Site-directed antisense oligonucleotide decreases the expression of amyloid precursor protein and reverses deficits in learning and memory in aged SAMP8 mice

Peptides

Volumn 21, Issue 12, 2000, Pages 1769-1775

  Kumar, Vijaya B ^a,b   Farr, Susan A ^a,b   Flood, James F ^a,b   Kamlesh, Vyas ^a,b   Franko, Mark ^a,b   Banks, William A ^a,b   Morley, John E ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ANTISENSE OLIGODEOXYNUCLEOTIDE; GENE PRODUCT; OLIGONUCLEOTIDE; PHOSPHOROTHIOIC ACID DERIVATIVE; PHOSPHOROTHIOLATED OLIGONUCLEOTIDE ANTIBODY; PROTEIN ANTIBODY; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN ANTIBODY; ANTISENSE OLIGONUCLEOTIDE; MONOCLONAL ANTIBODY;

ALZHEIMER DISEASE; AMNESIA; AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN LEVEL; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CORRELATION FUNCTION; DRUG EFFECT; GENE OVEREXPRESSION; HIPPOCAMPUS; HISTOPATHOLOGY; LEARNING DISORDER; MOUSE; MOUSE STRAIN; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; SHOCK; TRANSGENIC MOUSE; ANIMAL BEHAVIOR; AVOIDANCE BEHAVIOR; BRAIN REGION; DRUG MECHANISM; DRUG POTENCY; MEMORY CONSOLIDATION; NEUROPATHOLOGY; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; TREATMENT OUTCOME;

AGE FACTORS; ALZHEIMER DISEASE; AMYGDALA; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BLOTTING, WESTERN; ENZYME-LINKED IMMUNOSORBENT ASSAY; HIPPOCAMPUS; HUMANS; LEARNING; MAZE LEARNING; MEMORY; MICE; MICE, MUTANT STRAINS; OLIGONUCLEOTIDES, ANTISENSE; PROTEIN STRUCTURE, TERTIARY; RNA, MESSENGER; TIME FACTORS;

EID: 0034867485     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0196-9781(00)00339-9     Document Type: Article

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