Antisense against amyloid-β protein precursor reverses memory deficits and alters gene expression in neurotropic and insulin-signaling pathways in SAMP8 mice

Journal of Alzheimer's Disease

Volumn 46, Issue 2, 2015, Pages 535-548

  Armbrecht, Harvey J ^a,b   Siddiqui, Akbar M ^b   Green, Michael ^b   Farr, Susan A ^a,b   Kumar, Vijaya B ^a,b   Banks, William A ^a,b,c,d   Patrick, Ping ^b   Shah, Gul N ^b   Morley, John E ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c VA PUGET SOUND HEALTH CARE SYSTEM   (United States)

^d UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Antisense oligonucleotides; gene expression; MAPKsignaling; memory loss; phosphatidylinositol signaling; SAMP8 mouse

Indexed keywords

AMYLOID PRECURSOR PROTEIN; ANTISENSE OLIGONUCLEOTIDE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GLYCOGEN SYNTHASE KINASE 3BETA; INOSITOL PHOSPHATE; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE; NEUROTROPIN; PHOSPHATIDYLINOSITOL; AMYLOID BETA PROTEIN;

ADULT; AMNESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTISENSE THERAPY; ARTICLE; CALCIUM SIGNALING; CONTROLLED STUDY; FOOTSHOCK; GENE EXPRESSION; HIPPOCAMPUS; LEARNING; MEMORY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RNA DEGRADATION; SENESCENCE ACCELERATED MOUSE; SIGNAL TRANSDUCTION; T-MAZE TEST; ANIMAL; CHEMISTRY; DISEASE MODEL; DRUG EFFECTS; GENETICS; MAZE TEST; MEMORY DISORDERS; PHOSPHORYLATION;

AMYLOID BETA-PEPTIDES; ANIMALS; DISEASE MODELS, ANIMAL; GENE EXPRESSION; HIPPOCAMPUS; MAZE LEARNING; MEMORY; MEMORY DISORDERS; MICE; OLIGONUCLEOTIDES, ANTISENSE; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 84930422624     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-142760     Document Type: Article

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