Anti-lubricin monoclonal antibodies created using lubricin-knockout mice immunodetect lubricin in several species and in patients with healthy and diseased joints

PLoS ONE

Volumn 10, Issue 2, 2015, Pages

  Ai, Minrong ^a,f   Cui, Yajun ^a,g   Sy, Man Sun ^a   Lee, David M ^b,h   Zhang, Ling Xiu ^c   Larson, Katherine M ^c,d   Kurek, Kyle C ^e,i   Jay, Gregory D ^c,d   Warman, Matthew L ^a,e  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c RHODE ISLAND HOSPITAL   (United States)

^d Brown University   (United States)

^e BOSTON CHILDREN S HOSPITAL   (United States)

^f ELI LILLY AND COMPANY   (United States)

^g HARVARD SCHOOL OF DENTAL MEDICINE   (United States)

^h NOVARTIS PHARMA AG   (Switzerland)

ⁱ UNIVERSITY OF CALGARY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

LUBRICIN; LUBRICIN MONOCLONAL ANTIBODY; LYSYLGLUTAMYLPROLYLALANYLPROLYLTHREONYLTHREONYLTHREONINE; MONOCLONAL ANTIBODY; O LINKED OLIGOSACCHARIDE; OLIGOSACCHARIDE; PEPTIDE; PROTEIN; UNCLASSIFIED DRUG; EPITOPE; GLYCOPROTEIN; OLIGOPEPTIDE;

ADULT; AGED; ANTIBODY DETECTION; ANTIBODY SPECIFICITY; ANTIGEN BINDING; ANTIGEN RECOGNITION; ARTICLE; BLOOD SAMPLING; CAMPTODACTYLY ARTHROPATHY COXA VARA PERICARDITIS SYNDROME; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CROSS REACTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENETIC DISORDER; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNODETECTION; IMMUNOHISTOLOGY; IMMUNOPRECIPITATION; KNOCKOUT MOUSE; MALE; MIDDLE AGED; MOUSE; MUSCULOSKELETAL DISEASE; NONHUMAN; PROTEIN BLOOD LEVEL; PROTEIN PROCESSING; SYNOVIAL FLUID; WESTERN BLOTTING; AMINO ACID SEQUENCE; ANIMAL; BLOOD; CASE CONTROL STUDY; CHEMISTRY; COXA VARA; DEFICIENCY; GENETICS; HAND MALFORMATION; IMMUNOLOGY; JOINT; METABOLISM; NEUROPATHIC JOINT DISEASE; SYNOVITIS;

ANIMALIA; MUS;

ADULT; AGED; AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; ARTHROPATHY, NEUROGENIC; CASE-CONTROL STUDIES; COXA VARA; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES; FEMALE; GLYCOPROTEINS; HAND DEFORMITIES, CONGENITAL; HUMANS; JOINTS; MALE; MICE; MICE, KNOCKOUT; MIDDLE AGED; OLIGOPEPTIDES; OLIGOSACCHARIDES; SYNOVIAL FLUID; SYNOVITIS;

EID: 84922308933     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0116237     Document Type: Article

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