Human chondrocytes respond discordantly to the protein encoded by the osteoarthritis susceptibility gene GDF5

PLoS ONE

Volumn 9, Issue 1, 2014, Pages

  Ratnayake, Madhushika ^a   Plöger, Frank ^b   Santibanez Koref, Mauro ^a   Loughlin, John ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b Biopharm GmbH ^*  (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN RECEPTOR 1A; CELL PROTEIN; COLLAGEN; COLLAGEN TYPE 2A1; COLLAGENASE 3; GROWTH DIFFERENTIATION FACTOR 5; INTERSTITIAL COLLAGENASE; NOGGIN; RECOMBINANT PROTEIN; SMAD PROTEIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CARTILAGE CELL; CELL NUCLEUS; CELL STIMULATION; CONTROLLED STUDY; CULTURE TECHNIQUE; DOWN REGULATION; GDF5 GENE; GENE EXPRESSION; GENETIC SUSCEPTIBILITY; GENETIC TRANSFECTION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; JOINT PROSTHESIS; LUCIFERASE ASSAY; MONOLAYER CULTURE; OSTEOARTHRITIS; POLYMERASE CHAIN REACTION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; RECEPTOR BINDING; RECEPTOR GENE; WILD TYPE;

CARTILAGE; CELL LINE; CHONDROCYTES; DOWN-REGULATION; GENE EXPRESSION; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GROWTH DIFFERENTIATION FACTOR 5; HUMANS; OSTEOARTHRITIS; PHOSPHORYLATION; SMAD PROTEINS; TRANSFORMING GROWTH FACTOR BETA1; UP-REGULATION;

EID: 84907029403     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0086590     Document Type: Article

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