Methylenetetrahydrofolate reductase C677T gene polymorphism and colorectal cancer risk: A case-control study

Oncology Letters

Volumn 4, Issue 2, 2012, Pages 365-369

  Yin, Guancheng ^a,b   Ming, Hanxin ^b   Zheng, Xiao ^b   Xuan, Yi ^b   Liang, Jianwei ^b   Jin, Xing ^a  

^a SHANDONG UNIVERSITY   (China)

^b TAIAN CENTRAL HOSPITAL   (China)

Author keywords

Colorectal cancer; Homocysteine; Methylenetetrahydrofolate reductase; Polymorphism

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); GENOMIC DNA; HOMOCYSTEINE;

ADULT; AGED; AMINO ACID BLOOD LEVEL; ARTICLE; CANCER RISK; COLORECTAL CANCER; CONTROLLED STUDY; FEMALE; FLUORESCENCE POLARIZATION IMMUNOASSAY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC RISK; GENOTYPE; HOMOCYSTEINE BLOOD LEVEL; HOSPITAL BASED CASE CONTROL STUDY; HUMAN; MAJOR CLINICAL STUDY; MALE; REAL TIME POLYMERASE CHAIN REACTION;

EID: 84861984223     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2012.740     Document Type: Article

References (28)

1. Choi SW and Mason JB: Folate and carcinogenesis: an integrated scheme. J Nutr 130: 129-132, 2000.
2. Duthie SJ: Folic acid deficiency and cancer: mechanisms of DNA instability. Br Med Bull 55: 578-592, 1999.
3. Mason JB and Choi SW: The mechanisms by which folate depletion enhances colorectal carcinogenesis: a unified scheme. Nestle Nutr Workshop Ser Clin Perform Programme 4: 87-101, 2000.
4. Whiteside MA, Heimburger DC and Johanning GL: Micronutrients and cancer therapy. Nutr Rev 62: 142-147, 2004.
5. Peyrin-Biroulet L, Barraud H, Ancel D, Petit-Laurent F, BigardMA, Gueant JL and Bronowicki JP: Folate metabolism and colorectal carcinogenesis. Gastroenterol Clin Biol 28: 582-592, 2004.
6. Kato I, Dnistrian AM, Schwartz M, et al: Serum folate, homocysteine and colorectal cancer risk in women: a nested case-control study. Br J Cancer 79: 1917-1922, 1999.
7. Chen K, Song L, Jin MJ, Fan CH, Jiang QT and Yu WP: Association between genetic polymorphisms in folate metabolic enzyme genes and colorectal cancer: a nested case-control study. Zhonghua Zhong Liu Za Zhi 28: 429-432, 2006 (In Chinese).
8. Le Marchand L, Wilkens LR, Kolonel LN and Henderson BE: The MTHFR C677T polymorphism and colorectal cancer: the multiethnic cohort study. Cancer Epidemiol Biomarkers Prev 14: 1198-1203, 2005.
9. Kim JK, Kim S, Han JH, et al: Polymorphisms of 5,10-methylenetetrahydrofolate reductase and risk of stomach cancer in a Korean population. Anticancer Res 25: 2249-2252, 2005.
10. Zeybek U, Yaylim I, Yilmaz H, et al: Methylenetetrahydrofolate reductase C677T polymorphism in patients with gastric and colorectal cancer. Cell Biochem Funct 25: 419-422, 2007.
11. Vollset SE, Igland J, Jenab M, et al: The association of gastric cancer risk with plasma folate, cobalamin, and methylenetetrahydrofolate reductase polymorphisms in the European Prospective Investigation into Cancer and Nutrition. Cancer Epidemiol Biomarkers Prev 16: 2416-2424, 2007.
12. Frosst P, Blom HJ, Milos R, et al: A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 10: 111-113, 1995.
13. Finkelstein JD: The metabolism of homocysteine: pathways and regulation. Eur J Pediatr 157: 40-44, 1998.
14. Gudnason V, Stansbie D, Scott J, Bowron A, Nicaud V and Humphries S: C677T (thermolabile alanine/valine) polymorphism in methylenetetrahydrofolate reductase (MTHFR): its frequency and impact on plasma homocysteine concentration in different European populations. Atherosclerosis 136: 347-354, 1998.
15. Hultdin J, Van Guelpen B, Bergh A, Hallmans G and StattinP: Plasma folate, vitamin B12, and homocysteine and prostate cancer risk: a prospective study. Int J Cancer 113: 819-824, 2005.
16. Martínez-Poveda B, Chavarría T, Sánchez-Jiménez F, QuesadaAR and Medina MA: An in vitro evaluation of the effects of homocysteine thiolactone on key steps of angiogenesis and tumor invasion. Biochem Biophys Res Commun 311: 649-653, 2003.
17. Chavarría T, Rodríguez-Nieto S, Sánchez-Jiménez F, QuesadaAR and Medina MA: Homocysteine is a potent inhibitor of human tumor cell gelatinases. Biochem Biophys Res Commun 303: 572-575, 2003.
18. Schroecksnadel K, Frick B, Fiegl M, Winkler C, Denz HA and Fuchs D: Hyperhomocysteinaemia and immune activation in patients with cancer. Clin Chem Lab Med 45: 47-53, 2007.
19. Lever M, George PM, Dellow WJ, Scott RS and Chambers ST: Homocysteine, glycine betaine, and N, N-dimethylglycine in patients attending a lipid clinic. Metabolism 54: 1-14, 2005.
20. Morgenstern I, Raijmakers MT, Peters WH, et al: Homocysteine, cysteine, and glutathione in human colonic mucosa: elevated levels of homocysteine in patients with inflammatory bowel disease. Dig Dis Sci 48: 2083-2090, 2003.
21. Poddar R, Sivasubramanian N, Di Bello PM, et al: Homocysteine induces expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human aortic endothelial cells: implications for vascular disease. Circulation 103: 2717-2723, 2001.
22. Kim YI, Pogribny IP, Basnakian AG, et al: Folate deficiency in rats induces DNA strand breaks and hypomethylation within the p53 tumor suppressor gene. Am J Clin Nutr 65: 46-52, 1997.
23. Blount BC, Mack MM, Wehr CM, et al: Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. Proc Natl Acad Sci USA 94: 3290-3295, 1997.
24. Adams M, Smith PD, Martin D, Thompson JR, Lodwick D and Samani NJ: Genetic analysis of thermolabile methylenetetrahydrofolate reductase as a risk factor for myocardial infarction. QJM 89: 437-444, 1996.
25. Zuntar I, Topić E, Vukosavić D, et al: Croatian population data for the C677T polymorphism in methylenetetrahydrofolate reductase: frequencies in healthy and atherosclerotic study groups. Clin Chim Acta 335: 95-100, 2003.
26. Motulsky AG: Nutritional ecogenetics: homocysteine-related arteriosclerotic vascular disease, neural tube defects, and folic acid. Am J Hum Genet 58: 17-20, 1996.
27. Zhang L, Miyaki K, Araki J, Nakayama T and Muramatsu M: The relation between nicotinamide N-methyltransferase gene polymorphism and plasma homocysteine concentration in healthy Japanese men. Thromb Res 121: 55-58, 2007.
28. Goracy I, Cyrylowski L, Kaczmarczyk M, et al: C677T polymorphism of the methylenetetrahydrofolate reductase gene and the risk of ischemic stroke in Polish subjects. J Appl Genet 50: 63-67, 2009.