Serum total homocysteine concentrations in children and adolescents: Results from the Third National Health and Nutrition Examination survey (NHANES III)

Journal of Nutrition

Volumn 133, Issue 8, 2003, Pages 2643-2649

  Must, Aviva ^a,b   Jacques, Paul F ^a   Rogers, Gail ^a   Rosenberg, Irwin H ^a   Selhub, Jacob ^a  

^a TUFTS UNIVERSITY   (United States)

^b TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Age; Homocysteine; Nutrition surveys; Racial ethnic groups; Sex

Indexed keywords

HOMOCYSTEINE;

ADOLESCENT; ADULT; ADULT DISEASE; AGE; ARTICLE; CAUCASIAN; CHILD; CHILD NUTRITION; CONTROLLED STUDY; ETHNOLOGY; FEMALE; HEALTH SURVEY; HUMAN; MALE; NEGRO; NORMAL HUMAN; PERIPHERAL OCCLUSIVE ARTERY DISEASE; RACE DIFFERENCE; SERUM; SEX DIFFERENCE; UNITED STATES;

EID: 0042710878     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/133.8.2643     Document Type: Article

References (46)

1. Ueland, P. M., Refsum, H. & Brattström, L. (1992) Plasma homocysteine and cardiovascular disease. In: Atherosclerotic Cardiovascular Disease, Hemostasis, and Endothelial Function (Francis, R.B.J., ed.). Marcel Dekker, New York, NY.
2. Stampfer, M. J., Malinow, M. R., Willett, W. C., Newcomer, L. M., Upson, B., Ullmann, D., Tishler, P. V. & Hennekens, C. H. (1992) A prospective study of plasma homocyst(e)ine and risk of myocardial infarction in US physicians. J. Am. Med. Assoc. 268: 877-881.
3. Arnesen, E., Refsum, H., Bonaa, K. H., Ueland, P. M., Forde, O. H. & Nordrehaug, J. E. (1995) Serum total homocysteine and coronary heart disease. Int. J. Epidemiol. 24: 704-709.
4. Perry, I. J., Refsum, H., Morris, R. W., Ebrahim, S. B., Ueland, P. M. & Shaper, A. G. (1995) Prospective study of serum total homocysteine concentration and risk of stroke in middle-aged British men. Lancet 346: 1395-1398.
5. Perry, I. J., Refsum, H., Morris, R. W., Ebrahim, S. B., Ueland, P. M. & Shaper, A. G. (1996) Serum total homocysteine and coronary heart disease in middle-aged British men. Heart 75: 53 (abs.).
6. Malinow, M. R., Nieto, F. J., Szklo, M., Chambless, L. E. & Bond, G. (1993) Carotid artery intimal-medial wall thickening and plasma homocyst(e)ine in asymptomatic adults: The Atherosclerosis Risk in Communities Study. Circulation 87: 1107-1113.
7. Selhub, J., Jacques, P. F., Bostom, A. G., D'Agostino, R. B., Wilson, P. W., Belanger, A. J., O'Leary, D. H., Wolf, P. A., Schaefer, E. J. & Rosenberg, I. H. (1995) Association between plasma homocysteine concentrations and extracranial carotid-artery stenosis. N. Engl. J. Med. 332: 286-291.
8. Nygard, O., Nordrehaug, J. E., Refsum, H., Ueland, P. M., Farstad, M. & Vollset, S. E. (1997) Plasma homocysteine levels and mortality inpatients with coronary artery disease. N. Engl. J. Med. 337: 230-236.
9. De Laet, C., Wautrecht, J. C., Brasseur, D., Dramaix, M., Boeynaems, J. M., Decuyper, J. & Kahn, A. (1999) Plasma homocysteine concentration in a Belgian school-age population. Am. J. Clin. Nutr. 69: 968-972.
10. Delvin, E. E., Rozen, R., Merouani, A., Genest, J., Jr. & Lambert, M. (2000) Influence of methylenetetrahydrofolate reductase genotype, age, vitamin B-12, and folate status on plasma homocysteine in children. Am. J. Clin. Nutr. 72: 1469-1473.
11. van der Mooren, M. J., Wouters, M. G., Blom, H. J., Schellekens, L. A., Eskes, T. K. & Rolland, R. (1994) Hormone replacement therapy may reduce high serum homocysteine in postmenopausal women. Eur. J. Clin. Investig. 24: 733-736.
12. Osganian, S. K., Stampfer, M. J., Spiegelman, D., Rimm, E., Cutler, J. A., Feldman, H. A., Montgomery, D. H., Webber, L. S., Lytle L. A., Bausserman, L. & Nader, P. R. (1999) Distribution of and factors associated with serum homocysteine levels in children: Child and Adolescent Trial for Cardiovascular Health. J. Am. Med. Assoc. 281: 1189-1196.
13. Tonstad, S., Refsum, H., Sivertsen, M., Christophersen, B., Ose, L. & Ueland, P. M. (1996) Relation of total homocysteine and lipid levels in children to premature cardiovascular death in male relatives. Pediatr. Res. 40: 47-52.
14. Selhub, J., Jacques, P. F., Wilson, P. W., Rush, D. & Rosenberg, I. H. (1993) Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. J. Am. Med. Assoc. 270: 2693-2698.
15. Nygard, O., Vollset, S. E., Refsum, H., Stensvold, I., Tverdal, A., Nordrehaug, J. E., Ueland, M. & Kvale, G. (1995) Total plasma homocysteine and cardiovascular risk profile. The Hordaland Homocysteine Study. J. Am. Med. Assoc. 274: 1526-1533.
16. Brattström, L., Lindgren, A., Israelsson, B., Andersson, A. & Hultberg, B. (1994) Homocysteine and cysteine: determinants of plasma levels in middle-aged and elderly subjects. J. Intern. Med. 236: 633-641.
17. Koehler, K. M., Romero, L. J., Stauber, P. M., Pareo-Tubbeh, S. L., Liang, H. C., Baumgartner, R. N., Garry, P. J., Allen, R. H. & Stabler, S. P. (1996) Vitamin supplementation and other variables affecting serum homocysteine and methylmalonic acid concentrations in elderly men and women. J. Am. Coil. Nutr. 15:364-376.
18. Wouters, M. G., Moorrees, M. T., van der Mooren, M. J., Blom, H. J., Boers, G. H., Schellekens, L. A., Thomas, C. M. & Eskes, T. K. (1995) Plasma homocysteine and menopausal status. Eur. J. Clin. Investig. 25: 801-805.
19. Andersson, A. Brattström, L., Israelsson, B., Isaksson, A., Hamfelt, A. & Hultberg, B. (1992) Plasma homocysteine before and after methionine loading with regard to age, gender, and menopausal status. Eur. J. Clin. Investig. 22: 79-87.
20. Vilaseca, M. A., Moyano, D., Ferrer, I. & Artuch, R. (1997) Total homocysteine in pediatric patients. Clin. Chem. 43: 690-692.
21. Greenlund, K. J., Srinivasan, S. R., Xu, J. H., Dalferes, E., Jr., Myers, L., Pickoff, A. & Berenson, G. S. (1999) Plasma homocysteine distribution and its association with parental history of coronary artery disease in black and white children: the Bogalusa Heart Study. Circulation 99: 2144-2149.
22. Jacques, P. F., Rosenberg, I. H., Rogers, G., Selhub, J., Bowman, B. A., Gunter, E. W., Wright, J. D. & Johnson, C. L. (1999) Serum total homocysteine concentrations in adolescent and adult Americans: results from the third National Health and NuTrition Examination Survey. Am. J. Clin. Nutr. 69: 482-489.
23. Gunter, E. W., Lewis, B. G. & Koncikowski, S. M. (1996) Laboratory procedures used for the third National Health and Nutrition Examination Survey (NHANES III), 1988-1994. U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, Hyattsville, MD.
24. Ueland, P. M., Refsum, H., Stabler, S. P., Malinow, M. R., Andersson, A. & Allen, R. H. (1993) Total homocysteine in plasma or serum: methods and clinical applications. Clin. Chem. 39: 1764-1779.
25. Araki, A. & Sako, Y. (1987) Determination of free and total homocysteine in human plasma by high-performance liquid chromatography with fluorescence detection. J. Chromatogr. 422: 43-52.
26. Garg, U. C., Zheng, Z. J., Folsom, A. R., Moyer, Y. S., Tsai, M. Y., McGovern, P. & Eckfeldt, J. H. (1997) Short-term and long-term variability of plasma homocysteine measurement. Clin. Chem. 43: 141-145.
27. Shah, B., Barnwell, B. G. & Bieler, G. S. (1997) SUDAAN: User's Manual, Release 7.5. Research Triangle Institute, Research Triangle Park, NC.
28. SAS Institute, Inc. (1996) The SAS System for Windows, Version 6.12. SAS Institute, Cary, NC.
29. National Center For Health Statistics (1996) The third National Health and Nutrition Examination Survey (1988-94); reference manual and reports. Weight and estimation methodology report [CD-ROM]. Hyattsville, MD.
30. Chambers, J. B., Cleveland, W. S., Kleiner, B. & Tukey, P. A. (1983) Graphical Methods for Data Analysis. Duxbury Press, Boston, MA.
31. SPSS Inc. (2000) SPSS User's Guide. SPSS, Chicago, IL.
32. National Center For Health Statistics (1994) Plan and operation of the third National Health and Nutrition Examination Survey, 1988-94.
33. Rauh, M., Verwied, S., Knerr, I., Dorr, H. G., Sonnichsen, A. & Koletzko, B. (2001) Homocysteine concentrations in a German cohort of 500 individuals: reference ranges and determinants of plasma levels in healthy children and their parents. Amino Acids 20: 409-418.
34. Morris, M. S., Jacques, P. F., Rosenberg, I. H., Selhub, J., Bowman, B. A., Gunter, E. W., Wright, J. D. & Johnson, C. L. (2000) Serum total homocysteine concentration is related to self-reported heart attack or stroke history among men and women in the NHANES III. J. Nutr. 130: 3073-3076.
35. Hak, A. E., Bak, A. A., Undemans, J., Planellas, J., Coelingh Bennink, H. J., Hofman, A., Grobbee, D. E. & Witteman, J. C. (2001) The effect of hormone replacement therapy on serum homocysteine levels in perimenopausal women: a randomized controlled trial. Atherosclerosis 158: 437-443.
36. Giltay, E. J. & Gooren, L. J. (2000) Effects of sex steroid deprivation/administration on hair growth and skin sebum production in transsexual males and females. J. Clin. Endocrinol. Metab. 85: 2913-2921.
37. Ubbink, J. B., Vermaak, W. J., Bennett, J. M., Becker, P. J., van Staden, D. A. & Bissbort, S. (1991) The prevalence of homocysteinemia and hypercholesterolemia in angiographically defined coronary heart disease. Klin. Wochenschr. 69: 527-534.
38. Ubbink, J. B., Vermaak, W. J., Delport, R., van der Merwe, A., Becker, P. J. & Potgieter, H. (1995) Effective homocysteine metabolism may protect South African blacks against coronary heart disease. Am. J. Clin. Nutr. 62: 802-808.
39. McAndrew, P. E., Brandt, J. T., Pearl, D. K. & Prior, T. W. (1996) The incidence of the gene for thermolabile methylene tetrahydrofolate reductase in African Americans. Thromb Res. 83: 195-198.
40. Ford, E. S. & Bowman, B. A. (1999) Serum and red blood cell folate concentrations, race, and education: findings from the third National Health and Nutrition Examination Survey. Am. J. Clin. Nutr. 69: 476-481.
41. Ford, E. S. & Bowman, B. A. (1999) Serum folate and homocysteine concentrations in large population samples of US ethnic and racial groups (Reply). Am. J. Clin. Nutr. 70: 937-939.
42. Smit, E., Nieto, F. J., Crespo, C. J. & Mitchell, P. (1999) Estimates of animal and plant protein intake in US adults: results from the Third National Health and Nutrition Examination Survey, 1988-1991. J. Am. Diet. Assoc. 99: 813-820.
43. Krebs Smith, S. M., Cook, A., Subar, A. F., Cleveland, L., Friday, J. & Kahle, L. L. (1996) Fruit and vegetable intakes of children and adolescents in the United States. Arch. Pediatr. Adolesc. Med. 150: 81-86.
44. Boushey, C. L., Beresford, S. A. A., Omenn, G. S. & Motulsky, A. G. (1995) A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. J. Am. Med. Assoc. 274:1049-1057.
45. Kark, J. D., Sinnreich, R., Rosenberg, I. H., Jacques, P. F. & Selhub J. (2002) Plasma homocysteine and parental myocardial infarction in young adults in Jerusalem. Circulation 105: 2725-2729.
46. Morrison, J. A., Jacobsen, D. W., Sprecher, D. L., Robinson, K., Khoury, P. & Daniels, S. R. (1999) Serum glutathione in adolescent males predicts parental coronary heart disease. Circulation 100: 2244-2247.