Stat3 inhibits Beclin 1 expression through recruitment of HDAC3 in nonsmall cell lung cancer cells

Tumor Biology

Volumn 35, Issue 7, 2014, Pages 7097-7103

  Miao, Li Jun ^a   Huang, Feng Xiang ^a   Sun, Zhen Tao ^a   Zhang, Rui Xia ^a   Huang, Shi Fu ^a   Wang, Jing ^a  

^a ZHENGZHOU UNIVERSITY   (China)

Author keywords

Beclin 1; HDAC3; Nonsmall cell lung cancer; Stat3

Indexed keywords

BECLIN 1; HISTONE DEACETYLASE 3; INTERLEUKIN 6; STAT3 PROTEIN;

ARTICLE; CANCER CELL; CONTROLLED STUDY; DOWN REGULATION; HUMAN; HUMAN CELL; LUNG CANCER CELL LINE; LUNG CARCINOGENESIS; LUNG NON SMALL CELL CANCER; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REGULATORY MECHANISM; TRANSCRIPTION TERMINATION; TRANSIENT TRANSFECTION;

APOPTOSIS REGULATORY PROTEINS; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; GENE EXPRESSION REGULATION, NEOPLASTIC; HISTONE DEACETYLASES; HUMANS; INTERLEUKIN-6; MEMBRANE PROTEINS; PROMOTER REGIONS, GENETIC; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR;

EID: 84904876312     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-014-1961-6     Document Type: Article

References (28)

1. Risch A, Plass C. Lung cancer epigenetics and genetics. Int J Cancer. 2008;123:1-7. (Pubitemid 351705185)
2. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, et al. Cancer statistics, 2008. CA Cancer J Clin. 2008;58:71-96. (Pubitemid 351521864)
3. Choi AM, Ryter SW, Levine B. Autophagy in human health and disease. N Engl J Med. 2013;368:1845-6.
4. Lamb CA, Yoshimori T, Tooze SA. The autophagosome: origins unknown, biogenesis complex. Nat Rev Mol Cell Biol. 2013;14:759-74.
5. Pattingre S et al. Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell. 2005;122:927-39. (Pubitemid 41345209)
6. Qu X et al. Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest. 2003;112:1809-20. (Pubitemid 38063704)
7. Rosenfeldt MT, Ryan KM. Themultiple roles of autophagy in cancer. Carcinogenesis. 2011;32:955-63.
8. Zhou Wet al. Autophagic protein Beclin 1 serves as an independent positive prognostic biomarker for non-small cell lung cancer. PLoS One. 2013;8:e80338.
9. Yu H, Pardoll D, Jove R. STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer. 2009;9:798-809.
10. Yu H, Kortylewski M, Pardoll D. Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment. Nat Rev Immunol. 2007;7:41-51. (Pubitemid 46020826)
11. Deng J et al. S1PR1-STAT3 signaling is crucial for myeloid cell colonization at future metastatic sites. Cancer Cell. 2012;21:642-54.
12. Lee H et al. Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors. Cancer Cell. 2009;15:283-93.
13. Li XY et al. G protein-coupled receptor 48 upregulates estrogen receptor alpha expression via cAMP/PKA signaling in the male reproductive tract. Development. 2010;137:151-7.
14. Yang Z, Huo S, Shan Y, Liu H, Xu Y, Yao K, et al. STAT3 repressed USP7 expression is crucial for colon cancer development. FEBS Lett. 2012;586:3013-7.
15. Kang R et al. The Beclin 1 network regulates autophagy and apoptosis. Cell Death Differ. 2011;18:571-80.
16. Liu J et al. Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. Cell. 2011;147:223-34.
17. Caldera V, Mellai M, Annovazzi L, Valente G, Tessitore L, Schiffer D. Stat3 expression and its correlation with proliferation and apoptosis/autophagy in gliomas. J Oncol. 2008;2008:219241.
18. Vitale G et al. The PPAR-γ agonist troglitazone antagonizes survival pathways induced by STAT-3 in recombinant interferon-β treated pancreatic cancer cells. Biotechnol Adv. 2012;30:169-84.
19. Dicitore A et al. Type I interferon-mediated pathway interacts with peroxisome proliferator activated receptor-γ (PPAR-γ): at the crossroad of pancreatic cancer cell proliferation. Biochim Biophys Acta. 2014;1845:42-52.
20. Pratt J, Annabi B. Induction of autophagy biomarker BNIP3 requires a JAK2/STAT3 and MT1-MMP signaling interplay in Concanavalin-A-activated U87 glioblastoma cells. Cell Signal. 2014;26:917-24.
21. Liang XH, Jackson S, Seaman M, Brown K, Kempkes B, Hibshoosh H, et al. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature. 1999;402:672-6. (Pubitemid 129516338)
22. Yue Z, Jin S, Yang C, Levine AJ, Heintz N. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci U S A. 2003;100:15077-82. (Pubitemid 37518019)
23. Fu LL, Cheng Y, Liu B. Beclin-1: autophagic regulator and therapeutic target in cancer. Int J Biochem Cell Biol. 2013;45:921-4.
24. Zhu H, Wu H, Liu X, Li B, Chen Y, Ren X, et al. Regulation of autophagy by a beclin 1-targeted microRNA, miR-30a, in cancer cells. Autophagy. 2009;5:816-23.
25. Korkmaz G, le Sage C, Tekirdag KA, Agami R, Gozuacik D. miR-376b controls starvation and mTOR inhibition-related autophagy by targeting ATG4C and BECN1. Autophagy. 2012;8:165-76.
26. Minamiya Y, Ono T, Saito H, Takahashi N, Ito M, Motoyama S, et al. Strong expression of HDAC3 correlateswith a poor prognosis in patients with adenocarcinoma of the lung. Tumour Biol. 2010;31:533-9.
27. Shen S et al. Cytoplasmic STAT3 represses autophagy by inhibiting PKR activity. Mol Cell. 2012;48:667-80.
28. Siveen KS et al. Targeting the STAT3 signaling pathway in cancer: role of synthetic and natural inhibitors. Biochim Biophys Acta. 2014;1845:136-54.