PKCε-CREB-Nrf2 signalling induces HO-1 in the vascular endothelium and enhances resistance to inflammation and apoptosis

Cardiovascular Research

Volumn 106, Issue 3, 2015, Pages 509-519

  Mylroie, Hayley ^a   Dumont, Odile ^a   Bauer, Andrea ^a   Thornton, Clare C ^a   Mackey, John ^a   Calay, Damien ^a   Hamdulay, Shahir S ^a   Choo, Joan R ^a   Boyle, Joseph J ^a   Samarel, Allen M ^b   Randi, Anna M ^a   Evans, Paul C ^c   Mason, Justin C ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b LOYOLA UNIVERSITY CHICAGO   (United States)

^c UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

Apoptosis; Endothelium; Haem oxygenase 1; Inflammation; Protein kinase C epsilon

Indexed keywords

ANGIOTENSIN II; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; HEME OXYGENASE 1; INTERCELLULAR ADHESION MOLECULE 1; MESSENGER RNA; PHOSPHOTRANSFERASE; PROTEIN KINASE C EPSILON; PROTOPORPHYRIN ZINC; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR NRF2; CREB1 PROTEIN, HUMAN; CREB1 PROTEIN, MOUSE; ENZYME INHIBITOR; HMOX1 PROTEIN, HUMAN; HMOX1 PROTEIN, MOUSE; MEMBRANE PROTEIN; NFE2L2 PROTEIN, HUMAN; NFE2L2 PROTEIN, MOUSE; PRKCE PROTEIN, HUMAN; PRKCE PROTEIN, MOUSE; PROTOPORPHYRIN;

ADENOVIRUS INFECTION; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ENZYME ACTIVITY; FLOW CYTOMETRY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIUM; VASCULITIS; WILD TYPE; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; C57BL MOUSE; CELL CULTURE; DRUG EFFECTS; ENZYME ACTIVATION; ENZYME INDUCTION; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; INFLAMMATION; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PHOSPHORYLATION; RNA INTERFERENCE; TIME FACTOR; UMBILICAL VEIN ENDOTHELIAL CELL;

ANGIOTENSIN II; ANIMALS; APOPTOSIS; CELLS, CULTURED; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; ENDOTHELIAL CELLS; ENZYME ACTIVATION; ENZYME INDUCTION; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; HEME OXYGENASE-1; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INFLAMMATION; MEMBRANE PROTEINS; MICE, INBRED C57BL; MICE, KNOCKOUT; NF-E2-RELATED FACTOR 2; PHOSPHORYLATION; PROTEIN KINASE C-EPSILON; PROTOPORPHYRINS; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 84930360982     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvv131     Document Type: Article

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