Pretreatment of Rho kinase inhibitor inhibits systemic inflammation and prevents endotoxin-induced acute lung injury in mice

Journal of Surgical Research

Volumn 171, Issue 2, 2011, Pages

  Ding, Ren Yu ^a   Zhao, Dong Mei ^a   Zhang, Zhi Dan ^a   Guo, Ren Xuan ^a   Ma, Xiao Chun ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

acute lung injury; AP 1; fasudil; inflammation; Rho kinase; septic shock; survival

Indexed keywords

ENDOTOXIN; FASUDIL; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MESSENGER RNA; MYELOPEROXIDASE; SODIUM CHLORIDE; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA;

ACUTE LUNG INJURY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD CELL; BLOOD SAMPLING; CELL SURVIVAL; CONTROLLED STUDY; DNA BINDING; DRUG INDUCED DISEASE; ENDOTOXEMIA; ENZYME ACTIVITY; GENE EXPRESSION; HISTOPATHOLOGY; IMMUNE RESPONSE; LETHALITY; LUNG PARENCHYMA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEPSIS; SURVIVAL RATE;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; ACUTE LUNG INJURY; ANIMALS; DISEASE MODELS, ANIMAL; INFLAMMATION; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED C57BL; PEROXIDASE; PROTEIN KINASE INHIBITORS; RHO-ASSOCIATED KINASES; SURVIVAL RATE; TRANSCRIPTION FACTOR AP-1; TUMOR NECROSIS FACTOR-ALPHA;

EID: 81155139675     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2011.08.009     Document Type: Article

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