Effects of increased paternal age on sperm quality, reproductive outcome and associated epigenetic risks to offspring

Reproductive Biology and Endocrinology

Volumn 13, Issue 1, 2015, Pages

  Sharma, Rakesh ^a   Agarwal, Ashok ^a   Rohra, Vikram K ^a   Assidi, Mourad ^b   Abu Elmagd, Muhammad ^b   Turki, Rola F ^b  

^a LERNER RESEARCH INSTITUTE   (United States)

^b KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

Author keywords

Aneuploidy; Assisted reproductive techniques; Epigenetics; Genetics; Infertility; Offspring; Paternal age; Reproduction; Semen parameters; Sperm DNA damage; Telomere length

Indexed keywords

ANDROSTANOLONE; CASPASE; CYTOCHROME C; ESTROGEN; FOLLITROPIN; GONADORELIN; LUTEINIZING HORMONE; PRASTERONE; PROTEIN BAX; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE;

ACHONDROPLASIA; ACROCEPHALOSYNDACTYLY; AGE DISTRIBUTION; AGING; ANENCEPHALUS; ANEUPLOIDY; AUTISM; BIPOLAR DISORDER; CELL VIABILITY; CLEFT LIP; DISEASE ASSOCIATION; DNA FRAGMENTATION; EJACULATION; EPIGENETICS; FERTILIZATION IN VITRO; GREAT VESSELS TRANSPOSITION; HEART ATRIUM SEPTUM DEFECT; HEART VENTRICLE SEPTUM DEFECT; HUMAN; HYPOTHALAMUS HYPOPHYSIS GONAD SYSTEM; LEYDIG CELL; MORPHOLOGY; NEURAL TUBE DEFECT; NEUROFIBROMATOSIS TYPE 1; OSTEOGENESIS IMPERFECTA; PATERNAL AGE; PREECLAMPSIA; PROGENY; QUALITY OF LIFE; REPRODUCTION; REPRODUCTIVE SUCCESS; RETINOBLASTOMA; REVIEW; SCHIZOPHRENIA; SEXUAL BEHAVIOR; SINGLE NUCLEOTIDE POLYMORPHISM; SPERM QUALITY; SPERMATOGENESIS; SPERMATOZOON COUNT; SPERMATOZOON MOTILITY; SPONTANEOUS ABORTION; TELOMERE HOMEOSTASIS; TRACHEOESOPHAGEAL FISTULA; AGE; FEMALE; GENETIC EPIGENESIS; GENETICS; GENOME-WIDE ASSOCIATION STUDY; GENOMIC INSTABILITY; MALE; MENTAL DISEASE; PREGNANCY; PREGNANCY OUTCOME; RISK ASSESSMENT; SEMEN ANALYSIS; TELOMERE SHORTENING;

AGE FACTORS; AGING; EPIGENESIS, GENETIC; FEMALE; GENOME-WIDE ASSOCIATION STUDY; GENOMIC INSTABILITY; HUMANS; MALE; MENTAL DISORDERS; PATERNAL AGE; PREGNANCY; PREGNANCY OUTCOME; REPRODUCTION; RISK ASSESSMENT; SEMEN ANALYSIS; TELOMERE SHORTENING;

EID: 84930203836     PISSN: None     EISSN: 14777827     Source Type: Journal    
DOI: 10.1186/s12958-015-0028-x     Document Type: Review

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