Decay-accelerating factor induction on vascular endothelium by Vascular Endothelial Growth Factor (VEGF) is mediated via a VEGF receptor-2 (VEGP-R2)- and protein kinase C-α/ε (PKCα/ε)-dependent cytoprotective signaling pathway and is inhibited by cyclosporin A

Journal of Biological Chemistry

Volumn 279, Issue 40, 2004, Pages 41611-41618

  Mason, Justin C ^a   Steinberg, Rivka ^a   Lidington, Elaine A ^a   Kinderlerer, Anne R ^a   Ohba, Motoi ^b   Haskard, Dorian O ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b SHOWA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DISEASES; NITROGEN OXIDES; PROTEINS; SIGNALING;

DECAY-ACCELERATING FACTORS (DAF); ENDOTHELIAL CELLS (EC); VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF);

GENETIC ENGINEERING;

2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; CYCLOSPORIN A; DECAY ACCELERATING FACTOR; GROWTH FACTOR; IMMUNOSUPPRESSIVE AGENT; LY 290042; N(G) METHYLARGININE; NITRIC OXIDE SYNTHASE INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHOLIPASE C; PHOSPHOLIPASE C GAMMA; PHOSPHOLIPASE C INHIBITOR; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN KINASE C ALPHA; PROTEIN KINASE C EPSILON; SU 1498; U 71322; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2;

ARTICLE; BLOOD VESSEL INJURY; CELL PROTECTION; COMPLEMENT ACTIVATION; COMPLEMENT DEPENDENT CYTOTOXICITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENDOTHELIUM CELL; ENZYME INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN INDUCTION; SIGNAL TRANSDUCTION; UMBILICAL VEIN; VASCULAR ENDOTHELIUM;

ANTIGENS, CD55; CELLS, CULTURED; CYCLOSPORINE; ENDOTHELIUM, VASCULAR; GENE EXPRESSION REGULATION; HUMANS; ISOENZYMES; PROTEIN KINASE C; PROTEIN KINASE C-EPSILON; SIGNAL TRANSDUCTION; UMBILICAL VEINS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 4744342973     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M407981200     Document Type: Article

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