Mechanism of the association between Na+ binding and conformations at the intracellular gate in neurotransmitter:sodium symporters

Journal of Biological Chemistry

Volumn 290, Issue 22, 2015, Pages 13992-14003

  Stolzenberg, Sebastian ^a,b   Quick, Matthias ^c,d   Zhao, Chunfeng ^e   Gotfryd, Kamil ^f   Khelashvili, George ^a   Gether, Ulrik ^f   Loland, Claus J ^f   Javitch, Jonathan A ^c,d   Noskov, Sergei ^e,h   Weinstein, Harel ^a   Shi, Lei ^a,g  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b Cornell University   (United States)

^c Columbia University College of Physicians and Surgeons ^*  (United States)

^d NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^e UNIVERSITY OF CALGARY   (Canada)

^f UNIVERSITY OF COPENHAGEN   (Denmark)

^g NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^h CANADIAN INSTITUTES OF HEALTH RESEARCH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING SITES; BINS; MOLECULAR DYNAMICS; NEUROPHYSIOLOGY;

CONFORMATIONAL CHANGE; DOPAMINE TRANSPORTERS; EXPERIMENTAL VERIFICATION; INTERACTION NETWORKS; INTRAMOLECULAR DYNAMICS; MOLECULAR DYNAMICS SIMULATIONS; STRUCTURAL ELEMENTS; TRANSPORT MECHANISM;

SODIUM;

DOPAMINE TRANSPORTER; NEUROTRANSMITTER SODIUM SYMPORTER; NEUROTRANSMITTER TRANSPORTER; UNCLASSIFIED DRUG; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; ION; LIGAND; LITHIUM; METAL; PLASMA MEMBRANE NEUROTRANSMITTER TRANSPORTER; PROTEIN BINDING; SODIUM;

ALLOSTERISM; AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; CHEMICAL BINDING; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; MOLECULAR STABILITY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN INTERACTION; PROTEIN TRANSPORT; SODIUM BINDING; SODIUM TRANSPORT; CHEMISTRY; ESCHERICHIA COLI; HUMAN; METABOLISM; MOLECULAR DYNAMICS; MUTATION;

BACTERIA (MICROORGANISMS); EUKARYOTA;

ALLOSTERIC SITE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; ESCHERICHIA COLI; HUMANS; IONS; LIGANDS; LITHIUM; METALS; MOLECULAR DYNAMICS SIMULATION; MUTATION; NEUROTRANSMITTER AGENTS; PLASMA MEMBRANE NEUROTRANSMITTER TRANSPORT PROTEINS; PROTEIN BINDING; PROTEIN CONFORMATION; SODIUM;

EID: 84930656604     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.625343     Document Type: Article

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