Activation of sphingosine kinase-1 reverses the increase in lung vascular permeability through sphingosine-1-phosphate receptor signaling in endothelial cells

Circulation Research

Volumn 103, Issue 10, 2008, Pages 1164-1172

  Tauseef, Mohammad ^a,b   Kini, Vidisha ^a,b   Knezevic, Nebojsa ^a,b   Brannan, Melissa ^a,b   Ramchandaran, Ram ^a,b   Fyrst, Henrik ^c   Saba, Julie ^c   Vogel, Stephen M ^a,b   Malik, Asrar B ^a,b   Mehta, Dolly ^a,b  

^a Center for Lung and Vascular Biology   (United States)

^b UNIVERSITY OF ILLINOIS   (United States)

^c CHILDREN S HOSPITAL OAKLAND RESEARCH INSTITUTE   (United States)

Author keywords

Lung vascular permeability; PAR 1; RhoGTPases; S1P; S1P1; Sphingosine kinase; Thrombin

Indexed keywords

LIPOPOLYSACCHARIDE; PROTEINASE ACTIVATED RECEPTOR 1; RAC1 PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE KINASE 1; THROMBIN; AUTACOID; DRUG DERIVATIVE; HEMOSTATIC AGENT; LYSOPHOSPHOLIPID; NEUROPEPTIDE; PHOSPHOTRANSFERASE; RAC PROTEIN; RAC1 PROTEIN, HUMAN; RAC1 PROTEIN, MOUSE; S1PR1 PROTEIN, HUMAN; SPHINGOSINE; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1-PHOSPHATE; SPHINGOSINE KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL PERMEABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEFICIENCY; ENZYME RELEASE; ENZYME SYNTHESIS; HOMEOSTASIS; HUMAN; HUMAN CELL; LIGATION; LUNG; LUNG BLOOD VESSEL; LUNG EDEMA; MALE; MOUSE; NONHUMAN; PARACRINE SIGNALING; PRIORITY JOURNAL; VASCULAR ENDOTHELIUM; WILD TYPE; ANIMAL; CAPILLARY PERMEABILITY; CELL CULTURE; CELL JUNCTION; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; GENETICS; METABOLISM; MOUSE MUTANT; SIGNAL TRANSDUCTION;

ANIMALS; CAPILLARY PERMEABILITY; CELLS, CULTURED; ENZYME ACTIVATION; HEMOSTATICS; HUMANS; INFLAMMATION MEDIATORS; INTERCELLULAR JUNCTIONS; LIPOPOLYSACCHARIDES; LUNG; LYSOPHOSPHOLIPIDS; MICE; MICE, KNOCKOUT; NEUROPEPTIDES; PARACRINE COMMUNICATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PULMONARY EDEMA; RAC GTP-BINDING PROTEINS; RAC1 GTP-BINDING PROTEIN; RECEPTOR, PAR-1; RECEPTORS, LYSOSPHINGOLIPID; SIGNAL TRANSDUCTION; SPHINGOSINE; THROMBIN;

EID: 58149174403     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/01.RES.0000338501.84810.51     Document Type: Article

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