi, Richard ^b   Briggs, Michael D ^c   Boot Handford, Raymond P ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 2; GLUCOSE REGULATED PROTEIN 78; INITIATION FACTOR 2ALPHA; X BOX BINDING PROTEIN 1; THYROGLOBULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BONE GROWTH; CARTILAGE CELL; CELL PROLIFERATION; CELL STRUCTURE; CHONDRODYSPLASIA; CLINICAL FEATURE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION; GROWTH PLATE; MOUSE; MULTIPLE EPIPHYSEAL DYSPLASIA; NONHUMAN; PATHOGENESIS; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PSEUDOACHONDROPLASIA; TRANSGENIC MOUSE; UNFOLDED PROTEIN RESPONSE; ANIMAL; BONE DEVELOPMENT; CYTOLOGY; DWARFISM; EXTRACELLULAR MATRIX; FEMALE; GENETICS; MALE; METABOLISM; PATHOLOGY;

MUS; MUS MUSCULUS;

ANIMALS; BONE DEVELOPMENT; CELL PROLIFERATION; CHONDROCYTES; COLLAGEN TYPE II; DWARFISM; ENDOPLASMIC RETICULUM STRESS; EXTRACELLULAR MATRIX; FEMALE; GROWTH PLATE; MALE; MICE; MICE, TRANSGENIC; OSTEOCHONDRODYSPLASIAS; PROMOTER REGIONS, GENETIC; THYROGLOBULIN; UNFOLDED PROTEIN RESPONSE;

EID: 84923340852     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0117016     Document Type: Article

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