Optimizing recombinant antibodies for intracellular function using hitchhiker-mediated survival selection

Protein Engineering, Design and Selection

Volumn 27, Issue 10, 2014, Pages 351-358

  Waraho Zhmayev, Dujduan ^a,b   Meksiriporn, Bunyarit ^a   Portnoff, Alyse D ^a   DeLisa, Matthew P ^a   Bradbury, Andrew ^c  

^a School of Chemical and Molecular Engineering   (United States)

^b KING MONGKUT'S UNIVERSITY OF TECHNOLOGY THONBURI   (Thailand)

^c NONE

Author keywords

Antigen binding affinity; Directed evolution; Intracellular antibody engineering; Protein folding and stability; Twin arginine translocation

Indexed keywords

ANTIGENS; ARGININE; BINDING ENERGY; CYTOLOGY; ESCHERICHIA COLI; TRANSCRIPTION;

ANTIGEN-BINDING AFFINITY; DIMERIZATION DOMAIN; DIRECTED EVOLUTION; ESCHERICHIA COLI CELLS; INTRACELLULAR ANTIBODIES; INTRACELLULAR STABILITY; RECOMBINANT ANTIBODY; TWIN-ARGININE TRANSLOCATIONS;

ANTIBODIES;

ALPHA SYNUCLEIN; RECOMBINANT ANTIBODY; BASIC LEUCINE ZIPPER TRANSCRIPTION FACTOR; CARRIER PROTEIN; ESCHERICHIA COLI PROTEIN; GCN4 PROTEIN, S CEREVISIAE; HYBRID PROTEIN; PROTEIN BINDING; SACCHAROMYCES CEREVISIAE PROTEIN; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; TWIN-ARGININE TRANSLOCASE COMPLEX, E COLI;

ANTIGEN BINDING; BACTERIAL CELL; BACTERIAL GROWTH; CELL FRACTIONATION; CELL FUNCTION; CELL ISOLATION; CELL SURVIVAL; CONFERENCE PAPER; DIMERIZATION; ESCHERICHIA COLI; GENETIC SELECTION; IMMOBILIZATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN PURIFICATION; WESTERN BLOTTING; CHEMISTRY; CYTOPLASM; DIRECTED MOLECULAR EVOLUTION; GENETICS; INTRACELLULAR SPACE; METABOLISM; PROCEDURES; PROTEIN ENGINEERING; PROTEIN FOLDING; PROTEIN STABILITY;

ALPHA-SYNUCLEIN; BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS; DIRECTED MOLECULAR EVOLUTION; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; INTRACELLULAR SPACE; MEMBRANE TRANSPORT PROTEINS; PERIPLASM; PROTEIN BINDING; PROTEIN ENGINEERING; PROTEIN FOLDING; PROTEIN STABILITY; RECOMBINANT FUSION PROTEINS; SACCHAROMYCES CEREVISIAE PROTEINS; SINGLE-CHAIN ANTIBODIES;

EID: 84930801563     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzu038     Document Type: Conference Paper

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