Onset of heterogeneity in culture-expanded bone marrow stromal cells

Stem Cell Research

Volumn 11, Issue 3, 2013, Pages 1365-1377

  Whitfield, Matthew J ^a   Lee, Wong Cheng J ^b   Van Vliet, Krystyn J ^a,b  

^a Massachusetts Institute of Technology Cambridge   (United States)

^b SINGAPORE MIT ALLIANCE FOR RESEARCH AND TECHNOLOGY   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BONE MARROW CELL; BONE MARROW STROMAL CELL; CELL CULTURE; CELL CYCLE; CELL DIVISION; CELL HETEROGENEITY; CELL LINEAGE; CELL MIGRATION; CELL POPULATION; CELL STRUCTURE; DAUGHTER CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; STROMA CELL;

BMSC; BONE MARROW STROMAL CELL; GRAFT VERSUS HOST DISEASE; GVHD; MESENCHYMAL STEM CELL; MSC;

BONE MARROW CELLS; CELL DIVISION; CELL LINEAGE; CELL MOVEMENT; CELL PROLIFERATION; CELL SIZE; CELL TRACKING; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MESENCHYMAL STROMAL CELLS; REGENERATIVE MEDICINE; TIME FACTORS;

EID: 84885041023     PISSN: 18735061     EISSN: 18767753     Source Type: Journal    
DOI: 10.1016/j.scr.2013.09.004     Document Type: Article

References (46)

1. Bayreuther K., et al. Human skin fibroblasts in vitro differentiate along a terminal cell lineage. Proc. Natl. Acad. Sci. 1988, 85(14):5112-5116.
2. Bianco P., Robey P.G., Simmons P.J. Mesenchymal stem cells: revisiting history, concepts, and assays. Cell Stem Cell 2008, 2(4):313-319.
3. Bruder S.P., Jaiswal N., Haynesworth S.E. Growth kinetics, self-renewal, and the osteogenic potential of purified human mesenchymal stem cells during extensive subcultivation and following cryopreservation. J. Cell. Biochem. 1997, 64(2):278-294.
4. Caplan A.I. Mesenchymal stem cells. J. Orthop. Res. 1991, 9(5):641-650.
5. Carpenter A.E., et al. Cell profiler: image analysis software for identifying and quantifying cell phenotypes. Genome Biol. 2006, 7(10):R100.
6. Colter D.C., et al. Rapid expansion of recycling stem cells in cultures of plastic-adherent cells from human bone marrow. Proc. Natl. Acad. Sci. U. S. A. 2000, 97(7):3213-3218.
7. Colter D.C., Sekiya I., Prockop D.J. Identification of a subpopulation of rapidly self-renewing and multipotential adult stem cells in colonies of human marrow stromal cells. Proc. Natl. Acad. Sci. U. S. A. 2001, 98(14):7841-7845.
8. Cooper G. The Cell: A Molecular Approach 2000, Sinauer Associates, Sunderland (MA).
9. Costa M.R., et al. Continuous live imaging of adult neural stem cell division and lineage progression in vitro. Development 2011, 138(6):1057-1068.
10. Darling E.M., et al. Viscoelastic properties of human mesenchymally-derived stem cells and primary osteoblasts, chondrocytes, and adipocytes. J. Biomech. 2008, 41(2):454-464.
11. Deasy B., et al. Modeling stem cell population growth: incorporating terms for proliferative heterogeneity. Stem Cells 2003, 21(5):536-545.
12. Dimri G.P., et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl. Acad. Sci. 1995, 92(20):9363-9367.
13. Dominici M., et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 2006, 8(4):315-317.
14. Eilken H.M., Nishikawa S.-I., Schroeder T. Continuous single-cell imaging of blood generation from haemogenic endothelium. Nature 2009, 457(7231):896-900.
15. Goldstein S. Replicative senescence: the human fibroblast comes of age. Science 1990, 249(4973):1129-1133.
16. Haack-Sørensen M., et al. Mesenchymal stromal cell phenotype is not influenced by confluence during culture expansion. Stem Cell Rev. Rep. 2012, 1-15.
17. Halfon S., et al. Markers distinguishing mesenchymal stem cells from fibroblasts are downregulated with passaging. Stem Cells Dev. 2010, 20(1):53-66.
18. Hare J.M., et al. Comparison of allogeneic vs. autologous bone marrow-derived mesenchymal stem cells delivered by transendocardial injection in patients with ischemic cardiomyopathy: the POSEIDON randomized trial mesenchymal stem cells and ischemic cardiomyopathy. JAMA 2012, 308(22):2369-2379.
19. Hayflick L., Moorhead P.S. The serial cultivation of human diploid cell strains. Exp. Cell Res. 1961, 25(3):585-621.
20. Ingber D.E., Folkman J. Mechanochemical switching between growth and differentiation during fibroblast growth factor-stimulated angiogenesis in vitro: role of extracellular matrix. J. Cell Biol. 1989, 109(1):317-330.
21. Knoepfler P.S. Deconstructing stem cell tumorigenicity: a roadmap to safe regenerative medicine. Stem Cells 2009, 27(5):1050-1056.
22. Krinner A., et al. Individual fates of mesenchymal stem cells in vitro. BMC Syst. Biol. 2010, 4(1):73.
23. Kuznetsov S.A., et al. Single-colony derived strains of human marrow stromal fibroblasts form bone after transplantation in vivo. J. Bone Miner. Res. 1997, 12(9):1335-1347.
24. Lee W.C., et al. High-throughput cell cycle synchronization using inertial forces in spiral microchannels. Lab Chip 2011, 11(7):1359-1367.
25. Maloney J.M., et al. Mesenchymal stem cell mechanics from the attached to the suspended state. Biophys. J. 2010, 99(8):2479-2487.
26. McMurray R.J., et al. Nanoscale surfaces for the long-term maintenance of mesenchymal stem cell phenotype and multipotency. Nat. Mater. 2011, 10(8):637-644.
27. Muraglia A., Cancedda R., Quarto R. Clonal mesenchymal progenitors from human bone marrow differentiate in vitro according to a hierarchical model. J. Cell Sci. 2000, 113(Pt 7):1161-1166.
28. Neuhuber B., et al. Effects of plating density and culture time on bone marrow stromal cell characteristics. Exp. Hematol. 2008, 36(9):1176-1185.
29. Oswald J., et al. Mesenchymal stem cells can be differentiated into endothelial cells in vitro. Stem Cells 2004, 22(3):377-384.
30. Pevsner-Fischer M., Levin S., Zipori D. The origins of mesenchymal stromal cell heterogeneity. Stem Cell Rev. Rep. 2011, 7(3):560-568.
31. Ratajczak M.Z., et al. Bone marrow-home of versatile stem cells. Transfus. Med. Hemother. 2008, 35(3):248-259.
32. Ravin R., et al. Potency and fate specification in CNS stem cell populations in vitro. Cell Stem Cell 2008, 3(6):670-680.
33. Scherf N., et al. On the symmetry of siblings: automated single-cell tracking to quantify the behavior of hematopoietic stem cells in a biomimetic setup. Exp. Hematol. 2012, 40(2):119-130. (e9).
34. Schroeder T. Long-term single-cell imaging of mammalian stem cells. Nat. Methods 2011, 8(4s):S30-S35.
35. Seeger F.H., et al. Cell isolation procedures matter: a comparison of different isolation protocols of bone marrow mononuclear cells used for cell therapy in patients with acute myocardial infarction. Eur. Heart J. 2007, 28(6):766-772.
36. Sherwood S.W., et al. Defining cellular senescence in IMR-90 cells: a flow cytometric analysis. Proc. Natl. Acad. Sci. 1988, 85(23):9086-9090.
37. Siddappa R., et al. Donor variation and loss of multipotency during in vitro expansion of human mesenchymal stem cells for bone tissue engineering. J. Orthop. Res. 2007, 25(8):1029-1041.
38. Treiser M.D., et al. Cytoskeleton-based forecasting of stem cell lineage fates. Proc. Natl. Acad. Sci. 2010, 107(2):610-615.
39. von Bahr L., et al. Long-term complications, immunologic effects, and role of passage for outcome in mesenchymal stromal cell therapy. Biol. Blood Marrow Transplant. 2012, 18(4):557-564.
40. Wagner W., et al. Replicative senescence of mesenchymal stem cells: a continuous and organized process. PLoS One 2008, 3(5):e2213.
41. Wagner W., Ho A.D., Zenke M. Different facets of aging in human mesenchymal stem cells. Tissue Eng. B Rev. 2010, 16(4):445-453.
42. Wolfe M., et al. Isolation and culture of bone marrow-derived human multipotent stromal cells (hMSCs). Mesenchymal Stem Cells 2008, 3-25. Springer.
43. Xu W., et al. Mesenchymal stem cells from adult human bone marrow differentiate into a cardiomyocyte phenotype in vitro. Exp. Biol. Med. (Maywood) 2004, 229(7):623-631.
44. Ylostalo J., Bazhanov N., Prockop D.J. Reversible commitment to differentiation by human multipotent stromal cells in single-cell-derived colonies. Exp. Hematol. 2008, 36(10):1390-1402.
45. Zipori D. The hemopoietic stem cell niche versus the microenvironment of the multiple myeloma-tumor initiating cell. Cancer Microenviron. 2010, 3(1):15-28.
46. Zomorodian E., Baghaban Eslaminejad M. Mesenchymal stem cells as a potent cell source for bone regeneration. Stem Cells Int. 2012, 2012.