Cardiac-specific overexpression of dominant-negative CREB leads to increased mortality and mitochondrial dysfunction in female mice

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 299, Issue 6, 2010, Pages

  Watson, Peter A ^a,b   Birdsey, Nicholas ^a,b   Huggins, Gordon S ^c   Svensson, Eric ^d   Heppe, Daniel ^a   Knaub, Leslie ^a,b  

^a UNIVERSITY OF COLORADO   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c TUFTS MEDICAL CENTER   (United States)

^d UNIVERSITY OF CHICAGO   (United States)

Author keywords

Apoptosis; Cyclic nucleotide regulatory element binding protein; Mitochondria; Oxidative stress

Indexed keywords

ANTIOXIDANT; CITRATE SYNTHASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; ESTROGEN RELATED RECEPTOR ALPHA; GLUTATHIONE PEROXIDASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; REACTIVE OXYGEN METABOLITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CELL DENSITY; CELL FUNCTION; CELL ISOLATION; CELL STRUCTURE; CONTROLLED STUDY; FEMALE; HEART FAILURE; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART MUSCLE FIBER MEMBRANE; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; MORTALITY; MUSCLE FIBER CONTRACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; SEX DIFFERENCE; SURVIVAL; TRANSMISSION ELECTRON MICROSCOPY;

AGE FACTORS; ANIMALS; APOPTOSIS; CELL RESPIRATION; CITRATE (SI)-SYNTHASE; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; FEMALE; GENES, DOMINANT; GLUTATHIONE PEROXIDASE; HEART FAILURE; ION CHANNELS; MALE; MICE; MICE, INBRED ICR; MICE, TRANSGENIC; MITOCHONDRIA, HEART; MITOCHONDRIAL DISEASES; MITOCHONDRIAL PROTEINS; MYOCARDIAL CONTRACTION; MYOCARDIUM; OXIDATIVE STRESS; PHOSPHORYLATION; REACTIVE OXYGEN SPECIES; RECEPTORS, ESTROGEN; SEX FACTORS; SUPEROXIDE DISMUTASE; TIME FACTORS; TRANS-ACTIVATORS; UP-REGULATION;

EID: 78649742445     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00394.2010     Document Type: Article

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