ROCK2 primes the endothelium for vascular hyperpermeability responses by raising baseline junctional tension

Vascular Pharmacology

Volumn 70, Issue , 2015, Pages 45-54

  Beckers, Cora M L ^a   Knezevic, Nebojsa ^b   Valent, Erik T ^a   Tauseef, Mohammad ^b   Krishnan, Ramaswamy ^c   Rajendran, Kavitha ^c   Hardin, C Corey ^d   Aman, Jurjan ^a   van Bezu, Jan ^a   Sweetnam, Paul ^e   van Hinsbergh, Victor W M ^a   Mehta, Dolly ^b   van Nieuw Amerongen, Geerten P ^a,b  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF ILLINOIS   (United States)

^c BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

^e NONE   (United States)

Author keywords

Contraction; Endothelial; HUVEC; Permeability; Rho kinase

Indexed keywords

RHO ASSOCIATED KINASE 1; RHO ASSOCIATED KINASE 2; RHO KINASE; THROMBIN RECEPTOR; UNCLASSIFIED DRUG; PROTEIN KINASE INHIBITOR; ROCK1 PROTEIN, HUMAN; ROCK1 PROTEIN, MOUSE; ROCK2 PROTEIN, HUMAN; ROCK2 PROTEIN, MOUSE; THROMBIN;

ARTICLE; BLOOD VESSEL PERMEABILITY; CELL JUNCTION; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY MECHANISM; TENSION; VASCULAR ENDOTHELIUM; VASCULAR HYPERPERMEABILITY; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CAPILLARY PERMEABILITY; CELL CULTURE; DRUG EFFECTS; ENDOTHELIUM CELL; ENZYMOLOGY; GENETIC TRANSFECTION; GENETICS; IMPEDANCE; METABOLISM; RNA INTERFERENCE; SIGNAL TRANSDUCTION; STRESS FIBER; TIME FACTOR; TRANSGENIC MOUSE; UMBILICAL VEIN ENDOTHELIAL CELL;

ANIMALS; CAPILLARY PERMEABILITY; CELLS, CULTURED; ELECTRIC IMPEDANCE; ENDOTHELIAL CELLS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INTERCELLULAR JUNCTIONS; MICE, INBRED C57BL; MICE, TRANSGENIC; PROTEIN KINASE INHIBITORS; RHO-ASSOCIATED KINASES; RNA INTERFERENCE; SIGNAL TRANSDUCTION; STRESS FIBERS; THROMBIN; TIME FACTORS; TRANSFECTION;

EID: 84930766547     PISSN: 15371891     EISSN: 18793649     Source Type: Journal    
DOI: 10.1016/j.vph.2015.03.017     Document Type: Article

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