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Volumn 10, Issue 5, 2015, Pages

Elevated homocysteine level and folate deficiency associated with increased overall risk of carcinogenesis: Meta-analysis of 83 case-control studies involving 35,758 individuals

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MTHFR PROTEIN, HUMAN;

EID: 84930656445     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0123423     Document Type: Article
Times cited : (87)

References (121)
  • 3
    • 71949114575 scopus 로고    scopus 로고
    • Determinants of homocysteine levels in colorectal and breast cancer patients
    • PMID: 19846961
    • Ferroni P, Palmirotta R, Martini F, Riondino S, Savonarola A, Spila A, et al. Determinants of homocysteine levels in colorectal and breast cancer patients. Anticancer Res. 2009; 29: 4131-4138. PMID: 19846961
    • (2009) Anticancer Res , vol.29 , pp. 4131-4138
    • Ferroni, P.1    Palmirotta, R.2    Martini, F.3    Riondino, S.4    Savonarola, A.5    Spila, A.6
  • 4
    • 51849141964 scopus 로고    scopus 로고
    • Mathematical modeling of folate metabolism: Predicted effects of genetic polymorphisms on mechanisms and biomarkers relevant to carcinogenesis
    • PMID: 18628437
    • Ulrich CM, Neuhouser M, Liu AY, Boynton A, Gregory JR, Shane B, et al. Mathematical modeling of folate metabolism: predicted effects of genetic polymorphisms on mechanisms and biomarkers relevant to carcinogenesis. Cancer Epidemiol Biomarkers Prev. 2008; 17: 1822-1831. doi: 10.1158/1055-9965.EPI-07-2937 PMID: 18628437
    • (2008) Cancer Epidemiol Biomarkers Prev , vol.17 , pp. 1822-1831
    • Ulrich, C.M.1    Neuhouser, M.2    Liu, A.Y.3    Boynton, A.4    Gregory, J.R.5    Shane, B.6
  • 5
    • 84856595269 scopus 로고    scopus 로고
    • Folate intake and risk of pancreatic cancer: Pooled analysis of prospective cohort studies
    • PMID: 22034634
    • Bao Y, Michaud DS, Spiegelman D, Albanes D, Anderson KE, Bernstein L, et al. Folate intake and risk of pancreatic cancer: pooled analysis of prospective cohort studies. J Natl Cancer Inst. 2011; 103: 1840-1850. doi: 10.1093/jnci/djr431 PMID: 22034634
    • (2011) J Natl Cancer Inst , vol.103 , pp. 1840-1850
    • Bao, Y.1    Michaud, D.S.2    Spiegelman, D.3    Albanes, D.4    Anderson, K.E.5    Bernstein, L.6
  • 6
    • 77953308346 scopus 로고    scopus 로고
    • Circulating folate, vitamin B12, homocysteine, vitamin B12 transport proteins, and risk of prostate cancer: A case-control study, systematic review, and meta-analysis
    • PMID: 20501771
    • Collin SM, Metcalfe C, Refsum H, Lewis SJ, Zuccolo L, Smith GD, et al. Circulating folate, vitamin B12, homocysteine, vitamin B12 transport proteins, and risk of prostate cancer: a case-control study, systematic review, and meta-analysis. Cancer Epidemiol Biomarkers Prev. 2010; 19: 1632-1642. doi: 10.1158/1055-9965.EPI-10-0180 PMID: 20501771
    • (2010) Cancer Epidemiol Biomarkers Prev , vol.19 , pp. 1632-1642
    • Collin, S.M.1    Metcalfe, C.2    Refsum, H.3    Lewis, S.J.4    Zuccolo, L.5    Smith, G.D.6
  • 7
    • 33846998339 scopus 로고    scopus 로고
    • Folate and risk of breast cancer: A meta-analysis
    • PMID: 17202114
    • Larsson SC, Giovannucci E, Wolk A. Folate and risk of breast cancer: a meta-analysis. J Natl Cancer Inst. 2007; 99: 64-76. PMID: 17202114
    • (2007) J Natl Cancer Inst , vol.99 , pp. 64-76
    • Larsson, S.C.1    Giovannucci, E.2    Wolk, A.3
  • 8
    • 31544464325 scopus 로고    scopus 로고
    • Genetic and epigenetic interactions between folate and aging in carcinogenesis
    • PMID: 16317156
    • Jang H, Mason JB, Choi SW. Genetic and epigenetic interactions between folate and aging in carcinogenesis. J Nutr. 2005; 135: 2967S-2971S. PMID: 16317156
    • (2005) J Nutr , vol.135 , pp. 2967S-2971S
    • Jang, H.1    Mason, J.B.2    Choi, S.W.3
  • 9
    • 37349129228 scopus 로고    scopus 로고
    • Aspirin and folic acid for the prevention of recurrent colorectal adenomas
    • PMID: 18022173
    • Logan RF, Grainge MJ, Shepherd VC, Armitage NC, Muir KR. Aspirin and folic acid for the prevention of recurrent colorectal adenomas. Gastroenterology. 2008; 134: 29-38. PMID: 18022173
    • (2008) Gastroenterology , vol.134 , pp. 29-38
    • Logan, R.F.1    Grainge, M.J.2    Shepherd, V.C.3    Armitage, N.C.4    Muir, K.R.5
  • 10
    • 34249979299 scopus 로고    scopus 로고
    • Folic acid for the prevention of colorectal adenomas: A randomized clinical trial
    • PMID: 17551129
    • Cole BF, Baron JA, Sandler RS, Haile RW, Ahnen DJ, Bresalier RS, et al. Folic acid for the prevention of colorectal adenomas: a randomized clinical trial. JAMA. 2007; 297: 2351-2359. PMID: 17551129
    • (2007) JAMA , vol.297 , pp. 2351-2359
    • Cole, B.F.1    Baron, J.A.2    Sandler, R.S.3    Haile, R.W.4    Ahnen, D.J.5    Bresalier, R.S.6
  • 11
    • 72749116444 scopus 로고    scopus 로고
    • A randomized trial on folic acid supplementation and risk of recurrent colorectal adenoma
    • PMID: 19864409
    • Wu K, Platz EA, Willett WC, Fuchs CS, Selhub J, Rosner BA, et al. A randomized trial on folic acid supplementation and risk of recurrent colorectal adenoma. Am J Clin Nutr. 2009; 90: 1623-1631. doi: 10.3945/ajcn.2009.28319 PMID: 19864409
    • (2009) Am J Clin Nutr , vol.90 , pp. 1623-1631
    • Wu, K.1    Platz, E.A.2    Willett, W.C.3    Fuchs, C.S.4    Selhub, J.5    Rosner, B.A.6
  • 12
    • 71749111560 scopus 로고    scopus 로고
    • Cancer incidence and mortality after treatment with folic acid and vitamin B12
    • PMID: 19920236
    • Ebbing M, Bonaa KH, Nygard O, Arnesen E, Ueland PM, Nordrehaug JE, et al. Cancer incidence and mortality after treatment with folic acid and vitamin B12. JAMA. 2009; 302: 2119-2126. doi: 10.1001/jama.2009.1622 PMID: 19920236
    • (2009) JAMA , vol.302 , pp. 2119-2126
    • Ebbing, M.1    Bonaa, K.H.2    Nygard, O.3    Arnesen, E.4    Ueland, P.M.5    Nordrehaug, J.E.6
  • 13
    • 80555157731 scopus 로고    scopus 로고
    • Dietary folate, vitamin B6, vitamin B12 and methionine intake and the risk of breast cancer by oestrogen and progesterone receptor status
    • PMID: 21736840
    • Zhang CX, Ho SC, Chen YM, Lin FY, Fu JH, Cheng SZ. Dietary folate, vitamin B6, vitamin B12 and methionine intake and the risk of breast cancer by oestrogen and progesterone receptor status. Br J Nutr. 2011; 106: 936-943. doi: 10.1017/S0007114511001140 PMID: 21736840
    • (2011) Br J Nutr , vol.106 , pp. 936-943
    • Zhang, C.X.1    Ho, S.C.2    Chen, Y.M.3    Lin, F.Y.4    Fu, J.H.5    Cheng, S.Z.6
  • 14
    • 77953633351 scopus 로고    scopus 로고
    • Serum B vitamin levels and risk of lung cancer
    • PMID: 20551408
    • Johansson M, Relton C, Ueland PM, Vollset SE, Midttun O, Nygård O, et al. Serum B vitamin levels and risk of lung cancer. JAMA. 2010; 303: 2377-2385. doi: 10.1001/jama.2010.808 PMID: 20551408
    • (2010) JAMA , vol.303 , pp. 2377-2385
    • Johansson, M.1    Relton, C.2    Ueland, P.M.3    Vollset, S.E.4    Midttun, O.5    Nygård, O.6
  • 15
    • 84875856301 scopus 로고    scopus 로고
    • Folate-genetics and colorectal neoplasia: What we know and need to know next
    • PMID: 23401104
    • Figueiredo JC, Levine AJ, Crott JW, Baurley J, Haile RW. Folate-genetics and colorectal neoplasia: what we know and need to know next. Mol Nutr Food Res. 2013; 57: 607-627. doi: 10.1002/mnfr.201200278 PMID: 23401104
    • (2013) Mol Nutr Food Res , vol.57 , pp. 607-627
    • Figueiredo, J.C.1    Levine, A.J.2    Crott, J.W.3    Baurley, J.4    Haile, R.W.5
  • 16
    • 74549141702 scopus 로고    scopus 로고
    • Genetic variability in the MTHFR gene and colorectal cancer risk using the colorectal cancer family registry
    • PMID: 20056627
    • Levine AJ, Figueiredo JC, Lee W, Poynter JN, Conti D, Duggan DJ, et al. Genetic variability in the MTHFR gene and colorectal cancer risk using the colorectal cancer family registry. Cancer Epidemiol Biomarkers Prev. 2010; 19: 89-100. doi: 10.1158/1055-9965.EPI-09-0727 PMID: 20056627
    • (2010) Cancer Epidemiol Biomarkers Prev , vol.19 , pp. 89-100
    • Levine, A.J.1    Figueiredo, J.C.2    Lee, W.3    Poynter, J.N.4    Conti, D.5    Duggan, D.J.6
  • 17
    • 78649831580 scopus 로고    scopus 로고
    • Hyperhomocysteinemia, methylenetetrahydrofolate reductase c.677C>T polymorphism and risk of cancer: Cross-sectional and prospective studies and meta-analyses of 75,000 cases and 93,000 controls
    • PMID: 20473868
    • Zacho J, Yazdanyar S, Bojesen SE, Tybjaerg-Hansen A, Nordestgaard BG. Hyperhomocysteinemia, methylenetetrahydrofolate reductase c.677C>T polymorphism and risk of cancer: cross-sectional and prospective studies and meta-analyses of 75,000 cases and 93,000 controls. Int J Cancer. 2011; 128: 644-652. doi: 10.1002/ijc.25375 PMID: 20473868
    • (2011) Int J Cancer , vol.128 , pp. 644-652
    • Zacho, J.1    Yazdanyar, S.2    Bojesen, S.E.3    Tybjaerg-Hansen, A.4    Nordestgaard, B.G.5
  • 18
    • 65249091990 scopus 로고    scopus 로고
    • MTHFR C677T polymorphism contributes to prostate cancer risk among Caucasians: A meta-analysis of 3511 cases and 2762 controls
    • PMID: 19223177
    • Bai JL, Zheng MH, Xia X, Ter-Minassian M, Chen YP, Chen F. MTHFR C677T polymorphism contributes to prostate cancer risk among Caucasians: A meta-analysis of 3511 cases and 2762 controls. Eur J Cancer. 2009; 45: 1443-1449. doi: 10.1016/j.ejca.2009.01.020 PMID: 19223177
    • (2009) Eur J Cancer , vol.45 , pp. 1443-1449
    • Bai, J.L.1    Zheng, M.H.2    Xia, X.3    Ter-Minassian, M.4    Chen, Y.P.5    Chen, F.6
  • 19
    • 84863767544 scopus 로고    scopus 로고
    • Quantitative assessment of the effect of MTHFR polymorphisms on the risk of lung carcinoma
    • PMID: 22215214
    • Zhang Y, Chen GQ, Ji Y, Huang B, Shen WS, Deng LC, et al. Quantitative assessment of the effect of MTHFR polymorphisms on the risk of lung carcinoma. Mol Biol Rep. 2012; 39: 6203-6211. doi: 10.1007/s11033-011-1439-1 PMID: 22215214
    • (2012) Mol Biol Rep , vol.39 , pp. 6203-6211
    • Zhang, Y.1    Chen, G.Q.2    Ji, Y.3    Huang, B.4    Shen, W.S.5    Deng, L.C.6
  • 20
    • 9644259108 scopus 로고    scopus 로고
    • Tips for learners of evidence-based medicine: 3. Measures of observer variability (kappa statistic)
    • PMID: 15557592
    • McGinn T, Wyer PC, Newman TB, Keitz S, Leipzig R, For GG. Tips for learners of evidence-based medicine: 3. Measures of observer variability (kappa statistic). CMAJ. 2004; 171:1369-73. PMID: 15557592
    • (2004) CMAJ , vol.171 , pp. 1369-1373
    • McGinn, T.1    Wyer, P.C.2    Newman, T.B.3    Keitz, S.4    Leipzig, R.5    For, G.G.6
  • 21
    • 0037083552 scopus 로고    scopus 로고
    • Serum folate and homocysteine levels in head and neck squamous cell carcinoma
    • PMID: 11920469
    • Almadori G, Bussu F, Galli J, Cadoni G, Zappacosta B, Persichilli S, et al. Serum folate and homocysteine levels in head and neck squamous cell carcinoma. Cancer. 2002; 94: 1006-1011. PMID: 11920469
    • (2002) Cancer , vol.94 , pp. 1006-1011
    • Almadori, G.1    Bussu, F.2    Galli, J.3    Cadoni, G.4    Zappacosta, B.5    Persichilli, S.6
  • 22
    • 12344333239 scopus 로고    scopus 로고
    • Serum levels of folate, homocysteine, and vitamin B12 in head and neck squamous cell carcinoma and in laryngeal leukoplakia
    • PMID: 15593092
    • Almadori G, Bussu F, Galli J, Cadoni G, Zappacosta B, Persichilli S, et al. Serum levels of folate, homocysteine, and vitamin B12 in head and neck squamous cell carcinoma and in laryngeal leukoplakia. Cancer. 2005; 103: 284-292. PMID: 15593092
    • (2005) Cancer , vol.103 , pp. 284-292
    • Almadori, G.1    Bussu, F.2    Galli, J.3    Cadoni, G.4    Zappacosta, B.5    Persichilli, S.6
  • 23
    • 84884354784 scopus 로고    scopus 로고
    • A structural equation modelling approach to explore the role of B vitamins and immune markers in lung cancer risk
    • PMID: 23532743
    • Baltar VT, Xun WW, Johansson M, Ferrari P, Chuang SC, Relton C, et al. A structural equation modelling approach to explore the role of B vitamins and immune markers in lung cancer risk. Eur J Epidemiol. 2013; 28: 677-88. doi: 10.1007/s10654-013-9793-z PMID: 23532743
    • (2013) Eur J Epidemiol , vol.28 , pp. 677-688
    • Baltar, V.T.1    Xun, W.W.2    Johansson, M.3    Ferrari, P.4    Chuang, S.C.5    Relton, C.6
  • 24
    • 77957080722 scopus 로고    scopus 로고
    • Serum vitamin B12 and folate status among patients with chemotherapy treatment for advanced colorectal cancer
    • PMID: 19736606
    • Bystrom P, Bjorkegren K, Larsson A, Johansson L, Berglund A. Serum vitamin B12 and folate status among patients with chemotherapy treatment for advanced colorectal cancer. Ups J Med Sci. 2009; 114: 160-164. doi: 10.1080/03009730903027172 PMID: 19736606
    • (2009) Ups J Med Sci , vol.114 , pp. 160-164
    • Bystrom, P.1    Bjorkegren, K.2    Larsson, A.3    Johansson, L.4    Berglund, A.5
  • 25
    • 56849119374 scopus 로고    scopus 로고
    • Effect of Vitamin B (12) and Folate on Homocysteine levels in colorectal cancer
    • PMID: 23105766
    • Chandy S, Sadananda AM, Ramaswamy G, Ramachandra C, Krishnamoorthy L. Effect of Vitamin B (12) and Folate on Homocysteine levels in colorectal cancer. Indian J Clin Biochem. 2008; 23: 258-261. doi: 10.1007/s12291-008-0058-7 PMID: 23105766
    • (2008) Indian J Clin Biochem , vol.23 , pp. 258-261
    • Chandy, S.1    Sadananda, A.M.2    Ramaswamy, G.3    Ramachandra, C.4    Krishnamoorthy, L.5
  • 26
    • 77956975535 scopus 로고    scopus 로고
    • Polymorphisms in one-carbon metabolism pathway genes, urinary arsenic profile, and urothelial carcinoma
    • PMID: 20532609
    • Chung CJ, Pu YS, Su CT, Chen HW, Huang YK, Shiue HS, et al. Polymorphisms in one-carbon metabolism pathway genes, urinary arsenic profile, and urothelial carcinoma. Cancer Causes Control. 2010; 21: 1605-1613. doi: 10.1007/s10552-010-9589-3 PMID: 20532609
    • (2010) Cancer Causes Control , vol.21 , pp. 1605-1613
    • Chung, C.J.1    Pu, Y.S.2    Su, C.T.3    Chen, H.W.4    Huang, Y.K.5    Shiue, H.S.6
  • 27
    • 50449089655 scopus 로고    scopus 로고
    • The reduced folate carrier (RFC1) 80G > A and folate hydrolase 1 (FOLH1) 1561C > T polymorphisms and the risk of colorectal cancer: A nested case-referent study
    • PMID: 19172696
    • Eklof V, Van Guelpen B, Hultdin J, Johansson I, Hallmans G, Palmqvist R. The reduced folate carrier (RFC1) 80G > A and folate hydrolase 1 (FOLH1) 1561C > T polymorphisms and the risk of colorectal cancer: a nested case-referent study. Scand J Clin Lab Invest. 2008; 68: 393-401. doi: 10.1080/00365510701805431 PMID: 19172696
    • (2008) Scand J Clin Lab Invest , vol.68 , pp. 393-401
    • Eklof, V.1    Van Guelpen, B.2    Hultdin, J.3    Johansson, I.4    Hallmans, G.5    Palmqvist, R.6
  • 28
    • 33745582521 scopus 로고    scopus 로고
    • Association between squamous cell carcinoma of the head and neck and serum folate and homocysteine
    • PMID: 16821614
    • Eleftheriadou A, Chalastras T, Ferekidou E, Yiotakis I, Kyriou L, Tzagarakis M, et al. Association between squamous cell carcinoma of the head and neck and serum folate and homocysteine. Anticancer Res. 2006; 26: 2345-2348. PMID: 16821614
    • (2006) Anticancer Res , vol.26 , pp. 2345-2348
    • Eleftheriadou, A.1    Chalastras, T.2    Ferekidou, E.3    Yiotakis, I.4    Kyriou, L.5    Tzagarakis, M.6
  • 29
    • 34447569310 scopus 로고    scopus 로고
    • Case-control study evaluating the incidence of hyperhomocysteinemia in cancer patients in an internal medicine department
    • PMID: 17537549
    • Falvo N, Ghiringhelli F, Berthier S, Bonnotte B, Lorcerie B. [Case-control study evaluating the incidence of hyperhomocysteinemia in cancer patients in an internal medicine department]. Rev Med Interne. 2007; 28: 520-525. PMID: 17537549
    • (2007) Rev Med Interne , vol.28 , pp. 520-525
    • Falvo, N.1    Ghiringhelli, F.2    Berthier, S.3    Bonnotte, B.4    Lorcerie, B.5
  • 30
    • 77955665039 scopus 로고    scopus 로고
    • A prospective study of one-carbon metabolism biomarkers and risk of renal cell carcinoma
    • PMID: 20383577
    • Gibson TM, Weinstein SJ, Mayne ST, Pfeiffer RM, Selhub J, Taylor PR, et al. A prospective study of one-carbon metabolism biomarkers and risk of renal cell carcinoma. Cancer Causes Control. 2010; 21: 1061-1069. doi: 10.1007/s10552-010-9534-5 PMID: 20383577
    • (2010) Cancer Causes Control , vol.21 , pp. 1061-1069
    • Gibson, T.M.1    Weinstein, S.J.2    Mayne, S.T.3    Pfeiffer, R.M.4    Selhub, J.5    Taylor, P.R.6
  • 31
    • 78650825825 scopus 로고    scopus 로고
    • Evaluation of the roles of serum vitamin B(12), folate and homocysteine levels in laryngeal squamous cell carcinoma
    • PMID: 21227009
    • Gorgulu O, Selcuk T, Ozdemir S, Sayar C, Beyazit Y, Akbas Y. Evaluation of the roles of serum vitamin B(12), folate and homocysteine levels in laryngeal squamous cell carcinoma. J Int Med Res. 2010; 38: 2047-2052. PMID: 21227009
    • (2010) J Int Med Res , vol.38 , pp. 2047-2052
    • Gorgulu, O.1    Selcuk, T.2    Ozdemir, S.3    Sayar, C.4    Beyazit, Y.5    Akbas, Y.6
  • 32
    • 0035313298 scopus 로고    scopus 로고
    • Association of the B-vitamins pyridoxal 5′-phosphate (B(6)), B(12), and folate with lung cancer risk in older men
    • PMID: 11282797
    • Hartman TJ, Woodson K, Stolzenberg-Solomon R, Virtamo J, Selhub J, Barrett MJ, et al. Association of the B-vitamins pyridoxal 5′-phosphate (B(6)), B(12), and folate with lung cancer risk in older men. Am J Epidemiol. 2001; 153: 688-694. PMID: 11282797
    • (2001) Am J Epidemiol , vol.153 , pp. 688-694
    • Hartman, T.J.1    Woodson, K.2    Stolzenberg-Solomon, R.3    Virtamo, J.4    Selhub, J.5    Barrett, M.J.6
  • 33
    • 11944273390 scopus 로고    scopus 로고
    • Plasma folate, vitamin B12, and homocysteine and prostate cancer risk: A prospective study
    • PMID: 15499634
    • Hultdin J, Van Guelpen B, Bergh A, Hallmans G, Stattin P. Plasma folate, vitamin B12, and homocysteine and prostate cancer risk: a prospective study. Int J Cancer. 2005; 113: 819-824. PMID: 15499634
    • (2005) Int J Cancer , vol.113 , pp. 819-824
    • Hultdin, J.1    Van Guelpen, B.2    Bergh, A.3    Hallmans, G.4    Stattin, P.5
  • 34
    • 0034890691 scopus 로고    scopus 로고
    • Folate status among patients with non-small cell lung cancer: A case-control study
    • PMID: 11473373
    • Jatoi A, Daly BD, Kramer G, Mason JB. Folate status among patients with non-small cell lung cancer: a case-control study. J Surg Oncol. 2001; 77: 247-252. PMID: 11473373
    • (2001) J Surg Oncol , vol.77 , pp. 247-252
    • Jatoi, A.1    Daly, B.D.2    Kramer, G.3    Mason, J.B.4
  • 35
    • 80051546464 scopus 로고    scopus 로고
    • The elevated homocysteine stimulates changes of haemostatic function of plasma isolated from breast cancer patients
    • PMID: 21533764
    • Kedzierska M, Malinowska J, Glowacki R, Olas B, Bald E, Jeziorski A, et al. The elevated homocysteine stimulates changes of haemostatic function of plasma isolated from breast cancer patients. Mol Cell Biochem. 2011; 355: 193-199. doi: 10.1007/s11010-011-0854-x PMID: 21533764
    • (2011) Mol Cell Biochem , vol.355 , pp. 193-199
    • Kedzierska, M.1    Malinowska, J.2    Glowacki, R.3    Olas, B.4    Bald, E.5    Jeziorski, A.6
  • 37
    • 66649123133 scopus 로고    scopus 로고
    • Prospective study of plasma vitamin B6 and risk of colorectal cancer in men
    • PMID: 19336555
    • Lee JE, Li H, Giovannucci E, Lee IM, Selhub J, Stampfer M, et al. Prospective study of plasma vitamin B6 and risk of colorectal cancer in men. Cancer Epidemiol Biomarkers Prev. 2009; 18: 1197-1202. doi: 10.1158/1055-9965.EPI-08-1001 PMID: 19336555
    • (2009) Cancer Epidemiol Biomarkers Prev , vol.18 , pp. 1197-1202
    • Lee, J.E.1    Li, H.2    Giovannucci, E.3    Lee, I.M.4    Selhub, J.5    Stampfer, M.6
  • 38
    • 79952281669 scopus 로고    scopus 로고
    • Aberrations in one-carbon metabolism induce oxidative DNA damage in sporadic breast cancer
    • PMID: 21113649
    • Mohammad NS, Yedluri R, Addepalli P, Gottumukkala SR, Digumarti RR, Kutala VK. Aberrations in one-carbon metabolism induce oxidative DNA damage in sporadic breast cancer. Mol Cell Biochem. 2011; 349: 159-167. doi: 10.1007/s11010-010-0670-8 PMID: 21113649
    • (2011) Mol Cell Biochem , vol.349 , pp. 159-167
    • Mohammad, N.S.1    Yedluri, R.2    Addepalli, P.3    Gottumukkala, S.R.4    Digumarti, R.R.5    Kutala, V.K.6
  • 39
    • 58149265144 scopus 로고    scopus 로고
    • Plasma homocysteine, folate, and vitamin B12 levels in patients with laryngeal cancer
    • PMID: 19075131
    • Nacci A, Dallan I, Bruschini L, Traino AC, Panicucci E, Bruschini P, et al. Plasma homocysteine, folate, and vitamin B12 levels in patients with laryngeal cancer. Arch Otolaryngol Head Neck Surg. 2008; 134: 1328-1333. doi: 10.1001/archotol.134.12.1328 PMID: 19075131
    • (2008) Arch Otolaryngol Head Neck Surg , vol.134 , pp. 1328-1333
    • Nacci, A.1    Dallan, I.2    Bruschini, L.3    Traino, A.C.4    Panicucci, E.5    Bruschini, P.6
  • 40
    • 34247149967 scopus 로고    scopus 로고
    • Usefulness of homocysteine as a cancer marker: Total thiol compounds and folate levels in untreated lung cancer patients
    • PMID: 17465261
    • Ozkan Y, Yardim-Akaydin S, Firat H, Caliskan-Can E, Ardic S, Sim?ek B. Usefulness of homocysteine as a cancer marker: total thiol compounds and folate levels in untreated lung cancer patients. Anticancer Res. 2007; 27: 1185-1189. PMID: 17465261
    • (2007) Anticancer Res , vol.27 , pp. 1185-1189
    • Ozkan, Y.1    Yardim-Akaydin, S.2    Firat, H.3    Caliskan-Can, E.4    Ardic, S.5    Simşek, B.6
  • 41
    • 84862491547 scopus 로고    scopus 로고
    • Cervical cancer pathogenesis is associated with one-carbon metabolism
    • PMID: 22729741
    • Pathak S, Bhatla N, Singh N. Cervical cancer pathogenesis is associated with one-carbon metabolism. Mol Cell Biochem. 2012; 369: 1-7. doi: 10.1007/s11010-012-1362-3 PMID: 22729741
    • (2012) Mol Cell Biochem , vol.369 , pp. 1-7
    • Pathak, S.1    Bhatla, N.2    Singh, N.3
  • 42
    • 0038523843 scopus 로고    scopus 로고
    • Folate status, genomic DNA hypomethylation, and risk of colorectal adenoma and cancer: A case control study
    • PMID: 12730865
    • Pufulete M, Al-Ghnaniem R, Leather AJ, Appleby P, Gout S, Terry C, et al. Folate status, genomic DNA hypomethylation, and risk of colorectal adenoma and cancer: a case control study. Gastroenterology. 2003; 124: 1240-1248. PMID: 12730865
    • (2003) Gastroenterology , vol.124 , pp. 1240-1248
    • Pufulete, M.1    Al-Ghnaniem, R.2    Leather, A.J.3    Appleby, P.4    Gout, S.5    Terry, C.6
  • 43
    • 84858800305 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase (MTHFR) gene C677T, A1298C and G1793A polymorphisms: Association with risk for clear cell renal cell carcinoma and tumour behaviour in men
    • PMID: 21489764
    • Safarinejad MR, Shafiei N, Safarinejad S. Methylenetetrahydrofolate reductase (MTHFR) gene C677T, A1298C and G1793A polymorphisms: association with risk for clear cell renal cell carcinoma and tumour behaviour in men. Clin Oncol (R Coll Radiol). 2012; 24: 269-281. doi: 10.1016/j.clon.2011.03.005 PMID: 21489764
    • (2012) Clin Oncol (R Coll Radiol) , vol.24 , pp. 269-281
    • Safarinejad, M.R.1    Shafiei, N.2    Safarinejad, S.3
  • 44
    • 84655170188 scopus 로고    scopus 로고
    • Genetic susceptibility of methylenetetrahydrofolate reductase (MTHFR) gene C677T, A1298C, and G1793A polymorphisms with risk for bladder transitional cell carcinoma in men
    • PMID: 21046286
    • Safarinejad MR, Shafiei N, Safarinejad S. Genetic susceptibility of methylenetetrahydrofolate reductase (MTHFR) gene C677T, A1298C, and G1793A polymorphisms with risk for bladder transitional cell carcinoma in men. Med Oncol. 2011; 28 Suppl 1: S398-S412. doi: 10.1007/s12032-010-9723-9 PMID: 21046286
    • (2011) Med Oncol , vol.28 , pp. S398-S412
    • Safarinejad, M.R.1    Shafiei, N.2    Safarinejad, S.3
  • 45
    • 77958497609 scopus 로고    scopus 로고
    • Relationship between three polymorphisms of methylenetetrahydrofolate reductase (MTHFR C677T, A1298C, and G1793A) gene and risk of prostate cancer: A case-control study
    • PMID: 20564317
    • Safarinejad MR, Shafiei N, Safarinejad S. Relationship between three polymorphisms of methylenetetrahydrofolate reductase (MTHFR C677T, A1298C, and G1793A) gene and risk of prostate cancer: a case-control study. Prostate. 2010; 70: 1645-1657. doi: 10.1002/pros.21200 PMID: 20564317
    • (2010) Prostate , vol.70 , pp. 1645-1657
    • Safarinejad, M.R.1    Shafiei, N.2    Safarinejad, S.3
  • 46
    • 34347259943 scopus 로고    scopus 로고
    • Plasma folate, vitamin B6, vitamin B12, and homocysteine and pancreatic cancer risk in four large cohorts
    • PMID: 17545639
    • Schernhammer E, Wolpin B, Rifai N, Cochrane B, Manson JA, Ma J, et al. Plasma folate, vitamin B6, vitamin B12, and homocysteine and pancreatic cancer risk in four large cohorts. Cancer Res. 2007; 67: 5553-5560. PMID: 17545639
    • (2007) Cancer Res , vol.67 , pp. 5553-5560
    • Schernhammer, E.1    Wolpin, B.2    Rifai, N.3    Cochrane, B.4    Manson, J.A.5    Ma, J.6
  • 50
    • 84875630861 scopus 로고    scopus 로고
    • Serum folate and vitamin B12 concentrations in relation to prostate cancer risk - A Norwegian population-based nested case-control study of 3000 cases and 3000 controls within the JANUS cohort
    • PMID: 23508410
    • de Vogel S, Meyer K, Fredriksen A, Ulvik A, Ueland PM, Nygård O, et al. Serum folate and vitamin B12 concentrations in relation to prostate cancer risk - a Norwegian population-based nested case-control study of 3000 cases and 3000 controls within the JANUS cohort. Int J Epidemiol. 2013; 42: 201-210. doi: 10.1093/ije/dys199 PMID: 23508410
    • (2013) Int J Epidemiol , vol.42 , pp. 201-210
    • De Vogel, S.1    Meyer, K.2    Fredriksen, A.3    Ulvik, A.4    Ueland, P.M.5    Nygård, O.6
  • 51
    • 84930684809 scopus 로고    scopus 로고
    • Relationship between plasma homocysteine, folate and vitaminB12 levels and non-small cell lung cancer
    • Wei K, Huang Y. Relationship between plasma homocysteine, folate and vitaminB12 levels and non-small cell lung cancer. Int J Lab Med. 2012; 33: 699-701.
    • (2012) Int J Lab Med , vol.33 , pp. 699-701
    • Wei, K.1    Huang, Y.2
  • 52
    • 84930640410 scopus 로고    scopus 로고
    • Analysis of clinical significance for the detection of serum homocysteine for digestive system cancer patients. Modern preventive
    • Yan LD, Li P-ping Z. Analysis of clinical significance for the detection of serum homocysteine for digestive system cancer patients. Modern preventive Medicine. 2012; 39: 1754-1755.
    • (2012) Medicine , vol.39 , pp. 1754-1755
    • Yan, L.D.1    Li P-Ping, Z.2
  • 53
    • 84930673717 scopus 로고    scopus 로고
    • The clinical significance of Serumhomocystein inprimary hepatic carcinoma
    • Fu ZB, Shi ZN, Cheng LH, Rong NL, Di X. The clinical significance of Serumhomocystein inprimary hepatic carcinoma. Modern Oncology. 2010; 18: 767-768.
    • (2010) Modern Oncology , vol.18 , pp. 767-768
    • Fu, Z.B.1    Shi, Z.N.2    Cheng, L.H.3    Rong, N.L.4    Di, X.5
  • 54
    • 84930620635 scopus 로고    scopus 로고
    • Determination of pre and post-operative contents of plasma homocysteine and serum folic acid and vitamine B12 in patients with esophageal cancer and its clinical significance
    • He HM, Zhu F, Shi GL, Huangpu YM. Determination of pre and post-operative contents of plasma homocysteine and serum folic acid and vitamine B12 in patients with esophageal cancer and its clinical significance. MEDICAL JOURNAL OF THE CHINESE PEOPLE'S ARMED POLICE FORCES. 2010; 21: 481-482, 485.
    • (2010) Medical Journal of the Chinese People's Armed Police Forces , vol.21
    • He, H.M.1    Zhu, F.2    Shi, G.L.3    Huangpu, Y.M.4
  • 56
    • 84930666092 scopus 로고    scopus 로고
    • Clinical Significance of Determination of Changes of Plasma of Hcy and Serum Folic Acid, VitminB12 Levels After Operation in Patients with Primary Hepatic Cancer
    • Yang CX, Bian BX, Hu N. Clinical Significance of Determination of Changes of Plasma of Hcy and Serum Folic Acid, VitminB12 Levels After Operation in Patients with Primary Hepatic Cancer. JOURNAL OF RADIOIMMUNOLOGY. 2008; 21: 116-117.
    • (2008) Journal of Radioimmunology , vol.21 , pp. 116-117
    • Yang, C.X.1    Bian, B.X.2    Hu, N.3
  • 57
    • 84930658970 scopus 로고    scopus 로고
    • Clinical Significance of Determination of Changes of Serum Homocysteine Levels in Patients with Maligant Tumors of Digestive System
    • Zhu PM. Clinical Significance of Determination of Changes of Serum Homocysteine Levels in Patients with Maligant Tumors of Digestive System. JOURNAL OF RADIOIMMUNOLOGY. 2007; 20: 587-589.
    • (2007) Journal of Radioimmunology , vol.20 , pp. 587-589
    • Zhu, P.M.1
  • 58
    • 84930670187 scopus 로고    scopus 로고
    • Initial Investigation of the Level of Total Plasma Homocysteine in 7 Kinds of Tumor
    • Qiao R, Zhang J, Wang ZH, Liang GC, Wu YH. Initial Investigation of the Level of Total Plasma Homocysteine in 7 Kinds of Tumor. J Mod Lab Med. 2006; 21: 7-10.
    • (2006) J Mod Lab Med , vol.21 , pp. 7-10
    • Qiao, R.1    Zhang, J.2    Wang, Z.H.3    Liang, G.C.4    Wu, Y.H.5
  • 59
    • 84930646542 scopus 로고    scopus 로고
    • Relationship between plasma homocysteine and serum folate in patients with gynecology tumor
    • Xu J, Xu HM, Wang YM, Huang PZ, Li ZM. Relationship between plasma homocysteine and serum folate in patients with gynecology tumor. CHINA ONCOLOGY. 2000; 10: 78-80.
    • (2000) China Oncology , vol.10 , pp. 78-80
    • Xu, J.1    Xu, H.M.2    Wang, Y.M.3    Huang, P.Z.4    Li, Z.M.5
  • 60
    • 33750614452 scopus 로고    scopus 로고
    • Total plasma homocysteine and methylenetetrahydrofolate reductase C677T polymorphism in patients with colorectal carcinoma
    • PMID: 17036383
    • Battistelli S, Vittoria A, Stefanoni M, Bing C, Roviello F. Total plasma homocysteine and methylenetetrahydrofolate reductase C677T polymorphism in patients with colorectal carcinoma. World J Gastroenterol. 2006; 12: 6128-6132. PMID: 17036383
    • (2006) World J Gastroenterol , vol.12 , pp. 6128-6132
    • Battistelli, S.1    Vittoria, A.2    Stefanoni, M.3    Bing, C.4    Roviello, F.5
  • 61
    • 33845923845 scopus 로고    scopus 로고
    • Polymorphisms of 5,10-methylenetetrahydrofolate reductase (MTHFR C677T) and thymidylate synthase enhancer region (TSER) as a risk factor of cholangiocarcinoma in a Korean population
    • PMID: 17201138
    • Ko KH, Kim NK, Yim DJ, Hong SP, Park PW, Rim KS, et al. Polymorphisms of 5,10-methylenetetrahydrofolate reductase (MTHFR C677T) and thymidylate synthase enhancer region (TSER) as a risk factor of cholangiocarcinoma in a Korean population. Anticancer Res. 2006; 26: 4229-4233. PMID: 17201138
    • (2006) Anticancer Res , vol.26 , pp. 4229-4233
    • Ko, K.H.1    Kim, N.K.2    Yim, D.J.3    Hong, S.P.4    Park, P.W.5    Rim, K.S.6
  • 62
    • 75749086766 scopus 로고    scopus 로고
    • Homocysteine levels are associated with cervical cancer independent of methylene tetrahydrofolate reductase gene (MTHFR) polymorphisms in Indian population
    • PMID: 19793004
    • Kohaar I, Kumar J, Thakur N, Hussain S, Niyaz MK, Das BC, et al. Homocysteine levels are associated with cervical cancer independent of methylene tetrahydrofolate reductase gene (MTHFR) polymorphisms in Indian population. Biomarkers. 2010; 15: 61-68. doi: 10.3109/13547500903295881 PMID: 19793004
    • (2010) Biomarkers , vol.15 , pp. 61-68
    • Kohaar, I.1    Kumar, J.2    Thakur, N.3    Hussain, S.4    Niyaz, M.K.5    Das, B.C.6
  • 63
    • 77957286796 scopus 로고    scopus 로고
    • SHMT1 1420 and MTHFR 677 variants are associated with rectal but not colon cancer
    • PMID: 20920350
    • Komlosi V, Hitre E, Pap E, Adleff V, Reti A, Szekely E, et al. SHMT1 1420 and MTHFR 677 variants are associated with rectal but not colon cancer. BMC Cancer. 2010; 10: 525. doi: 10.1186/1471-2407-10-525 PMID: 20920350
    • (2010) BMC Cancer , vol.10 , pp. 525
    • Komlosi, V.1    Hitre, E.2    Pap, E.3    Adleff, V.4    Reti, A.5    Szekely, E.6
  • 64
    • 12144291633 scopus 로고    scopus 로고
    • Genetic and plasma markers of venous thromboembolism in patients with high grade glioma
    • PMID: 14977830
    • Sciacca FL, Ciusani E, Silvani A, Corsini E, Frigerio S, Pogliani S, et al. Genetic and plasma markers of venous thromboembolism in patients with high grade glioma. Clin Cancer Res. 2004; 10: 1312-1317. PMID: 14977830
    • (2004) Clin Cancer Res , vol.10 , pp. 1312-1317
    • Sciacca, F.L.1    Ciusani, E.2    Silvani, A.3    Corsini, E.4    Frigerio, S.5    Pogliani, S.6
  • 65
    • 84885468504 scopus 로고    scopus 로고
    • Systemic folate status, rectal mucosal folate concentration and dietary intake in patients at differential risk of bowel cancer (The FAB2 Study)
    • PMID: 23271614
    • Williams EA, Welfare M, Spiers A, Hill MH, Bal W, Gibney ER, et al. Systemic folate status, rectal mucosal folate concentration and dietary intake in patients at differential risk of bowel cancer (The FAB2 Study). Eur J Nutr. 2013; 52: 1801-1810. doi: 10.1007/s00394-012-0483-5 PMID: 23271614
    • (2013) Eur J Nutr , vol.52 , pp. 1801-1810
    • Williams, E.A.1    Welfare, M.2    Spiers, A.3    Hill, M.H.4    Bal, W.5    Gibney, E.R.6
  • 66
    • 84861984223 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase C677T gene polymorphism and colorectal cancer risk: A case-control study
    • PMID: 22844384
    • Yin G, Ming H, Zheng X, Xuan Y, Liang J, Jin X. Methylenetetrahydrofolate reductase C677T gene polymorphism and colorectal cancer risk: A case-control study. Oncol Lett. 2012; 4: 365-369. PMID: 22844384
    • (2012) Oncol Lett , vol.4 , pp. 365-369
    • Yin, G.1    Ming, H.2    Zheng, X.3    Xuan, Y.4    Liang, J.5    Jin, X.6
  • 67
    • 70349653752 scopus 로고    scopus 로고
    • The effects of tamoxifen on homocysteine levels in breast cancer patients
    • Eroglu A, Egin Y, Akar N. The effects of tamoxifen on homocysteine levels in breast cancer patients. CENTRAL EUROPEAN JOURNAL OF MEDICINE. 2009; 4: 450-453.
    • (2009) Central European Journal of Medicine , vol.4 , pp. 450-453
    • Eroglu, A.1    Egin, Y.2    Akar, N.3
  • 70
    • 84870418830 scopus 로고    scopus 로고
    • Changes in plasma thiol levels induced by different phases of treatment in breast cancer; the role of commercial extract from black chokeberry
    • PMID: 22949034
    • Kedzierska M, Glowacki R, Czernek U, Szydlowska-Pazera K, Potemski P, Piekarski J, et al. Changes in plasma thiol levels induced by different phases of treatment in breast cancer; the role of commercial extract from black chokeberry. Mol Cell Biochem. 2013; 372: 47-55. doi: 10.1007/s11010-012-1444-2 PMID: 22949034
    • (2013) Mol Cell Biochem , vol.372 , pp. 47-55
    • Kedzierska, M.1    Glowacki, R.2    Czernek, U.3    Szydlowska-Pazera, K.4    Potemski, P.5    Piekarski, J.6
  • 71
    • 77950240233 scopus 로고    scopus 로고
    • Plasma homocysteine and cysteine and risk of breast cancer in women
    • PMID: 20197471
    • Lin J, Lee IM, Song Y, Cook NR, Selhub J, Manson JE, et al. Plasma homocysteine and cysteine and risk of breast cancer in women. Cancer Res. 2010; 70: 2397-2405. doi: 10.1158/0008-5472.CAN-09-3648 PMID: 20197471
    • (2010) Cancer Res , vol.70 , pp. 2397-2405
    • Lin, J.1    Lee, I.M.2    Song, Y.3    Cook, N.R.4    Selhub, J.5    Manson, J.E.6
  • 72
    • 84875827580 scopus 로고    scopus 로고
    • Homocysteine, cysteine, and risk of incident colorectal cancer in the Women's Health Initiative observational cohort
    • PMID: 23426034
    • Miller JW, Beresford SA, Neuhouser ML, Cheng TY, Song X, Brown EC, et al. Homocysteine, cysteine, and risk of incident colorectal cancer in the Women's Health Initiative observational cohort. Am J Clin Nutr. 2013; 97: 827-834. doi: 10.3945/ajcn.112.049932 PMID: 23426034
    • (2013) Am J Clin Nutr , vol.97 , pp. 827-834
    • Miller, J.W.1    Beresford, S.A.2    Neuhouser, M.L.3    Cheng, T.Y.4    Song, X.5    Brown, E.C.6
  • 74
    • 84930621363 scopus 로고    scopus 로고
    • Clinical Significance of Measurement of Changes of Serum CA125, Hcy and HE4 Levels After Operation in Patients with Ovarian Cancer
    • Zhang CY. Clinical Significance of Measurement of Changes of Serum CA125, Hcy and HE4 Levels After Operation in Patients with Ovarian Cancer. JOURNAL OF RADIOIMMUNOLOGY. 2012; 25: 406-408.
    • (2012) Journal of Radioimmunology , vol.25 , pp. 406-408
    • Zhang, C.Y.1
  • 76
    • 84930621155 scopus 로고    scopus 로고
    • Clinical Assessment of Determination of Changes of Serum CA72-4, Hcy and CysC Levels Both Before and After Operation in Patients with Gastric Cancer
    • Ding HB, Nan YG, Jiang CY. Clinical Assessment of Determination of Changes of Serum CA72-4, Hcy and CysC Levels Both Before and After Operation in Patients with Gastric Cancer. JOURNAL OF RADIOIMMUNOLOGY. 2011; 24: 639-641.
    • (2011) Journal of Radioimmunology , vol.24 , pp. 639-641
    • Ding, H.B.1    Nan, Y.G.2    Jiang, C.Y.3
  • 77
    • 84930650463 scopus 로고    scopus 로고
    • Clinical Significance of Determination of Changes on Serum Hcy, CA-72-4 and VEGF Levels Both Before and After Operation in Patients with Esophageal Cancer
    • He BH, Chen GH, Pan YP, Shao ZF. Clinical Significance of Determination of Changes on Serum Hcy, CA-72-4 and VEGF Levels Both Before and After Operation in Patients with Esophageal Cancer. JOURNAL OF RADIOIMMUNOLOGY. 2012; 25: 500-502.
    • (2012) Journal of Radioimmunology , vol.25 , pp. 500-502
    • He, B.H.1    Chen, G.H.2    Pan, Y.P.3    Shao, Z.F.4
  • 78
    • 84930634062 scopus 로고    scopus 로고
    • Clinical Significance of Determination of Changes of Serum Hcy, IGF-II and TSGF Levels After Operation in Patients with Esophageal Cancer
    • He BH, Chen GH, Pan YP. Clinical Significance of Determination of Changes of Serum Hcy, IGF-II and TSGF Levels After Operation in Patients with Esophageal Cancer. JOURNAL OF RADIOIMMUNOLOGY. 2010; 23: 491-492.
    • (2010) Journal of Radioimmunology , vol.23 , pp. 491-492
    • He, B.H.1    Chen, G.H.2    Pan, Y.P.3
  • 79
    • 84930633194 scopus 로고    scopus 로고
    • The detection and analysis of serum homocysteine and cystatin C level in patients with malignancy
    • Li HL, Li HM, Li B. The detection and analysis of serum homocysteine and cystatin C level in patients with malignancy. Chinese Journal of Primary Medicine and Pharmacy. 2012; 19: 3208-3209.
    • (2012) Chinese Journal of Primary Medicine and Pharmacy , vol.19 , pp. 3208-3209
    • Li, H.L.1    Li, H.M.2    Li, B.3
  • 80
    • 84930666953 scopus 로고    scopus 로고
    • Clinical significance of measurement of serum vascular endothelial growth factor(VEGF) and plasma homocysteine(HCY) levels before and after operation in patients with gastric cancer
    • Tai YH, Wang F, Tang ZQ. Clinical significance of measurement of serum vascular endothelial growth factor(VEGF) and plasma homocysteine(HCY) levels before and after operation in patients with gastric cancer. JOURNAL OF HUAIHAI MEDICINE. 2009; 27: 195-196.
    • (2009) Journal of Huaihai Medicine. , vol.27 , pp. 195-196
    • Tai, Y.H.1    Wang, F.2    Tang, Z.Q.3
  • 81
    • 84930651802 scopus 로고    scopus 로고
    • Clinical value of combination of AFU, GGT, ALP and Hcy for diagnosis in patients with primary hepatocarcinoma
    • Huang YQ, Liu B, Zahng YH. Clinical value of combination of AFU, GGT, ALP and Hcy for diagnosis in patients with primary hepatocarcinoma. China Journal of Modern Medicine. 2011; 21: 1359-1361.
    • (2011) China Journal of Modern Medicine , vol.21 , pp. 1359-1361
    • Huang, Y.Q.1    Liu, B.2    Zahng, Y.H.3
  • 82
    • 84930638329 scopus 로고    scopus 로고
    • The value of serum homocysteine in primary hepatocarcinoma
    • Zhang SH, Liang ZJ, Huang FW. The value of serum homocysteine in primary hepatocarcinoma. Modern Oncology. 2012; 20: 2580-2581.
    • (2012) Modern Oncology , vol.20 , pp. 2580-2581
    • Zhang, S.H.1    Liang, Z.J.2    Huang, F.W.3
  • 83
    • 77952764206 scopus 로고    scopus 로고
    • Study on the association between total plasma homocysteine levles, dietary habits and the risk of gastric cancer
    • Wang LN, Ke Q, Chen WS, Zhou Y, Tan YF, Wang JM, et al. Study on the association between total plasma homocysteine levles, dietary habits and the risk of gastric cancer. Chin J Epidemiol. 2007; 28: 528-531.
    • (2007) Chin J Epidemiol , vol.28 , pp. 528-531
    • Wang, L.N.1    Ke, Q.2    Chen, W.S.3    Zhou, Y.4    Tan, Y.F.5    Wang, J.M.6
  • 85
    • 84930680425 scopus 로고    scopus 로고
    • Initial investigation of serum homocysteine as cancer biomarker
    • Wang LY, Ma L, Su JR. Initial investigation of serum homocysteine as cancer biomarker. International Journal of Surgery. 2012; 39: 752-755.
    • (2012) International Journal of Surgery , vol.39 , pp. 752-755
    • Wang, L.Y.1    Ma, L.2    Su, J.R.3
  • 86
    • 84930637966 scopus 로고    scopus 로고
    • The value of combined of AFP, AFU and Hcy for diagnosis in patients with primary hepatocarcinoma
    • Lan LD, Huang RY, He B. The value of combined of AFP, AFU and Hcy for diagnosis in patients with primary hepatocarcinoma. CHINESE AND FOREIGN MEDICAL RESEARCH. 2011; 9: 53-54.
    • (2011) Chinese and Foreign Medical Research , vol.9 , pp. 53-54
    • Lan, L.D.1    Huang, R.Y.2    He, B.3
  • 87
    • 84930671925 scopus 로고    scopus 로고
    • Clinical Significance of Measurement of Changes of Plasma Leptin and Serum Hcy, NPY Levels Before and After Chemotherapy in Patients with Lung Cancer
    • Ma JG, Yao JP, Mao CH, Zhao XG. Clinical Significance of Measurement of Changes of Plasma Leptin and Serum Hcy, NPY Levels Before and After Chemotherapy in Patients with Lung Cancer. JOURNAL OF RADIOIMMUNOLOGY. 2011; 24: 502-504.
    • (2011) Journal of Radioimmunology , vol.24 , pp. 502-504
    • Ma, J.G.1    Yao, J.P.2    Mao, C.H.3    Zhao, X.G.4
  • 88
    • 84930631274 scopus 로고    scopus 로고
    • Level of Total Plasma Homocysteine in Colorectal Cancer and Liver Cancer Patients and its Influence in Proliferation
    • Qiao R, Zhang J, Hu XQ, Liang GC, Wu YH. Level of Total Plasma Homocysteine in Colorectal Cancer and Liver Cancer Patients and its Influence in Proliferation. Chin J Misdiagn. 2009; 9: 2773-2775.
    • (2009) Chin J Misdiagn , vol.9 , pp. 2773-2775
    • Qiao, R.1    Zhang, J.2    Hu, X.Q.3    Liang, G.C.4    Wu, Y.H.5
  • 89
    • 84930685867 scopus 로고    scopus 로고
    • Clinical significance of combined detection to serum levels of CA153, HCY and VEGF before and after operation to breast cancer patients
    • Wang R, Zhou J, Sun J. Clinical significance of combined detection to serum levels of CA153, HCY and VEGF before and after operation to breast cancer patients. CHINESE JOURNAL OF SURGICAL ONCOLOGY. 2011; 03: 341-343.
    • (2011) Chinese Journal of Surgical Oncology , vol.3 , pp. 341-343
    • Wang, R.1    Zhou, J.2    Sun, J.3
  • 92
    • 84930682528 scopus 로고    scopus 로고
    • Expression and significance on homocysteine in primary hepatic carcinoma
    • Du X, Li SK, Huang SX. Expression and significance on homocysteine in primary hepatic carcinoma. Modern Preventive Medicine. 2012; 39: 3379-3380.
    • (2012) Modern Preventive Medicine , vol.39 , pp. 3379-3380
    • Du, X.1    Li, S.K.2    Huang, S.X.3
  • 93
    • 84930658757 scopus 로고    scopus 로고
    • Clinical Significance of Combined Detection of Serum Hcy, HE4 and SA Levels in Patients with Ovarian Cancer
    • Chen XC. Clinical Significance of Combined Detection of Serum Hcy, HE4 and SA Levels in Patients with Ovarian Cancer. JOURNAL OF RADIOIMMUNOLOGY. 2012; 25: 187-188.
    • (2012) Journal of Radioimmunology , vol.25 , pp. 187-188
    • Chen, X.C.1
  • 94
    • 84930653918 scopus 로고    scopus 로고
    • Clinical Significance of Determination the Changes of Serum Hcy,CEA and VEGF Levels After Operation in Patients with Esophageal Cancer
    • Wang XY. Clinical Significance of Determination the Changes of Serum Hcy,CEA and VEGF Levels After Operation in Patients with Esophageal Cancer. JOURNAL OF RADIOIMMUNOLOGY. 2011; 24: 622-624.
    • (2011) Journal of Radioimmunology , vol.24 , pp. 622-624
    • Wang, X.Y.1
  • 95
    • 84930675685 scopus 로고    scopus 로고
    • Roles of VWT, GMP-140, TPP Hcy in diagnosing prethrombosis state of lung cancer
    • Zhang XQ, Ni SS. Roles of VWT, GMP-140, TPP Hcy in diagnosing prethrombosis state of lung cancer. Journal of clinical pulmonary. 2010; 15: 1433-1435.
    • (2010) Journal of Clinical Pulmonary , vol.15 , pp. 1433-1435
    • Zhang, X.Q.1    Ni, S.S.2
  • 96
    • 84930657500 scopus 로고    scopus 로고
    • Diagnostic Values of Combined Measurement of Serum CA19-9, Hcy, CA50 and Sialic Acid in Patients with Pancreatic Cancer
    • Zhu WX. Diagnostic Values of Combined Measurement of Serum CA19-9, Hcy, CA50 and Sialic Acid in Patients with Pancreatic Cancer. JOURNAL OF RADIOIMMUNOLOGY. 2011; 24: 132-133.
    • (2011) Journal of Radioimmunology , vol.24 , pp. 132-133
    • Zhu, W.X.1
  • 97
    • 84930631261 scopus 로고    scopus 로고
    • Clinical Significance of Determination of Changes of Serum Hcy, IGF-II and TSGF Levels After Chemotherapy in Patients with Lung Cancer
    • Ji YJ, Wang X, Liu ZH. Clinical Significance of Determination of Changes of Serum Hcy, IGF-II and TSGF Levels After Chemotherapy in Patients with Lung Cancer. JOURNAL OF RADIOIMMUNOLOGY. 2008; 12: 512-514.
    • (2008) Journal of Radioimmunology , vol.12 , pp. 512-514
    • Ji, Y.J.1    Wang, X.2    Liu, Z.H.3
  • 98
    • 84930620815 scopus 로고    scopus 로고
    • Analysis of the relationship between serum homocysteine level and breast tumor
    • Deng YL, Zheng LP. Analysis of the relationship between serum homocysteine level and breast tumor. Modern Preventive Medicine. 2012; 34:87-89.
    • (2012) Modern Preventive Medicine , vol.34 , pp. 87-89
    • Deng, Y.L.1    Zheng, L.P.2
  • 100
    • 84930623946 scopus 로고    scopus 로고
    • Clinical Significance of Changes of SerumCA50, CA242 and Hcy Levels in postoperative Patients with Colorectal Cancer
    • PMID: 22992277
    • Ge YB, Shi SD. Clinical Significance of Changes of SerumCA50, CA242 and Hcy Levels in postoperative Patients with Colorectal Cancer. JOURNAL OF RADIOIMMUNOLOGY. 2012; 25: 12-14. doi: 10.1186/1687-9856-2012-25 PMID: 22992277
    • (2012) Journal of Radioimmunology , vol.25 , pp. 12-14
    • Ge, Y.B.1    Shi, S.D.2
  • 103
    • 79952140468 scopus 로고    scopus 로고
    • Folate and cancer: How DNA damage, repair and methylation impact on colon carcinogenesis
    • PMID: 20544289
    • Duthie SJ. Folate and cancer: how DNA damage, repair and methylation impact on colon carcinogenesis. J Inherit Metab Dis. 2011; 34: 101-109. doi: 10.1007/s10545-010-9128-0 PMID: 20544289
    • (2011) J Inherit Metab Dis , vol.34 , pp. 101-109
    • Duthie, S.J.1
  • 104
    • 84862812218 scopus 로고    scopus 로고
    • Oxidative DNA damage and global DNA hypomethylation are related to folate deficiency in chromate manufacturing workers
    • Wang TC, Song YS, Wang H, Zhang J, Yu SF, Gu YE, et al. Oxidative DNA damage and global DNA hypomethylation are related to folate deficiency in chromate manufacturing workers. J Hazard Mater. 2012; 213-214: 440-446.
    • (2012) J Hazard Mater , vol.213-214 , pp. 440-446
    • Wang, T.C.1    Song, Y.S.2    Wang, H.3    Zhang, J.4    Yu, S.F.5    Gu, Y.E.6
  • 105
    • 33646715354 scopus 로고    scopus 로고
    • Folate intake, alcohol use, and postmenopausal breast cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial
    • PMID: 16600944
    • Stolzenberg-Solomon RZ, Chang SC, Leitzmann MF, Johnson KA, Johnson C, Buys SS, et al. Folate intake, alcohol use, and postmenopausal breast cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Am J Clin Nutr. 2006; 83: 895-904. PMID: 16600944
    • (2006) Am J Clin Nutr , vol.83 , pp. 895-904
    • Stolzenberg-Solomon, R.Z.1    Chang, S.C.2    Leitzmann, M.F.3    Johnson, K.A.4    Johnson, C.5    Buys, S.S.6
  • 106
    • 34249979299 scopus 로고    scopus 로고
    • Folic acid for the prevention of colorectal adenomas: A randomized clinical trial
    • PMID: 17551129
    • Cole BF, Baron JA, Sandler RS, Haile RW, Ahnen DJ, Bresalier RS, et al. Folic acid for the prevention of colorectal adenomas: a randomized clinical trial. JAMA. 2007); 297: 2351-2359. PMID: 17551129
    • (2007) JAMA , vol.297 , pp. 2351-2359
    • Cole, B.F.1    Baron, J.A.2    Sandler, R.S.3    Haile, R.W.4    Ahnen, D.J.5    Bresalier, R.S.6
  • 107
    • 71749111560 scopus 로고    scopus 로고
    • Cancer incidence and mortality after treatment with folic acid and vitamin B12
    • PMID: 19920236
    • Ebbing M, Bonaa KH, Nygard O, Arnesen E, Ueland PM, Nordrehaug JE, et al. Cancer incidence and mortality after treatment with folic acid and vitamin B12. JAMA. 2009; 302: 2119-2126. doi: 10.1001/jama.2009.1622 PMID: 19920236
    • (2009) JAMA , vol.302 , pp. 2119-2126
    • Ebbing, M.1    Bonaa, K.H.2    Nygard, O.3    Arnesen, E.4    Ueland, P.M.5    Nordrehaug, J.E.6
  • 108
    • 64949110935 scopus 로고    scopus 로고
    • Folic acid and risk of prostate cancer: Results from a randomized clinical trial
    • PMID: 19276452
    • Figueiredo JC, Grau MV, Haile RW, Sandler RS, Summers RW, Bresalier RS, et al. Folic acid and risk of prostate cancer: results from a randomized clinical trial. J Natl Cancer Inst. 2009; 101: 432-435. doi: 10.1093/jnci/djp019 PMID: 19276452
    • (2009) J Natl Cancer Inst , vol.101 , pp. 432-435
    • Figueiredo, J.C.1    Grau, M.V.2    Haile, R.W.3    Sandler, R.S.4    Summers, R.W.5    Bresalier, R.S.6
  • 109
    • 34447550432 scopus 로고    scopus 로고
    • A temporal association between folic acid fortification and an increase in colorectal cancer rates
    • may be illuminating important biological principles: A hypothesis. PMID: 17626997
    • Mason JB, Dickstein A, Jacques PF, Haggarty P, Selhub J, Dallal G, et al. A temporal association between folic acid fortification and an increase in colorectal cancer rates may be illuminating important biological principles: a hypothesis. Cancer Epidemiol Biomarkers Prev. 2007; 16: 1325-1329. PMID: 17626997
    • (2007) Cancer Epidemiol Biomarkers Prev , vol.16 , pp. 1325-1329
    • Mason, J.B.1    Dickstein, A.2    Jacques, P.F.3    Haggarty, P.4    Selhub, J.5    Dallal, G.6
  • 110
    • 0034307291 scopus 로고    scopus 로고
    • Effects of dietary folate on intestinal tumorigenesis in the apcMin mouse
    • PMID: 11034085
    • Song J, Medline A, Mason JB, Gallinger S, Kim YI. Effects of dietary folate on intestinal tumorigenesis in the apcMin mouse. Cancer Res. 2000; 60: 5434-5440. PMID: 11034085
    • (2000) Cancer Res , vol.60 , pp. 5434-5440
    • Song, J.1    Medline, A.2    Mason, J.B.3    Gallinger, S.4    Kim, Y.I.5
  • 111
    • 34250197957 scopus 로고    scopus 로고
    • Folate and colorectal cancer: An evidence-based critical review
    • PMID: 17295418
    • Kim YI. Folate and colorectal cancer: an evidence-based critical review. Mol Nutr Food Res. 2007; 51: 267-292. PMID: 17295418
    • (2007) Mol Nutr Food Res , vol.51 , pp. 267-292
    • Kim, Y.I.1
  • 112
    • 33846998339 scopus 로고    scopus 로고
    • Folate and risk of breast cancer: A meta-analysis
    • PMID: 17202114
    • Larsson SC, Giovannucci E, Wolk A. Folate and risk of breast cancer: a meta-analysis. J Natl Cancer Inst. 2007; 99: 64-76. PMID: 17202114
    • (2007) J Natl Cancer Inst , vol.99 , pp. 64-76
    • Larsson, S.C.1    Giovannucci, E.2    Wolk, A.3
  • 113
    • 84891830724 scopus 로고    scopus 로고
    • Alcohol consumption and breast cancer risk among women from five ethnic groups with light to moderate intakes: The Multiethnic Cohort Study
    • PMID: 24037751
    • Park SY, Kolonel LN, Lim U, White KK, Henderson BE, Wilkens LR. Alcohol consumption and breast cancer risk among women from five ethnic groups with light to moderate intakes: The Multiethnic Cohort Study. Int J Cancer. 2013; 134: 1504-1510. doi: 10.1002/ijc.28476 PMID: 24037751
    • (2013) Int J Cancer , vol.134 , pp. 1504-1510
    • Park, S.Y.1    Kolonel, L.N.2    Lim, U.3    White, K.K.4    Henderson, B.E.5    Wilkens, L.R.6
  • 114
    • 84874621106 scopus 로고    scopus 로고
    • Association of Mediterranean diet, dietary supplements and alcohol consumption with breast density among women in South Germany: A cross-sectional study
    • PMID: 23497280
    • Voevodina O, Billich C, Arand B, Nagel G. Association of Mediterranean diet, dietary supplements and alcohol consumption with breast density among women in South Germany: a cross-sectional study. BMC Public Health. 2013; 13: 203. doi: 10.1186/1471-2458-13-203 PMID: 23497280
    • (2013) BMC Public Health , vol.13 , pp. 203
    • Voevodina, O.1    Billich, C.2    Arand, B.3    Nagel, G.4
  • 115
    • 0029978383 scopus 로고    scopus 로고
    • Plasma homocysteine concentrations in a population with a low coronary heart disease prevalence
    • PMID: 8642466
    • Ubbink JB, Delport R, Vermaak WJ. Plasma homocysteine concentrations in a population with a low coronary heart disease prevalence. J Nutr. 1996; 126:1254S-57S. PMID: 8642466
    • (1996) J Nutr , vol.126 , pp. 1254S-57S
    • Ubbink, J.B.1    Delport, R.2    Vermaak, W.J.3
  • 116
    • 0042710878 scopus 로고    scopus 로고
    • Serum total homocysteine concentrations in children and adolescents: Results from the third National Health and Nutrition Examination Survey (NHANES III)
    • PMID: 12888652
    • Must A, Jacques PF, Rogers G, Rosenberg IH, Selhub J. Serum total homocysteine concentrations in children and adolescents: results from the third National Health and Nutrition Examination Survey (NHANES III). J Nutr. 2003; 133:2643-49. PMID: 12888652
    • (2003) J Nutr , vol.133 , pp. 2643-2649
    • Must, A.1    Jacques, P.F.2    Rogers, G.3    Rosenberg, I.H.4    Selhub, J.5
  • 117
    • 0029101432 scopus 로고
    • Effective homocysteine metabolism may protect South African blacks against coronary heart disease
    • PMID: 7572713
    • Ubbink JB, Vermaak WJ, Delport R, van der Merwe A, Becker PJ, et al. Effective homocysteine metabolism may protect South African blacks against coronary heart disease. Am J Clin Nutr. 1995; 62:802-8. PMID: 7572713
    • (1995) Am J Clin Nutr , vol.62 , pp. 802-808
    • Ubbink, J.B.1    Vermaak, W.J.2    Delport, R.3    Van Der Merwe, A.4    Becker, P.J.5
  • 118
    • 84861437536 scopus 로고    scopus 로고
    • A case-control nutrigenomic study on the synergistic activity of folate and vitamin B12 in cervical cancer progression
    • PMID: 22519865
    • Ragasudha PN, Thulaseedharan JV, Wesley R, Jayaprakash PG, Lalitha P, Pillai MR. A case-control nutrigenomic study on the synergistic activity of folate and vitamin B12 in cervical cancer progression. Nutr Cancer. 2012; 64: 550-558. doi: 10.1080/01635581.2012.675618 PMID: 22519865
    • (2012) Nutr Cancer , vol.64 , pp. 550-558
    • Ragasudha, P.N.1    Thulaseedharan, J.V.2    Wesley, R.3    Jayaprakash, P.G.4    Lalitha, P.5    Pillai, M.R.6
  • 119
    • 34447123755 scopus 로고    scopus 로고
    • Low intake of vitamin B-6 is associated with increased risk of colorectal cancer in Japanese men
    • PMID: 17585035
    • Ishihara J, Otani T, Inoue M, Iwasaki M, Sasazuki S, Tsugane S. Low intake of vitamin B-6 is associated with increased risk of colorectal cancer in Japanese men. J Nutr. 2007; 137: 1808-1814. PMID: 17585035
    • (2007) J Nutr , vol.137 , pp. 1808-1814
    • Ishihara, J.1    Otani, T.2    Inoue, M.3    Iwasaki, M.4    Sasazuki, S.5    Tsugane, S.6
  • 121
    • 0030938481 scopus 로고    scopus 로고
    • V677 mutation of methylenetetrahydrofolate reductases and cardiovascular disease in Canadian Inuit
    • PMID: 9130949
    • Hegele RA, Tully C, Young TK, Connelly PW. V677 mutation of methylenetetrahydrofolate reductases and cardiovascular disease in Canadian Inuit. Lancet. 1997; 349:1221-2. PMID: 9130949
    • (1997) Lancet , vol.349 , pp. 1221-1222
    • Hegele, R.A.1    Tully, C.2    Young, T.K.3    Connelly, P.W.4


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