메뉴 건너뛰기




Volumn 11, Issue 3, 2015, Pages 229-237

Beclin 1 biology and its role in heart disease

Author keywords

Autophagy; Beclin 1; Gene expression; Heart; MicroRNA; Post translational modification; Protein interaction

Indexed keywords

BECLIN 1; APOPTOSIS REGULATORY PROTEIN; BECN1 PROTEIN, HUMAN; MEMBRANE PROTEIN; MICRORNA;

EID: 84930688637     PISSN: 1573403X     EISSN: 18756557     Source Type: Journal    
DOI: 10.2174/1573403X10666141106104606     Document Type: Article
Times cited : (47)

References (88)
  • 1
    • 0034537290 scopus 로고    scopus 로고
    • Autophagy as a regulated pathway of cellular degradation
    • Klionsky DJ, Emr SD. Autophagy as a regulated pathway of cellular degradation. Science 2000; 290: 1717-21.
    • (2000) Science , vol.290 , pp. 1717-1721
    • Klionsky, D.J.1    Emr, S.D.2
  • 2
    • 27644484061 scopus 로고    scopus 로고
    • Autophagy: Molecular machinery for self-eating
    • Yorimitsu T, Klionsky DJ. Autophagy: molecular machinery for self-eating. Cell Death Differ 2005; 12: 1542-52.
    • (2005) Cell Death Differ , vol.12 , pp. 1542-1552
    • Yorimitsu, T.1    Klionsky, D.J.2
  • 4
    • 84873660610 scopus 로고    scopus 로고
    • Autophagy in human health and disease
    • Choi AM, Ryter SW, Levine B. Autophagy in human health and disease. N Engl J Med 2013; 368: 1845-6.
    • (2013) N Engl J Med , vol.368 , pp. 1845-1846
    • Choi, A.M.1    Ryter, S.W.2    Levine, B.3
  • 5
    • 10744225487 scopus 로고    scopus 로고
    • A unified nomenclature for yeast autophagy-related genes
    • Klionsky DJ, Cregg JM, Dunn WA Jr, et al. A unified nomenclature for yeast autophagy-related genes. Dev Cell 2003; 5: 539-45.
    • (2003) Dev Cell , vol.5 , pp. 539-545
    • Klionsky, D.J.1    Cregg, J.M.2    Dunn, W.A.3
  • 6
    • 0344142468 scopus 로고    scopus 로고
    • Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21
    • Aita VM, Liang XH, Murty VV, et al. Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21. Genomics 1999; 59: 59-65.
    • (1999) Genomics , vol.59 , pp. 59-65
    • Aita, V.M.1    Liang, X.H.2    Murty, V.V.3
  • 7
    • 34250669930 scopus 로고    scopus 로고
    • An Arabidopsis homolog of yeast ATG6/VPS30 is essential for pollen germination
    • Fujiki Y, Yoshimoto K, Ohsumi Y. An Arabidopsis homolog of yeast ATG6/VPS30 is essential for pollen germination. Plant Physiol 2007; 143: 1132-9.
    • (2007) Plant Physiol , vol.143 , pp. 1132-1139
    • Fujiki, Y.1    Yoshimoto, K.2    Ohsumi, Y.3
  • 8
    • 34249037565 scopus 로고    scopus 로고
    • Crystal structure of the Bcl-XL- Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein
    • Oberstein A, Jeffrey PD, Shi Y. Crystal structure of the Bcl-XL- Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein. J Biol Chem 2007; 282: 13123-32.
    • (2007) J Biol Chem , vol.282 , pp. 13123-13132
    • Oberstein, A.1    Jeffrey, P.D.2    Shi, Y.3
  • 9
    • 84862023791 scopus 로고    scopus 로고
    • Imperfect interface of Beclin1 coiled-coil domain regulates homodimer and heterodimer formation with Atg14L and UVRAG
    • Li X, He L, Che KH, et al. Imperfect interface of Beclin1 coiled-coil domain regulates homodimer and heterodimer formation with Atg14L and UVRAG. Nat Commun 2012; 3: 662.
    • (2012) Nat Commun , vol.3 , pp. 662
    • Li, X.1    He, L.2    Che, K.H.3
  • 10
    • 39049194057 scopus 로고    scopus 로고
    • The evolutionarily conserved domain of Beclin 1 is required for Vps34 binding, autophagy and tumor suppressor function
    • Furuya N, Yu J, Byfield M, Pattingre S, Levine B. The evolutionarily conserved domain of Beclin 1 is required for Vps34 binding, autophagy and tumor suppressor function. Autophagy 2005; 1: 46-52.
    • (2005) Autophagy , vol.1 , pp. 46-52
    • Furuya, N.1    Yu, J.2    Byfield, M.3    Pattingre, S.4    Levine, B.5
  • 11
    • 84862023791 scopus 로고    scopus 로고
    • Imperfect interface of Beclin1 coiled-coil domain regulates homodimer and heterodimer formation with Atg14L and UVRAG
    • Li X, He L, Che KH, et al. Imperfect interface of Beclin1 coiled-coil domain regulates homodimer and heterodimer formation with Atg14L and UVRAG. Nat Commun 2012; 3: 662.
    • (2012) Nat Commun , vol.3 , pp. 662
    • Li, X.1    He, L.2    Che, K.H.3
  • 12
    • 84862777560 scopus 로고    scopus 로고
    • Crystal structure and biochemical analyses reveal Beclin 1 as a novel membrane binding protein
    • Huang W, Choi W, Hu W, et al. Crystal structure and biochemical analyses reveal Beclin 1 as a novel membrane binding protein. Cell Res 2012; 22: 473-89.
    • (2012) Cell Res , vol.22 , pp. 473-489
    • Huang, W.1    Choi, W.2    Hu, W.3
  • 13
    • 84860875222 scopus 로고    scopus 로고
    • Structure of the novel C-terminal domain of vacuolar protein sorting 30/autophagy-related protein 6 and its specific role in autophagy
    • Noda NN, Kobayashi T, Adachi W, Fujioka Y, Ohsumi Y, Inagaki F. Structure of the novel C-terminal domain of vacuolar protein sorting 30/autophagy-related protein 6 and its specific role in autophagy. J Biol Chem 2012; 287: 16256-66.
    • (2012) J Biol Chem , vol.287 , pp. 16256-16266
    • Noda, N.N.1    Kobayashi, T.2    Adachi, W.3    Fujioka, Y.4    Ohsumi, Y.5    Inagaki, F.6
  • 14
    • 0035032723 scopus 로고    scopus 로고
    • Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network
    • Kihara A, Kabeya Y, Ohsumi Y, Yoshimori T. Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network. EMBO Rep 2001; 2: 330-5.
    • (2001) EMBO Rep , vol.2 , pp. 330-335
    • Kihara, A.1    Kabeya, Y.2    Ohsumi, Y.3    Yoshimori, T.4
  • 15
    • 79952628267 scopus 로고    scopus 로고
    • The Beclin 1 network regulates autophagy and apoptosis
    • Kang R, Zeh HJ, Lotze MT, Tang D. The Beclin 1 network regulates autophagy and apoptosis. Cell Death Differ 2011; 18: 571-80.
    • (2011) Cell Death Differ , vol.18 , pp. 571-580
    • Kang, R.1    Zeh, H.J.2    Lotze, M.T.3    Tang, D.4
  • 16
    • 77951237303 scopus 로고    scopus 로고
    • The Beclin 1 interactome
    • He C, Levine B. The Beclin 1 interactome. Curr Opin Cell Biol 2010; 22: 140-9.
    • (2010) Curr Opin Cell Biol , vol.22 , pp. 140-149
    • He, C.1    Levine, B.2
  • 17
    • 58049192897 scopus 로고    scopus 로고
    • Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase
    • Sun Q, Fan W, Chen K, Ding X, Chen S, Zhong Q. Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase. Proc Natl Acad Sci USA 2008; 105: 19211-6.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 19211-19216
    • Sun, Q.1    Fan, W.2    Chen, K.3    Ding, X.4    Chen, S.5    Zhong, Q.6
  • 18
    • 59249089394 scopus 로고    scopus 로고
    • Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG
    • Itakura E, Kishi C, Inoue K, Mizushima N. Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. Mol Biol Cell 2008; 19: 5360-72.
    • (2008) Mol Biol Cell , vol.19 , pp. 5360-5372
    • Itakura, E.1    Kishi, C.2    Inoue, K.3    Mizushima, N.4
  • 19
    • 33745751085 scopus 로고    scopus 로고
    • Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG
    • Liang C, Feng P, Ku B, et al. Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. Nat Cell Biol 2006; 8: 688-99.
    • (2006) Nat Cell Biol , vol.8 , pp. 688-699
    • Liang, C.1    Feng, P.2    Ku, B.3
  • 20
    • 34848899280 scopus 로고    scopus 로고
    • Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis
    • Takahashi Y, Coppola D, Matsushita N, et al. Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis. Nat Cell Biol 2007; 9: 1142-51.
    • (2007) Nat Cell Biol , vol.9 , pp. 1142-1151
    • Takahashi, Y.1    Coppola, D.2    Matsushita, N.3
  • 21
    • 66349103167 scopus 로고    scopus 로고
    • Atg14 and UVRAG: Mutually exclusive subunits of mammalian Beclin 1-PI3K complexes
    • Itakura E, Mizushima N. Atg14 and UVRAG: mutually exclusive subunits of mammalian Beclin 1-PI3K complexes. Autophagy 2009; 5: 534-6.
    • (2009) Autophagy , vol.5 , pp. 534-536
    • Itakura, E.1    Mizushima, N.2
  • 22
    • 46449120732 scopus 로고    scopus 로고
    • Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking
    • Liang C, Lee JS, Inn KS, et al. Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking. Nat Cell Biol 2008; 10: 776-87.
    • (2008) Nat Cell Biol , vol.10 , pp. 776-787
    • Liang, C.1    Lee, J.S.2    Inn, K.S.3
  • 23
    • 64049113909 scopus 로고    scopus 로고
    • Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex
    • Zhong Y, Wang QJ, Li X, et al. Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex. Nat Cell Biol 2009; 11: 468-76.
    • (2009) Nat Cell Biol , vol.11 , pp. 468-476
    • Zhong, Y.1    Wang, Q.J.2    Li, X.3
  • 24
    • 64049086758 scopus 로고    scopus 로고
    • Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages
    • Matsunaga K, Saitoh T, Tabata K, et al. Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages. Nat Cell Biol 2009; 11: 385-96.
    • (2009) Nat Cell Biol , vol.11 , pp. 385-396
    • Matsunaga, K.1    Saitoh, T.2    Tabata, K.3
  • 25
    • 80053501671 scopus 로고    scopus 로고
    • Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13
    • Liu J, Xia H, Kim M, et al. Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. Cell 2011; 147: 223-34.
    • (2011) Cell , vol.147 , pp. 223-234
    • Liu, J.1    Xia, H.2    Kim, M.3
  • 26
    • 84891370240 scopus 로고    scopus 로고
    • Essential role for UVRAG in autophagy and maintenance of cardiac function
    • Song Z, An L, Ye Y, et al. Essential role for UVRAG in autophagy and maintenance of cardiac function. Cardiovasc Res 2014; 101: 48-56.
    • (2014) Cardiovasc Res , vol.101 , pp. 48-56
    • Song, Z.1    An, L.2    Ye, Y.3
  • 27
    • 34347344990 scopus 로고    scopus 로고
    • Ambra1 regulates autophagy and development of the nervous system
    • Fimia GM, Stoykova A, Romagnoli A, et al. Ambra1 regulates autophagy and development of the nervous system. Nature 2007; 447: 1121-5.
    • (2007) Nature , vol.447 , pp. 1121-1125
    • Fimia, G.M.1    Stoykova, A.2    Romagnoli, A.3
  • 28
    • 84885869476 scopus 로고    scopus 로고
    • WASH inhibits autophagy through suppression of Beclin 1 ubiquitination
    • Xia P, Wang S, Du Y, et al. WASH inhibits autophagy through suppression of Beclin 1 ubiquitination. EMBO J 2013; 32: 268-596.
    • (2013) EMBO J , vol.32 , pp. 268-596
    • Xia, P.1    Wang, S.2    Du, Y.3
  • 29
    • 25144457455 scopus 로고    scopus 로고
    • Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy
    • Pattingre S, Tassa A, Qu X, et al. Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 2005; 122: 927-39.
    • (2005) Cell , vol.122 , pp. 927-939
    • Pattingre, S.1    Tassa, A.2    Qu, X.3
  • 30
    • 34248998801 scopus 로고    scopus 로고
    • Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1
    • Maiuri MC, Le Toumelin G, Criollo A, et al. Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1. EMBO J 2007; 26: 2527-39.
    • (2007) EMBO J , vol.26 , pp. 2527-2539
    • Maiuri, M.C.1    Le Toumelin, G.2    Criollo, A.3
  • 31
    • 78751621004 scopus 로고    scopus 로고
    • MCL-1 is a stress sensor that regulates autophagy in a developmentally regulated manner
    • Germain M, Nguyen AP, Le Grand JN, et al. MCL-1 is a stress sensor that regulates autophagy in a developmentally regulated manner. EMBO J 2011; 30: 395-407.
    • (2011) EMBO J , vol.30 , pp. 395-407
    • Germain, M.1    Nguyen, A.P.2    Le Grand, J.N.3
  • 32
    • 84893690813 scopus 로고    scopus 로고
    • Rhes, a striatal-selective protein implicated in Huntington disease, binds beclin-1 and activates autophagy
    • Mealer RG, Murray AJ, Shahani N, Subramaniam S, Snyder SH. Rhes, a striatal-selective protein implicated in Huntington disease, binds beclin-1 and activates autophagy. J Biol Chem 2014; 289: 3547-54.
    • (2014) J Biol Chem , vol.289 , pp. 3547-3554
    • Mealer, R.G.1    Murray, A.J.2    Shahani, N.3    Subramaniam, S.4    Snyder, S.H.5
  • 33
    • 79953796695 scopus 로고    scopus 로고
    • Mitochondrial Bcl-2 inhibits Ambra1-induced autophagy
    • Strappazzon F, Vietri-Rudan M, Campello S, et al. Mitochondrial Bcl-2 inhibits Ambra1-induced autophagy. EMBO J 2011; 30: 1195-208.
    • (2011) EMBO J , vol.30 , pp. 1195-1208
    • Strappazzon, F.1    Vietri-Rudan, M.2    Campello, S.3
  • 34
    • 0000906170 scopus 로고    scopus 로고
    • Induction of autophagy and inhibition of tumorigenesis by beclin 1
    • Liang XH, Jackson S, Seaman M, et al. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 1999; 402: 672-6.
    • (1999) Nature , vol.402 , pp. 672-676
    • Liang, X.H.1    Jackson, S.2    Seaman, M.3
  • 35
    • 9144240441 scopus 로고    scopus 로고
    • Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
    • Qu X, Yu J, Bhagat G, et al. Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest 2003; 112: 1809-20.
    • (2003) J Clin Invest , vol.112 , pp. 1809-1820
    • Qu, X.1    Yu, J.2    Bhagat, G.3
  • 36
    • 0345166111 scopus 로고    scopus 로고
    • Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor
    • Yue Z, Jin S, Yang C, Levine AJ, Heintz N. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci USA 2003; 100: 15077-82.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 15077-15082
    • Yue, Z.1    Jin, S.2    Yang, C.3    Levine, A.J.4    Heintz, N.5
  • 37
    • 84859142474 scopus 로고    scopus 로고
    • Low expression of Beclin 1, associated with high Bcl-xL, predicts a malignant phenotype and poor prognosis of gastric cancer
    • Zhou WH, Tang F, Xu J, et al. Low expression of Beclin 1, associated with high Bcl-xL, predicts a malignant phenotype and poor prognosis of gastric cancer. Autophagy 2012; 8: 389-400.
    • (2012) Autophagy , vol.8 , pp. 389-400
    • Zhou, W.H.1    Tang, F.2    Xu, J.3
  • 38
    • 77954242444 scopus 로고    scopus 로고
    • Autophagy-active beclin-1 correlates with favourable clinical outcome in non-Hodgkin lymphomas
    • Nicotra G, Mercalli F, Peracchio C, et al. Autophagy-active beclin-1 correlates with favourable clinical outcome in non-Hodgkin lymphomas. Mod Pathol 2010; 23: 937-50.
    • (2010) Mod Pathol , vol.23 , pp. 937-950
    • Nicotra, G.1    Mercalli, F.2    Peracchio, C.3
  • 39
    • 84874598403 scopus 로고    scopus 로고
    • Beclin-1: Autophagic regulator and therapeutic target in cancer
    • Fu LL, Cheng Y, Liu B. Beclin-1: autophagic regulator and therapeutic target in cancer. Int J Biochem Cell Biol 2013; 45: 9214.
    • (2013) Int J Biochem Cell Biol , vol.45 , pp. 9214
    • Fu, L.L.1    Cheng, Y.2    Liu, B.3
  • 40
    • 11144245626 scopus 로고    scopus 로고
    • The role of autophagy during the early neonatal starvation period
    • Kuma A, Hatano M, Matsui M, et al. The role of autophagy during the early neonatal starvation period. Nature 2004; 432: 1032-6.
    • (2004) Nature , vol.432 , pp. 1032-1036
    • Kuma, A.1    Hatano, M.2    Matsui, M.3
  • 41
    • 21044455137 scopus 로고    scopus 로고
    • Impairment of starvation-induced and constitutive autophagy in ^4tg7-deficient mice
    • Komatsu M, Waguri S, Ueno T, et al. Impairment of starvation-induced and constitutive autophagy in ^4tg7-deficient mice. J Cell Biol 2005; 169: 425-34.
    • (2005) J Cell Biol , vol.169 , pp. 425-434
    • Komatsu, M.1    Waguri, S.2    Ueno, T.3
  • 42
    • 45749114895 scopus 로고    scopus 로고
    • The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice
    • Pickford F, Masliah E, Britschgi M, et al. The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice. J Clin Invest 2008; 118: 2190-9.
    • (2008) J Clin Invest , vol.118 , pp. 2190-2199
    • Pickford, F.1    Masliah, E.2    Britschgi, M.3
  • 43
    • 84879899999 scopus 로고    scopus 로고
    • Beclin 1 mitigates motor and neuropathological deficits in genetic mouse models of Machado-Joseph disease
    • Nascimento-Ferreira I, Nöbrega C, Vasconcelos-Ferreira A, et al. Beclin 1 mitigates motor and neuropathological deficits in genetic mouse models of Machado-Joseph disease. Brain 2013; 136: 217-388.
    • (2013) Brain , vol.136 , pp. 217-388
    • Nascimento-Ferreira, I.1    Nöbrega, C.2    Vasconcelos-Ferreira, A.3
  • 44
    • 84884185631 scopus 로고    scopus 로고
    • Microglial beclin 1 regulates retromer trafficking and phagocytosis and is impaired in Alzheimer's disease
    • Lucin KM, O'Brien CE, Bieri G, et al. Microglial beclin 1 regulates retromer trafficking and phagocytosis and is impaired in Alzheimer's disease. Neuron 2013; 79: 873-86.
    • (2013) Neuron , vol.79 , pp. 873-886
    • Lucin, K.M.1    O'brien, C.E.2    Bieri, G.3
  • 45
    • 0035870257 scopus 로고    scopus 로고
    • Beclin 1 contains a leucine-rich nuclear export signal that is required for its autophagy and tumor suppressor function
    • Liang XH, Yu J, Brown K, Levine B. Beclin 1 contains a leucine-rich nuclear export signal that is required for its autophagy and tumor suppressor function. Cancer Res 2001; 61: 3443-9.
    • (2001) Cancer Res , vol.61 , pp. 3443-3449
    • Liang, X.H.1    Yu, J.2    Brown, K.3    Levine, B.4
  • 46
    • 33744916798 scopus 로고    scopus 로고
    • Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1
    • Shibata M, Lu T, Furuya T, et al. Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1. J Biol Chem 2006; 281: 14474-85.
    • (2006) J Biol Chem , vol.281 , pp. 14474-14485
    • Shibata, M.1    Lu, T.2    Furuya, T.3
  • 47
    • 84881025556 scopus 로고    scopus 로고
    • Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome
    • Salminen A, Kaarniranta K, Kauppinen A, et al. Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome. Prog Neurobiol 2013; 106 107: 33-54.
    • (2013) Prog Neurobiol , vol.106-107 , pp. 33-54
    • Salminen, A.1    Kaarniranta, K.2    Kauppinen, A.3
  • 48
    • 84864942148 scopus 로고    scopus 로고
    • Bim inhibits autophagy by recruiting Beclin 1 to microtubules
    • Luo S, Garcia-Arencibia M, Zhao R, et al. Bim inhibits autophagy by recruiting Beclin 1 to microtubules. Mol Cell 2012; 47: 359-70.
    • (2012) Mol Cell , vol.47 , pp. 359-370
    • Luo, S.1    Garcia-Arencibia, M.2    Zhao, R.3
  • 49
    • 84869147050 scopus 로고    scopus 로고
    • Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation
    • Wang RC, Wei Y, An Z, et al. Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation. Science 2012; 338: 956-9.
    • (2012) Science , vol.338 , pp. 956-959
    • Wang, R.C.1    Wei, Y.2    An, Z.3
  • 50
    • 84890833205 scopus 로고    scopus 로고
    • BECN1/Beclin 1 is recruited into lipid rafts by prion to activate autophagy in response to amyloid ß 42
    • Nah J, Pyo JO, Jung S, et al. BECN1/Beclin 1 is recruited into lipid rafts by prion to activate autophagy in response to amyloid ß 42. Autophagy 2013; 9: 2009-21.
    • (2013) Autophagy , vol.9 , pp. 2009-2021
    • Nah, J.1    Pyo, J.O.2    Jung, S.3
  • 51
    • 69449092228 scopus 로고    scopus 로고
    • Schneider C. P65/RelA binds and activates the beclin 1 promoter
    • Copetti T, Demarchi F, Schneider C. p65/RelA binds and activates the beclin 1 promoter. Autophagy 2009; 5: 858-9.
    • (2009) Autophagy , vol.5 , pp. 858-859
    • Copetti, T.1    Demarchi, F.2
  • 53
    • 84904876312 scopus 로고    scopus 로고
    • Stat3 inhibits Beclin 1 expression through recruitment of HDAC3 in nonsmall cell lung cancer cells
    • Miao LJ, Huang FX, Sun ZT, Zhang RX, Huang SF, Wang J. Stat3 inhibits Beclin 1 expression through recruitment of HDAC3 in nonsmall cell lung cancer cells. Tumour Biol 2014; 35: 7097-103.
    • (2014) Tumour Biol , vol.35 , pp. 7097-7103
    • Miao, L.J.1    Huang, F.X.2    Sun, Z.T.3    Zhang, R.X.4    Huang, S.F.5    Wang, J.6
  • 54
    • 84872311621 scopus 로고    scopus 로고
    • XBP1 mRNA splicing triggers an autophagic response in endothelial cells through BECLIN-1 transcriptional activation
    • Margariti A, Li H, Chen T, et al. XBP1 mRNA splicing triggers an autophagic response in endothelial cells through BECLIN-1 transcriptional activation. J Biol Chem 2013; 288: 859-72.
    • (2013) J Biol Chem , vol.288 , pp. 859-872
    • Margariti, A.1    Li, H.2    Chen, T.3
  • 55
    • 84864362949 scopus 로고    scopus 로고
    • Histone deacetylase 6 functions as a tumor suppressor by activating c-Jun NH2-Terminal kinase-mediated Beclin 1-dependent autophagic cell death in liver cancer
    • Jung KH, Noh JH, Kim JK, et al. Histone deacetylase 6 functions as a tumor suppressor by activating c-Jun NH2-Terminal kinase-mediated Beclin 1-dependent autophagic cell death in liver cancer. Hepatology 2012; 56: 644-57.
    • (2012) Hepatology , vol.56 , pp. 644-657
    • Jung, K.H.1    Noh, J.H.2    Kim, J.K.3
  • 56
    • 69249153394 scopus 로고    scopus 로고
    • Regulating Beclin 1 Pathway Regulates Autophagy via a non-canonical MEK/ERK signaling
    • Wang J, Whiteman MW, Lian H, et al. Regulating Beclin 1 Pathway Regulates Autophagy via a non-canonical MEK/ERK signaling. J Biol Chem 2009; 284: 21412-24.
    • (2009) J Biol Chem , vol.284 , pp. 21412-21424
    • Wang, J.1    Whiteman, M.W.2    Lian, H.3
  • 57
    • 77952272127 scopus 로고    scopus 로고
    • Genetic and epigenetic silencing of the beclin 1 gene in sporadic breast tumors
    • Li Z, Chen B, Wu Y, Jin F, Xia Y, Liu X. Genetic and epigenetic silencing of the beclin 1 gene in sporadic breast tumors. BMC Cancer 2010; 10: 98.
    • (2010) BMC Cancer , vol.10 , pp. 98
    • Li, Z.1    Chen, B.2    Wu, Y.3    Jin, F.4    Xia, Y.5    Liu, X.6
  • 59
    • 85046981182 scopus 로고    scopus 로고
    • MiR-376b controls starvation and mTOR inhibition-related autophagy by targeting ATG4C and BECN1
    • Korkmaz G, le Sage C, Tekirdag KA, Agami R, Gozuacik D. miR-376b controls starvation and mTOR inhibition-related autophagy by targeting ATG4C and BECN1. Autophagy 2012; 8: 165-76.
    • (2012) Autophagy , vol.8 , pp. 165-176
    • Korkmaz, G.1    Le Sage, C.2    Tekirdag, K.A.3    Agami, R.4    Gozuacik, D.5
  • 61
    • 84899824936 scopus 로고    scopus 로고
    • MicroRNA-216b/Beclin 1 axis regulates autophagy and apoptosis in human Tenon's capsule fibroblasts upon hydroxycamptothecin exposure
    • Xu X, Fu Y, Tong J, et al. MicroRNA-216b/Beclin 1 axis regulates autophagy and apoptosis in human Tenon's capsule fibroblasts upon hydroxycamptothecin exposure. Exp Eye Res 2014; 123: 4355.
    • (2014) Exp Eye Res , vol.123 , pp. 4355
    • Xu, X.1    Fu, Y.2    Tong, J.3
  • 62
    • 84899730819 scopus 로고    scopus 로고
    • MiR-17-5p Downregulation Contributes to Paclitaxel Resistance of Lung Cancer Cells through Altering Beclin1 Expression
    • Chatterjee A, Chattopadhyay D, Chakrabarti G. miR-17-5p Downregulation Contributes to Paclitaxel Resistance of Lung Cancer Cells through Altering Beclin1 Expression. PLoS One 2014; 9: e95716.
    • (2014) Plos One , vol.9
    • Chatterjee, A.1    Chattopadhyay, D.2    Chakrabarti, G.3
  • 63
    • 84899085190 scopus 로고    scopus 로고
    • MicroRNA-i30a regulates autophagy of endothelial progenitor cells through Runx3
    • Xu Q, Meng S, Liu B, et al. MicroRNA-i30a regulates autophagy of endothelial progenitor cells through Runx3. Clin Exp Pharmacol Physiol 2014; 41: 351-357.
    • (2014) Clin Exp Pharmacol Physiol , vol.41 , pp. 351-357
    • Xu, Q.1    Meng, S.2    Liu, B.3
  • 64
    • 84904541192 scopus 로고    scopus 로고
    • Down-regulation of miRNA-30a alleviates cerebral ischemic injury through enhancing Beclin i-mediated autophagy
    • Wang P, Liang J, Li Y, et al. Down-regulation of miRNA-30a alleviates cerebral ischemic injury through enhancing Beclin i-mediated autophagy. Neurochem Res 20i4; 39: 1279-91.
    • Neurochem Res 20I4 , vol.39 , pp. 279-291
    • Wang, P.1    Liang, J.2    Li, Y.3
  • 65
    • 61849102389 scopus 로고    scopus 로고
    • DAP-kinase-mediated phosphorylation on the BH3 domain of beclin i promotes dissociation of beclin i from Bcl-XL and induction of autophagy
    • Zalckvar E, Berissi H, Mizrachy L, et al. DAP-kinase-mediated phosphorylation on the BH3 domain of beclin i promotes dissociation of beclin i from Bcl-XL and induction of autophagy. EMBO Rep 2009; i0: 285-92.
    • (2009) EMBO Rep , vol.10 , pp. 285-292
    • Zalckvar, E.1    Berissi, H.2    Mizrachy, L.3
  • 66
    • 84880331368 scopus 로고    scopus 로고
    • ULKi induces autophagy by phosphorylating Beclin-i and activating VPS34 lipid kinase
    • Russell RC, Tian Y, Yuan H, et al. ULKi induces autophagy by phosphorylating Beclin-i and activating VPS34 lipid kinase. Nat Cell Biol 2013; i5: 741-50.
    • (2013) Nat Cell Biol , vol.15 , pp. 741-750
    • Russell, R.C.1    Tian, Y.2    Yuan, H.3
  • 67
    • 84883499836 scopus 로고    scopus 로고
    • Role of Membrane Association and Atgi4-Dependent Phosphorylation in Beclin-i-Mediated Autophagy
    • Fogel AI, Dlouhy BJ, Wang C, et al. Role of Membrane Association and Atgi4-Dependent Phosphorylation in Beclin-i-Mediated Autophagy. Mol Cell Biol 2013; 33: 3675-88.
    • (2013) Mol Cell Biol , vol.33 , pp. 3675-3688
    • Fogel, A.I.1    Dlouhy, B.J.2    Wang, C.3
  • 68
    • 84884262668 scopus 로고    scopus 로고
    • EGFR-mediated Beclin i phosphorylation in autophagy suppression, tumor progression, and tumor chemoresistance
    • Wei Y, Zou Z, Becker N, et al. EGFR-mediated Beclin i phosphorylation in autophagy suppression, tumor progression, and tumor chemoresistance. Cell 2013; 154: i269-84.
    • (2013) Cell , vol.54 , pp. 1184-1269
    • Wei, Y.1    Zou, Z.2    Becker, N.3
  • 69
    • 84872586081 scopus 로고    scopus 로고
    • Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy
    • Kim J, Kim YC, Fang C, et al. Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy. Cell 2013; 152: 290-303.
    • (2013) Cell , vol.152 , pp. 290-303
    • Kim, J.1    Kim, Y.C.2    Fang, C.3
  • 70
    • 84055219407 scopus 로고    scopus 로고
    • Nedd4- dependent lysine-ii-linked polyubiquitination of the tumour suppressor Beclin i
    • Platta HW, Abrahamsen H, Thoresen SB, Stenmark H. Nedd4- dependent lysine-ii-linked polyubiquitination of the tumour suppressor Beclin i. Biochem J 2012; 441: 399-406.
    • (2012) Biochem J , vol.441 , pp. 399-406
    • Platta, H.W.1    Abrahamsen, H.2    Thoresen, S.B.3    Stenmark, H.4
  • 71
    • 77953858790 scopus 로고    scopus 로고
    • TRAF6 and A20 regulate lysine 63-linked ubiquitination of Beclin-i to control TLR4-induced autophagy
    • Shi CS, Kehrl JH. TRAF6 and A20 regulate lysine 63-linked ubiquitination of Beclin-i to control TLR4-induced autophagy. Sci Signal 2010; 3: 42.
    • (2010) Sci Signal , vol.3 , pp. 42
    • Shi, C.S.1    Kehrl, J.H.2
  • 72
    • 57749089665 scopus 로고    scopus 로고
    • Caspasemediated cleavage of ATG6/Beclin-i links apoptosis to autophagy in HeLa cells
    • Cho DH, Jo YK, Hwang JJ, Lee YM, Roh SA, Kim JC. Caspasemediated cleavage of ATG6/Beclin-i links apoptosis to autophagy in HeLa cells. Cancer Lett 2009; 274: 95-100.
    • (2009) Cancer Lett , vol.274 , pp. 95-100
    • Cho, D.H.1    Jo, Y.K.2    Hwang, J.J.3    Lee, Y.M.4    Roh, S.A.5    Kim, J.C.6
  • 73
    • 79953230490 scopus 로고    scopus 로고
    • Beclin i cleavage by caspase-3 inactivates autophagy and promotes apoptosis
    • Zhu Y, Zhao L, Liu L, et al. Beclin i cleavage by caspase-3 inactivates autophagy and promotes apoptosis. Protein Cell 2010; 1: 468-77.
    • (2010) Protein Cell , vol.1 , pp. 468-477
    • Zhu, Y.1    Zhao, L.2    Liu, L.3
  • 74
    • 78649636176 scopus 로고    scopus 로고
    • Caspase-mediated cleavage of Beclin-i inactivates Beclin-i-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria
    • Wirawan E, Vande Walle L, Kersse K, et al. Caspase-mediated cleavage of Beclin-i inactivates Beclin-i-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria. Cell Death Dis 2010; 1: 18.
    • (2010) Cell Death Dis , vol.1 , pp. 18
    • Wirawan, E.1    Vande Walle, L.2    Kersse, K.3
  • 75
  • 76
    • 79956144655 scopus 로고    scopus 로고
    • Following cytochrome c release, autophagy is inhibited during chemotherapy-induced apoptosis by caspase 8-mediated cleavage of Beclin
    • Li H, Wang P, Sun Q, et al. Following cytochrome c release, autophagy is inhibited during chemotherapy-induced apoptosis by caspase 8-mediated cleavage of Beclin. Cancer Res 2011; 71: 3625-34.
    • (2011) Cancer Res , vol.71 , pp. 3625-3634
    • Li, H.1    Wang, P.2    Sun, Q.3
  • 77
    • 80053392430 scopus 로고    scopus 로고
    • Cleaving Beclin i to suppress autophagy in chemotherapy-induced apoptosis
    • Li H, Wang P, Yu J, Zhang L. Cleaving Beclin i to suppress autophagy in chemotherapy-induced apoptosis. Autophagy 2011; 7: 1239-41.
    • (2011) Autophagy , vol.7 , pp. 1239-1241
    • Li, H.1    Wang, P.2    Yu, J.3    Zhang, L.4
  • 78
    • 84872005452 scopus 로고    scopus 로고
    • TRAIL induces autophagic protein cleavage through caspase activation in melanoma cell lines under arginine deprivation
    • You M, Savaraj N, Kuo MT, et al. TRAIL induces autophagic protein cleavage through caspase activation in melanoma cell lines under arginine deprivation. Mol Cell Biochem 2013; 374: 181-90.
    • (2013) Mol Cell Biochem , vol.374 , pp. 181-190
    • You, M.1    Savaraj, N.2    Kuo, M.T.3
  • 79
    • 79960029137 scopus 로고    scopus 로고
    • Calpain-mediated cleavage of Beclin-i and autophagy deregulation following retinal ischemic injury in vivo
    • Russo R, Berliocchi L, Adornetto A, et al. Calpain-mediated cleavage of Beclin-i and autophagy deregulation following retinal ischemic injury in vivo. Cell Death Dis 2011; 2: e144.
    • (2011) Cell Death Dis , vol.2
    • Russo, R.1    Berliocchi, L.2    Adornetto, A.3
  • 80
    • 34147168105 scopus 로고    scopus 로고
    • Distinct roles of autophagy in the heart during ischemia and reperfusion: Roles of AMP-activated protein kinase and Beclin i in mediating autophagy
    • Matsui Y, Takagi H, Qu X, et al. Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin i in mediating autophagy. Circ Res 2007; 100: 914-22.
    • (2007) Circ Res , vol.100 , pp. 914-922
    • Matsui, Y.1    Takagi, H.2    Qu, X.3
  • 81
    • 33744536558 scopus 로고    scopus 로고
    • Urocortin inhibits Beclini-mediated autophagic cell death in cardiac myocytes exposed to ischaemia/reperfusion injury
    • i] Valentim L, Laurence KM, Townsend PA, et al. Urocortin inhibits Beclini-mediated autophagic cell death in cardiac myocytes exposed to ischaemia/reperfusion injury. J Mol Cell Cardiol 2006; 40: 846-52.
    • (2006) J Mol Cell Cardiol , vol.40 , pp. 846-852
    • Valentim, L.1    Laurence, K.M.2    Townsend, P.A.3
  • 82
    • 84863192578 scopus 로고    scopus 로고
    • Impaired autophagosome clearance contributes to cardiomyocyte death in ischemia/reperfusion injury
    • Ma X, Liu H, Foyil SR, et al. Impaired autophagosome clearance contributes to cardiomyocyte death in ischemia/reperfusion injury. Circulation 2012; 125: 3170-81.
    • (2012) Circulation , vol.125 , pp. 3170-3181
    • Ma, X.1    Liu, H.2    Foyil, S.R.3
  • 83
    • 84879604162 scopus 로고    scopus 로고
    • NF-KB-mediated induction of autophagy in cardiac ischemia/reperfusion injury
    • Zeng M, Wei X, Wu Z, et al. NF-KB-mediated induction of autophagy in cardiac ischemia/reperfusion injury. Biochem Biophys Res Commun 2013; 436: i80-5.
    • Biochem Biophys Res Commun 2013 , vol.436 , pp. 115-180
    • Zeng, M.1    Wei, X.2    Wu, Z.3
  • 84
    • 34447133404 scopus 로고    scopus 로고
    • Cardiac autophagy is a maladaptive response to hemodynamic stress
    • Zhu H, Tannous P, Johnstone JL, et al. Cardiac autophagy is a maladaptive response to hemodynamic stress. J Clin Invest 2007; 117: 1782-93.
    • (2007) J Clin Invest , vol.117 , pp. 1782-1793
    • Zhu, H.1    Tannous, P.2    Johnstone, J.L.3
  • 85
    • 84897423410 scopus 로고    scopus 로고
    • Activating transcription factor 3 protects against pressure-overload heart failure via the autophagy molecule Beclin-1 pathways
    • Lin H, Li H, Chen H, et al. Activating transcription factor 3 protects against pressure-overload heart failure via the autophagy molecule Beclin-1 pathways. Mol Pharmacol 2014; 85: 682-91.
    • (2014) Mol Pharmacol , vol.85 , pp. 682-691
    • Lin, H.1    Li, H.2    Chen, H.3
  • 86
    • 84872240012 scopus 로고    scopus 로고
    • MiR-30-regulated autophagy mediates angiotensin II-induced myocardial hypertrophy
    • Pan W, Zhong Y, Cheng C, et al. MiR-30-regulated autophagy mediates angiotensin II-induced myocardial hypertrophy. PLoS One 2013; 8: e53950.
    • (2013) Plos One , vol.8
    • Pan, W.1    Zhong, Y.2    Cheng, C.3
  • 87
    • 84887495190 scopus 로고    scopus 로고
    • Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2
    • Maejima Y, Kyoi S, Zhai P, et al. Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2. Nat Med 2013; 19: 1478-88.
    • (2013) Nat Med , vol.19 , pp. 1478-1488
    • Maejima, Y.1    Kyoi, S.2    Zhai, P.3
  • 88
    • 64349111699 scopus 로고    scopus 로고
    • Toward the development of a potent and selective organoruthenium mammalian sterile 20 kinase inhibitor
    • Anand R, Maksimoska J, Pagano N, et al. Toward the development of a potent and selective organoruthenium mammalian sterile 20 kinase inhibitor. J Med Chem 2009; 52: 1602-11.
    • (2009) J Med Chem , vol.52 , pp. 1602-1611
    • Anand, R.1    Maksimoska, J.2    Pagano, N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.