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Volumn 37, Issue 9, 2014, Pages 783-788

Review of the protective effects of rutin on the metabolic function as an important dietary flavonoid

Author keywords

Anti diabetes; Anti glycation; Hepatoprotective; Rutin

Indexed keywords

FLAVONOID; RUTOSIDE;

EID: 84908698574     PISSN: 03914097     EISSN: 17208386     Source Type: Journal    
DOI: 10.1007/s40618-014-0096-3     Document Type: Review
Times cited : (201)

References (56)
  • 1
    • 0347063903 scopus 로고    scopus 로고
    • Tartary buckwheat (Fagopyrum tataricum Gaertn.) as a source of dietary rutin and quercitrin
    • Fabjan N, Rode J, Kosir IJ, Wang Z, Zhang Z, Kreft I (2003) Tartary buckwheat (Fagopyrum tataricum Gaertn.) as a source of dietary rutin and quercitrin. J Agric Food Chem 51:6452-6455
    • (2003) J Agric Food Chem , vol.51 , pp. 6452-6455
    • Fabjan, N.1    Rode, J.2    Kosir, I.J.3    Wang, Z.4    Zhang, Z.5    Kreft, I.6
  • 2
    • 0033230132 scopus 로고    scopus 로고
    • Extraction of rutin from buckwheat (Fagopyrum esculentum Moench) seeds and determination by capillary electrophoresis
    • Kreft S, Knapp M, Kreft I (1999) Extraction of rutin from buckwheat (Fagopyrum esculentum Moench) seeds and determination by capillary electrophoresis. J Agric Food Chem 47:4649-4652
    • (1999) J Agric Food Chem , vol.47 , pp. 4649-4652
    • Kreft, S.1    Knapp, M.2    Kreft, I.3
  • 3
    • 33845668735 scopus 로고    scopus 로고
    • Isocratic RP-HPLC method for rutin determination in solid oral dosage forms
    • Kuntic V, Pejic N, Ivkovic B et al (2007) Isocratic RP-HPLC method for rutin determination in solid oral dosage forms. J Pharm Biomed Anal 43:718-721
    • (2007) J Pharm Biomed Anal , vol.43 , pp. 718-721
    • Kuntic, V.1    Pejic, N.2    Ivkovic, B.3
  • 4
    • 84858004372 scopus 로고    scopus 로고
    • Estimation of in vitro neuroprotective properties and quantification of rutin and fatty acids in buckwheat (Fagopyrum esculentum Moench) cultivated in Turkey
    • Gulpinar AR, Orhan IE, Kan A, Senol FS, Celik SA, Kartal M (2012) Estimation of in vitro neuroprotective properties and quantification of rutin and fatty acids in buckwheat (Fagopyrum esculentum Moench) cultivated in Turkey. Food Res Int 46:536-543
    • (2012) Food Res Int , vol.46 , pp. 536-543
    • Gulpinar, A.R.1    Orhan, I.E.2    Kan, A.3    Senol, F.S.4    Celik, S.A.5    Kartal, M.6
  • 5
    • 77955658821 scopus 로고    scopus 로고
    • Dynamic stereochemistry of rutin (vitamin P) in solution: Theoretical approaches and experimental validation
    • Ghiasi M, Taheri S, Tafazzoli M (2010) Dynamic stereochemistry of rutin (vitamin P) in solution: theoretical approaches and experimental validation. Carbohydr Res 345:1760-1766
    • (2010) Carbohydr Res , vol.345 , pp. 1760-1766
    • Ghiasi, M.1    Taheri, S.2    Tafazzoli, M.3
  • 6
    • 84861834042 scopus 로고    scopus 로고
    • Nicotiflorin, rutin and chlorogenic acid: Phenylpropanoids involved differently in quantitative resistance of potato tubers to biotrophic and necrotrophic pathogens
    • Kroner A, Marnet N, Andrivon D, Val F (2012) Nicotiflorin, rutin and chlorogenic acid: phenylpropanoids involved differently in quantitative resistance of potato tubers to biotrophic and necrotrophic pathogens. Plant Physiol Biochem 57:23-31
    • (2012) Plant Physiol Biochem , vol.57 , pp. 23-31
    • Kroner, A.1    Marnet, N.2    Andrivon, D.3    Val, F.4
  • 7
    • 0029057329 scopus 로고
    • Quercetin metabolites in plasma of rats fed diets containing rutin or quercetin
    • Manach C, Morand C, Texier O (1995) Quercetin metabolites in plasma of rats fed diets containing rutin or quercetin. J Nutr 125:1911-1922
    • (1995) J Nutr , vol.125 , pp. 1911-1922
    • Manach, C.1    Morand, C.2    Texier, O.3
  • 8
    • 0027519171 scopus 로고
    • Suppression of active oxygen-induced cytotoxicity by flavonoids
    • Nakayama T, Yamada M, Osawa T, Kawakishi S (1993) Suppression of active oxygen-induced cytotoxicity by flavonoids. Biochem Pharmacol 45:265-267
    • (1993) Biochem Pharmacol , vol.45 , pp. 265-267
    • Nakayama, T.1    Yamada, M.2    Osawa, T.3    Kawakishi, S.4
  • 10
    • 68149124472 scopus 로고    scopus 로고
    • Dietary phenolics: Chemistry, bioavailability and effects on health
    • Crozier A, Jaganath IB, Clifford MN (2009) Dietary phenolics: chemistry, bioavailability and effects on health. Nat Prod Rep 26:1001-1043
    • (2009) Nat Prod Rep , vol.26 , pp. 1001-1043
    • Crozier, A.1    Jaganath, I.B.2    Clifford, M.N.3
  • 12
    • 0034494884 scopus 로고    scopus 로고
    • Respective bioavailability of quercetin aglycone and its glycosides in a rat model
    • Morand C, Manach C, Crespy V, Remesy C (2000) Respective bioavailability of quercetin aglycone and its glycosides in a rat model. BioFactors 12:169-174
    • (2000) BioFactors , vol.12 , pp. 169-174
    • Morand, C.1    Manach, C.2    Crespy, V.3    Remesy, C.4
  • 13
    • 23844481074 scopus 로고    scopus 로고
    • Absorption of quercetin and rutin in rat small intestine
    • Carbonaro M, Grant G (2005) Absorption of quercetin and rutin in rat small intestine. Ann Nutr Metab 49:178-182
    • (2005) Ann Nutr Metab , vol.49 , pp. 178-182
    • Carbonaro, M.1    Grant, G.2
  • 14
    • 0033661837 scopus 로고    scopus 로고
    • Pharmacokinetics of quercetin from quercetin aglycone and rutin in healthy volunteers
    • Erlund I, Kosonen T, Alfthan G (2000) Pharmacokinetics of quercetin from quercetin aglycone and rutin in healthy volunteers. Eur J Clin Pharmacol 56:545-553
    • (2000) Eur J Clin Pharmacol , vol.56 , pp. 545-553
    • Erlund, I.1    Kosonen, T.2    Alfthan, G.3
  • 15
    • 0038357911 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of antioxidants and their impact on systemic oxidative stress
    • Schwedhelm E, Maas R, Troost R, Boger RH (2003) Clinical pharmacokinetics of antioxidants and their impact on systemic oxidative stress. Clin Pharmacokinet 42:437-459
    • (2003) Clin Pharmacokinet , vol.42 , pp. 437-459
    • Schwedhelm, E.1    Maas, R.2    Troost, R.3    Boger, R.H.4
  • 16
    • 33749249943 scopus 로고    scopus 로고
    • The relative contribution of the small and large intestine to the absorption and metabolism of rutin in man
    • Jaganath IB, Mullen W, Edwards CA, Crozier A (2006) The relative contribution of the small and large intestine to the absorption and metabolism of rutin in man. Free Radic Res 40:1035-1046
    • (2006) Free Radic Res , vol.40 , pp. 1035-1046
    • Jaganath, I.B.1    Mullen, W.2    Edwards, C.A.3    Crozier, A.4
  • 18
    • 28844453299 scopus 로고    scopus 로고
    • Antioxidant flavonol glycosides in mulberry (Morus alba L.) leaves isolated based on LDL antioxidant activity
    • Katsube T, Imawaka N, Kawano Y, Yamazaki Y, Shiwaku K, Yamane Y (2006) Antioxidant flavonol glycosides in mulberry (Morus alba L.) leaves isolated based on LDL antioxidant activity. Food Chem 97:25-31
    • (2006) Food Chem , vol.97 , pp. 25-31
    • Katsube, T.1    Imawaka, N.2    Kawano, Y.3    Yamazaki, Y.4    Shiwaku, K.5    Yamane, Y.6
  • 20
    • 84874934910 scopus 로고    scopus 로고
    • Rutin potentiates calcium uptake via voltage-dependent calcium channel associated with stimulation of glucose uptake in skeletal muscle
    • Kappel VD, Zanatta L, Postal BG, Silva FR (2013) Rutin potentiates calcium uptake via voltage-dependent calcium channel associated with stimulation of glucose uptake in skeletal muscle. Arch Biochem Biophys 532:55-60
    • (2013) Arch Biochem Biophys , vol.532 , pp. 55-60
    • Kappel, V.D.1    Zanatta, L.2    Postal, B.G.3    Silva, F.R.4
  • 21
    • 84869809410 scopus 로고    scopus 로고
    • Chlorogenic acid and rutin play a major role in the in vivo antidiabetic activity of Morus alba leaf extract on type II diabetic rats
    • Hunyadi A, Martins A, Hsieh TJ, Seres A, Zupko I (2012) Chlorogenic acid and rutin play a major role in the in vivo antidiabetic activity of Morus alba leaf extract on type II diabetic rats. PLoS One 7:e50619
    • (2012) PLoS One , vol.7 , pp. e50619
    • Hunyadi, A.1    Martins, A.2    Hsieh, T.J.3    Seres, A.4    Zupko, I.5
  • 22
    • 79958211266 scopus 로고    scopus 로고
    • Rutin attenuates metabolic changes, nonalcoholic steatohepatitis, and cardiovascular remodeling in high-carbohydrate, high-fat diet-fed rats
    • Panchal SK, Poudyal H, Arumugam TV, Brown L (2011) Rutin attenuates metabolic changes, nonalcoholic steatohepatitis, and cardiovascular remodeling in high-carbohydrate, high-fat diet-fed rats. J Nutr 141:1062-1069
    • (2011) J Nutr , vol.141 , pp. 1062-1069
    • Panchal, S.K.1    Poudyal, H.2    Arumugam, T.V.3    Brown, L.4
  • 23
    • 84857720782 scopus 로고    scopus 로고
    • Natural products as antiglycation agents: Possible therapeutic potential for diabetic complications
    • Elosta A, Ghous T, Ahmed N (2012) Natural products as antiglycation agents: possible therapeutic potential for diabetic complications. Curr Diabetes Rev 8:92-108
    • (2012) Curr Diabetes Rev , vol.8 , pp. 92-108
    • Elosta, A.1    Ghous, T.2    Ahmed, N.3
  • 24
    • 77952987719 scopus 로고    scopus 로고
    • Non-enzymatic glycation of proteins: From diabetes to cancer
    • Ansari NA, Rasheed Z (2010) Non-enzymatic glycation of proteins: from diabetes to cancer. Biomed Khim 56:168-178
    • (2010) Biomed Khim , vol.56 , pp. 168-178
    • Ansari, N.A.1    Rasheed, Z.2
  • 25
    • 0025298662 scopus 로고
    • Prevention of diabetes-increased aging effect on rat collagen-linked fluorescence by aminoguanidine and rutin
    • Odetti PR, Borgoglio A, De Pascale A, Rolandi R, Adezati L (1990) Prevention of diabetes-increased aging effect on rat collagen-linked fluorescence by aminoguanidine and rutin. Diabetes 39:796-801
    • (1990) Diabetes , vol.39 , pp. 796-801
    • Odetti, P.R.1    Borgoglio, A.2    De Pascale, A.3    Rolandi, R.4    Adezati, L.5
  • 26
    • 0041975037 scopus 로고    scopus 로고
    • Inhibition of glycation reaction in tissue protein incubations by water soluble rutin derivative
    • Nagasawa T, Tabata N, Ito Y, Nishizawa N, Aiba Y, Kitts DD (2003) Inhibition of glycation reaction in tissue protein incubations by water soluble rutin derivative. Mol Cell Biochem 249:3-10
    • (2003) Mol Cell Biochem , vol.249 , pp. 3-10
    • Nagasawa, T.1    Tabata, N.2    Ito, Y.3    Nishizawa, N.4    Aiba, Y.5    Kitts, D.D.6
  • 28
    • 84863593197 scopus 로고    scopus 로고
    • Inhibition of advanced glycation end-product formation on eye lens protein by rutin
    • Muthenna P, Akileshwari C, Saraswat M, Bhanuprakash Reddy G (2012) Inhibition of advanced glycation end-product formation on eye lens protein by rutin. Br J Nutr 107:941-949
    • (2012) Br J Nutr , vol.107 , pp. 941-949
    • Muthenna, P.1    Akileshwari, C.2    Saraswat, M.3    Bhanuprakash Reddy, G.4
  • 29
    • 0033947733 scopus 로고    scopus 로고
    • Evidence for protective and antioxidant properties of rutin, a natural flavone, against ethanol induced gastric lesions
    • La Casa C, Villegas I, La De Alarcón Lastra C, Motilva V, Martín Calero MJ (2000) Evidence for protective and antioxidant properties of rutin, a natural flavone, against ethanol induced gastric lesions. J Ethnopharmacol 71:45-53
    • (2000) J Ethnopharmacol , vol.71 , pp. 45-53
    • La Casa, C.1    Villegas, I.2    La De Alarcón Lastra, C.3    Motilva, V.4    Martín Calero, M.J.5
  • 30
    • 77955783931 scopus 로고    scopus 로고
    • Gastroprotective effect of rutin against indomethacin-induced ulcers in rats
    • Abdel-Raheem IT (2010) Gastroprotective effect of rutin against indomethacin-induced ulcers in rats. Basic Clin Pharmacol Toxicol 107:742-750
    • (2010) Basic Clin Pharmacol Toxicol , vol.107 , pp. 742-750
    • Abdel-Raheem, I.T.1
  • 31
    • 84856074938 scopus 로고    scopus 로고
    • Differential protective effects of quercetin, resveratrol, rutin and epigallocatechin gallate against mitochondrial dysfunction induced by indomethacin in Caco-2 cells
    • Carrasco-Pozo C, Mizgier ML, Speisky H, Gotteland M (2012) Differential protective effects of quercetin, resveratrol, rutin and epigallocatechin gallate against mitochondrial dysfunction induced by indomethacin in Caco-2 cells. Chem Biol Interact 195:199-205
    • (2012) Chem Biol Interact , vol.195 , pp. 199-205
    • Carrasco-Pozo, C.1    Mizgier, M.L.2    Speisky, H.3    Gotteland, M.4
  • 32
    • 24044511500 scopus 로고    scopus 로고
    • Metabolic and pharmacological properties of rutin, a dietary quercetin glycoside, for treatment of inflammatory bowel disease
    • Kim H, Kong H, Choi B et al (2005) Metabolic and pharmacological properties of rutin, a dietary quercetin glycoside, for treatment of inflammatory bowel disease. Pharm Res 22:1499-1509
    • (2005) Pharm Res , vol.22 , pp. 1499-1509
    • Kim, H.1    Kong, H.2    Choi, B.3
  • 34
    • 84655163812 scopus 로고    scopus 로고
    • Coated chitosan pellets containing rutin intended for the treatment of inflammatory bowel disease: In vitro characteristics and in vivo evaluation
    • Rabišková M, Bautzová T, Gajdziok J et al (2012) Coated chitosan pellets containing rutin intended for the treatment of inflammatory bowel disease: in vitro characteristics and in vivo evaluation. Int J Pharm 422:151-159
    • (2012) Int J Pharm , vol.422 , pp. 151-159
    • Rabišková, M.1    Bautzová, T.2    Gajdziok, J.3
  • 35
    • 11844279094 scopus 로고    scopus 로고
    • Dietary rutin, but not its aglycone quercetin, ameliorates dextran sulfate sodium-induced experimental colitis in mice: Attenuation of proinflammatory gene expression
    • Kwon KH, Murakami A, Tanaka T, Ohigashi H (2005) Dietary rutin, but not its aglycone quercetin, ameliorates dextran sulfate sodium-induced experimental colitis in mice: attenuation of proinflammatory gene expression. Biochem Pharmacol 69:395-406
    • (2005) Biochem Pharmacol , vol.69 , pp. 395-406
    • Kwon, K.H.1    Murakami, A.2    Tanaka, T.3    Ohigashi, H.4
  • 36
    • 84879359123 scopus 로고    scopus 로고
    • Protective effect of rutin against acute gastric mucosal lesions induced by ischemia-reperfusion
    • Liu Y, Gou L, Fu X, Li S, Lan N, Yin X (2013) Protective effect of rutin against acute gastric mucosal lesions induced by ischemia-reperfusion. Pharm Biol 51:914-919
    • (2013) Pharm Biol , vol.51 , pp. 914-919
    • Liu, Y.1    Gou, L.2    Fu, X.3    Li, S.4    Lan, N.5    Yin, X.6
  • 37
    • 84867194602 scopus 로고    scopus 로고
    • Differential hepatoprotective mechanisms of rutin and quercetin in CCl (4)-intoxicated BALB/cN mice
    • Domitrović R, Jakovac H, Vasiljev Marchesi V et al (2012) Differential hepatoprotective mechanisms of rutin and quercetin in CCl (4)-intoxicated BALB/cN mice. Acta Pharmacol Sin 33:1260-1270
    • (2012) Acta Pharmacol Sin , vol.33 , pp. 1260-1270
    • Domitrović, R.1    Jakovac, H.2    Vasiljev Marchesi, V.3
  • 38
    • 79952082354 scopus 로고    scopus 로고
    • Rutin inhibits oleic acid induced lipid accumulation via reducing lipogenesis and oxidative stress in hepatocarcinoma cells
    • Wu CH, Lin MC, Wang HC, Yang MY, Jou MJ, Wang CJ (2011) Rutin inhibits oleic acid induced lipid accumulation via reducing lipogenesis and oxidative stress in hepatocarcinoma cells. J Food Sci 76:T65-T72
    • (2011) J Food Sci , vol.76 , pp. T65-T72
    • Wu, C.H.1    Lin, M.C.2    Wang, H.C.3    Yang, M.Y.4    Jou, M.J.5    Wang, C.J.6
  • 40
    • 33750042821 scopus 로고    scopus 로고
    • Rutin improves the antioxidant status in streptozotocin-induced diabetic rat tissues
    • Kamalakkannan N, Stanely Mainzen Prince P (2006) Rutin improves the antioxidant status in streptozotocin-induced diabetic rat tissues. Mol Cell Biochem 293:211-219
    • (2006) Mol Cell Biochem , vol.293 , pp. 211-219
    • Kamalakkannan, N.1    Stanely Mainzen Prince, P.2
  • 41
    • 33645103657 scopus 로고    scopus 로고
    • Antihyperglycaemic and antioxidant effect of rutin, a polyphenolic flavonoid, in streptozotocin-induced diabetic wistar rats
    • Kamalakkannan N, Prince PS (2006) Antihyperglycaemic and antioxidant effect of rutin, a polyphenolic flavonoid, in streptozotocin-induced diabetic wistar rats. Basic Clin Pharmacol Toxicol 98:97-103
    • (2006) Basic Clin Pharmacol Toxicol , vol.98 , pp. 97-103
    • Kamalakkannan, N.1    Prince, P.S.2
  • 42
    • 33747074105 scopus 로고    scopus 로고
    • The influence of rutin on the extracellular matrix in streptozotocin-induced diabetic rat kidney
    • Kamalakkannan N, Stanely Mainzen Prince P (2006) The influence of rutin on the extracellular matrix in streptozotocin-induced diabetic rat kidney. J Pharm Pharmacol 58:1091-1098
    • (2006) J Pharm Pharmacol , vol.58 , pp. 1091-1098
    • Kamalakkannan, N.1    Stanely Mainzen Prince, P.2
  • 43
    • 77649236635 scopus 로고    scopus 로고
    • Influence of rutin treatment on biochemical alterations in experimental diabetes
    • Fernandes AA, Novelli EL, Okoshi K et al (2010) Influence of rutin treatment on biochemical alterations in experimental diabetes. Biomed Pharmacother 64:214-219
    • (2010) Biomed Pharmacother , vol.64 , pp. 214-219
    • Fernandes, A.A.1    Novelli, E.L.2    Okoshi, K.3
  • 44
    • 77953902140 scopus 로고    scopus 로고
    • Antihyperglycaemic and protective effects of flavonoids on streptozotocin-induced diabetic rats
    • Rauter AP, Martins A, Borges C et al (2010) Antihyperglycaemic and protective effects of flavonoids on streptozotocin-induced diabetic rats. Phytother Res 24:S133-S138
    • (2010) Phytother Res , vol.24 , pp. S133-S138
    • Rauter, A.P.1    Martins, A.2    Borges, C.3
  • 45
    • 84867849002 scopus 로고    scopus 로고
    • Preventive effects of rutin on the development of experimental diabetic nephropathy in rats
    • Hao HH, Shao ZM, Tang DQ et al (2012) Preventive effects of rutin on the development of experimental diabetic nephropathy in rats. Life Sci 91:959-967
    • (2012) Life Sci , vol.91 , pp. 959-967
    • Hao, H.H.1    Shao, Z.M.2    Tang, D.Q.3
  • 46
    • 21844440850 scopus 로고    scopus 로고
    • Partial reversal by rutin and quercetin of impaired cardiac function in streptozotocin-induced diabetic rats
    • Krishna KM, Annapurna A, Gopal GS et al (2005) Partial reversal by rutin and quercetin of impaired cardiac function in streptozotocin-induced diabetic rats. Can J Physiol Pharmacol 83:343-355
    • (2005) Can J Physiol Pharmacol , vol.83 , pp. 343-355
    • Krishna, K.M.1    Annapurna, A.2    Gopal, G.S.3
  • 47
    • 0036545415 scopus 로고    scopus 로고
    • Combination of vitamin C and rutin on neuropathy and lung damage of diabetes mellitus rats
    • Je HD, Shin CY, Park SY et al (2002) Combination of vitamin C and rutin on neuropathy and lung damage of diabetes mellitus rats. Arch Pharm Res 25:184-190
    • (2002) Arch Pharm Res , vol.25 , pp. 184-190
    • Je, H.D.1    Shin, C.Y.2    Park, S.Y.3
  • 48
    • 77951931613 scopus 로고    scopus 로고
    • Epigallocatechin gallate (EGCG) and rutin suppress the glucotoxicity through activating IRS2 and AMPK signaling in rat pancreatic beta cells
    • Cai EP, Lin JK (2009) Epigallocatechin gallate (EGCG) and rutin suppress the glucotoxicity through activating IRS2 and AMPK signaling in rat pancreatic beta cells. J Agric Food Chem 57:9817-9827
    • (2009) J Agric Food Chem , vol.57 , pp. 9817-9827
    • Cai, E.P.1    Lin, J.K.2
  • 49
    • 84862559689 scopus 로고    scopus 로고
    • Effects of rutin on the expression of PPARc in skeletal muscles of db/db mice
    • Cai Y, Fan C, Yan J, Tian N, Ma X (2012) Effects of rutin on the expression of PPARc in skeletal muscles of db/db mice. Planta Med 78:861-865
    • (2012) Planta Med , vol.78 , pp. 861-865
    • Cai, Y.1    Fan, C.2    Yan, J.3    Tian, N.4    Ma, X.5
  • 50
    • 84874620802 scopus 로고    scopus 로고
    • The role of calcium in intracellular pathways of rutin in rat pancreatic islets: Potential insulin secretagogue effect
    • Kappel VD, Frederico MJ, Postal BG, Mendes CP, Cazarolli LH, Silva FR (2013) The role of calcium in intracellular pathways of rutin in rat pancreatic islets: potential insulin secretagogue effect. Eur J Pharmacol 702:264-268
    • (2013) Eur J Pharmacol , vol.702 , pp. 264-268
    • Kappel, V.D.1    Frederico, M.J.2    Postal, B.G.3    Mendes, C.P.4    Cazarolli, L.H.5    Silva, F.R.6
  • 51
    • 73349100639 scopus 로고    scopus 로고
    • Comparative evaluation of quercetin, isoquercetin and rutin as inhibitors of alpha-glucosidase
    • Li YQ, Zhou FC, Gao F, Bian JS, Shan F (2009) Comparative evaluation of quercetin, isoquercetin and rutin as inhibitors of alpha-glucosidase. J Agric Food Chem 57:11463-11468
    • (2009) J Agric Food Chem , vol.57 , pp. 11463-11468
    • Li, Y.Q.1    Zhou, F.C.2    Gao, F.3    Bian, J.S.4    Shan, F.5
  • 52
    • 0036915813 scopus 로고    scopus 로고
    • Protective effect of rutin on paracetamol- and CCl4-induced hepatotoxicity in rodents
    • Janbaz KH, Saeed SA, Gilani AH (2002) Protective effect of rutin on paracetamol- and CCl4-induced hepatotoxicity in rodents. Fitoterapia 73:557-563
    • (2002) Fitoterapia , vol.73 , pp. 557-563
    • Janbaz, K.H.1    Saeed, S.A.2    Gilani, A.H.3
  • 53
    • 79959998518 scopus 로고    scopus 로고
    • Study of the hepatoprotective effects of rutin on acetaminophen and carbon tetrachloride-induced liver injury in rats
    • Ziaee A, Zamansoltani F, Nassiri-Asl M, Hadigol T, Ghasemi M (2011) Study of the hepatoprotective effects of rutin on acetaminophen and carbon tetrachloride-induced liver injury in rats. Pharm Sci 17:35-42
    • (2011) Pharm Sci , vol.17 , pp. 35-42
    • Ziaee, A.1    Zamansoltani, F.2    Nassiri-Asl, M.3    Hadigol, T.4    Ghasemi, M.5
  • 54
    • 84867087393 scopus 로고    scopus 로고
    • CCl4-induced hepatotoxicity: Protective effect of rutin on p53, CYP2E1 and the antioxidative status in rat
    • Khan RA, Khan MR, Sahreen S (2012) CCl4-induced hepatotoxicity: protective effect of rutin on p53, CYP2E1 and the antioxidative status in rat. BMC Complement Altern Med 12:178
    • (2012) BMC Complement Altern Med , vol.12 , pp. 178
    • Khan, R.A.1    Khan, M.R.2    Sahreen, S.3
  • 55
    • 79959939621 scopus 로고    scopus 로고
    • Dose response effect of rutin a dietary antioxidant on alcohol-induced prooxidant and antioxidant imbalancea histopathologic study
    • Shenbagam M, Nalini N (2011) Dose response effect of rutin a dietary antioxidant on alcohol-induced prooxidant and antioxidant imbalancea histopathologic study. Fundam Clin Pharmacol 25:493-502
    • (2011) Fundam Clin Pharmacol , vol.25 , pp. 493-502
    • Shenbagam, M.1    Nalini, N.2
  • 56
    • 84861189108 scopus 로고    scopus 로고
    • Influence of rutin on biochemical alterations in hyperammonemia in rats
    • Mahmoud AM (2012) Influence of rutin on biochemical alterations in hyperammonemia in rats. Exp Toxicol Pathol 64:783-789
    • (2012) Exp Toxicol Pathol , vol.64 , pp. 783-789
    • Mahmoud, A.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.