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Volumn 56, Issue 2, 2015, Pages 440-448

Neuroprotective Effects of Rutin in Streptozotocin-Induced Diabetic Rat Retina

Author keywords

Antioxidant; Neurodegeneration; Neurotrophic factor; Retina; Rutin

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CASPASE 3; GLUCOSE; GLUTATHIONE; INSULIN; NERVE GROWTH FACTOR; PROTEIN BCL 2; RUTOSIDE; STREPTOZOCIN; THIOBARBITURIC ACID REACTIVE SUBSTANCE; ANTIDIABETIC AGENT; GLUCOSE BLOOD LEVEL; NEUROPROTECTIVE AGENT;

EID: 84930480483     PISSN: 08958696     EISSN: 15591166     Source Type: Journal    
DOI: 10.1007/s12031-015-0561-2     Document Type: Article
Times cited : (100)

References (59)
  • 1
    • 79953764493 scopus 로고    scopus 로고
    • Epicatechin blocks pro-nerve growth factor (proNGF)-mediated retinal neurodegeneration via inhibition of p75 neurotrophin receptor expression in a rat model of diabetes
    • COI: 1:CAS:528:DC%2BC3MXhsFKjtLs%3D, PID: 21136036
    • Al-Gayyar MM, Matragoon S, Pillai BA, Ali TK, Abdelsaid MA, El-Remessy AB (2011) Epicatechin blocks pro-nerve growth factor (proNGF)-mediated retinal neurodegeneration via inhibition of p75 neurotrophin receptor expression in a rat model of diabetes. Diabetologia 54:669–680
    • (2011) Diabetologia , vol.54 , pp. 669-680
    • Al-Gayyar, M.M.1    Matragoon, S.2    Pillai, B.A.3    Ali, T.K.4    Abdelsaid, M.A.5    El-Remessy, A.B.6
  • 2
    • 42449100783 scopus 로고    scopus 로고
    • Peroxynitrite mediates retinal neurodegeneration by inhibiting nerve growth factor survival signaling in experimental and human diabetes
    • COI: 1:CAS:528:DC%2BD1cXksVGktbY%3D, PID: 18285558
    • Ali TK, Matragoon S, Pillai BA, Liou GI, El-Remessy AB (2008) Peroxynitrite mediates retinal neurodegeneration by inhibiting nerve growth factor survival signaling in experimental and human diabetes. Diabetes 57:889–898
    • (2008) Diabetes , vol.57 , pp. 889-898
    • Ali, T.K.1    Matragoon, S.2    Pillai, B.A.3    Liou, G.I.4    El-Remessy, A.B.5
  • 4
    • 84885868900 scopus 로고    scopus 로고
    • Recent advances in understanding the anti-diabetic actions of dietary flavonoids
    • Babu PV, Liu D, Gilbert ER (2013) Recent advances in understanding the anti-diabetic actions of dietary flavonoids. J Nutr Biochem 11:1777–1789
    • (2013) J Nutr Biochem , vol.11 , pp. 1777-1789
    • Babu, P.V.1    Liu, D.2    Gilbert, E.R.3
  • 5
    • 0032529103 scopus 로고    scopus 로고
    • Neural apoptosis in the retina during experimental and human diabetes. Early onset and effect of insulin
    • COI: 1:CAS:528:DyaK1cXlsFaqsrg%3D, PID: 9710447
    • Barber AJ, Lieth E, Khin SA, Antonetti DA, Buchanan AG, Gardner TW (1998) Neural apoptosis in the retina during experimental and human diabetes. Early onset and effect of insulin. J Clin Invest 102:783–791
    • (1998) J Clin Invest , vol.102 , pp. 783-791
    • Barber, A.J.1    Lieth, E.2    Khin, S.A.3    Antonetti, D.A.4    Buchanan, A.G.5    Gardner, T.W.6
  • 6
    • 79953269159 scopus 로고    scopus 로고
    • The significance of vascular and neural apoptosis to the pathology of diabetic retinopathy
    • COI: 1:CAS:528:DC%2BC3MXmslWjtLg%3D, PID: 21357409
    • Barber AJ, Gardner TW, Abcouwer SF (2011) The significance of vascular and neural apoptosis to the pathology of diabetic retinopathy. Invest Ophthalmol Vis Sci 52(2):1156–1163
    • (2011) Invest Ophthalmol Vis Sci. , vol.52 , Issue.2 , pp. 1156-1163
    • Barber, A.J.1    Gardner, T.W.2    Abcouwer, S.F.3
  • 7
    • 5744233877 scopus 로고    scopus 로고
    • Brain derived neurotrophic factor
    • Biomed Pharmacother
    • Binder DK, Scharfman HE (2004) Brain derived neurotrophic factor. Growth Factors 22:123–131 64:214–219, Biomed Pharmacother
    • (2004) Growth Factors 22:123–131 , vol.64 , pp. 214-219
    • Binder, D.K.1    Scharfman, H.E.2
  • 9
    • 11144328863 scopus 로고    scopus 로고
    • Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and beta-cell damage in rat pancreas
    • COI: 1:CAS:528:DC%2BD2MXjvFGq, PID: 15629256
    • Coskun O, Kanter M, Korkmaz A, Oter S (2005) Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and beta-cell damage in rat pancreas. Pharmacol Res 51:117–123
    • (2005) Pharmacol Res , vol.51 , pp. 117-123
    • Coskun, O.1    Kanter, M.2    Korkmaz, A.3    Oter, S.4
  • 10
    • 68149124472 scopus 로고    scopus 로고
    • Dietary phenolics: chemistry, bioavailability and effects on health
    • COI: 1:CAS:528:DC%2BD1MXptFGmsr8%3D, PID: 19636448
    • Crozier A, Jaganath IB, Clifford MN (2009) Dietary phenolics: chemistry, bioavailability and effects on health. Nat Prod Rep 26:1001–1043
    • (2009) Nat Prod Rep , vol.26 , pp. 1001-1043
    • Crozier, A.1    Jaganath, I.B.2    Clifford, M.N.3
  • 13
    • 84875330228 scopus 로고    scopus 로고
    • Effects of olive polyphenol administration on nerve growth factor and brain derived neurotrophic factor in the mouse brain
    • PID: 23466052
    • De Nicoló S, Tarani L, Ceccanti M et al (2013) Effects of olive polyphenol administration on nerve growth factor and brain derived neurotrophic factor in the mouse brain. Nutrition 29:681–687
    • (2013) Nutrition , vol.29 , pp. 681-687
    • De Nicoló, S.1    Tarani, L.2    Ceccanti, M.3
  • 15
    • 79955008744 scopus 로고    scopus 로고
    • Curcumin prevents experimental diabetic retinopathy in rats through its hypoglycemic, antioxidant, and anti-inflammatory mechanisms
    • COI: 1:CAS:528:DC%2BC3MXkvVSru70%3D, PID: 21314438
    • Gupta SK, Kumar B, Nag TC, Agrawal SS, Agrawal R, Agrawal P, Saxena R, Srivastava S (2011) Curcumin prevents experimental diabetic retinopathy in rats through its hypoglycemic, antioxidant, and anti-inflammatory mechanisms. J Ocul Pharmacol Ther 27:123–130
    • (2011) J Ocul Pharmacol Ther. , vol.27 , pp. 123-130
    • Gupta, S.K.1    Kumar, B.2    Nag, T.C.3    Agrawal, S.S.4    Agrawal, R.5    Agrawal, P.6    Saxena, R.7    Srivastava, S.8
  • 16
    • 0020626421 scopus 로고
    • Flavonoids, a class of natural products of high pharmacological potency
    • COI: 1:CAS:528:DyaL3sXktVSjtrw%3D, PID: 6342623
    • Havsteen B (1983) Flavonoids, a class of natural products of high pharmacological potency. Biochem Pharmacol 32:1141–1148
    • (1983) Biochem Pharmacol. , vol.32 , pp. 1141-1148
    • Havsteen, B.1
  • 17
    • 84908698574 scopus 로고    scopus 로고
    • Review of the protective effects of rutin on the metabolic function as an important dietary flavonoid
    • PID: 24879037, Invest 102:783–791
    • Hosseinzadeh H, Nassiri-Asl M (2014) Review of the protective effects of rutin on the metabolic function as an important dietary flavonoid. J Endocrinol Invest 37:783–788, Invest 102:783–791
    • (2014) J Endocrinol Invest. , vol.37 , pp. 783-788
    • Hosseinzadeh, H.1    Nassiri-Asl, M.2
  • 18
    • 4744373549 scopus 로고    scopus 로고
    • The hypoglycemic effects of hesperidin and naringin are partly mediated by hepatic glucose-regulating enzymes in C57BL/KsJ-db/db mice
    • COI: 1:CAS:528:DC%2BD2cXosV2jtrY%3D, PID: 15465737
    • Jung UJ, Lee MK, Jeong KS, Choi MS (2004) The hypoglycemic effects of hesperidin and naringin are partly mediated by hepatic glucose-regulating enzymes in C57BL/KsJ-db/db mice. J Nutr 134:2499–2503
    • (2004) J Nutr. , vol.134 , pp. 2499-2503
    • Jung, U.J.1    Lee, M.K.2    Jeong, K.S.3    Choi, M.S.4
  • 19
    • 33645103657 scopus 로고    scopus 로고
    • Antihyperglycaemic and antioxidant effect of rutin, a polyphenolic flavonoid, in streptozotocin-induced diabetic Wistar rats
    • COI: 1:CAS:528:DC%2BD28XhsFegsbc%3D, PID: 16433898
    • Kamalakkannan N, Prince PS (2006a) Antihyperglycaemic and antioxidant effect of rutin, a polyphenolic flavonoid, in streptozotocin-induced diabetic Wistar rats. Basic Clin Pharmacol Toxicol 98:97–103
    • (2006) Basic Clin Pharmacol Toxicol. , vol.98 , pp. 97-103
    • Kamalakkannan, N.1    Prince, P.S.2
  • 20
    • 33750042821 scopus 로고    scopus 로고
    • Rutin improves the antioxidant status in streptozotocin-induced diabetic rat tissues
    • COI: 1:CAS:528:DC%2BD28Xht1Gms7%2FK, PID: 16786186
    • Kamalakkannan N, Prince PS (2006b) Rutin improves the antioxidant status in streptozotocin-induced diabetic rat tissues. Mol Cell Biochem 293:211–219
    • (2006) Mol Cell Biochem. , vol.293 , pp. 211-219
    • Kamalakkannan, N.1    Prince, P.S.2
  • 22
    • 84868251099 scopus 로고    scopus 로고
    • Protective effects of rutin against potassium bromate induced nephrotoxicity in rats
    • COI: 1:CAS:528:DC%2BC3sXjsVSiur0%3D, PID: 23116356
    • Khan RA, Khan MR, Sahreen S (2012) Protective effects of rutin against potassium bromate induced nephrotoxicity in rats. BMC Complement Altern Med 12:204
    • (2012) BMC Complement Altern Med. , vol.12 , pp. 204
    • Khan, R.A.1    Khan, M.R.2    Sahreen, S.3
  • 23
    • 67449119682 scopus 로고    scopus 로고
    • Rutin supplementation in the diet has protective effects against toxicant-induced hippocampal injury by suppression of microglial activation and pro-inflammatory cytokines: protective effect of rutin against toxicant-induced hippocampal injury
    • COI: 1:CAS:528:DC%2BD1MXntVGntr0%3D, PID: 19156514
    • Koda T, Kuroda Y, Imai H (2009) Rutin supplementation in the diet has protective effects against toxicant-induced hippocampal injury by suppression of microglial activation and pro-inflammatory cytokines: protective effect of rutin against toxicant-induced hippocampal injury. Cell Mol Neurobiol 29:523–531
    • (2009) Cell Mol Neurobiol. , vol.29 , pp. 523-531
    • Koda, T.1    Kuroda, Y.2    Imai, H.3
  • 24
    • 34247394257 scopus 로고    scopus 로고
    • Oxidative stress and diabetic retinopathy
    • PID: 17641741
    • Kowluru RA, Chan PS (2007) Oxidative stress and diabetic retinopathy. Exp Diabetes Res 2007:43603
    • (2007) Exp Diabetes Res. , vol.2007 , pp. 43603
    • Kowluru, R.A.1    Chan, P.S.2
  • 25
    • 34247542013 scopus 로고    scopus 로고
    • Effects of curcumin on retinal oxidative stress and inflammation in diabetes
    • Kowluru RA, Kanwar M (2007) Effects of curcumin on retinal oxidative stress and inflammation in diabetes. Nutr Metab (Lond) 16:4–8
    • (2007) Nutr. Metab (Lond). , vol.16 , pp. 4-8
    • Kowluru, R.A.1    Kanwar, M.2
  • 26
    • 12944302088 scopus 로고    scopus 로고
    • Re-institution of good metabolic control in diabetic rats and activation of caspase-3 and nuclear transcriptional factor (NF-kappaB) in the retina
    • COI: 1:CAS:528:DC%2BD2MXltVekuw%3D%3D, PID: 15660203
    • Kowluru RA, Chakrabarti S, Chen S (2004) Re-institution of good metabolic control in diabetic rats and activation of caspase-3 and nuclear transcriptional factor (NF-kappaB) in the retina. Acta Diabetol 41:194–199
    • (2004) Acta Diabetol. , vol.41 , pp. 194-199
    • Kowluru, R.A.1    Chakrabarti, S.2    Chen, S.3
  • 27
    • 0031919598 scopus 로고    scopus 로고
    • Glial reactivity and impaired glutamate metabolism in short-term experimental diabetic retinopathy. Penn State Retina Research Group
    • COI: 1:CAS:528:DyaK1cXjs1Sgsbg%3D, PID: 9588455
    • Lieth E, Barber AJ, Xu B, Dice C, Ratz MJ, Tanase D, Strother JM (1998) Glial reactivity and impaired glutamate metabolism in short-term experimental diabetic retinopathy. Penn State Retina Research Group. Diabetes 47:815–820
    • (1998) Diabetes , vol.47 , pp. 815-820
    • Lieth, E.1    Barber, A.J.2    Xu, B.3    Dice, C.4    Ratz, M.J.5    Tanase, D.6    Strother, J.M.7
  • 28
    • 84892492922 scopus 로고    scopus 로고
    • Dietary flavonoids intake and risk of type 2 diabetes: a meta-analysis of prospective cohort studies
    • PID: 23591151
    • Liu YJ, Zhan J, Liu XL, Wang Y, Ji J, He QQ (2013) Dietary flavonoids intake and risk of type 2 diabetes: a meta-analysis of prospective cohort studies. Clin Nutr 33:59–63
    • (2013) Clin Nutr. , vol.33 , pp. 59-63
    • Liu, Y.J.1    Zhan, J.2    Liu, X.L.3    Wang, Y.4    Ji, J.5    He, Q.Q.6
  • 29
    • 77955153046 scopus 로고    scopus 로고
    • NGF-dependent activation of TrkA pathway: a mechanism for the neuroprotective effect of troxerutin in D-galactose-treated mice
    • COI: 1:CAS:528:DC%2BC3cXhtFKht7bL, PID: 20456366
    • Lu J, Wu DM, Hu B, Zheng YL, Zhang ZF, Wang YJ (2010) NGF-dependent activation of TrkA pathway: a mechanism for the neuroprotective effect of troxerutin in D-galactose-treated mice. Brain Pathol 20:952–965
    • (2010) Brain Pathol. , vol.20 , pp. 952-965
    • Lu, J.1    Wu, D.M.2    Hu, B.3    Zheng, Y.L.4    Zhang, Z.F.5    Wang, Y.J.6
  • 30
    • 84899631802 scopus 로고    scopus 로고
    • Possible involvement of nitric oxide mechanism in the neuroprotective effect of rutin against immobilization stress induced anxiety like behaviour, oxidative damage in mice
    • COI: 1:CAS:528:DC%2BC2MXmt1Sis7c%3D, PID: 24905301
    • Machawal L, Kumar A (2014) Possible involvement of nitric oxide mechanism in the neuroprotective effect of rutin against immobilization stress induced anxiety like behaviour, oxidative damage in mice. Pharmacol Rep 66:15–21
    • (2014) Pharmacol Rep. , vol.66 , pp. 15-21
    • Machawal, L.1    Kumar, A.2
  • 31
    • 84878240917 scopus 로고    scopus 로고
    • Rutin, a bioflavonoid antioxidant protects rat pheochromocytoma (PC-12) cells against 6-hydroxydopamine (6-OHDA)-induced neurotoxicity
    • COI: 1:CAS:528:DC%2BC3sXht1yhtLvK, PID: 23670213
    • Magalingam KB, Radhakrishnan A, Haleagrahara N (2013) Rutin, a bioflavonoid antioxidant protects rat pheochromocytoma (PC-12) cells against 6-hydroxydopamine (6-OHDA)-induced neurotoxicity. Int J Mol Med 32:235–240
    • (2013) Int J Mol Med , vol.32 , pp. 235-240
    • Magalingam, K.B.1    Radhakrishnan, A.2    Haleagrahara, N.3
  • 32
    • 84930473619 scopus 로고    scopus 로고
    • Quercetin glycosides induced neuroprotection by changes in the gene expression in a cellular model of Parkinson’s disease
    • COI: 1:CAS:528:DC%2BC2cXhtlOrt77E, PID: 25129099
    • Magalingam KB, Radhakrishnan A, Ramdas P, Haleagrahara N (2015) Quercetin glycosides induced neuroprotection by changes in the gene expression in a cellular model of Parkinson’s disease. J Mol Neurosci 55(3):609–617
    • (2015) J Mol Neurosci. , vol.55 , Issue.3 , pp. 609-617
    • Magalingam, K.B.1    Radhakrishnan, A.2    Ramdas, P.3    Haleagrahara, N.4
  • 34
    • 0036224782 scopus 로고    scopus 로고
    • Caspase activation in retinas of diabetic and galactosemic mice and diabetic patients
    • COI: 1:CAS:528:DC%2BD38Xis1Oisrg%3D, PID: 11916941
    • Mohr S, Xi X, Tang J, Kern TS (2002) Caspase activation in retinas of diabetic and galactosemic mice and diabetic patients. Diabetes 51:1172–1179
    • (2002) Diabetes , vol.51 , pp. 1172-1179
    • Mohr, S.1    Xi, X.2    Tang, J.3    Kern, T.S.4
  • 36
    • 84930278768 scopus 로고    scopus 로고
    • Rutin alleviates neurodegeneration through inhibiting apoptotic pathway activation in dopaminergic neuronal cells
    • Na JY, Kim S, Song K, Kwon J (2013) Rutin alleviates neurodegeneration through inhibiting apoptotic pathway activation in dopaminergic neuronal cells. Cell Mol Neurobiol 34(7):1071–1079
    • (2013) Cell Mol Neurobiol. , vol.34 , Issue.7 , pp. 1071-1079
    • Na, J.Y.1    Kim, S.2    Song, K.3    Kwon, J.4
  • 37
    • 79960730016 scopus 로고    scopus 로고
    • Neuroprotective effects of flavonoids on hypoxia-, glutamate-, and oxidative stress-induced retinal ganglion cell death
    • COI: 1:CAS:528:DC%2BC3MXpsl2gt7g%3D, PID: 21753864
    • Nakayama M, Aihara M, Chen YN, Araie M, Tomita-Yokotani K, Iwashina T (2011) Neuroprotective effects of flavonoids on hypoxia-, glutamate-, and oxidative stress-induced retinal ganglion cell death. Mol Vis 17:1784–1793
    • (2011) Mol Vis. , vol.17 , pp. 1784-1793
    • Nakayama, M.1    Aihara, M.2    Chen, Y.N.3    Araie, M.4    Tomita-Yokotani, K.5    Iwashina, T.6
  • 39
    • 84859106189 scopus 로고    scopus 로고
    • Recent advances in understanding the biochemical and molecular mechanism of diabetic retinopathy
    • PID: 22226482
    • Ola MS, Nawaz MI, Siddiquei MM et al (2012) Recent advances in understanding the biochemical and molecular mechanism of diabetic retinopathy. J Diabetes Complicat 26:56–64
    • (2012) J Diabetes Complicat , vol.26 , pp. 56-64
    • Ola, M.S.1    Nawaz, M.I.2    Siddiquei, M.M.3
  • 40
    • 84879692686 scopus 로고    scopus 로고
    • Telmisartan ameliorates neurotrophic support and oxidative stress in the retina of streptozotocin-induced diabetic rats
    • COI: 1:CAS:528:DC%2BC3sXms1Ohur4%3D, PID: 23624827
    • Ola MS, Ahmed MM, Abuohashish HM, Al-Rejaie SS, Alhomida AS (2013a) Telmisartan ameliorates neurotrophic support and oxidative stress in the retina of streptozotocin-induced diabetic rats. Neurochem Res 38:1572–1579
    • (2013) Neurochem Res , vol.38 , pp. 1572-1579
    • Ola, M.S.1    Ahmed, M.M.2    Abuohashish, H.M.3    Al-Rejaie, S.S.4    Alhomida, A.S.5
  • 41
    • 84875109485 scopus 로고    scopus 로고
    • Neurodegeneration and neuroprotection in diabetic retinopathy
    • COI: 1:CAS:528:DC%2BC3sXitlGqu70%3D, PID: 23358247
    • Ola MS, Nawaz MI, Khan HA, Alhomida AS (2013b) Neurodegeneration and neuroprotection in diabetic retinopathy. Int J Mol Sci 14:2559–2572
    • (2013) Int J Mol Sci , vol.14 , pp. 2559-2572
    • Ola, M.S.1    Nawaz, M.I.2    Khan, H.A.3    Alhomida, A.S.4
  • 42
    • 84903380285 scopus 로고    scopus 로고
    • Flavonoid, morin inhibits oxidative stress, inflammation and enhances neurotrophic support in the brain of streptozotocin-induced diabetic rats
    • PID: 24413816
    • Ola MS, Aleisa AM, Al-Rejaie SS, Abuohashish HM, Parmar MY, Alhomida AS, Ahmed MM (2014) Flavonoid, morin inhibits oxidative stress, inflammation and enhances neurotrophic support in the brain of streptozotocin-induced diabetic rats. Neurol Sci 35:1003–1008
    • (2014) Neurol Sci. , vol.35 , pp. 1003-1008
    • Ola, M.S.1    Aleisa, A.M.2    Al-Rejaie, S.S.3    Abuohashish, H.M.4    Parmar, M.Y.5    Alhomida, A.S.6    Ahmed, M.M.7
  • 44
    • 77953474824 scopus 로고    scopus 로고
    • Plant polyphenols as dietary antioxidants in human health and disease
    • Pandey KB, Rizvi SI (2009) Plant polyphenols as dietary antioxidants in human health and disease. Oxid Med Cell Longev (5):270–278
    • (2009) Oxid Med Cell Longev (5) , pp. 270-278
    • Pandey, K.B.1    Rizvi, S.I.2
  • 45
    • 9244249143 scopus 로고    scopus 로고
    • Grape seed-derived procyanidins have an antihyperglycemic effect in streptozotocin-induced diabetic rats and insulinomimetic activity in insulin-sensitive cell lines
    • COI: 1:CAS:528:DC%2BD2cXptVyhtbw%3D, PID: 15271880
    • Pinent M, Blay M, Bladé MC, Salvadó MJ, Arola L, Ardévol A (2004) Grape seed-derived procyanidins have an antihyperglycemic effect in streptozotocin-induced diabetic rats and insulinomimetic activity in insulin-sensitive cell lines. Endocrinology 145:4985–4990
    • (2004) Endocrinology. , vol.145 , pp. 4985-4990
    • Pinent, M.1    Blay, M.2    Bladé, M.C.3    Salvadó, M.J.4    Arola, L.5    Ardévol, A.6
  • 46
    • 33750072937 scopus 로고    scopus 로고
    • Protective effect of rutin on lipids, lipoproteins, lipid metabolizing enzymes and glycoproteins in streptozotocin-induced diabetic rats
    • Prince PS, Kannan NK (2006) Protective effect of rutin on lipids, lipoproteins, lipid metabolizing enzymes and glycoproteins in streptozotocin-induced diabetic rats. J Pharm Pharmacol 58:1373–1383
    • (2006) J Pharm Pharmacol. , vol.58 , pp. 1373-1383
    • Prince, P.S.1    Kannan, N.K.2
  • 47
    • 34548471990 scopus 로고    scopus 로고
    • Neuroprotective effects of quercetin and rutin on spatial memory impairment in an 8-arm radial maze task and neuronal death induced by repeated cerebral ischemia in rats
    • COI: 1:CAS:528:DC%2BD2sXhtVaks7bP, PID: 17666865
    • Pu F, Mishima K, Irie K, Motohashi K, Tanaka Y, Orito K, Egawa T, Kitamura Y, Egashira N, Iwasaki K, Fujiwara M (2007) Neuroprotective effects of quercetin and rutin on spatial memory impairment in an 8-arm radial maze task and neuronal death induced by repeated cerebral ischemia in rats. J Pharmacol Sci 104:329–334
    • (2007) J Pharmacol Sci. , vol.104 , pp. 329-334
    • Pu, F.1    Mishima, K.2    Irie, K.3    Motohashi, K.4    Tanaka, Y.5    Orito, K.6    Egawa, T.7    Kitamura, Y.8    Egashira, N.9    Iwasaki, K.10    Fujiwara, M.11
  • 48
    • 85018132921 scopus 로고    scopus 로고
    • Flavonoids in health and diseases, Marcel Dekker, New York, NY
    • Rice-Evans CA, and Packer L (1998) Flavonoids in health and diseases, Marcel Dekker, New York, NY. Vol: 1, 163–177
    • (1998) Vol , vol.1 , pp. 163-177
    • Rice-Evans, C.A.1    Packer, L.2
  • 49
    • 77952089530 scopus 로고    scopus 로고
    • Neurodegenerative influence of oxidative stress in the retina of a murine model of diabetes
    • COI: 1:CAS:528:DC%2BC3cXktlGgtbY%3D, PID: 20162412
    • Sasaki M, Ozawa Y, Kurihara T, Kubota S, Yuki K, Noda K, Kobayashi S, Ishida S, Tsubota K (2010) Neurodegenerative influence of oxidative stress in the retina of a murine model of diabetes. Diabetologia 53:971–979
    • (2010) Diabetologia , vol.53 , pp. 971-979
    • Sasaki, M.1    Ozawa, Y.2    Kurihara, T.3    Kubota, S.4    Yuki, K.5    Noda, K.6    Kobayashi, S.7    Ishida, S.8    Tsubota, K.9
  • 51
    • 4344599833 scopus 로고    scopus 로고
    • Involvement of brain derived neurotrophic factor in early retinal neuropathy of streptozotocin-induced diabetes in rats: therapeutic potential of brain derived neurotrophic factor for dopaminergic amacrine cells
    • COI: 1:CAS:528:DC%2BD2cXns1ShsLw%3D, PID: 15331553
    • Seki M, Tanaka T, Nawa H, Usui T, Fukuchi T, Ikeda K, Abe H, Takei N (2004) Involvement of brain derived neurotrophic factor in early retinal neuropathy of streptozotocin-induced diabetes in rats: therapeutic potential of brain derived neurotrophic factor for dopaminergic amacrine cells. Diabetes 53:2412–2419
    • (2004) Diabetes , vol.53 , pp. 2412-2419
    • Seki, M.1    Tanaka, T.2    Nawa, H.3    Usui, T.4    Fukuchi, T.5    Ikeda, K.6    Abe, H.7    Takei, N.8
  • 52
    • 84880241949 scopus 로고    scopus 로고
    • Rutin: therapeutic potential and recent advances in drug delivery
    • COI: 1:CAS:528:DC%2BC3sXhtVyksrrK, PID: 23795677
    • Sharma S, Ali A, Ali J, Sahni JK, Baboota S (2013) Rutin: therapeutic potential and recent advances in drug delivery. Expert Opin Investig Drugs 22:1063–1079
    • (2013) Expert Opin Investig Drugs. , vol.22 , pp. 1063-1079
    • Sharma, S.1    Ali, A.2    Ali, J.3    Sahni, J.K.4    Baboota, S.5
  • 53
    • 66649114798 scopus 로고    scopus 로고
    • Diabetic retinal neurodegeneration is associated with mitochondrial oxidative stress and is improved by an angiotensin receptor blocker in a model combining hypertension and diabetes
    • COI: 1:CAS:528:DC%2BD1MXntFanurc%3D, PID: 19289456
    • Silva KC, Rosales MA, Biswas SK, Lopes de Faria JB, Lopes de Faria JM (2009) Diabetic retinal neurodegeneration is associated with mitochondrial oxidative stress and is improved by an angiotensin receptor blocker in a model combining hypertension and diabetes. Diabetes 58:1382–1390
    • (2009) Diabetes. , vol.58 , pp. 1382-1390
    • Silva, K.C.1    Rosales, M.A.2    Biswas, S.K.3    Lopes de Faria, J.B.4    Lopes de Faria, J.M.5
  • 55
    • 0041589462 scopus 로고    scopus 로고
    • Antidiabetic effects of quercetin in streptozocin-induced diabetic rats
    • COI: 1:CAS:528:DC%2BD3sXmsVCiur4%3D, PID: 12927910
    • Vessal M, Hemmati M, Vasei M (2003) Antidiabetic effects of quercetin in streptozocin-induced diabetic rats. Comp Biochem Physiol C Toxicol Pharmacol 135C:357–364
    • (2003) Comp Biochem Physiol C Toxicol Pharmacol. , vol.135C , pp. 357-364
    • Vessal, M.1    Hemmati, M.2    Vasei, M.3
  • 57
    • 84984537489 scopus 로고    scopus 로고
    • Comparative study of quercetin and its two glycoside derivatives quercitrin and rutin against methylmercury (MeHg)-induced ROS production in rat brain slices
    • COI: 1:CAS:528:DC%2BD1MXhtlynt7rI, PID: 19902180
    • Wagner C, Vargas AP, Roos DH, Morel AF, Farina M, Nogueira CW, Aschner M, Rocha JB (2010) Comparative study of quercetin and its two glycoside derivatives quercitrin and rutin against methylmercury (MeHg)-induced ROS production in rat brain slices. Arch Toxicol 84(2):89–97
    • (2010) Arch Toxicol. , vol.84 , Issue.2 , pp. 89-97
    • Wagner, C.1    Vargas, A.P.2    Roos, D.H.3    Morel, A.F.4    Farina, M.5    Nogueira, C.W.6    Aschner, M.7    Rocha, J.B.8
  • 58
    • 84930483739 scopus 로고    scopus 로고
    • World Health Organization. Diabetes Fact Sheet Number 312; WHO: Geneva, Switzerland; Available online
    • World Health Organization. Diabetes Fact Sheet Number 312; WHO: Geneva, Switzerland; Available online: http://www.who.int/mediacentre/factsheets/fs312/en
  • 59
    • 84880202236 scopus 로고    scopus 로고
    • Flavonoids induce the synthesis and secretion of neurotrophic factors in cultured rat astrocytes: a signaling response mediated by estrogen receptor
    • PID: 23878590
    • Xu SL, Bi CW, Choi RC, Zhu KY, Miernisha A, Dong TT, Tsim KW (2013) Flavonoids induce the synthesis and secretion of neurotrophic factors in cultured rat astrocytes: a signaling response mediated by estrogen receptor. Evid Based Complement Alternat Med 2013:127075
    • (2013) Evid Based Complement Alternat Med , vol.2013 , pp. 127075
    • Xu, S.L.1    Bi, C.W.2    Choi, R.C.3    Zhu, K.Y.4    Miernisha, A.5    Dong, T.T.6    Tsim, K.W.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.