메뉴 건너뛰기




Volumn 9, Issue 8, 2014, Pages

FTO is a relevant factor for the development of the metabolic syndrome in mice

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; LEPTIN; FTO PROTEIN, MOUSE; LYASE; MIXED FUNCTION OXIDASE;

EID: 84930447908     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0105349     Document Type: Article
Times cited : (18)

References (46)
  • 2
    • 3242795814 scopus 로고    scopus 로고
    • Intra-abdominal fat is a major determinant of the National Cholesterol Education Program Adult Treatment Panel III criteria for the metabolic syndrome
    • DOI 10.2337/diabetes.53.8.2087
    • Carr DB, Utzschneider KM, Hull RL, Kodama K, Retzlaff BM, et al. (2004) Intra-abdominal fat is a major determinant of the National Cholesterol Education Program Adult Treatment Panel III criteria for the metabolic syndrome. Diabetes 53: 2087-2094. (Pubitemid 38970759)
    • (2004) Diabetes , vol.53 , Issue.8 , pp. 2087-2094
    • Carr, D.B.1    Utzschneider, K.M.2    Hull, R.L.3    Kodama, K.4    Retzlaff, B.M.5    Brunzell, J.D.6    Shofer, J.B.7    Fish, B.E.8    Knopp, R.H.9    Kahn, S.E.10
  • 3
    • 0037463608 scopus 로고    scopus 로고
    • The metabolic syndrome: Prevalence and associated risk factor findings in the US population from the Third National Health and Nutrition Examination Survey, 1988-1994
    • DOI 10.1001/archinte.163.4.427
    • Park YW, Zhu S, Palaniappan L, Heshka S, Carnethon MR, et al. (2003) The metabolic syndrome: prevalence and associated risk factor findings in the US population from the Third National Health and Nutrition Examination Survey, 1988-1994. Arch Intern Med 163: 427-436. (Pubitemid 36241019)
    • (2003) Archives of Internal Medicine , vol.163 , Issue.4 , pp. 427-436
    • Park, Y.-W.1    Zhu, S.2    Palaniappan, L.3    Heshka, S.4    Carnethon, M.R.5    Heymsfield, S.B.6
  • 4
    • 42949116365 scopus 로고    scopus 로고
    • Lipid accumulation in non-adipose tissue and lipotoxicity
    • DOI 10.1016/j.physbeh.2007.11.049, PII S0031938407004805
    • van Herpen NA, Schrauwen-Hinderling VB (2008) Lipid accumulation in non-adipose tissue and lipotoxicity. Physiol Behav 94: 231-241. (Pubitemid 351615422)
    • (2008) Physiology and Behavior , vol.94 , Issue.2 , pp. 231-241
    • Van Herpen, N.A.1    Schrauwen-Hinderling, V.B.2
  • 5
    • 58849088969 scopus 로고    scopus 로고
    • Ectopic lipids and organ function
    • Szendroedi J, Roden M (2009) Ectopic lipids and organ function. Curr Opin Lipidol 20: 50-56.
    • (2009) Curr Opin Lipidol , vol.20 , pp. 50-56
    • Szendroedi, J.1    Roden, M.2
  • 6
    • 11144265737 scopus 로고    scopus 로고
    • The new concept of adipose tissue function
    • Hauner H (2004) The new concept of adipose tissue function. Physiol Behav 83: 653-658.
    • (2004) Physiol Behav , vol.83 , pp. 653-658
    • Hauner, H.1
  • 9
    • 0029157428 scopus 로고
    • Transient increase in obese gene expression after food intake or insulin administration
    • Saladin R, De Vos P, Guerre-Millo M, Leturque A, Girard J, et al. (1995) Transient increase in obese gene expression after food intake or insulin administration. Nature 377: 527-529.
    • (1995) Nature , vol.377 , pp. 527-529
    • Saladin, R.1    De Vos, P.2    Guerre-Millo, M.3    Leturque, A.4    Girard, J.5
  • 10
    • 0029020677 scopus 로고
    • Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity
    • Considine RV, Considine EL, Williams CJ, Nyce MR, Magosin SA, et al. (1995) Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity. J Clin Invest 95: 2986-2988.
    • (1995) J Clin Invest , vol.95 , pp. 2986-2988
    • Considine, R.V.1    Considine, E.L.2    Williams, C.J.3    Nyce, M.R.4    Magosin, S.A.5
  • 11
    • 0032915413 scopus 로고    scopus 로고
    • Hypothalamic agouti-related protein messenger ribonucleic acid is inhibited by leptin and stimulated by fasting
    • DOI 10.1210/en.140.2.814
    • Mizuno TM, Mobbs CV (1999) Hypothalamic agouti-related protein messenger ribonucleic acid is inhibited by leptin and stimulated by fasting. Endocrinology 140: 814-817. (Pubitemid 29058217)
    • (1999) Endocrinology , vol.140 , Issue.2 , pp. 814-817
    • Mizuno, T.M.1    Mobbs, C.V.2
  • 12
    • 0031054014 scopus 로고    scopus 로고
    • Leptin activates neurons in ventrobasal hypothalamus and brainstem
    • DOI 10.1210/en.138.2.839
    • Elmquist JK, Ahima RS, Maratos-Flier E, Flier JS, Saper CB (1997) Leptin activates neurons in ventrobasal hypothalamus and brainstem. Endocrinology 138: 839-842. (Pubitemid 27110941)
    • (1997) Endocrinology , vol.138 , Issue.2 , pp. 839-842
    • Elmquist, J.K.1    Ahima, R.S.2    Maratos-Flier, E.3    Flier, J.S.4    Saper, C.B.5
  • 15
    • 0032014836 scopus 로고    scopus 로고
    • A leptin missense mutation associated with hypogonadism and morbid obesity
    • Strobel A, Issad T, Camoin L, Ozata M, Strosberg AD (1998) A leptin missense mutation associated with hypogonadism and morbid obesity. Nat Genet 18: 213-215.
    • (1998) Nat Genet , vol.18 , pp. 213-215
    • Strobel, A.1    Issad, T.2    Camoin, L.3    Ozata, M.4    Strosberg, A.D.5
  • 18
    • 34249799917 scopus 로고    scopus 로고
    • The physiology of obese-hyperglycemic mice [ob/ob mice]
    • Lindström P (2007) The physiology of obese-hyperglycemic mice [ob/ob mice]. ScientificWorldJournal 7: 666-685.
    • (2007) ScientificWorldJournal , vol.7 , pp. 666-685
    • Lindström, P.1
  • 20
    • 0029073613 scopus 로고
    • Weight-reducing effects of the plasma protein encoded by the obese gene
    • Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, et al. (1995) Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269: 543-546.
    • (1995) Science , vol.269 , pp. 543-546
    • Halaas, J.L.1    Gajiwala, K.S.2    Maffei, M.3    Cohen, S.L.4    Chait, B.T.5
  • 21
    • 1642565342 scopus 로고    scopus 로고
    • Additive effects of leptin and topiramate in reducing fat deposition in lean and obese ob/ob mice
    • DOI 10.1016/j.physbeh.2003.08.013
    • Lalonde J, Samson P, Poulin S, Deshaies Y, Richard D (2004) Additive effects of leptin and topiramate in reducing fat deposition in lean and obese ob/ob mice. Physiol Behav 80: 415-420. (Pubitemid 38117016)
    • (2004) Physiology and Behavior , vol.80 , Issue.4 , pp. 415-420
    • Lalonde, J.1    Samson, P.2    Poulin, S.3    Deshaies, Y.4    Richard, D.5
  • 22
    • 84855905289 scopus 로고    scopus 로고
    • The increased protein level of URAT1 was observed in obesity/metabolic syndrome model mice
    • Doshi M, Takiue Y, Saito H, Hosoyamada M (2011) The increased protein level of URAT1 was observed in obesity/metabolic syndrome model mice. Nucleosides Nucleotides Nucleic Acids 30: 1290-1294.
    • (2011) Nucleosides Nucleotides Nucleic Acids , vol.30 , pp. 1290-1294
    • Doshi, M.1    Takiue, Y.2    Saito, H.3    Hosoyamada, M.4
  • 23
    • 41449098953 scopus 로고    scopus 로고
    • Hepatic Steatosis in Leptin-Deficient Mice Is Promoted by the PPARgamma Target Gene Fsp27
    • DOI 10.1016/j.cmet.2008.03.003, PII S1550413108000740
    • Matsusue K, Kusakabe T, Noguchi T, Takiguchi S, Suzuki T, et al. (2008) Hepatic steatosis in leptin-deficient mice is promoted by the PPARgamma target gene Fsp27. Cell Metab 7: 302-311. (Pubitemid 351455219)
    • (2008) Cell Metabolism , vol.7 , Issue.4 , pp. 302-311
    • Matsusue, K.1    Kusakabe, T.2    Noguchi, T.3    Takiguchi, S.4    Suzuki, T.5    Yamano, S.6    Gonzalez, F.J.7
  • 24
    • 0035996844 scopus 로고    scopus 로고
    • Attenuation of hypercholesterolemia and hyperglycemia in ob/ob mice by NPY Y2 receptor ablation
    • DOI 10.1016/S0196-9781(02)00042-6, PII S0196978102000426
    • Naveilhan P, Svensson L, Nystrom S, Ekstrand AJ, Ernfors P (2002) Attenuation of hypercholesterolemia and hyperglycemia in ob/ob mice by NPY Y2 receptor ablation. Peptides 23: 1087-1091. (Pubitemid 34786296)
    • (2002) Peptides , vol.23 , Issue.6 , pp. 1087-1091
    • Naveilhan, P.1    Svensson, L.2    Nystrom, S.3    Ekstrand A.Jonas4    Ernfors, P.5
  • 25
    • 77950078871 scopus 로고    scopus 로고
    • Nobiletin improves hyperglycemia and insulin resistance in obese diabetic ob/ob mice
    • Lee YS, Cha BY, Saito K, Yamakawa H, Choi SS, et al. (2010) Nobiletin improves hyperglycemia and insulin resistance in obese diabetic ob/ob mice. Biochem Pharmacol 79: 1674-1683.
    • (2010) Biochem Pharmacol , vol.79 , pp. 1674-1683
    • Lee, Y.S.1    Cha, B.Y.2    Saito, K.3    Yamakawa, H.4    Choi, S.S.5
  • 26
    • 47949106019 scopus 로고    scopus 로고
    • Captopril normalizes insulin signaling and insulin-regulated substrate metabolism in obese (ob/ob) mouse hearts
    • Tabbi-Anneni I, Buchanan J, Cooksey RC, Abel ED (2008) Captopril normalizes insulin signaling and insulin-regulated substrate metabolism in obese (ob/ob) mouse hearts. Endocrinology 149: 4043-4050.
    • (2008) Endocrinology , vol.149 , pp. 4043-4050
    • Tabbi-Anneni, I.1    Buchanan, J.2    Cooksey, R.C.3    Abel, E.D.4
  • 27
    • 34247636362 scopus 로고    scopus 로고
    • PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism
    • Medina-Gomez G, Gray SL, Yetukuri L, Shimomura K, Virtue S, et al. (2007) PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism. PLoS Genet 3: e64.
    • (2007) PLoS Genet , vol.3
    • Medina-Gomez, G.1    Gray, S.L.2    Yetukuri, L.3    Shimomura, K.4    Virtue, S.5
  • 28
    • 84859575363 scopus 로고    scopus 로고
    • Genetic determinants of common obesity and their value in prediction
    • Loos RJ (2012) Genetic determinants of common obesity and their value in prediction. Best Pract Res Clin Endocrinol Metab 26: 211-226.
    • (2012) Best Pract Res Clin Endocrinol Metab , vol.26 , pp. 211-226
    • Loos, R.J.1
  • 30
    • 42449153273 scopus 로고    scopus 로고
    • Genetic variants of FTO influence adiposity, insulin sensitivity, leptin levels, and resting metabolic rate in the Quebec Family Study
    • Do R, Bailey SD, Desbiens K, Belisle A, Montpetit A, et al. (2008) Genetic variants of FTO influence adiposity, insulin sensitivity, leptin levels, and resting metabolic rate in the Quebec Family Study. Diabetes 57: 1147-1150.
    • (2008) Diabetes , vol.57 , pp. 1147-1150
    • Do, R.1    Bailey, S.D.2    Desbiens, K.3    Belisle, A.4    Montpetit, A.5
  • 31
    • 66749088733 scopus 로고    scopus 로고
    • Effect of an FTO polymorphism on fat mass, obesity, and type 2 diabetes mellitus in the French MONICA Study
    • Legry V, Cottel D, Ferrieres J, Arveiler D, Andrieux N, et al. (2009) Effect of an FTO polymorphism on fat mass, obesity, and type 2 diabetes mellitus in the French MONICA Study. Metabolism 58: 971-975.
    • (2009) Metabolism , vol.58 , pp. 971-975
    • Legry, V.1    Cottel, D.2    Ferrieres, J.3    Arveiler, D.4    Andrieux, N.5
  • 33
    • 79957945033 scopus 로고    scopus 로고
    • Involvement of leptin receptor long isoform (LepRb)-STAT3 signaling pathway in brain fat mass- and obesity-associated (FTO) downregulation during energy restriction
    • Wang P, Yang FJ, Du H, Guan YF, Xu TY, et al. (2011) Involvement of leptin receptor long isoform (LepRb)-STAT3 signaling pathway in brain fat mass- and obesity-associated (FTO) downregulation during energy restriction. Mol Med 17: 523-532.
    • (2011) Mol Med , vol.17 , pp. 523-532
    • Wang, P.1    Yang, F.J.2    Du, H.3    Guan, Y.F.4    Xu, T.Y.5
  • 34
    • 78649464259 scopus 로고    scopus 로고
    • Cut-like homeobox 1 (CUX1) regulates expression of the fat mass and obesity-associated and retinitis pigmentosa GTPase regulator-interacting protein-1-like (RPGRIP1L) genes and coordinates leptin receptor signaling
    • Stratigopoulos G, LeDuc CA, Cremona ML, Chung WK, Leibel RL (2011) Cut-like homeobox 1 (CUX1) regulates expression of the fat mass and obesity-associated and retinitis pigmentosa GTPase regulator-interacting protein-1-like (RPGRIP1L) genes and coordinates leptin receptor signaling. J Biol Chem 286: 2155-2170.
    • (2011) J Biol Chem , vol.286 , pp. 2155-2170
    • Stratigopoulos, G.1    LeDuc, C.A.2    Cremona, M.L.3    Chung, W.K.4    Leibel, R.L.5
  • 35
    • 84873520661 scopus 로고    scopus 로고
    • Adult onset global loss of the fto gene alters body composition and metabolism in the mouse
    • McMurray F, Church CD, Larder R, Nicholson G, Wells S, et al. (2013) Adult onset global loss of the fto gene alters body composition and metabolism in the mouse. PLoS Genet 9: e1003166.
    • (2013) PLoS Genet , vol.9
    • McMurray, F.1    Church, C.D.2    Larder, R.3    Nicholson, G.4    Wells, S.5
  • 37
    • 84883169345 scopus 로고    scopus 로고
    • FTO deficiency induces UCP-1 expression and mitochondrial uncoupling in adipocytes
    • Tews D, Fischer-Posovszky P, Fromme T, Klingenspor M, Fischer J, et al. (2013) FTO deficiency induces UCP-1 expression and mitochondrial uncoupling in adipocytes. Endocrinology 154: 3141-3151.
    • (2013) Endocrinology , vol.154 , pp. 3141-3151
    • Tews, D.1    Fischer-Posovszky, P.2    Fromme, T.3    Klingenspor, M.4    Fischer, J.5
  • 38
    • 78649512744 scopus 로고    scopus 로고
    • The fat mass and obesity associated gene FTO functions in the brain to regulate postnatal growth in mice
    • Gao X, Shin YH, Li M, Wang F, Tong Q, et al. (2010) The fat mass and obesity associated gene FTO functions in the brain to regulate postnatal growth in mice. PLoS One 5: e14005.
    • (2010) PLoS One , vol.5
    • Gao, X.1    Shin, Y.H.2    Li, M.3    Wang, F.4    Tong, Q.5
  • 39
    • 84863304598 scopus 로고    scopus 로고
    • R Core Team R Foundation for Statistical Computing, Vienna, Austria. Available
    • R Core Team (2014) R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. Available: http://www.r-project.org/.
    • (2014) R: A Language and Environment for Statistical Computing
  • 40
    • 84887447664 scopus 로고    scopus 로고
    • FGF19 action in the brain induces insulin-independent glucose lowering
    • Epub ahead of print
    • Morton GJ, Matsen ME, Bracy DP, Meek TH, Nguyen HT, et al. (2013) FGF19 action in the brain induces insulin-independent glucose lowering. J Clin Invest [Epub ahead of print].
    • (2013) J Clin Invest
    • Morton, G.J.1    Matsen, M.E.2    Bracy, D.P.3    Meek, T.H.4    Nguyen, H.T.5
  • 41
    • 28944446431 scopus 로고    scopus 로고
    • The many faces of PPARgamma
    • Lehrke M, Lazar MA (2005) The many faces of PPARgamma. Cell 123: 993-999.
    • (2005) Cell , vol.123 , pp. 993-999
    • Lehrke, M.1    Lazar, M.A.2
  • 42
    • 84879901497 scopus 로고    scopus 로고
    • Relation of the rs9939609 gene variant in FTO with metabolic syndrome in obese female patients
    • de Luis DA, Aller R, Conde R, Izaola O, de la Fuente B, et al. (2013) Relation of the rs9939609 gene variant in FTO with metabolic syndrome in obese female patients. J Diabetes Complications 27: 346-350.
    • (2013) J Diabetes Complications , vol.27 , pp. 346-350
    • De Luis, D.A.1    Aller, R.2    Conde, R.3    Izaola, O.4    De La Fuente, B.5
  • 43
    • 84861009215 scopus 로고    scopus 로고
    • Genetic variants in FTO associated with metabolic syndrome: A meta- and gene-based analysis
    • Wang H, Dong S, Xu H, Qian J, Yang J (2012) Genetic variants in FTO associated with metabolic syndrome: a meta- and gene-based analysis. Mol Biol Rep 39: 5691-5698.
    • (2012) Mol Biol Rep , vol.39 , pp. 5691-5698
    • Wang, H.1    Dong, S.2    Xu, H.3    Qian, J.4    Yang, J.5
  • 44
    • 84868130511 scopus 로고    scopus 로고
    • Development of cell-active N6-methyladenosine RNA demethylase FTO inhibitor
    • Chen B, Ye F, Yu L, Jia G, Huang X, et al. (2012) Development of cell-active N6-methyladenosine RNA demethylase FTO inhibitor. J Am Chem Soc 134: 17963-17971.
    • (2012) J Am Chem Soc , vol.134 , pp. 17963-17971
    • Chen, B.1    Ye, F.2    Yu, L.3    Jia, G.4    Huang, X.5
  • 45
    • 84890120542 scopus 로고    scopus 로고
    • The biology of FTO: From nucleic acid demethylase to amino acid sensor
    • Epub ahead of print
    • Gulati P, Yeo GS (2013) The biology of FTO: from nucleic acid demethylase to amino acid sensor. Diabetologia: [Epub ahead of print].
    • (2013) Diabetologia
    • Gulati, P.1    Yeo, G.S.2
  • 46
    • 84877699660 scopus 로고    scopus 로고
    • Structural Basis for Inhibition of the Fat Mass and Obesity Associated Protein (FTO)
    • Aik W, Demetriades M, Hamdan MK, Bagg EA, Yeoh KK, et al. (2013) Structural Basis for Inhibition of the Fat Mass and Obesity Associated Protein (FTO). J Med Chem 56: 3680-3688.
    • (2013) J Med Chem , vol.56 , pp. 3680-3688
    • Aik, W.1    Demetriades, M.2    Hamdan, M.K.3    Bagg, E.A.4    Yeoh, K.K.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.