Cartilage-specific ablation of XBP1 signaling in mouse results in a chondrodysplasia characterized by reduced chondrocyte proliferation and delayed cartilage maturation and mineralization

Osteoarthritis and Cartilage

Volumn 23, Issue 4, 2015, Pages 661-670

  Cameron, T L ^a   Gresshoff, I L ^a   Bell, K M ^a   Pirog K A ^b   Sampurno, L ^a   Hartley, C L ^c   Sanford, E M ^a   Wilson, R ^a   Ermann, J ^d,e   Boot Handford, R P ^f   Glimcher, L H ^g   Briggs, M D ^b   Bateman, J F ^a,h  

^a MURDOCH CHILDREN'S RESEARCH INSTITUTE   (Australia)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c MANCHESTER UNIVERSITY NHS FOUNDATION TRUST   (United Kingdom)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

^f UNIVERSITY OF MANCHESTER   (United Kingdom)

^g WEILL CORNELL MEDICAL COLLEGE   (United States)

^h UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Chondrodysplasia; Endochondral ossification; ER stress; Growth plate; XBP1

Indexed keywords

COLLAGEN TYPE 10; COLLAGEN TYPE 2; PROTEIN IRE1; SONIC HEDGEHOG PROTEIN; TUNICAMYCIN; X BOX BINDING PROTEIN 1; DNA BINDING PROTEIN; ERN2 PROTEIN, MOUSE; MEMBRANE PROTEIN; PROTEIN SERINE THREONINE KINASE; REGULATORY FACTOR X TRANSCRIPTION FACTORS; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BONE GROWTH; BONE MATURATION; BONE MINERALIZATION; CARTILAGE CELL; CARTILAGE MATRIX; CELL CULTURE; CELL PROLIFERATION; CHONDRODYSPLASIA; CONTROLLED STUDY; EMBRYO; ENCHONDRAL OSSIFICATION; ENDOPLASMIC RETICULUM STRESS; EXON; GROWTH PLATE; HISTOLOGY; IMMUNOFLUORESCENCE; MORPHOMETRICS; MOUSE; NICK END LABELING; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UNFOLDED PROTEIN RESPONSE; UPREGULATION; ANIMAL; ARTICULAR CARTILAGE; DISEASE MODEL; GENE DELETION; GENETICS; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; TRANSGENIC MOUSE;

ANIMALS; APOPTOSIS; CALCIFICATION, PHYSIOLOGIC; CARTILAGE, ARTICULAR; CELL PROLIFERATION; CHONDROCYTES; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; ENDOPLASMIC RETICULUM STRESS; GENE DELETION; GROWTH PLATE; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; OSTEOCHONDRODYSPLASIAS; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 84924855824     PISSN: 10634584     EISSN: 15229653     Source Type: Journal    
DOI: 10.1016/j.joca.2015.01.001     Document Type: Article

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