Chronic anatabine treatment reduces Alzheimer's disease (AD)-like pathology and improves socio-behavioral deficits in a transgenic mouse model of AD

PLoS ONE

Volumn 10, Issue 5, 2015, Pages

  Verma, Megha ^a,b   Beaulieu Abdelahad, David ^a   Ait Ghezala, Ghania ^a   Li, Rena ^a   Crawford, Fiona ^a   Mullan, Michael ^a,c   Paris, Daniel ^a  

^a ROSKAMP INSTITUTE   (United States)

^b OPEN UNIVERSITY   (United Kingdom)

^c Rock Creek Pharmaceuticals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALOID; AMYLOID BETA PROTEIN; ANATABINE; BETA SECRETASE 1; COMPLEMENTARY DNA; CYCLOOXYGENASE 2; DRINKING WATER; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; PLACEBO; STAT3 PROTEIN; UNCLASSIFIED DRUG; NERVE PROTEIN; PYRIDINE DERIVATIVE;

ALZHEIMER DISEASE; AMYLOIDOSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACE1 GENE; BEHAVIOR DISORDER; BRAIN TISSUE; CONTROLLED STUDY; COX 2 GENE; DRUG EFFECT; ELEVATED PLUS MAZE TEST; FEMALE; GENE EXPRESSION; GLIOSIS; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; INOS GENE; MALE; MEMORY DISORDER; MOUSE; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; RNA EXTRACTION; SOCIAL BEHAVIOR; SOCIAL INTERACTION; SOCIO BEHAVIORAL DEFICIT; TRANSGENIC MOUSE; WILD TYPE; ANIMAL; ANIMAL BEHAVIOR; DISEASE MODEL; DRUG EFFECTS; GENETICS; METABOLISM; PATHOLOGY;

MUS; MUS MUSCULUS; NICOTIANA TABACUM; SOLANACEAE;

ALKALOIDS; ALZHEIMER DISEASE; ANIMALS; BEHAVIOR, ANIMAL; DISEASE MODELS, ANIMAL; MICE; MICE, TRANSGENIC; NERVE TISSUE PROTEINS; PYRIDINES; SOCIAL BEHAVIOR;

EID: 84930221902     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0128224     Document Type: Article

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