Genetic and epigenetic interactions between folate and aging in carcinogenesis

Journal of Nutrition

Volumn 135, Issue 12, 2005, Pages

  Jang, Hyeran ^a   Mason, Joel B ^a   Choi, Sang Woon ^a  

^a TUFTS UNIVERSITY   (United States)

Author keywords

1 Carbon metabolism; Aging; DNA methylation; Folate; Uracil misincorporation

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); CARBON; DNA; FOLIC ACID; HISTONE; HOMOCYSTEINE; METHYLENETETRAHYDROFOLIC ACID; MITOCHONDRIAL DNA;

AGING; BIOACCUMULATION; CANCER PREVENTION; CANCER RISK; CARBON METABOLISM; CARCINOGENESIS; COLON CANCER; COLON CARCINOGENESIS; COLON MUCOSA; CONFERENCE PAPER; DEPLETION; DIET SUPPLEMENTATION; DIETARY INTAKE; DNA METHYLATION; EPIGENETICS; FOLATE METABOLISM; GENE EXPRESSION; GENETIC ANALYSIS; HUMAN; HYPERHOMOCYSTEINEMIA; MITOCHONDRION; NONHUMAN; NUCLEOTIDE METABOLISM; NUCLEOTIDE SEQUENCE; PROTEIN METHYLATION;

EID: 31544464325     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.1093/jn/135.12.2967s     Document Type: Conference Paper

References (64)

1. Choi SW, Friso S, Dolnikowski GG, Bagley PJ, Edmondson AN, Smith DE, Mason JB. Biochemical and molecular aberrations in the rat colon due to folate depletion are age-specific. J Nutr. 2003;133(4):1206-12.
2. Choi SW, Friso S, Keyes MK, Mason JB. Folate supplementation increases genomic DNA methylation in the liver of elder rats. Br J Nutr. 2005;93(1):31-5.
3. Crott JW, Choi SW, Ordovas JM, Ditelberg JS, Mason JB. Effects of dietary folate and aging on gene expression in the colonic mucosa of rats: implications for carcinogenesis. Carcinogenesis. 2004;25(1):69-76.
4. Crott JW, Choi SW, Branda RF, Mason JB. Accumulation of mitochondrial DNA deletions is age, tissue and folate-dependent in rats. Mutat Res. 2005;570(1):63-70.
5. Kim YI. Folate and carcinogenesis: Evidence, mechanisms, and implications. J Nutr Biochem. 1999;10:66-8.
6. Kim YI. Folate, colorectal carcinogenesis, and DNA methylation: lessons from animal studies. Environ Mol Mutagen. 2004;44(1):10-25.
7. Cravo ML, Mason JB, Dayal Y, Hutchinson M., Smith D, Selhub J, Rosenberg IH. Folate deficiency enhances the development of colonic neoplasia in dimethylhydrazine-treated rats. Cancer Res. 1992;52(18):5002-6.
8. Blount BC, Mack MM, Wehr CM, MacGregor JT, Hiatt RA, Wang G, Wickramasinghe SN, Everson RB, Ames BN. Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. Proc Natl Acad Sci U S A. 1997;94(7):3290-5.
9. Choi SW, Mason JB. Folate status: effects on pathways of colorectal carcinogenesis. J Nutr. 2002;132(8 Suppl):2413S-8.
10. Wagner C. Biochemical role of folate in cellular metabolism. In: Bailey L, editor. Folate in health and disease. New York: Marcel Dekker; 1995. p. 23-42.
11. Mason JB, Choi SW. Folate and carcinogenesis: developing a unifying hypothesis. Adv Enzyme Regul. 2000;40:127-41.
12. Branda RF, Blickensderfer DB. Folate deficiency increases genetic damage caused by alkylating agents and gamma-irradiation in Chinese hamster ovary cells. Cancer Res. 1993;53(22):5401-8.
13. Choi SW, Kim YI, Weitzel JN, Mason JB. Folate depletion impairs DNA excision repair in the colon of the rat. Gut. 1998;43(1):93-9.
14. Melnyk S, Pogribna M, Miller BJ, Basnakian AG, Pogribny IP, James SJ. Uracil misincorporation, DNA strand breaks, and gene amplification are associated with tumorigenic cell transformation in folate deficient/repleted Chinese hamster ovary cells. Cancer Lett. 1999;146:35-44.
15. Ames BN, Wakimoto P. Are vitamin and mineral deficiencies a major cancer risk? Nat Rev Cancer. 2002;2(9):694-704.
16. Duthie SJ, Hawdon A. DNA instability (strand breakage, uracil misincorporation, and defective repair) is increased by folic acid depletion in human lymphocytes in vitro. FASEB J. 1998;12(14):1491-7.
17. Friso S, Choi SW, Girelli D, Mason JB, Dolnikowski GG, Bagley PJ, Olivieri O, Jacques PF, Rosenberg IH, et al. A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status. Proc Natl Acad Sci U S A. 2002;99(8):5606-11.
18. Yi P, Melnyk S, Pogribna M, Pogribny IP, Hine RJ, James SJ. Increase in plasma homocysteine associated with parallel increases in plasma S-adenosylhomocysteine and lymphocyte DNA hypomethylation. J Biol Chem. 2000;275(38):29318-23.
19. Craig SA. Betaine in human nutrition. Am J Clin Nutr. 2004;80(3):539-49.
20. Verhoef P, Steenge GR, Boelsma E, van Vliet T, Olthof MR, Katan MB. Dietary serine and cystine attenuate the homocysteine-raising effect of dietary methionine: a randomized crossover trial in humans. Am J Clin Nutr. 2004;80(3):674-9.
21. Li E, Bestor TH, Jaenisch R. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell. 1992;69(6):915-26.
22. Panning B, Jaenisch R. RNA and the epigenetic regulation of X chromosome inactivation. Cell. 1998;93(3):305-8.
23. Li E, Beard C, Jaenisch R. Role for DNA methylation in genomic imprinting. Nature. 1993;366(6453):362-5.
24. Walsh CP, Chaillet JR, Bestor TH. Transcription of IAP endogenous retroviruses is constrained by cytosine methylation. Nat Genet. 1998;20(2):116-7.
25. Fraga MF, Herranz M, Espada J, Ballestar E, Paz MF, Ropero S, Erkek E, Bozdogan O, Peinado H, et al. A mouse skin multistage carcinogenesis model reflects the aberrant DNA methylation patterns of human tumors. Cancer Res. 2004;64(16):5527-34.
26. Chen RZ, Pettersson U, Beard C, Jackson-Grusby L, Jaenisch R. DNA hypomethylation leads to elevated mutation rates. Nature. 1998;395(6697):89-93.
27. Yoder JA, Walsh CP, Bestor TH. Cytosine methylation and the ecology of intragenomic parasites. Trends Genet. 1997;13(8):335-40.
28. Feinberg AP. Imprinting of a genomic domain of 11p15 and loss of imprinting in cancer: an introduction. Cancer Res. 1999;59(7 Suppl):1743s-6.
29. Goelz SE, Vogelstein B, Hamilton SR, Feinberg AP. Hypomethylation of DNA from benign and malignant human colon neoplasms. Science. 1985;228(4696):187-90.
30. Robertson KD, Jones PA. DNA methylation: past, present and future directions. Carcinogenesis. 2000;21(3):461-7.
31. Merlo A, Herman JG, Mao L, Lee DJ, Gabrielson E, Burger PC, Baylin SB, Sidransky D. 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nat Med. 1995;1(7):686-92.
32. Gonzalez-Zulueta M, Bender CM, Yang AS, Nguyen T, Beart RW, Van Tornout JM, Jones PA. Methylation of the 5′ CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing. Cancer Res. 1995;55(20):4531-5.
33. Herman JG, Merlo A, Mao L, Lapidus RG, Issa JP, Davidson NE, Sidransky D, Baylin SB. Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers. Cancer Res. 1995;55(20):4525-30.
34. Schneede J, Refsum H, Ueland PM. Biological and environmental determinants of plasma homocysteine. Semin Thromb Hemost. 2000;26(3):263-79.
35. Selhub J, Jacques PF, Wilson PWF, Rush D, Rosenberg IH. Vitamin status and intake as primary determinant of homocysteinemia in the elderly population. J. Am. Med. Assoc. 1993;270(22):2693-8.
36. Hernanz A, Fernandez-Vivancos E, Montiel C, Vazquez JJ, Arnalich F. Changes in the intracellular homocysteine and glutathione content associated with aging. Betaine supplementation and plasma homocysteine in healthy volunteers [letter]. Life Sci. 2000;67(11):1317-24.
37. Finkelstein JD. Methionine metabolism in mammals: effects of age, diet, and hormones on three enzymes of the pathway in rat tissues. Arch Biochem Biophys. 1962;122:583-90.
38. Mays LL, Borek E, Finch CE. Glycine N-methyltransferase is a regulatory enzyme which increases in ageing animals. Nature. 1973;243(5407):411-3.
39. Ingenbleek Y, Young VR. The essentiality of sulfur is closely related to nitrogen metabolism: a clue to hyperhomocysteinaemia. Nutr Res Revs. 2004;17:135-51.
40. Ingenbleek Y, Hardillier E, Jung L. Subclinical protein malnutrition is a determinant of hyperhomocysteinemia. Nutrition. 2002;18(1):40-6.
41. Kim YI. Folate and DNA methylation: a mechanistic link between folate deficiency and colorectal cancer? Cancer Epidemiol Biomarkers Prev. 2004;13(4):511-9.
42. Vanyushin BF, Nemirovsky LE, Klimenko VV, Vasiliev VK, Belozersky AN. The 5-methylcytosine in DNA of rats. Tissue and age specificity and the changes induced by hydrocortisone and other agents. Gerontologia. 1973;19(3):138-52.
43. Vanyushin BF, Mazin AL, Vasilyev VK, Belozersky AN. The content of 5-methylcytosine in animal DNA: the species and tissue specificity. Biochim Biophys Acta. 1973;299(3):397-403.
44. Wilson VL, Smith RA, Ma S, Cutler RG. Genomic 5-methyldeoxycytidine decreases with age. J Biol Chem. 1987;262(21):9948-51.
45. Issa JP, Ottaviano YL, Celano P, Hamilton SR, Davidson NE, Baylin SB. Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon. Nat Genet. 1994;7(4):536-40.
46. Post WS, Goldschmidt-Clermont PJ, Wilhide CC, Heldman AW, Sussman MS, Ouyang P, Milliken EE, Issa JP. Methylation of the estrogen receptor gene is associated with aging and atherosclerosis in the cardiovascular system. Cardiovasc Res. 1999;43(4):985-91.
47. Atamna H, Cheung I, Ames BN. A method for detecting abasic sites in living cells: age-dependent changes in base excision repair. Proc Natl Acad Sci U S A. 2000;97(2):686-91.
48. Szczesny B, Hazra TK, Papaconstantinou J, Mitra S, Boldogh I. Agedependent deficiency in import of mitochondrial DNA glycosylases required for repair of oxidatively damaged bases. Proc Natl Acad Sci U S A. 2003;100(19):10670-5.
49. Lewis PD, Baxter P, Paul Griffiths A, Parry JM, Skibinski DO. Detection of damage to the mitochondrial genome in the oncocytic cells of Warthin's tumour. J Pathol. 2000;191(3):274-81.
50. Maximo V, Soares P, Seruca R, Rocha AS, Castro P, Sobrinho-Simoes M. Microsatellite instability, mitochondrial DNA large deletions, and mitochondrial DNA mutations in gastric carcinoma. Genes Chromosomes Cancer. 2001;32(2):136-43.
51. Clarke S. Aging as war between chemical and biochemical processes: protein methylation and the recognition of age-damaged proteins for repair. Ageing Res Rev. 2003;2(3):263-85.
52. O'Connor CM, Aswad DW, Clarke S. Mammalian brain and erythrocyte carboxyl methyltransferases are similar enzymes that recognize both D-aspartyl and L-isoaspartyl residues in structurally altered protein substrates. Proc Natl Acad Sci U S A. 1984;81(24):7757-61.
53. Aswad DW, Johnson BA, Langmack EL, Shirokawa JM. Modification of isoaspartyl peptides and proteins by protein carboxyl methyltransferase from bovine brain. Adv Exp Med Biol. 1988;231:247-59.
54. Ghandour H, Lin BF, Choi SW, Mason JB, Selhub J. Folate status and age affect the accumulation of L-isoaspartyl residues in rat liver proteins. J Nutr. 2002;132(6):1357-60.
55. Young AL, Carter WG, Doyle HA, Mamula MJ, Aswad DW. Structural integrity of histone H2B in vivo requires the activity of protein L-isoaspartate O-methyltransferase, a putative protein repair enzyme. J Biol Chem. 2001;276(40):37161-5.
56. Zhu WY, Alliegro MA, Melera PW. The rate of folate receptor alpha (FR alpha) synthesis in folate depleted CHL cells is regulated by a translational mechanism sensitive to media folate levels, while stable overexpression of its mRNA is mediated by gene amplification and an increase in transcript half-life. J Cell Biochem. 2001;81(2):205-19.
57. Jansen G, Kathmann I, Rademaker BC, Braakhuis BJ, Westerhof GR, Rijksen G, Schornagel JH. Expression of a folate binding protein in L1210 cells grown in low folate medium. Cancer Res. 1989;49(8):1959-63.
58. Kim YI, Shirwadkar S, Choi SW, Puchyr M, Wang Y, Mason JB. Effects of dietary folate on DNA strand breaks within mutation-prone exons of the p53 gene in rat colon. Gastroenterology. 2000;119(1):151-61.
59. Jhaveri MS, Wagner C, Trepel JB. Impact of extracellular folate levels on global gene expression. Mol Pharmacol. 2001;60(6):1288-95.
60. Geiman TM, Robertson KD. Chromatin remodeling, histone modifications, and DNA methylation-how does it all fit together? J Cell Biochem. 2002;87(2):117-25.
61. Lachner M, Jenuwein T. The many faces of histone lysine methylation. Curr Opin Cell Biol. 2002;14(3):286-98.
62. Kim KC, Geng L, Huang S. Inactivation of a histone methyltransferase by mutations in human cancers. Cancer Res. 2003;63(22):7619-23.
63. Kass SU, Pruss D, Wolffe AP. How does DNA methylation repress transcription? Trends Genet. 1997;13(11):444-9.
64. Leu YW, Yan PS, Fan M, Jin VX, Liu JC, Curran EM, Welshons WV, Wei SH, Davuluri RV, et al. Loss of estrogen receptor signaling triggers epigenetic silencing of downstream targets in breast cancer. Cancer Res. 2004;64(22):8184-92.