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Volumn 2015, Issue , 2015, Pages

High OCT4 and low p16INK4A expressions determine in vitro lifespan of mesenchymal stem cells

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; INTERLEUKIN 6; INTERLEUKIN 8; OCTAMER TRANSCRIPTION FACTOR 4; PROTEIN P16; PROTEIN P21; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX2;

EID: 84930649976     PISSN: None     EISSN: 16879678     Source Type: Journal    
DOI: 10.1155/2015/369828     Document Type: Article
Times cited : (37)

References (37)
  • 1
    • 47249166372 scopus 로고    scopus 로고
    • Replicative senescence of mesenchymal stem cells: A continuous and organized process
    • W.Wagner, P. Horn, M. Castoldi et al., "Replicative senescence of mesenchymal stem cells: A continuous and organized process," PLoS ONE, vol. 3, no. 5, article e2213, 2008.
    • (2008) PLoS ONE , vol.3 , Issue.5
    • Wagner, W.1    Horn, P.2    Castoldi, M.3
  • 2
    • 34548186667 scopus 로고    scopus 로고
    • Cellular senescence: When bad things happen to good cells
    • J. Campisi and F. d'Adda di Fagagna, "Cellular senescence: when bad things happen to good cells," Nature ReviewsMolecular Cell Biology, vol. 8, no. 9, pp. 729-740, 2007.
    • (2007) Nature ReviewsMolecular Cell Biology , vol.8 , Issue.9 , pp. 729-740
    • Campisi, J.1    D'adda Di Fagagna, F.2
  • 3
    • 0344622606 scopus 로고
    • Theserial cultivation of human diploid cell strains
    • L.Hayflick and P. S.Moorhead, "Theserial cultivation of human diploid cell strains," Experimental Cell Research, vol. 25, no. 3, pp. 585-621, 1961.
    • (1961) Experimental Cell Research , vol.25 , Issue.3 , pp. 585-621
    • Hayflick, L.1    Moorhead, P.S.2
  • 4
    • 38049059966 scopus 로고    scopus 로고
    • DNA damage, cellular senescence and organismal ageing: Causal or correlative?
    • J.-H. Chen, C. N. Hales, and S. E. Ozanne, "DNA damage, cellular senescence and organismal ageing: causal or correlative?" Nucleic Acids Research, vol. 35, no. 22, pp. 7417-7428, 2007.
    • (2007) Nucleic Acids Research , vol.35 , Issue.22 , pp. 7417-7428
    • Chen, J.-H.1    Hales, C.N.2    Ozanne, S.E.3
  • 5
    • 84892366974 scopus 로고    scopus 로고
    • Cell biology: The beginning of the end
    • J. Campisi, "Cell biology: The beginning of the end," Nature, vol. 505, no. 7481, pp. 35-36, 2014.
    • (2014) Nature , vol.505 , Issue.7481 , pp. 35-36
    • Campisi, J.1
  • 6
    • 79951912532 scopus 로고    scopus 로고
    • Four faces of cellular senescence
    • F. Rodier and J. Campisi, "Four faces of cellular senescence," Journal of Cell Biology, vol. 192, no. 4, pp. 547-556, 2011.
    • (2011) Journal of Cell Biology , vol.192 , Issue.4 , pp. 547-556
    • Rodier, F.1    Campisi, J.2
  • 8
    • 33646946746 scopus 로고    scopus 로고
    • Senescence-associated betagalactosidase is lysosomal beta-galactosidase
    • B. Y. Lee, J. A. Han, J. S. Im et al., "Senescence-associated betagalactosidase is lysosomal beta-galactosidase," Aging Cell, vol. 5, no. 2, pp. 187-195, 2006.
    • (2006) Aging Cell , vol.5 , Issue.2 , pp. 187-195
    • Lee, B.Y.1    Han, J.A.2    Im, J.S.3
  • 9
    • 0001510491 scopus 로고    scopus 로고
    • The RB and p53 pathways in cancer
    • C. J. Sherr and F. McCormick, "The RB and p53 pathways in cancer," Cancer Cell, vol. 2, no. 2, pp. 103-112, 2002.
    • (2002) Cancer Cell , vol.2 , Issue.2 , pp. 103-112
    • Sherr, C.J.1    McCormick, F.2
  • 10
    • 33747587608 scopus 로고    scopus 로고
    • Regulation of the INK4b-ARF-INK4a tumour suppressor locus: All for one or one for all
    • J. Gil and G. Peters, "Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all," Nature Reviews Molecular Cell Biology, vol. 7, no. 9, pp. 667-677, 2006.
    • (2006) Nature Reviews Molecular Cell Biology , vol.7 , Issue.9 , pp. 667-677
    • Gil, J.1    Peters, G.2
  • 11
    • 34548186667 scopus 로고    scopus 로고
    • Cellular senescence: When bad things happen to good cells
    • J. Campisi and F. D. di Fagagna, "Cellular senescence: when bad things happen to good cells," Nature ReviewsMolecular Cell Biology, vol. 8, no. 9, pp. 729-740, 2007.
    • (2007) Nature ReviewsMolecular Cell Biology , vol.8 , Issue.9 , pp. 729-740
    • Campisi, J.1    Di Fagagna, F.D.2
  • 12
    • 84874603171 scopus 로고    scopus 로고
    • Cellular senescence and the senescent secretory phenotype: Therapeutic opportunities
    • T. Tchkonia, Y. Zhu, J. van Deursen, J. Campisi, and J. L. Kirkland, "Cellular senescence and the senescent secretory phenotype: therapeutic opportunities," Journal of Clinical Investigation, vol. 123, no. 3, pp. 966-972, 2013.
    • (2013) Journal of Clinical Investigation , vol.123 , Issue.3 , pp. 966-972
    • Tchkonia, T.1    Zhu, Y.2    Van Deursen, J.3    Campisi, J.4    Kirkland, J.L.5
  • 13
    • 84859483420 scopus 로고    scopus 로고
    • Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin
    • M. C. Velarde, J. M. Flynn,N.U.Day, S.Melov, and J. Campisi, "Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin," Aging, vol. 4, no. 1, pp. 3-12, 2012.
    • (2012) Aging , vol.4 , Issue.1 , pp. 3-12
    • Velarde, M.C.1    Flynn, J.M.2    Day, N.U.3    Melov, S.4    Campisi, J.5
  • 14
    • 84866054806 scopus 로고    scopus 로고
    • MTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis
    • R. Iglesias-Bartolome, V. Patel, A. Cotrim et al., "MTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis," Cell Stem Cell, vol. 11, no. 3, pp. 401-414, 2012.
    • (2012) Cell Stem Cell , vol.11 , Issue.3 , pp. 401-414
    • Iglesias-Bartolome, R.1    Patel, V.2    Cotrim, A.3
  • 15
    • 84872527628 scopus 로고    scopus 로고
    • MTOR is a key modulator of ageing and age-related disease
    • S. C. Johnson, P. S. Rabinovitch, andM. Kaeberlein, "MTOR is a key modulator of ageing and age-related disease," Nature, vol. 493, no. 7432, pp. 338-345, 2013.
    • (2013) Nature , vol.493 , Issue.7432 , pp. 338-345
    • Johnson, S.C.1    Rabinovitch, P.S.2    Kaeberlein, M.3
  • 16
    • 84904409445 scopus 로고    scopus 로고
    • Inhibition of Akt/mTOR attenuates age-related changes in mesenchymal stem cells
    • B. Gharibi, S. Farzadi, M. Ghuman, and F. J.Hughes, "Inhibition of Akt/mTOR attenuates age-related changes in mesenchymal stem cells," Stem Cells, vol. 32, no. 8, pp. 2256-2266, 2014.
    • (2014) Stem Cells , vol.32 , Issue.8 , pp. 2256-2266
    • Gharibi, B.1    Farzadi, S.2    Ghuman, M.3    Hughes, F.J.4
  • 18
    • 0032582513 scopus 로고    scopus 로고
    • Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4
    • J. Nichols, B. Zevnik, K. Anastassiadis et al., "Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4," Cell, vol. 95, no. 3, pp. 379-391, 1998.
    • (1998) Cell , vol.95 , Issue.3 , pp. 379-391
    • Nichols, J.1    Zevnik, B.2    Anastassiadis, K.3
  • 19
    • 84864304203 scopus 로고    scopus 로고
    • Oct4 and Nanog directly regulate Dnmt1 to maintain selfrenewal and undifferentiated state in mesenchymal stem cells
    • C.-C. Tsai, P.-F. Su, Y.-F. Huang, T.-L. Yew, and S.-C. Hung, "Oct4 and Nanog directly regulate Dnmt1 to maintain selfrenewal and undifferentiated state in mesenchymal stem cells," Molecular Cell, vol. 47, no. 2, pp. 169-182, 2012.
    • (2012) Molecular Cell , vol.47 , Issue.2 , pp. 169-182
    • Tsai, C.-C.1    Su, P.-F.2    Huang, Y.-F.3    Yew, T.-L.4    Hung, S.-C.5
  • 20
    • 67649231424 scopus 로고    scopus 로고
    • Aging and replicative senescence have related effects on human stem and progenitor cells
    • W. Wagner, S. Bork, P. Horn et al., "Aging and replicative senescence have related effects on human stem and progenitor cells," PLoS ONE, vol. 4, no. 6,Article ID e5846, 2009.
    • (2009) PLoS ONE , vol.4 , Issue.6
    • Wagner, W.1    Bork, S.2    Horn, P.3
  • 21
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCRand the 2-ΔΔT method
    • K. J. Livak and T. D. Schmittgen, "Analysis of relative gene expression data using real-time quantitative PCRand the 2-ΔΔT method," Methods, vol. 25, no. 4, pp. 402-408, 2001.
    • (2001) Methods , vol.25 , Issue.4 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 22
    • 33747713246 scopus 로고    scopus 로고
    • Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement
    • M. Dominici, K. Le Blanc, I. Mueller et al., "Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement," Cytotherapy, vol. 8, no. 4, pp. 315-317, 2006.
    • (2006) Cytotherapy , vol.8 , Issue.4 , pp. 315-317
    • Dominici, M.1    Le Blanc, K.2    Mueller, I.3
  • 23
    • 84885041023 scopus 로고    scopus 로고
    • Onset of heterogeneity in culture-expanded bone marrow stromal cells
    • M. J. Whitfield, W. C. J. Lee, and K. J. van Vliet, "Onset of heterogeneity in culture-expanded bone marrow stromal cells," Stem Cell Research, vol. 11, no. 3, pp. 1365-1377, 2013.
    • (2013) Stem Cell Research , vol.11 , Issue.3 , pp. 1365-1377
    • Whitfield, M.J.1    Lee, W.C.J.2    Van Vliet, K.J.3
  • 24
    • 77955077191 scopus 로고    scopus 로고
    • Different facets of aging in human mesenchymal stem cells
    • W. Wagner, A. D. Ho, and M. Zenke, "Different facets of aging in human mesenchymal stem cells," Tissue Engineering Part B: Reviews, vol. 16, no. 4, pp. 445-453, 2010.
    • (2010) Tissue Engineering Part B: Reviews , vol.16 , Issue.4 , pp. 445-453
    • Wagner, W.1    Ho, A.D.2    Zenke, M.3
  • 25
    • 84882967491 scopus 로고    scopus 로고
    • Intra-subject variability in human bone marrow stromal cell (BMSC) replicative senescence: Molecular changes associated with BMSC senescence
    • J. Ren, D. F. Stroncek, Y. Zhao et al., "Intra-subject variability in human bone marrow stromal cell (BMSC) replicative senescence: Molecular changes associated with BMSC senescence," Stem Cell Research, vol. 11, no. 3, pp. 1060-1073, 2013.
    • (2013) Stem Cell Research , vol.11 , Issue.3 , pp. 1060-1073
    • Ren, J.1    Stroncek, D.F.2    Zhao, Y.3
  • 27
    • 78649640378 scopus 로고    scopus 로고
    • Thehemopoietic stemcell niche versus the microenvironment of the multiple myeloma-tumor initiating cell
    • D. Zipori, "Thehemopoietic stemcell niche versus the microenvironment of the multiple myeloma-tumor initiating cell," Cancer Microenvironment, vol. 3, no. 1, pp. 15-28, 2010.
    • (2010) Cancer Microenvironment , vol.3 , Issue.1 , pp. 15-28
    • Zipori, D.1
  • 28
    • 0034056758 scopus 로고    scopus 로고
    • Clonal mesenchymal progenitors from human bonemarrow differentiate in vitro according to a hierarchical model
    • A. Muraglia, R. Cancedda, and R. Quarto, "Clonal mesenchymal progenitors from human bonemarrow differentiate in vitro according to a hierarchical model," Journal of Cell Science, vol. 113, no. 7, pp. 1161-1166, 2000.
    • (2000) Journal of Cell Science , vol.113 , Issue.7 , pp. 1161-1166
    • Muraglia, A.1    Cancedda, R.2    Quarto, R.3
  • 29
    • 84899924529 scopus 로고    scopus 로고
    • Proof of principle: Quality control of therapeutic cell preparations using senescence-associated DNAmethylation changes
    • A. Schellenberg, S. Mauen, C. M. Koch, R. Jans, P. De Waele, and W. Wagner, "Proof of principle: quality control of therapeutic cell preparations using senescence-associated DNAmethylation changes," BMC Research Notes, vol. 7, no. 1, article 254, 2014.
    • (2014) BMC Research Notes , vol.7 , Issue.1
    • Schellenberg, A.1    Mauen, S.2    Koch, C.M.3    Jans, R.4    De Waele, P.5    Wagner, W.6
  • 30
    • 34748889531 scopus 로고    scopus 로고
    • Expression of the p16INK4A gene is associated closely with senescence of human mesenchymal stem cells and is potentially silenced by DNA methylation during in vitro expansion
    • K. R. Shibata, T. Aoyama, Y. Shima et al., "Expression of the p16INK4A gene is associated closely with senescence of human mesenchymal stem cells and is potentially silenced by DNA methylation during in vitro expansion," Stem Cells, vol. 25, no. 9, pp. 2371-2382, 2007.
    • (2007) Stem Cells , vol.25 , Issue.9 , pp. 2371-2382
    • Shibata, K.R.1    Aoyama, T.2    Shima, Y.3
  • 31
    • 84865620125 scopus 로고    scopus 로고
    • Upregulation of p16INK4A promotes cellular senescence of bone marrow-derived mesenchymal stem cells from systemic lupus erythematosus patients
    • Z.Gu, X. Cao, J. Jiang et al., "Upregulation of p16INK4A promotes cellular senescence of bone marrow-derived mesenchymal stem cells from systemic lupus erythematosus patients," Cellular Signalling, vol. 24, no. 12, pp. 2307-2314, 2012.
    • (2012) Cellular Signalling , vol.24 , Issue.12 , pp. 2307-2314
    • Gu, Z.1    Cao, X.2    Jiang, J.3
  • 32
    • 2342570379 scopus 로고    scopus 로고
    • Hallmarks of senescence in carcinogenesis and cancer therapy
    • J. W. Shay and I. B. Roninson, "Hallmarks of senescence in carcinogenesis and cancer therapy," Oncogene, vol. 23, no. 16, pp. 2919-2933, 2004.
    • (2004) Oncogene , vol.23 , Issue.16 , pp. 2919-2933
    • Shay, J.W.1    Roninson, I.B.2
  • 33
    • 84891713034 scopus 로고    scopus 로고
    • Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor
    • J.-P. Coppé, C. K. Patil, F. Rodier et al., "Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor," PLoS Biology, vol. 6, no. 12, pp. 2853-2868, 2008.
    • (2008) PLoS Biology , vol.6 , Issue.12 , pp. 2853-2868
    • Coppé, J.-P.1    Patil, C.K.2    Rodier, F.3
  • 34
    • 84892731189 scopus 로고    scopus 로고
    • Cellular senescence and its effector programs
    • R. Salama, M. Sadaie, M. Hoare, and M. Narita, "Cellular senescence and its effector programs," Genes & Development, vol. 28, no. 2, pp. 99-114, 2014.
    • (2014) Genes & Development , vol.28 , Issue.2 , pp. 99-114
    • Salama, R.1    Sadaie, M.2    Hoare, M.3    Narita, M.4
  • 35
    • 84901484906 scopus 로고    scopus 로고
    • TGF-β1 induces senescence of bone marrow mesenchymal stem cells via increase of mitochondrial ROS production
    • J.Wu, J. Niu, X. Li, X.Wang, Z. Guo, and F. Zhang, "TGF-β1 induces senescence of bone marrow mesenchymal stem cells via increase of mitochondrial ROS production," BMC Developmental Biology, vol. 14, no. 1, article 21, 2014.
    • (2014) BMC Developmental Biology , vol.14 , Issue.1
    • Wu, J.1    Niu, J.2    Li, X.3    Wang, X.4    Guo, Z.5    Zhang, F.6
  • 36
    • 84859539293 scopus 로고    scopus 로고
    • Distinct lineage specification roles for NANOG, OCT4, and SOX2 in human embryonic stem cells
    • Z.Wang, E. Oron,B.Nelson, S. Razis, andN. Ivanova, "Distinct lineage specification roles for NANOG, OCT4, and SOX2 in human embryonic stem cells," Cell Stem Cell, vol. 10, no. 4, pp. 440-454, 2012.
    • (2012) Cell Stem Cell , vol.10 , Issue.4 , pp. 440-454
    • Wang, Z.1    Oron, E.2    Nelson, B.3    Razis, S.4    Ivanova, N.5
  • 37
    • 84871705613 scopus 로고    scopus 로고
    • Functional comparison of chronological and in vitro aging: Differential role of the cytoskeleton and mitochondria in mesenchymal stromal cells
    • S. Geissler, M. Textor, J. Kühnisch et al., "Functional comparison of chronological and in vitro aging: differential role of the cytoskeleton and mitochondria in mesenchymal stromal cells," PLoS ONE, vol. 7, no. 12
    • (2012) PLoS ONE , vol.7 , Issue.12
    • Geissler, S.1    Textor, M.2    Kühnisch, J.3


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