Decreased levels of nucleotide pyrophosphatase phosphodiesterase 1 are associated with cartilage calcification in osteoarthritis and trigger osteoarthritic changes in mice

Annals of the Rheumatic Diseases

Volumn 71, Issue 7, 2012, Pages 1249-1253

  Bertrand, Jessica ^a   Nitschke, Y ^b   Fuerst, M ^c   Hermann, S ^d   Schafers M ^b,d   Sherwood, J ^a   Nalesso, G ^a   Ruether, W ^e   Rutsch, F ^b   Dell'Accio, F ^a   Pap, T ^b  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^c MedBaltic ^*  (Germany)

^d UNIVERSITY OF MÜNSTER   (Germany)

^e UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 10; FLUORINE 18; MESSENGER RNA; NUCLEOTIDE PYROPHOSPHATASE PHOSPHODIESTERASE; PHOSPHODIESTERASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE METABOLISM; CALCIFICATION; CARTILAGE; CARTILAGE CALCIFICATION; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE ASSOCIATION; DISEASE SEVERITY; DOWN REGULATION; ENZYME ACTIVITY; EXPERIMENTAL MOUSE; GENE; GENE EXPRESSION; GENETIC CORRELATION; HETEROZYGOSITY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; IN VIVO STUDY; INFLAMMATION; LOSS OF FUNCTION MUTATION; MAJOR CLINICAL STUDY; MOUSE; NONHUMAN; NPP1 GENE; OSSIFICATION; OSTEOARTHRITIS; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE STUDY; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WILD TYPE;

ALKALINE PHOSPHATASE; ANIMALS; ARTHRITIS, EXPERIMENTAL; BIOLOGICAL MARKERS; CALCINOSIS; CARTILAGE, ARTICULAR; COLLAGEN TYPE X; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; MICE; MICE, KNOCKOUT; OSTEOARTHRITIS, KNEE; PHOSPHATE TRANSPORT PROTEINS; PHOSPHORIC DIESTER HYDROLASES; PYROPHOSPHATASES; RNA, MESSENGER; SEVERITY OF ILLNESS INDEX; SIGNAL TRANSDUCTION; STIFLE;

EID: 84862566402     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/annrheumdis-2011-200892     Document Type: Article

References (17)

1. Atzeni F, Sarzi-Puttini P, Bevilacqua M. Calcium deposition and associated chronic diseases (atherosclerosis, diffuse idiopathic skeletal hyperostosis, and others). Rheum Dis Clin North Am 2006;32:413-26, viii.
2. Fuerst M, Bertrand J, Lammers L, et al. Calcification of articular cartilage in human osteoarthritis. Arthritis Rheum 2009;60:2694-703.
3. Rutsch F, Nitschke Y, Terkeltaub R. Genetics in arterial calcification: pieces of a puzzle and cogs in a wheel. Circ Res 2011;109:578-92.
4. Ea HK, Nguyen C, Bazin D, et al. Articular cartilage calcification in osteoarthritis: insights into crystal-induced stress. Arthritis Rheum 2011;63:10-18.
5. Terkeltaub RA. Inorganic pyrophosphate generation and disposition in pathophysiology. Am J Physiol, Cell Physiol 2001;281:C1-C11.
6. Hessle L, Johnson KA, Anderson HC, et al. Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization. Proc Natl Acad Sci USA 2002;99:9445-9.
7. Ho AM, Johnson MD, Kingsley DM. Role of the mouse ank gene in control of tissue calcification and arthritis. Science 2000;289:265-70.
8. Terkeltaub R, Rosenbach M, Fong F, et al. Causal link between nucleotide pyrophosphohydrolase overactivity and increased intracellular inorganic pyrophosphate generation demonstrated by transfection of cultured fibroblasts and osteoblasts with plasma cell membrane glycoprotein-1. Relevance to calcium pyrophosphate dihydrate deposition disease. Arthritis Rheum 1994;37:934-41.
9. Johnson K, Hashimoto S, Lotz M, et al. Up-regulated expression of the phosphodiesterase nucleotide pyrophosphatase family member PC-1 is a marker and pathogenic factor for knee meniscal cartilage matrix calcification. Arthritis Rheum 2001;44:1071-81.
10. Rutsch F, Terkeltaub R. Parallels between arterial and cartilage calcification: what understanding artery calcification can teach us about chondrocalcinosis. Curr Opin Rheumatol 2003;15:302-10.
11. Suk EK, Malkin I, Dahm S, et al. Association of ENPP1 gene polymorphisms with hand osteoarthritis in a Chuvasha population. Arthritis Res Ther 2005;7:R1082-90.
12. Okawa A, Nakamura I, Goto S, et al. Mutation in Npps in a mouse model of ossification of the posterior longitudinal ligament of the spine. Nat Genet 1998;19:271-3.
13. Glasson SS, Blanchet TJ, Morris EA. The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129/SvEv mouse. Osteoarthr Cartil 2007;15:1061-9.
14. Ostergaard K, Petersen J, Andersen CB, et al. Histologic/histochemical grading system for osteoarthritic articular cartilage: reproducibility and validity. Arthritis Rheum 1997;40:1766-71.
15. Lotz M, Rosen F, McCabe G, et al. Interleukin 1 beta suppresses transforming growth factor-induced inorganic pyrophosphate (PPi) production and expression of the PPi-generating enzyme PC-1 in human chondrocytes. Proc Natl Acad Sci USA 1995;92:10364-8.
16. von der Mark K, Kirsch T, Nerlich A, et al. Type X collagen synthesis in human osteoarthritic cartilage. Indication of chondrocyte hypertrophy. Arthritis Rheum 1992;35:806-11.
17. Goldring MB, Otero M, Tsuchimochi K, et al. Defining the roles of inflammatory and anabolic cytokines in cartilage metabolism. Ann Rheum Dis 2008;67 (Suppl 3):iii75-82.