A comprehensive assessment of parental age and psychiatric disorders

JAMA Psychiatry

Volumn 71, Issue 3, 2014, Pages 301-309

  McGrath, John J ^a   Petersen, Liselotte ^b   Agerbo, Esben ^b   Mors, Ole ^b   Mortensen, Preben Bo ^b   Pedersen, Carsten Bøcker ^b  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b H LUNDBECK A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; AUTISM; CHILD; CHILDHOOD DISEASE; CLINICAL ASSESSMENT; COHORT ANALYSIS; CONTROLLED STUDY; DENMARK; DEVELOPMENTAL DISORDER; DISEASE ASSOCIATION; EATING DISORDER; FEMALE; HUMAN; HYPERKINESIA; INTERNATIONAL CLASSIFICATION OF DISEASES; MAJOR CLINICAL STUDY; MALE; MATERNAL AGE; MENTAL DEFICIENCY; MENTAL DISEASE; MIDDLE AGED; MOOD DISORDER; NEUROSIS; PATERNAL AGE; PERSONALITY DISORDER; PRESCHOOL CHILD; PROGENY; RISK ASSESSMENT; SCHIZOPHRENIA; SCHOOL CHILD; SOMATOFORM DISORDER; STRESS; SUBSTANCE ABUSE; SUBSTANCE USE; YOUNG ADULT;

ADOLESCENT; ADULT; AGE FACTORS; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; DENMARK; FEMALE; HUMANS; MALE; MATERNAL AGE; MENTAL DISORDERS; MIDDLE AGED; PATERNAL AGE; REGISTRIES; RISK; YOUNG ADULT;

EID: 84896786321     PISSN: 2168622X     EISSN: None     Source Type: Journal    
DOI: 10.1001/jamapsychiatry.2013.4081     Document Type: Article

References (55)

1. Miller B,Messias E, Miettunen J, et al. Meta-analysis of paternal age and schizophrenia risk in male versus female offspring. Schizophr Bull. 2011;37(5):1039-1047
2. Hultman CM, Sandin S, Levine SZ, Lichtenstein P, Reichenberg A. Advancing paternal age and risk of autism: new evidence from a population-based study and ameta-analysis of epidemiological studies. Mol Psychiatry. 2011;16(12):1203- 1212
3. Malaspina D, Harlap S, Fennig S, et al. Advancing paternal age and the risk of schizophrenia. Arch Gen Psychiatry. 2001;58(4):361-367
4. Kong A, Frigge ML, Masson G, et al. Rate of de novo mutations and the importance of father's age to disease risk. Nature. 2012;488(7412):471-475
5. Kirov G, Pocklington AJ, Holmans P, et al. De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia. Mol Psychiatry. 2012;17(2):142-153
6. O'Roak BJ, Vives L, Girirajan S, et al. Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations. Nature. 2012;485(7397):246-250
7. Sanders SJ, MurthaMT, Gupta AR, et al. De novo mutations revealed by whole-exome sequencing are strongly associated with autism. Nature. 2012;485(7397):237-241
8. Frans EM, Sandin S, Reichenberg A, Lichtenstein P, Långström N, Hultman CM. Advancing paternal age and bipolar disorder. Arch Gen Psychiatry. 2008;65(9):1034-1040
9. Frans EM, Sandin S, Reichenberg A, et al. Autism risk across generations: a population-based study of advancing grandpaternal and paternal age. JAMA Psychiatry. 2013;70(5):516-521
10. Frans EM, McGrath JJ, Sandin S, et al. Advanced paternal and grandpaternal age and schizophrenia: a three-generation perspective. Schizophr Res. 2011;133(1-3):120-124
11. Fergusson DM,Woodward LJ. Maternal age and educational and psychosocial outcomes in early adulthood. J Child Psychol Psychiatry. 1999;40(3):479-489
12. Moffitt TE; E-Risk Study Team. Teen-aged mothers in contemporary Britain. J Child Psychol Psychiatry. 2002;43(6):727-742
13. Sutcliffe AG, Barnes J, Belsky J, Gardiner J, Melhuish E. The health and development of children born to older mothers in the United Kingdom: observational study using longitudinal cohort data. BMJ. 2012;345:e5116. doi:10.1136/bmj.e5116
14. Mills M, Rindfuss RR, McDonald P, te Velde E; ESHRE Reproduction and Society Task Force. Why do people postpone parenthood? reasons and social policy incentives. Hum Reprod Update. 2011;17(6):848-860
15. Wellings K,Wadsworth J, Johnson A, Field J, MacdowallW. Teenage fertility and life chances. Rev Reprod. 1999;4(3):184-190
16. Boden JM, Fergusson DM, John Horwood L. Early motherhood and subsequent life outcomes. J Child Psychol Psychiatry. 2008;49(2):151-160
17. Lawlor DA, ShawM. Too much too young? teenage pregnancy is not a public health problem. Int J Epidemiol. 2002;31(3):552-554
18. Pedersen CB, Gøtzsche H, Møller JO, Mortensen PB. The Danish Civil Registration System: a cohort of eight million persons. Dan Med Bull. 2006;53(4):441-449
19. Mors O, Perto GP, Mortensen PB. The Danish Psychiatric Central Research Register. Scand J Public Health. 2011;39(7)(suppl):54-57
20. World Health Organization. Classification of Diseases: Extended Danish-Latin Version of the World Health Organization International Classification of Diseases, 8th Revision, 1965. Copenhagen, Denmark: Danish National Board of Health; 1971
21. World Health Organization. The ICD-10 Classification of Mental and Behavioural Disorders: Diagnostic Criteria for Research. Geneva, Switzerland:World Health Organization; 1993.
22. Cantor-Graae E, Pedersen CB. Full spectrum of psychiatric disorders related to foreign migration: a Danish population-based cohort study. JAMA Psychiatry. 2013;70(4):427-435
23. The GENMOD Procedure: SAS/STAT 9.2 User's Guide. Cary, NC: SAS Institute Inc; 2008
24. Breslow NE, Day NE. The Design and Analysis of Cohort Studies. Vol II. Lyon, France: International Agency for Research on Cancer; 1987. Statistical Methods in Cancer Research.
25. Clayton D, Hills M. Statistical Models in Epidemiology. Oxford, England: Oxford University Press; 1993
26. Pedersen CB. No evidence of time trends in the urban-rural differences in schizophrenia risk among five million people born in Denmark from 1910 to 1986. Psychol Med. 2006;36(2):211-219
27. Pedersen CB, Mortensen PB. Family history, place and season of birth as risk factors for schizophrenia in Denmark: a replication and reanalysis. Br J Psychiatry. July 2001;179: 46-52
28. Breslow NE. Generalized linear models: checking assumptions and strengthening conclusions. Statistica Applicata. 1996;8: 23-41
29. El-Saadi O, Pedersen CB, McNeil TF, et al. Paternal and maternal age as risk factors for psychosis: findings from Denmark, Sweden and Australia. Schizophr Res. 2004;67(2-3): 227-236
30. Zhu JL, VestergaardM, Madsen KM, Olsen J. Paternal age and mortality in children. Eur J Epidemiol. 2008;23(7):443-447
31. Galéra C, Côté SM, BouvardMP, et al. Early risk factors for hyperactivity-impulsivity and inattention trajectories from age 17 months to 8 years. Arch Gen Psychiatry. 2011;68(12):1267-1275
32. Sciberras E, Ukoumunne OC, Efron D. Predictors of parent-reported attention-deficit /hyperactivity disorder in children aged 6-7 years: a national longitudinal study. J Abnorm Child Psychol. 2011;39(7):1025-1034
33. Gustafsson P, Källén K. Perinatal, maternal, and fetal characteristics of children diagnosed with attention-deficit-hyperactivity disorder: results from a population-based study utilizing the Swedish Medical Birth Register. Dev Med Child Neurol. 2011;53(3):263-268
34. Saha S, Barnett AG, Buka SL, McGrath JJ. Maternal age and paternal age are associated with distinct childhood behavioural outcomes in a general population birth cohort. Schizophr Res. 2009;115(2-3):130-135
35. FeliceME, Feinstein RA, Fisher MM, et al. Adolescent pregnancy-current trends and issues: 1998 American Academy of Pediatrics Committee on Adolescence, 1998-1999. Pediatrics. 1999;103(2):516-520
36. Rich-Edwards J. Teen pregnancy is not a public health crisis in the United States: it is time we made it one. Int J Epidemiol. 2002;31(3):555-556
37. Schmidt L, Sobotka T, Bentzen JG, Nyboe Andersen A; ESHRE Reproduction and Society Task Force. Demographic and medical consequences of the postponement of parenthood. Hum Reprod Update. 2012;18(1):29-43
38. Foldi CJ, Eyles DW,McGrath JJ, Burne TH. Advanced paternal age is associated with alterations in discrete behavioural domains and cortical neuroanatomy of C57BL/6J mice. Eur J Neurosci. 2010;31(3):556-564.
39. Smith RG, Kember RL,Mill J, et al. Advancing paternal age is associated with deficits in social and exploratory behaviors in the offspring: a mouse model. PLoS One. 2009;4(12):e8456.
40. Flatscher-Bader T, Foldi CJ, Chong S, et al. Increased de novo copy number variants in the offspring of older males. Transl Psychiatry. 2011;1:e34. doi:10.1038/tp.2011.30
41. Goriely A, McGrath JJ, Hultman CM, Wilkie AO, Malaspina D. "Selfish spermatogonial selection": a novel mechanism for the association between advanced paternal age and neurodevelopmental disorders. Am J Psychiatry. 2013;170(6): 599-608.
42. CorneliusMD, Day NL. Developmental consequences of prenatal tobacco exposure. Curr Opin Neurol. 2009;22(2):121-125.
43. Linnet KM, Dalsgaard S, Obel C, et al. Maternal lifestyle factors in pregnancy risk of attention deficit hyperactivity disorder and associated behaviors: review of the current evidence. Am J Psychiatry. 2003;160(6):1028- 1040.
44. VineMF. Smoking and male reproduction: a review. Int J Androl. 1996;19(6):323-337.
45. Petersen L, Mortensen PB, Pedersen CB. Paternal age at birth of first child and risk of schizophrenia. Am J Psychiatry. 2011;168(1): 82-88.
46. Pedersen CB, McGrath J, Mortensen PB, Petersen L. The importance of father's age to schizophrenia risk [published onlineMay 28, 2013]. Mol Psychiatry. doi:10.1038/mp.2013.69.
47. Jaffe AE, EatonWW, Straub RE, Marenco S, Weinberger DR. Paternal age, de novo mutations and schizophrenia [published online June 11, 2013]. Mol Psychiatry. doi:10.1038/mp.2013.76
48. Opler MG, Harlap S, Ornstein K, et al. Time-to-pregnancy and risk of schizophrenia. Schizophr Res. 2010;118(1-3):76-80.
49. Herman DB, Brown AS, Opler MG, et al. Does unwantedness of pregnancy predict schizophrenia in the offspring? findings from a prospective birth cohort study. Soc Psychiatry Psychiatr Epidemiol. 2006;41(8):605-610.
50. Kessing L. Validity of diagnoses and other clinical register data in patients with affective disorder. Eur Psychiatry. 1998;13(8):392-398.
51. Kristjansson E, Allebeck P, Wistedt B. Validity of the diagnosis schizophrenia in a psychiatric inpatient. Nord J Psychiatry. 1987;43:229-234.
52. Wellings K,Wadsworth J, Johnson A, Field J, MacdowallW. Teenage fertility and life chances. Rev Reprod. 1999;4(3):184-190
53. Uggerby P, Østergaard SD, Røge R, Correll CU, Nielsen J. The validity of the schizophrenia diagnosis in the Danish Psychiatric Central Research Register is good. Dan Med J. 2013;60(2):A4578. http://www.danmedj.dk/ portal/page/portal/danmedj.dk/dmj-forside/PAST-ISSUE/2013/DMJ-2013-02/A4578. Accessed December 9, 2013
54. Lauritsen MB, Jørgensen M, Madsen KM, et al. Validity of childhood autism in the Danish Psychiatric Central Register: findings from a cohort sample born 1990-1999. J Autism Dev Disord. 2010;40(2):139-148.
55. Pedersen CB, Gøtzsche H, Møller JO, Mortensen PB. The Danish Civil Registration System: a cohort of eight million persons. Dan Med Bull. 2006;53(4):441-449