Substrate stiffening promotes endothelial monolayer disruption through enhanced physical forces

American Journal of Physiology - Cell Physiology

Volumn 300, Issue 1, 2011, Pages

  Krishnan, Ramaswamy ^a   Klumpers, Darinka D ^a   Park, Chan Y ^a   Rajendran, Kavitha ^a   Trepat, Xavier ^b   Van Bezu, Jan ^c   Van Hinsbergh, Victor W M ^c   Carman, Christopher V ^d   Brain, Joseph D ^a   Fredberg, Jeffrey J ^a   Butler, James P ^d   Van Nieuw Amerongen, Geerten P ^c  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b UNIVERSITY OF BARCELONA   (Spain)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Cell cell contact; Cell substrate contact; Contraction; Human umbilical vein endothelial cells; Permeability; Rho kinase; Substrate stiffness; Thrombin; Traction force; Vascular endothelial cadherin

Indexed keywords

CADHERIN; RHO KINASE; THROMBIN;

ARTICLE; CELL ADHESION; CELL CONTACT; CELL DISRUPTION; CELL INTERACTION; CELLULAR FORCE; ENDOTHELIUM CELL; ENZYME ACTIVITY; FORCE; HUMAN; HUMAN CELL; MICROENVIRONMENT; PRIORITY JOURNAL;

ACRYLIC RESINS; ANTIGENS, CD; BIOMECHANICS; CADHERINS; CELL ADHESION; CELLS, CULTURED; CULTURE MEDIA; ENDOTHELIAL CELLS; HUMANS; MEMBRANES, ARTIFICIAL; MICROSCOPY; RHO-ASSOCIATED KINASES; THROMBIN;

EID: 78649699036     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00195.2010     Document Type: Article

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