Heat shock protein 90 inhibitor regulates necroptotic cell death via down-regulation of receptor interacting proteins

Pharmazie

Volumn 70, Issue 3, 2015, Pages 193-198

  Park, Seung Yeon ^a   Shim, Jung Hyun ^b   Chae, Jung Ii ^c   Cho, Young Sik ^a  

^a Keimyung University   (South Korea)

^b Mokpo National University   (South Korea)

^c Chonbuk National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ALVESPIMYCIN; CASPASE; HEAT SHOCK PROTEIN 90; RECEPTOR INTERACTING PROTEIN 1; RECEPTOR INTERACTING PROTEIN 3; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; 17-(DIMETHYLAMINOETHYLAMINO)-17-DEMETHOXYGELDANAMYCIN; BENZOQUINONE DERIVATIVE; BENZYLOXYCARBONYL-VALYL-ALANYL-ASPARTIC ACID; CASPASE 3; CASPASE 7; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; MACROCYCLIC LACTAM; OLIGOPEPTIDE; RALBP1 PROTEIN, MOUSE; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE; RIPK3 PROTEIN, MOUSE;

ARTICLE; CANCER RESISTANCE; CELL DEATH; CELL PROTECTION; CYTOTOXICITY; DOWN REGULATION; ENZYME ACTIVITY; ISCHEMIA; L929 CELL LINE; NECROPTOSIS; ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; METABOLISM; MOUSE; NECROSIS; TUMOR CELL LINE;

ANIMALS; BENZOQUINONES; CASPASE 3; CASPASE 7; CELL DEATH; CELL LINE, TUMOR; DOWN-REGULATION; GTPASE-ACTIVATING PROTEINS; HSP90 HEAT-SHOCK PROTEINS; LACTAMS, MACROCYCLIC; MICE; NECROSIS; OLIGOPEPTIDES; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84930243260     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: 10.1691/ph.2015.4689     Document Type: Article

References (32)

1. Chen WW, Yu H, Fan HB, Zhang CC, Zhang M, Zhang C, Cheng Y, Kong J, Liu CF, Geng D, Xu X (2012) RIP1 mediates the protection of geldanamycin on neuronal injury induced by oxygen-glucose deprivation combined with zVAD in primary cortical neurons. J Neurochem 120: 70-77.
2. Cho YS, Challa S, Moquin D, Genga R, Ray TD, Guildford M, Chan FK (2009) Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. Cell 137: 1112-1123.
3. Cho YS, Park SY, Shin HS, Chan FK (2010) Physiological consequences of programmed necrosis, an alternative form of cell demise. Mol Cells 29: 327-332.
4. Declercq W, Vanden Berghe T, Vandenabeele P (2009) RIP kinases at the crossroads of cell death and survival. Cell 138: 229-232.
5. Dorn GW, 2nd (2013) Molecular mechanisms that differentiate apoptosis from programmed necrosis. Toxicol Pathol 41: 227-234.
6. Goetz MP, Toft DO, Ames MM, Erlichman C (2003) The Hsp90 chaperone complex as a novel target for cancer therapy. Ann Oncol 14: 1169-1176.
7. Grenert JP, Sullivan WP, Fadden P, Haystead TA, Clark J, Mimnaugh E, Krutzsch H, Ochel HJ, Schulte TW, Sausville E, Neckers LM, Toft DO (1997) The amino-terminal domain of heat shock protein 90 (hsp90) that binds geldanamycin is an ATP/ADP switch domain that regulates hsp90 conformation. J Biol Chem 272: 23843-23850.
8. He S, Wang L, Miao L, Wang T, Du F, Zhao L, Wang X (2009) Receptor interacting protein kinase-3 determines cellular necrotic response to TNFalpha. Cell 137: 1100-1111.
9. Hitomi J, Christofferson DE, Ng A, Yao J, Degterev A, Xavier RJ, Yuan J (2008) Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway. Cell 135: 1311-1323.
10. Huang J, Wu L, Tashiro S, Onodera S, Ikejima T (2005) The augmentation of TNFalpha-induced cell death in murine L929 fibrosarcoma by the pancaspase inhibitor Z-VAD-fmk through pre-mitochondrial and MAPKdependent pathways. Acta Med Okayama 59: 253-260.
11. Kanamaru Y, Sekine S, Ichijo H, Takeda K (2012) The phosphorylationdependent regulation of mitochondrial proteins in stress responses. J Signal Transduct 2012: 931215.
12. Miyata Y (2003) Molecular chaperone HSP90 as a novel target for cancer chemotherapy. Nihon Yakurigaku Zasshi 121: 33-42.
13. Miyata Y (2005) Hsp90 inhibitor geldanamycin and its derivatives as novel cancer chemotherapeutic agents. Curr Pharm Des 11: 1131-1138.
14. Moquin DM, McQuade T, Chan FK (2013) CYLD deubiquitinates RIP1 in the TNFalpha-induced necrosome to facilitate kinase activation and programmed necrosis. PLoS One 8: e76841.
15. Narayan N, Lee IH, Borenstein R, Sun J, Wong R, Tong G, Fergusson MM, Liu J, Rovira, II, Cheng HL, Wang G, Gucek M, Lombard D, AltFW, Sack MN, Murphy E, Cao L, Finkel T (2012) The NAD-dependent deacetylase SIRT2 is required for programmed necrosis. Nature 492: 199-204.
16. Neckers L, Ivy SP (2003) Heat shock protein 90. Curr Opin Oncol 15: 419-424.
17. Neckers L, Kern A, Tsutsumi S (2007) Hsp90 inhibitors disrupt mitochondrial homeostasis in cancer cells. Chem Biol 14: 1204-1206.
18. Park SY, Shim JH, Cho YS (2014) Distinctive roles of receptor-interacting protein kinases 1 and 3 in caspase-independent cell death of L929. Cell Biochem Funct 32: 62-69.
19. Pearl LH, Prodromou C (2006) Structure and mechanism of the Hsp90 molecular chaperone machinery. Annu Rev Biochem 75: 271-294.
20. Pirkkala L, Nykanen P, Sistonen L (2001) Roles of the heat shock transcription factors in regulation of the heat shock response and beyond. Faseb J 15: 1118-1131.
21. Sawai H, Domae N (2011) Discrimination between primary necrosis and apoptosis by necrostatin-1 in Annexin V-positive/propidium iodidenegative cells. Biochem Biophys Res Commun 411: 569-573.
22. Sun L, Wang H, Wang Z, He S, Chen S, Liao D, Wang L, Yan J, LiuW, Lei X, Wang X (2012) Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell 148: 213-227.
23. Tafani M, Schneider TG, Pastorino JG, Farber JL (2000) Cytochrome c-dependent activation of caspase-3 by tumor necrosis factor requires induction of the mitochondrial permeability transition. Am J Pathol 156: 2111-2121.
24. Thon L, Mohlig H, Mathieu S, Lange A, Bulanova E, Winoto-Morbach S, Schutze S, Bulfone-Paus S, Adam D (2005) Ceramide mediates caspaseindependent programmed cell death. Faseb J 19: 1945-1956.
25. Vanlangenakker N, Bertrand MJ, Bogaert P, Vandenabeele P, Vanden Berghe T (2011) TNF-induced necroptosis in L929 cells is tightly regulated by multiple TNFR1 complex I and II members. Cell Death Dis 2: e230.
26. Vercammen D, Beyaert R, Denecker G, Goossens V, Van Loo G, Declercq W, Grooten J, Fiers W, Vandenabeele P (1998) Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor. J Exp Med 187: 1477-1485.
27. Wang Z, Jiang H, Chen S, Du F, Wang X (2012) The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways. Cell 148: 228-243.
28. Wu YT, Tan HL, Huang Q, Sun XJ, Zhu X, ShenHM(2011) zVAD-induced necroptosis in L929 cells depends on autocrine production of TNFalpha mediated by the PKC-MAPKs-AP-1 pathway. Cell Death Differ 18: 26-37.
29. Zhang DW, Shao J, Lin J, Zhang N, Lu BJ, Lin SC, Dong MQ, Han J (2009) RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science 325: 332-336.
30. Zhang DW, Zheng M, Zhao J, Li YY, Huang Z, Li Z, Han J (2011) Multiple death pathways in TNF-treated fibroblasts: RIP3- and RIP1-dependent and independent routes. Cell Res 21: 368-371.
31. Zhang T, Hamza A, Cao X, Wang B, Yu S, Zhan CG, Sun D (2008) A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells. Mol Cancer Ther 7: 162-170.
32. Zhou Z, Han V, Han J (2012) New components of the necroptotic pathway. Protein Cell 3: 811-817.