NbIT - A New Information Theory-Based Analysis of Allosteric Mechanisms Reveals Residues that Underlie Function in the Leucine Transporter LeuT

PLoS Computational Biology

Volumn 10, Issue 5, 2014, Pages

  LeVine, Michael V ^a   Weinstein, Harel ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BINDING SITES; COMPLEX NETWORKS; COMPUTATION THEORY; ENZYME ACTIVITY; MOLECULAR DYNAMICS;

ALLOSTERIC COUPLING; ALLOSTERIC MECHANISMS; ALLOSTERY; BIOMOLECULAR SYSTEM; ENZYMATIC ACTIVITIES; FUNCTIONAL SITES; MICRO-DOMAINS; MOLECULAR SCALE; OUTPUT SIGNAL; PHYSIOLOGICAL FUNCTIONS;

INFORMATION THEORY;

BACTERIAL PROTEIN; CARRIER PROTEIN; LEUCINE TRANSPORTER; UNCLASSIFIED DRUG; AMINO ACID TRANSPORTER; LEUCINE; PROTEIN BINDING;

ALLOSTERISM; ANALYTIC METHOD; ARTICLE; BINDING SITE; CHANNEL GATING; CONCEPTUAL FRAMEWORK; ENTROPY; INFORMATION SCIENCE; MEDICAL INFORMATION; MOLECULAR DYNAMICS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN STABILITY; RESIDUE ANALYSIS; ALGORITHM; CHEMICAL MODEL; CHEMISTRY; COMPUTER SIMULATION; PROTEIN CONFORMATION; PROTEIN TERTIARY STRUCTURE; ULTRASTRUCTURE;

ALGORITHMS; ALLOSTERIC REGULATION; ALLOSTERIC SITE; AMINO ACID TRANSPORT SYSTEMS; BACTERIAL PROTEINS; BINDING SITES; COMPUTER SIMULATION; INFORMATION THEORY; LEUCINE; MODELS, CHEMICAL; MOLECULAR DYNAMICS SIMULATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY;

EID: 84901660019     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1003603     Document Type: Article

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