Trazodone treatment protects neuronal-like cells from inflammatory insult by inhibiting NF-κB, p38 and JNK

Cellular Signalling

Volumn 27, Issue 8, 2015, Pages 1609-1629

  Daniele, Simona ^a   Da Pozzo, Eleonora ^a   Zappelli, Elisa ^a   Martini, Claudia ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

Cytokine release; Depression; Inflammation; Neuroprotection; Trazodone

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CD133 ANTIGEN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MAMMALIAN TARGET OF RAPAMYCIN; MICROTUBULE ASSOCIATED PROTEIN 2; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NESTIN; NEURON SPECIFIC NUCLEAR PROTEIN; SEROTONIN 2 RECEPTOR; STRESS ACTIVATED PROTEIN KINASE; TRAZODONE; TUMOR NECROSIS FACTOR ALPHA; ANTIINFLAMMATORY AGENT; BRAIN-DERIVED NEUROTROPHIC FACTOR, HUMAN; CREB1 PROTEIN, HUMAN; IFNG PROTEIN, HUMAN; IL10 PROTEIN, HUMAN; IL6 PROTEIN, HUMAN; NEUROPROTECTIVE AGENT; PROTEIN KINASE INHIBITOR; SEROTONIN 2 ANTAGONIST;

ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL PROTECTION; CELL STRESS; CELL SURVIVAL; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE EXPRESSION; GENE INDUCTION; HUMAN; HUMAN CELL; IN VITRO STUDY; INTRACELLULAR TRANSPORT; NERVE CELL DIFFERENTIATION; NERVOUS SYSTEM INFLAMMATION; NEUROPROTECTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; SIGNAL TRANSDUCTION; ANTAGONISTS AND INHIBITORS; CELL LINE; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; INFLAMMATION; METABOLISM; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; PATHOLOGY; TIME;

ANTI-INFLAMMATORY AGENTS; APOPTOSIS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION; INTERFERON-GAMMA; INTERLEUKIN-10; INTERLEUKIN-6; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIPOPOLYSACCHARIDES; NEURAL STEM CELLS; NEUROGENESIS; NEUROPROTECTIVE AGENTS; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN KINASE INHIBITORS; SEROTONIN 5-HT2 RECEPTOR ANTAGONISTS; SIGNAL TRANSDUCTION; TIME FACTORS; TRAZODONE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84930180727     PISSN: 08986568     EISSN: 18733913     Source Type: Journal    
DOI: 10.1016/j.cellsig.2015.04.006     Document Type: Article

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