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Volumn 34, Issue 6, 2015, Pages 612-619

Lycopene-rich tomato oleoresin modulates plasma adiponectin concentration and mRNA levels of adiponectin, SIRT1, and FoxO1 in adipose tissue of obese rats

Author keywords

Adiponectin; FoxO1; lycopene; obesity; SIRT1

Indexed keywords

ADIPONECTIN; CD36 ANTIGEN; LYCOPENE; MESSENGER RNA; OLEORESIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PLANT MEDICINAL PRODUCT; SIRTUIN 1; TRANSCRIPTION FACTOR FKHR; UNCLASSIFIED DRUG; CAROTENOID; FORKHEAD TRANSCRIPTION FACTOR; FOXO1 PROTEIN, RAT; NERVE PROTEIN; OLEORESINS; PLANT EXTRACT; SIRT1 PROTEIN, RAT;

EID: 84930440254     PISSN: 09603271     EISSN: 14770903     Source Type: Journal    
DOI: 10.1177/0960327114551395     Document Type: Article
Times cited : (34)

References (54)
  • 2
    • 4344607526 scopus 로고    scopus 로고
    • Endocrine regulation of energy metabolism: review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin, and resistin
    • Meier U, Gressner AM. Endocrine regulation of energy metabolism: review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin, and resistin. Clin Chem. 2004 ; 50: 1511-1525
    • (2004) Clin Chem , vol.50 , pp. 1511-1525
    • Meier, U.1    Gressner, A.M.2
  • 3
    • 72449141637 scopus 로고    scopus 로고
    • Transcriptional and post-translational regulation of adiponectin
    • Liu M, Liu F. Transcriptional and post-translational regulation of adiponectin. Biochem J. 2009 ; 425: 41-52
    • (2009) Biochem J , vol.425 , pp. 41-52
    • Liu, M.1    Liu, F.2
  • 4
    • 80052904773 scopus 로고    scopus 로고
    • Adiponectin - its potential to predict and prevent coronary artery disease
    • Skrabal CA, Czaja J, Honz K, et al. Adiponectin - its potential to predict and prevent coronary artery disease. Thorac Cardiovasc Surg. 2011 ; 59: 201-206
    • (2011) Thorac Cardiovasc Surg , vol.59 , pp. 201-206
    • Skrabal, C.A.1    Czaja, J.2    Honz, K.3
  • 5
    • 74949113508 scopus 로고    scopus 로고
    • The relationship between adipokines, metabolic parameters and insulin resistance in patients with metabolic syndrome and type 2 diabetes
    • Lee JM, Kim SR, Yoo SJ, et al. The relationship between adipokines, metabolic parameters and insulin resistance in patients with metabolic syndrome and type 2 diabetes. J Int Med Res. 2009 ; 37: 1803-18012
    • (2009) J Int Med Res , vol.37 , pp. 1803-18012
    • Lee, J.M.1    Kim, S.R.2    Yoo, S.J.3
  • 6
    • 40749111945 scopus 로고    scopus 로고
    • Mechanisms for the anti-inflammatory effects of adiponectin in macrophages
    • Huang H, Park PH, McMullen MR, et al. Mechanisms for the anti-inflammatory effects of adiponectin in macrophages. J Gastroenterol Hepatol. 2008 ; 23: S50 - S53
    • (2008) J Gastroenterol Hepatol , vol.23 , pp. 50-S53
    • Huang, H.1    Park, P.H.2    McMullen, M.R.3
  • 7
    • 84859023893 scopus 로고    scopus 로고
    • Adiponectin: regulation of its production and its role in human diseases
    • Shehzad A, Iqbal W, Shehzad O, et al. Adiponectin: regulation of its production and its role in human diseases. Hormones (Athens). 2012 ; 11: 8-20
    • (2012) Hormones (Athens) , vol.11 , pp. 8-20
    • Shehzad, A.1    Iqbal, W.2    Shehzad, O.3
  • 9
    • 3042681042 scopus 로고    scopus 로고
    • Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma
    • Picard F, Kurtev M, Chung N, et al. Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature. 2004 ; 429: 771-776
    • (2004) Nature , vol.429 , pp. 771-776
    • Picard, F.1    Kurtev, M.2    Chung, N.3
  • 10
    • 79953898189 scopus 로고    scopus 로고
    • Sirtuin 1 in lipid metabolism and obesity
    • Schug TT, Li X. Sirtuin 1 in lipid metabolism and obesity. Ann Med. 2011 ; 43: 198-211
    • (2011) Ann Med , vol.43 , pp. 198-211
    • Schug, T.T.1    Li, X.2
  • 11
    • 0037237279 scopus 로고    scopus 로고
    • The forkhead transcription factor FoxO1 regulates adipocyte differentiation
    • Nakae J, Kitamura T, Kitamura Y, et al. The forkhead transcription factor FoxO1 regulates adipocyte differentiation. Dev Cell. 2003 ; 4: 119-129
    • (2003) Dev Cell , vol.4 , pp. 119-129
    • Nakae, J.1    Kitamura, T.2    Kitamura, Y.3
  • 12
    • 33845985335 scopus 로고    scopus 로고
    • SIRT1 regulates adiponectin gene expression through Foxo1-C/enhancer-binding protein alpha transcriptional complex
    • Qiao L, Shao J. SIRT1 regulates adiponectin gene expression through Foxo1-C/enhancer-binding protein alpha transcriptional complex. J Biol Chem. 2006 ; 281: 39915-33924
    • (2006) J Biol Chem , vol.281 , pp. 39915-33924
    • Qiao, L.1    Shao, J.2
  • 13
    • 79955781048 scopus 로고    scopus 로고
    • Resveratrol upregulated SIRT1, FOXO1, and adiponectin and downregulated PPARγ1-3 mRNA expression in human visceral adipocytes
    • Costa CS, Rohden F, Hammes TO, et al. Resveratrol upregulated SIRT1, FOXO1, and adiponectin and downregulated PPARγ1-3 mRNA expression in human visceral adipocytes. Obes Surg. 2011 ; 21: 356-361
    • (2011) Obes Surg , vol.21 , pp. 356-361
    • Costa, C.S.1    Rohden, F.2    Hammes, T.O.3
  • 14
    • 0030474043 scopus 로고    scopus 로고
    • Lycopene: a biologically important carotenoid for humans?
    • Stahl W, Sies H. Lycopene: a biologically important carotenoid for humans?. Arch Biochem Biophys. 1996 ; 336: 1-9
    • (1996) Arch Biochem Biophys , vol.336 , pp. 1-9
    • Stahl, W.1    Sies, H.2
  • 15
    • 0036847464 scopus 로고    scopus 로고
    • Chemistry, distribution, and metabolism of tomato carotenoids and their impact on human health
    • Khachik F, Carvalho L, Bernstein PS, et al. Chemistry, distribution, and metabolism of tomato carotenoids and their impact on human health. Exp Biol Med (Maywood). 2002 ; 227: 845-851
    • (2002) Exp Biol Med (Maywood) , vol.227 , pp. 845-851
    • Khachik, F.1    Carvalho, L.2    Bernstein, P.S.3
  • 16
    • 0027817633 scopus 로고
    • Physical quenching of singlet oxygen and cis-trans isomerization of carotenoids
    • Stahl W, Sies H. Physical quenching of singlet oxygen and cis-trans isomerization of carotenoids. Ann NY Acad Sci. 1993 ; 691: 10-19
    • (1993) Ann NY Acad Sci , vol.691 , pp. 10-19
    • Stahl, W.1    Sies, H.2
  • 17
    • 0024464691 scopus 로고
    • Lycopene as the most efficient biological carotenoid singlet oxygen quencher
    • Di Mascio P, Kaiser S, Sies H. Lycopene as the most efficient biological carotenoid singlet oxygen quencher. Arch Biochem Biophys. 1989 ; 274: 532-538
    • (1989) Arch Biochem Biophys , vol.274 , pp. 532-538
    • Di Mascio, P.1    Kaiser, S.2    Sies, H.3
  • 18
    • 0142216401 scopus 로고    scopus 로고
    • Antioxidant activity of carotenoids
    • Stahl W, Sies H. Antioxidant activity of carotenoids. Mol Aspects Med. 2003 ; 24: 345-351
    • (2003) Mol Aspects Med , vol.24 , pp. 345-351
    • Stahl, W.1    Sies, H.2
  • 19
    • 43549100851 scopus 로고    scopus 로고
    • Lycopene inhibits TNF-alpha-induced endothelial ICAM-1 expression and monocyte-endothelial adhesion
    • Hung CF, Huang TF, Chen BH, et al. Lycopene inhibits TNF-alpha-induced endothelial ICAM-1 expression and monocyte-endothelial adhesion. Eur J Pharmacol. 2008 ; 586: 275-282
    • (2008) Eur J Pharmacol , vol.586 , pp. 275-282
    • Hung, C.F.1    Huang, T.F.2    Chen, B.H.3
  • 20
    • 69249220365 scopus 로고    scopus 로고
    • Anti-inflammatory effect of lycopene on carrageenan-induced paw oedema and hepatic ischaemia-reperfusion in the rat
    • Bignotto L, Rocha J, Sepodes B, et al. Anti-inflammatory effect of lycopene on carrageenan-induced paw oedema and hepatic ischaemia-reperfusion in the rat. Br J Nutr. 2009 ; 102: 126-133
    • (2009) Br J Nutr , vol.102 , pp. 126-133
    • Bignotto, L.1    Rocha, J.2    Sepodes, B.3
  • 21
    • 77949270779 scopus 로고    scopus 로고
    • Lycopene suppresses LPS-induced NO and IL-6 production by inhibiting the activation of ERK, p38MAPK, and NF-kappaB in macrophages
    • Feng D, Ling WH, Duan RD. Lycopene suppresses LPS-induced NO and IL-6 production by inhibiting the activation of ERK, p38MAPK, and NF-kappaB in macrophages. Inflamm Res. 2010 ; 59: 115-121
    • (2010) Inflamm Res , vol.59 , pp. 115-121
    • Feng, D.1    Ling, W.H.2    Duan, R.D.3
  • 22
    • 33845866857 scopus 로고    scopus 로고
    • Inflammation and metabolic disorders
    • Hotamisligil GS. Inflammation and metabolic disorders. Nature. 2006 ; 444: 860-867
    • (2006) Nature , vol.444 , pp. 860-867
    • Hotamisligil, G.S.1
  • 23
    • 85030119010 scopus 로고    scopus 로고
    • Chronic inflammation in obesity and the metabolic syndrome
    • Monteiro R, Azevedo I. Chronic inflammation in obesity and the metabolic syndrome. Mediators Inflamm.:
    • Mediators Inflamm
    • Monteiro, R.1    Azevedo, I.2
  • 24
    • 70350625212 scopus 로고    scopus 로고
    • The effect of tomato-derived lycopene on low carotenoids and enhanced systemic inflammation and oxidation in severe obesity
    • Markovits N, Ben Amotz A, Levy Y. The effect of tomato-derived lycopene on low carotenoids and enhanced systemic inflammation and oxidation in severe obesity. Isr Med Assoc J. 2009 ; 11: 598-601
    • (2009) Isr Med Assoc J , vol.11 , pp. 598-601
    • Markovits, N.1    Ben Amotz, A.2    Levy, Y.3
  • 25
    • 84877987697 scopus 로고    scopus 로고
    • Tomato juice consumption reduces systemic inflammation in overweight and obese females
    • Ghavipour M, Saedisomeolia A, Djalali M, et al. Tomato juice consumption reduces systemic inflammation in overweight and obese females. Br J Nutr. 2013 ; 109: 2031-2035
    • (2013) Br J Nutr , vol.109 , pp. 2031-2035
    • Ghavipour, M.1    Saedisomeolia, A.2    Djalali, M.3
  • 26
    • 79953331412 scopus 로고    scopus 로고
    • CD36 is involved in lycopene and lutein uptake by adipocytes and adipose tissue cultures
    • Moussa M, Gouranton E, Gleize B, et al. CD36 is involved in lycopene and lutein uptake by adipocytes and adipose tissue cultures. Mol Nutr Food Res. 2011 ; 55: 578-584
    • (2011) Mol Nutr Food Res , vol.55 , pp. 578-584
    • Moussa, M.1    Gouranton, E.2    Gleize, B.3
  • 27
    • 79958791073 scopus 로고    scopus 로고
    • Lycopene inhibits proinflammatory cytokine and chemokine expression in adipose tissue
    • Gouranton E, Thabuis C, Riollet C, et al. Lycopene inhibits proinflammatory cytokine and chemokine expression in adipose tissue. J Nutr Biochem. 2011 ; 22: 642-648
    • (2011) J Nutr Biochem , vol.22 , pp. 642-648
    • Gouranton, E.1    Thabuis, C.2    Riollet, C.3
  • 28
    • 84861692997 scopus 로고    scopus 로고
    • Lycopene attenuates LPS-induced TNF-α secretion in macrophages and inflammatory markers in adipocytes exposed to macrophage-conditioned media
    • Marcotorchino J, Romier B, Gouranton E, et al. Lycopene attenuates LPS-induced TNF-α secretion in macrophages and inflammatory markers in adipocytes exposed to macrophage-conditioned media. Mol Nutr Food Res. 2012 ; 56: 725-732
    • (2012) Mol Nutr Food Res , vol.56 , pp. 725-732
    • Marcotorchino, J.1    Romier, B.2    Gouranton, E.3
  • 29
    • 84887216118 scopus 로고    scopus 로고
    • Lycopene supplementation modulates plasma concentrations and epididymal adipose tissue mRNA of leptin, resistin and IL-6 in diet-induced obese rats
    • Luvizotto RA, Nascimento AF, Imaizumi E, et al. Lycopene supplementation modulates plasma concentrations and epididymal adipose tissue mRNA of leptin, resistin and IL-6 in diet-induced obese rats. Br J Nutr. 2013 ; 110: 1803-1809
    • (2013) Br J Nutr , vol.110 , pp. 1803-1809
    • Luvizotto, R.A.1    Nascimento, A.F.2    Imaizumi, E.3
  • 30
    • 52149088842 scopus 로고    scopus 로고
    • The functional role of some tomato products on lipid profile and liver function in adult rats
    • Ibrahim HS, Ahmed LA, El-din MME. The functional role of some tomato products on lipid profile and liver function in adult rats. J Med Food. 2008 ; 11: 551-559
    • (2008) J Med Food , vol.11 , pp. 551-559
    • Ibrahim, H.S.1    Ahmed, L.A.2    El-din, M.M.E.3
  • 31
    • 67649683053 scopus 로고    scopus 로고
    • Amelioration of spreptozocin induced diabetes mellitus oxidative stress and dyslipidemia in rats by tomato extract lycopene
    • Ali MM, Agha FG. Amelioration of spreptozocin induced diabetes mellitus oxidative stress and dyslipidemia in rats by tomato extract lycopene. Scand J Clin Lab Invest. 2009 ; 69: 371-379
    • (2009) Scand J Clin Lab Invest , vol.69 , pp. 371-379
    • Ali, M.M.1    Agha, F.G.2
  • 32
    • 84930469087 scopus 로고    scopus 로고
    • Lycopene prevents development of steatohepatitis in experimental nonalcoholic steatohepatitis model induced by high-fat diet
    • Bahcecioglu IH, Kuzu N, Metin K, et al. Lycopene prevents development of steatohepatitis in experimental nonalcoholic steatohepatitis model induced by high-fat diet. Vet Med Int.:
    • Vet Med Int
    • Bahcecioglu, I.H.1    Kuzu, N.2    Metin, K.3
  • 33
    • 77949876397 scopus 로고    scopus 로고
    • Dietary lycopene and tomato extract supplementations inhibit nonalcoholic steatohepatitis-promoted hepatocarcinogenesis in rats
    • Wang Y, Ausman LM, Greenberg AS, et al. Dietary lycopene and tomato extract supplementations inhibit nonalcoholic steatohepatitis-promoted hepatocarcinogenesis in rats. Int J Canc. 2010 ; 126: 1788-1796
    • (2010) Int J Canc , vol.126 , pp. 1788-1796
    • Wang, Y.1    Ausman, L.M.2    Greenberg, A.S.3
  • 34
    • 0036192664 scopus 로고    scopus 로고
    • A food-based formulation provides lycopene with the same bioavailability to humans as that from tomato paste
    • Richelle M, Bortlik K, Liardet S, et al. A food-based formulation provides lycopene with the same bioavailability to humans as that from tomato paste. J Nutr. 2002 ; 132: 404-408
    • (2002) J Nutr , vol.132 , pp. 404-408
    • Richelle, M.1    Bortlik, K.2    Liardet, S.3
  • 35
    • 34250652557 scopus 로고    scopus 로고
    • Effect of lycopene on doxorubicin-induced cardiotoxicity: an echocardiographic, histological, and morphometrical assessment
    • Ferreira ALA, Russell RM, Rocha NS, et al. Effect of lycopene on doxorubicin-induced cardiotoxicity: an echocardiographic, histological, and morphometrical assessment. Basic Clin Pharmacol Toxicol. 2007 ; 101: 16-24
    • (2007) Basic Clin Pharmacol Toxicol , vol.101 , pp. 16-24
    • Ferreira, A.L.A.1    Russell, R.M.2    Rocha, N.S.3
  • 36
    • 0029827928 scopus 로고    scopus 로고
    • Human plasma carotenoid response to the ingestion of controlled diets high in fruits and vegetables
    • Yeum KJ, Booth SL, Sadowski JA, et al. Human plasma carotenoid response to the ingestion of controlled diets high in fruits and vegetables. Am J Clin Nutr. 1996 ; 64: 594-602
    • (1996) Am J Clin Nutr , vol.64 , pp. 594-602
    • Yeum, K.J.1    Booth, S.L.2    Sadowski, J.A.3
  • 37
    • 79957579500 scopus 로고    scopus 로고
    • Long-term high-fat diet-induced obesity decreases the cardiac leptin receptor without apparent lipotoxicity
    • Nascimento AF, Luvizotto RA, Leopoldo AS, et al. Long-term high-fat diet-induced obesity decreases the cardiac leptin receptor without apparent lipotoxicity. Life Sci. 2011 ; 88: 1031-1038
    • (2011) Life Sci , vol.88 , pp. 1031-1038
    • Nascimento, A.F.1    Luvizotto, R.A.2    Leopoldo, A.S.3
  • 38
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method
    • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 2001 ; 25: 402-408
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 39
    • 79151484704 scopus 로고    scopus 로고
    • Adipokines in inflammation and metabolic disease
    • Ouchi N, Parker JL, Lugus JJ, et al. Adipokines in inflammation and metabolic disease. Nat Rev Immunol. 2011 ; 11: 85-97
    • (2011) Nat Rev Immunol , vol.11 , pp. 85-97
    • Ouchi, N.1    Parker, J.L.2    Lugus, J.J.3
  • 41
    • 70350545480 scopus 로고    scopus 로고
    • Obesity, the PI3K/Akt signal pathway and colon cancer
    • Huang XF, Chen JZ. Obesity, the PI3K/Akt signal pathway and colon cancer. Obes Rev. 2009 ; 10: 610-616
    • (2009) Obes Rev , vol.10 , pp. 610-616
    • Huang, X.F.1    Chen, J.Z.2
  • 42
    • 84875607466 scopus 로고    scopus 로고
    • Metabolic syndrome and triple-negative breast cancer: a new paradigm
    • Davis AA, Kaklamani VG. Metabolic syndrome and triple-negative breast cancer: a new paradigm. Int J Breast Canc.:
    • Int J Breast Canc
    • Davis, A.A.1    Kaklamani, V.G.2
  • 43
    • 84255205669 scopus 로고    scopus 로고
    • Plasma adiponectin concentration and its association with metabolic syndrome in patients with heart failure
    • Won H, Kang SM, Shin MJ, et al. Plasma adiponectin concentration and its association with metabolic syndrome in patients with heart failure. Yonsei Med J. 2012 ; 53: 91-98
    • (2012) Yonsei Med J , vol.53 , pp. 91-98
    • Won, H.1    Kang, S.M.2    Shin, M.J.3
  • 44
    • 84863266181 scopus 로고    scopus 로고
    • Apo-10′-lycopenoic acid, a lycopene metabolite, increases sirtuin 1 mRNA and protein levels and decreases hepatic fat accumulation in ob/ob mice
    • Chung J, Koo K, Lian F, et al. Apo-10′-lycopenoic acid, a lycopene metabolite, increases sirtuin 1 mRNA and protein levels and decreases hepatic fat accumulation in ob/ob mice. J Nutr. 2012 ; 142: 405-410
    • (2012) J Nutr , vol.142 , pp. 405-410
    • Chung, J.1    Koo, K.2    Lian, F.3
  • 46
    • 0141719702 scopus 로고    scopus 로고
    • Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
    • Howitz KT, Bitterman KJ, Cohen HY, et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature. 2003 ; 425: 191-196
    • (2003) Nature , vol.425 , pp. 191-196
    • Howitz, K.T.1    Bitterman, K.J.2    Cohen, H.Y.3
  • 47
    • 33745962138 scopus 로고    scopus 로고
    • Therapeutic potential of resveratrol: the in vivo evidence
    • Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov. 2006 ; 5: 493-506
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 493-506
    • Baur, J.A.1    Sinclair, D.A.2
  • 48
    • 78851468921 scopus 로고    scopus 로고
    • Neuroprotective properties of resveratrol and derivatives
    • Richard T, Pawlus AD, Iglésias ML, et al. Neuroprotective properties of resveratrol and derivatives. Ann N Y Acad Sci. 2011 ; 1215: 103-108
    • (2011) Ann N Y Acad Sci , vol.1215 , pp. 103-108
    • Richard, T.1    Pawlus, A.D.2    Iglésias, M.L.3
  • 49
    • 52749091816 scopus 로고    scopus 로고
    • SirT1 gain of function increases energy efficiency and prevents diabetes in mice
    • Banks AS, Kon N, Knight C, et al. SirT1 gain of function increases energy efficiency and prevents diabetes in mice. Cell Metab. 2008 ; 8: 333-341
    • (2008) Cell Metab , vol.8 , pp. 333-341
    • Banks, A.S.1    Kon, N.2    Knight, C.3
  • 51
    • 78049257829 scopus 로고    scopus 로고
    • PPARγ: a circadian transcription factor in adipogenesis and osteogenesis
    • Kawai M, Rosen CJ. PPARγ: a circadian transcription factor in adipogenesis and osteogenesis. Nat Rev Endocrinol. 2010 ; 6: 629-636
    • (2010) Nat Rev Endocrinol , vol.6 , pp. 629-636
    • Kawai, M.1    Rosen, C.J.2
  • 52
    • 41849093037 scopus 로고    scopus 로고
    • The role of FoxO in the regulation of metabolism
    • Gross DN, van den Heuvel AP, Birnbaum MJ. The role of FoxO in the regulation of metabolism. Oncogene. 2008 ; 27: 2320-2336
    • (2008) Oncogene , vol.27 , pp. 2320-2336
    • Gross, D.N.1    Van Den Heuvel, A.P.2    Birnbaum, M.J.3
  • 53
    • 67649216515 scopus 로고    scopus 로고
    • CD36, a scavenger receptor involved in immunity, metabolism, angiogenesis, and behavior
    • Silverstein RL, Febbraio M. CD36, a scavenger receptor involved in immunity, metabolism, angiogenesis, and behavior. Sci Signal. 2 (72). re3
    • Sci Signal , vol.2 , Issue.72 , pp. re3
    • Silverstein, R.L.1    Febbraio, M.2
  • 54
    • 70349562018 scopus 로고    scopus 로고
    • Site-specific concentrations of carotenoids in adipose tissue: relations with dietary and serum carotenoid concentrations in healthy adults
    • Chung HY, Ferreira AL, Epstein S, et al. Site-specific concentrations of carotenoids in adipose tissue: relations with dietary and serum carotenoid concentrations in healthy adults. Am J Clin Nutr. 2009 ; 90: 533-539
    • (2009) Am J Clin Nutr , vol.90 , pp. 533-539
    • Chung, H.Y.1    Ferreira, A.L.2    Epstein, S.3


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