Systemic folate status, rectal mucosal folate concentration and dietary intake in patients at differential risk of bowel cancer (The FAB2 Study)

European Journal of Nutrition

Volumn 52, Issue 7, 2013, Pages 1801-1810

  Williams, Elizabeth A ^a   Welfare, Mark ^b   Spiers, Alison ^c   Hill, Marilyn H ^a   Bal, Wendy ^c   Gibney, Eileen R ^d   Duckworth, Yvonne ^c   Powers, Hilary J ^a   Mathers, John C ^c  

^a Department of Oncology   (United Kingdom)

^b NORTH TYNESIDE GENERAL HOSPITAL   (United Kingdom)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

^d UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

Adenomatous polyps; Colorectal cancer; Diet; Folate

Indexed keywords

5 METHYLTETRAHYDROFOLIC ACID; FOLIC ACID; HOMOCYSTEINE;

ADULT; AGED; ALCOHOL CONSUMPTION; ARTICLE; CANCER RISK; CARBOHYDRATE INTAKE; COLON POLYPOSIS; COLORECTAL CANCER; CONTROLLED STUDY; DIETARY INTAKE; DISEASE ASSOCIATION; ERYTHROCYTE LEVEL; FAT INTAKE; FEMALE; FOLIC ACID BLOOD LEVEL; FOOD FREQUENCY QUESTIONNAIRE; GENETIC POLYMORPHISM; GENOTYPE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; NUTRITIONAL STATUS; PROTEIN INTAKE; RECTUM BIOPSY; RECTUM MUCOSA; SELF REPORT; TISSUE LEVEL;

COHORT STUDIES; COLORECTAL NEOPLASMS; DIET; ERYTHROCYTES; FEMALE; FOLIC ACID; GLUTATHIONE REDUCTASE; HOMOCYSTEINE; HUMANS; INTESTINAL MUCOSA; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; NUTRITION ASSESSMENT; NUTRITIONAL STATUS; QUESTIONNAIRES; RISK FACTORS; TETRAHYDROFOLATES; VITAMIN B 12;

EID: 84885468504     PISSN: 14366207     EISSN: 14366215     Source Type: Journal    
DOI: 10.1007/s00394-012-0483-5     Document Type: Article

References (61)

1. Giovannucci E, Stampfer MJ, Colditz GA, Rimm EB, Trichopoulos D, Rosner BA, Speizer FE et al (1993) Folate, methionine, and alcohol intake and risk of colorectal adenoma. J Natl Cancer Inst 85:875-884
2. Giovannucci E, Rimm EB, Ascherio A, Stampfer MJ, Colditz GA, Willett WC (1995) Alcohol, low-methionine-low-folate diets, and risk of colon cancer in men. J Natl Cancer Inst 87:265-273
3. Terry P, Jain M, Miller AB, Howe GR, Rohan TE (2002) Dietary intake of folic acid and colorectal cancer risk in a cohort of women. Int J Cancer 97:864-867
4. Fuchs CS, Willett WC, Colditz GA, Hunter DJ, Stampfer MJ, Speizer FE, Giovannucci EL (2002) The influence of folate and multivitamin use on the familial risk of colon cancer in women. Cancer Epidemiol Biomarkers Prev 11:227-234
5. Konings EJ, Goldbohm RA, Brants HA, Saris WH, van den Brandt PA (2002) Intake of dietary folate vitamers and risk of colorectal carcinoma: results from the Netherlands Cohort Study. Cancer 95:1421-1433
6. Flood A, Caprario L, Chaterjee N, Lacey JV, Schairer C, Schatzkin A (2002) Folate, methionine, alcohol, and colorectal cancer in a prospective study of women in the United States. Cancer Causes Control 13:551-561
7. Harnack L, Jacobs DJ, Nicodemus K, Lazovich D, Anderson K, Folsom A (2002) Relationship of folate, vitamin B-6, vitamin B-12, and methionine intake to incidence of colorectal cancers. Nutr Cancer 43:152-158
8. Sanjoaquin MA, Allen N, Couto E, Roddam AW, Key TJ (2005) Folate intake and colorectal cancer risk: a meta-Analytical approach. Int J Cancer 113:825-828
9. Kim D-H, Smith-Warner S, Spiegelman D, Yaun S-S, Colditz G, Freudenheim J, Giovannucci E et al (2010) Pooled analyses of 13 prospective cohort studies on folate intake and colon cancer. Cancer Causes Control 21:1919-1930
10. Tseng M, Murray SC, Kupper LL, Sandier RS (1996) Micronutrients and the risk of colorectal adenomas. Am J Epidemiol 144:1005-1014
11. Cole BF, Baron JA, Sandler RS, Haile RW, Ahnen DJ, Bresalier RS, McKeown-Eyssen G et al (2007) Folic acid for the prevention of colorectal adenomas: a randomized clinical trial. JAMA 297:2351-2359
12. Logan RFA, Grainge MJ, Shepherd VC, Armitage NC, Muir KR (2008) Aspirin and folic acid for the prevention of recurrent colorectal adenomas. Gastroenterology 134:29-38
13. Mathers JC (2009) Folate intake and bowel cancer risk. Genes Nutr 4:173-178
14. Le Marchand L, Wilkens LR, Kolonel LN, Henderson BE (2005) The MTHFR C677T Polymorphism and Colorectal Cancer: the Multiethnic Cohort Study. Cancer Epidemiol Biomarkers Prev 14:1198-1203
15. Sharp L, Little J (2004) Polymorphisms in genes involved in folate metabolism and colorectal neoplasia: a HuGE review. Am J Epidemiol 159:423-443
16. Sharp L, Little J, Brockton N, Cotton S, Masson L, Haites N, Cassidy J (2008) Polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, intakes of folate and related B vitamins and colorectal cancer: a case-control study in a population with relatively low folate intake. Br J Nutr 99: 379-389
17. Su LJ, Arab L (2001) Nutritional status of folate and colon cancer risk: evidence from NHANES I epidemiologic follow-up study. Ann Epidemiol 11:65-72
18. Giovannucci E (2004) Alcohol, one-carbon metabolism, and colorectal cancer: recent insights from molecular studies. J Nutr 134:2475S-2481S
19. van den Donk M, Buijsse B, van den Berg SW, Ocke MC, Harryvan JL, Nagengast FM, Kok FJ et al (2005) Dietary intake of folate and riboflavin, MTHFR C677T genotype, and colorectal adenoma risk: a Dutch case-control study. Cancer Epidemiol Biomarkers Prev 14:1562-1566
20. Powers HJ, Hill MH, Welfare M, Spiers A, Bal W, Russell J, Duckworth Y et al (2007) Responses of biomarkers of folate and riboflavin status to folate and riboflavin supplementation in healthy and colorectal polyp Patients (The FAB2 Study). Cancer Epidemiol Biomarkers Prev 16:2128-2135
21. Choi S-W, Mason JB (2002) Folate status: effects on pathways of colorectal carcinogenesis. J Nutr 132:2413S-2418S
22. Jang H, Mason JB, Choi S-W (2005) Genetic and epigenetic interactions between folate and aging in carcinogenesis. J Nutr 135:2967S-2971S
23. Kim YI, Fawaz K, Knox T, Mee Lee Y, Norton R, Arora S, Paiva L et al (1998) Colonic mucosal concentrations of folate correlate well with blood measurements of folate status in persons with colorectal polyps. Am J Clin Nutr 68:866-872
24. Piyathilake C, Hine R, Dasanayake A, Richards E, Freeberg L, Vaughn W, Krumdieck C (1992) Effect of smoking on folate levels in buccal mucosal cells. Int J Cancer 52:566-569
25. Meenan J, O'Hallinan E, Scott J, Weir DG (1997) Epithelial cell folate depletion occurs in neoplastic but not adjacent normal colon mucosa. Gastroenterology 112:1163-1168
26. Kim YI, Baik HW, Fawaz K, Knox T, Lee YM, Norton R, Libby E et al (2001) Effects of folate supplementation on two provisional molecular markers of colon cancer: a prospective, randomized trial. Am J Gastroenterol 96:184-195
27. Flood A, Mason JB, Liu Z, Cash BD, Schatzkin A, Schoenfeld PS, Cross AJ (2011) Concentration of folate in colorectal tissue biopsies predicts prevalence of adenomatous polyps. Gut 60:66-72
28. Bingham S, Gill C, Welch A, Cassidy A, Runswick S, Oakes S, Lubin R et al (1997) Validation of dietary assessment methods in the UK arm of EPIC using weighed records, and 24-hour urinary nitrogen and potassium and serum vitamin C and carotenoids as biomarkers. Int J Epidemiol 26:S137-S151
29. Welch AA, Luben R, Khaw KT, Bingham SA (2005) The CAFE computer program for nutritional analysis of the EPIC-Norfolk food frequency questionnaire and identification of extreme nutrient values. J Hum Nutr Diet 18:99-116
30. Holland B, Welch A, Unwin I, Buss D, Paul A, Southgate D (1991) McCance and Widdowson's the composition of foods, 5th edn. Royal Society of Chemistry and MAFF, London
31. Curtis PJ, Adamson AJ, Mathers JC (2012) Effects on nutrient intake of a family-based intervention to promote increased consumption of low-fat starchy foods through education, cooking skills and personalised goal setting: the Family Food and Health Project. Br J Nutr 107:1833-1844
32. Loehrer MT, Haefeli WE, Angst CP, Browne G, Frick G, Fowler B (1996) Effect of methionine loading on 5-methyltetrahydrofolate, S-Adenosylmethionine and S-Adenosylhomocysteine in plasma of healthy humans. Clin Sci 91:79-86
33. Donnelly JG, Pronovost C (2000) Evaluation of the Abbott IMxTM fluorescence polarization immunoassay and the Bio- Rad enzyme immunoassay for homocysteine: comparison with high-performance liquid chromatography. Ann Clin Biochem 37:194-198
34. Powers H, Bates C, Duerden J (1983) Effects of riboflavin deficiency in rats on some aspects of iron metabolism. Int J Vitam Nutr Res 53:371-376
35. Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Boers GJH et al (1995) A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 10:111-113
36. Hill MHE, Bradley A, Mushtaq S, Williams EA, Powers HJ (2009) Effects of methodological variation on assessment of riboflavin status using the erythrocyte glutathione reductase activation coefficient assay. Br J Nutr 102:273-278
37. Henderson L, Irving K, Gregory J, Bates C, Prentice A, Perks J, Swan G et al (2003) The National Diet and Nutrition Survey: adults aged 19 to 64 years, vol 3: vitamin and mineral intake and urinary analytes. TSO, London
38. Cade JE, Burley VJ, Greenwood DC, Women's Cohort Study Steering Group (2007) Dietary fibre and risk of breast cancer in the UK Women's Cohort Study. Int J Epidemiol 36:431-438
39. Calvert C, Cade J, Barrett J, Woodhouse A, (1997) Using cross-check questions to address the problem of misreporting of specific food groups on Food Frequency Questionnaires. Eur J Clin Nutr 51:708-712
40. Brunner E, Stallone D, Juneja M, Bingham S, Marmot M (2001) Dietary assessment in Whitehall II: comparison of 7 d diet diary and food-frequency questionnaire and validity against biomarkers. Eur J Clin Nutr 86:405-414
41. Henderson L, Gregory J, Swan G (2002) The National Diet and Nutrition Survey:adults aged 16 to 64 years. TSO, London
42. World Cancer Research Fund/American Institute for Cancer Research (2007) Food, nutrition, physical activity and the prevention of cancer: a global perspective. AICR, Washington, DC
43. Matthew JA, Fellows IW, Prior A, Kennedy HJ, Bobbin R, Johnson IT (1997) Habitual intake of fruits and vegetables amongst patients at increased risk of colorectal neoplasia. Cancer Lett 114:255-258
44. Rushton D, Hoare J, Henderson L, Gregory J, Bates C, Prentice A, BirchMet al (2004) The National Diet and Nutrition Survey: adults aged 19 to 64 years: nutritional status (anthropometry and blood analytes) blood pressure and physical activity. TSO, London
45. Moat SJ, Ashfield-Watt PA, Powers HJ, Newcombe RG, McDowell IF (2003) Effect of riboflavin status on the homocysteine- lowering effect of folate in relation to the MTHFR (C677T) genotype. Clin Chem 49:295-302
46. Clarke R, Grimley Evans J, Schneede J, Nexo E, Bates C, Fletcher A, Prentice A et al (2004) Vitamin B12 and folate deficiency in later life. Age Ageing 33:34-41
47. Pufulete M, Al-Ghnaniem R, Leather A, Appleby P, Gout S, Terry C, Emery P et al (2003) Folate status, genomic DNA hypomethylation, and risk of colorectal adenoma and cancer: a case control study. Gastroenterology 124:1240-1248
48. Paspatis G, Kalafatis E, Oros L, Xourgias V, Koutsioumpa P, Karamanolis D (1995) Folate status and adenomatous colonic polyps. A colonoscopically controlled study. Dis Colon Rectum 38:64-67
49. Porcelli B, Frosi B, Rosi F, Arezzini L, Civitelli S, Tanzini G, Marinello E (1996) Levels of folic acid in plasma and in red blood cells of colorectal cancer patients. Biomed Pharmacother 50:303-305
50. Polley ACJ, Mulholland F, Pin C, Williams EA, Bradburn DM, Mills SJ, Mathers JC et al (2006) Proteomic analysis reveals field-wide changes in protein expression in the morphologically normal mucosa of patients with colorectal neoplasia. Cancer Res 66:6553-6562
51. Daniel CR, Bostick RM, Flanders WD, Long Q, Fedirko V, Sidelnikov E, Seabrook ME (2009) TGF-A expression as a potential biomarker of risk within the normal-Appearing colorectal mucosa of patients with and without incident sporadic adenoma. Cancer Epidemiol Biomarkers Prevent 18:65-73
52. Hao CY, Moore DH, Chiu YS, Wong P, Bennington JL, Smith AP, Chen LC et al (2005) Altered gene expression in normal colonic mucosa of individuals with polyps of the colon. Dis Colon Rectum 48:2329-2335
53. Smith AP, Chiu YSY, Lee NM (2012) Towards universal screening for colon cancer: a cheap, reliable, noninvasive test using gene expression analysis of rectal swabs. ISRN Gastroenterol 2012:2018
54. Belshaw NJ, Elliott GO, Foxall RJ, Dainty JR, Pal N, Coupe A, Garg D et al (2008) Profiling CpG island field methylation in both morphologically normal and neoplastic human colonic mucosa. Br J Cancer 99:136-142
55. O'Keefe SJD, Ou J, Aufreiter S, O'Connor D, Sharma S, Sepulveda J, Fukuwatari T et al (2009) Products of the colonic microbiota mediate the effects of diet on colon cancer risk. J Nutr 139:2044-2048
56. Kim TH, Yang J, Darling PB, O'Connor DL (2004) A large pool of available folate exists in the large intestine of human infants and piglets. J Nutr 134:1389-1394
57. Dudeja PK, Torania SA, Said HM (1997) Evidence for the existence of a carrier-mediated folate uptake mechanism in human colonic luminal membranes. Am J Physiol Gastrointest Liver Physiol 272:G1408-G1415
58. Aufreiter S, Gregory JF, Pfeiffer CM, Fazili Z, Kim Y-I, Marcon N, Kamalaporn P et al (2009) Folate is absorbed across the colon of adults: evidence from cecal infusion of 13C-labeled [6S]-5- formyltetrahydrofolic acid. Am J Clin Nutr 90:116-123
59. Shen X, Rawls JF, Randall T, Burcal L, Mpande CN, Jenkins N, Jovov N et al (2010) Molecular characterization of mucosal adherent bacteria and associations with colorectal adenomas. Gut Microbes 1:138-147
60. Pagnini C, Corleto VD, Mangoni ML, Pilozzi E, Torre MS, Marchese R, Carnuccio A et al (2011) Alteration of local microflora and [alpha]-defensins hyper-production in colonic adenoma mucosa. J Clin Gastroenterol 45:602-610
61. Department of Health (1991) Report on Health and Social subjects 41. Dietary reference values for food energy and nutrients for the United Kingdom. HMSO, London