Rutin, a bioflavonoid antioxidant protects rat pheochromocytoma (PC-12) cells against 6-hydroxydopamine (6-OHDA)-induced neurotoxicity

International Journal of Molecular Medicine

Volumn 32, Issue 1, 2013, Pages 235-240

  Magalingam, Kasthuri Bai ^a   Radhakrishnan, Ammu ^a   Haleagrahara, Nagaraja ^b  

^a INTERNATIONAL MEDICAL UNIVERSITY   (Malaysia)

^b JAMES COOK UNIVERSITY   (Australia)

Author keywords

6 hydroxydopamine; Antioxidants; Bioflavonoids; Neurotoxicity; Oxidative stress

Indexed keywords

ASCORBIC ACID; CATALASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; MALONALDEHYDE; OXIDOPAMINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; RUTOSIDE; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; CELL CULTURE; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME ANALYSIS; LIPID PEROXIDATION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PHEOCHROMOCYTOMA; PRIORITY JOURNAL; RAT;

ANIMALS; ANTIOXIDANTS; CATALASE; CELL LINE, TUMOR; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; FLAVONOIDS; GLUTATHIONE; LIPID PEROXIDATION; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; OXIDOPAMINE; PHEOCHROMOCYTOMA; RATS; RUTIN; SUPEROXIDE DISMUTASE;

EID: 84878240917     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2013.1375     Document Type: Article

References (17)

1. Uslu C, Taysi S and Bakan N: Lipid peroxidation and antioxidant enzyme activities in experimental maxillary sinusitis. Ann Clin Lab Sci 33: 18-22, 2003. (Pubitemid 36336995)
2. Nagata H, Takekoshi S, Takagi T, Honma T and Watanabe K: Antioxidative action of flavonoids, quercetin and catechin, mediated by the activation of glutathione peroxidase. Tokai J Exp Clin Med 24: 1-11, 1999. (Pubitemid 29403853)
3. Agati G, Azzarello E, Pollastri S and Tattini M: Flavonoids as antioxidants in plants: location and functional significance. Plant Sci 196: 67-76, 2012.
4. Nöthlings U, Murphy SP, Wilkens LR, Henderson BE and Kolonel LN: Flavonols and pancreatic cancer risk: the multiethnic cohort study. Am J Epidemiol 166: 924-931, 2007. (Pubitemid 47511689)
5. Stewart LK, Soileau JL, Ribnicky D, Wang ZQ, Raskin I, Poulev A, Majewski M, Cefalu WT and Gettys TW: Quercetin transiently increases energy expenditure but persistently decreases circulating markers of inflammation in C57BL/6J mice fed a high-fat diet. Metabolism 57 (7 Suppl 1): S39-S46, 2008. (Pubitemid 351814697)
6. Wu LL, Yang XB, Huang ZM, Liu HZ and Wu GX: In vivo and in vitro antiviral activity of hyperoside extracted from Abelmoschus manihot (L) medik. Acta Pharmacol Sin 28: 404-409, 2007.
7. Khan MM, Ahmad A, Ishrat T, Khuwaja G, Srivastawa P, Khan MB, Raza SS, Javed H, Vaibhav K, Khan A and Islam F: Rutin protects the neural damage induced by transient focal ischemia in rats. Brain Res 1292: 123-135, 2009.
8. Suzuki T, Honda Y and Mukasa Y: Effects of UV-B radiation, cold and desiccation stress on rutin concentration and rutin glucosidase activity in tartary buckwheat (Fagopyrum tataricum) leaves. Plant Sci 168: 1303-1307, 2005. (Pubitemid 40413287)
9. Ramassamy C: Emerging role of polyphenolic compounds in the treatment of neurodegenerative diseases: a review of their intracellular targets. Eur J Pharmacol 545: 51-64, 2006.
10. Hollman PC and Katan MB: Bioavailability and health effects of dietary flavonols in man. Arch Toxicol Suppl 20: 237-248, 1998.
11. Blum D, Torch S, Lambeng N, Nissou M, Benabid AL, Sadoul R and Verna JM: Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease. Prog Neurobiol 65: 135-172, 2001. (Pubitemid 32524182)
12. Nikam S, Nikam P, Ahaley SK and Sontakke AV: Oxidative stress in Parkinson's disease. Indian J Clin Biochem 24: 98-101, 2009.
13. Double KL, Reyes S, Werry EL and Halliday GM: Selective cell death in neurodegeneration: why are some neurons spared in vulnerable regions? Prog Neurobiol 92: 316-329, 2010.
14. Walkinshaw G and Waters CM: Neurotoxin-induced cell death in neuronal PC12 cells is mediated by induction of apoptosis. Neuroscience 63: 975-987, 1994. (Pubitemid 24366149)
15. Yu DH, Bao YM, An LJ and Yang M: Protection of PC12 cells against superoxide-induced damage by isoflavonoids from Astragalus mongholicus. Biomed Environ Sci 22: 50-54, 2009.
16. Qu CP, Xu ZR, Liu GJ, Liu C, Li Y, Wei ZG and Liu GF: Differential expression of copper-zinc superoxide dismutase gene of Polygonum sibiricum leaves, stems and underground stems, subjected to high-salt stress. Int J Mol Sci 11: 5234-5245. 2010.
17. Hollman PC and Katan MB: Dietary flavonoids: intake, health effects and bioavailability. Food Chem Toxicol 37: 937-942, 1999. (Pubitemid 29481795)