The pro-inflammatory cytokine interferon-gamma is an important driver of neuropathology and behavioural sequelae in experimental pneumococcal meningitis

Brain, Behavior, and Immunity

Volumn 40, Issue , 2014, Pages 252-268

  Too, L K ^a   Ball, Helen J ^a   McGregor, Iain S ^a   Hunt, Nicholas H ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Central nervous system; Cytokine; IntelliCage; Interferon gamma; Neurological disease; Neurological sequelae; Neuropathology; Pneumococcal meningitis

Indexed keywords

CEFTRIAXONE; GAMMA INTERFERON; INTERLEUKIN 1BETA; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; TUMOR NECROSIS FACTOR; CYTOKINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBIOTIC THERAPY; ARTICLE; BACTERIAL CLEARANCE; BLOOD BRAIN BARRIER; BRAIN CORTEX; BRAIN DAMAGE; BRAIN HEMORRHAGE; CELL DEATH; CEREBROSPINAL FLUID LEVEL; COGNITIVE DEFECT; COHORT ANALYSIS; CONTROLLED STUDY; EXECUTIVE FUNCTION; FEMALE; GENOTYPE; HIPPOCAMPUS; HYPERACTIVITY; MEMBRANE PERMEABILITY; MORTALITY; MOUSE; NERVE CELL DEGENERATION; NEUROPATHOLOGY; NONHUMAN; PHOTOSTIMULATION; PNEUMOCOCCAL MENINGITIS; PRIORITY JOURNAL; SINGLE DRUG DOSE; STREPTOCOCCUS PNEUMONIAE; UPREGULATION; WORKING MEMORY; ANIMAL; ANIMAL BEHAVIOR; BRAIN; C57BL MOUSE; COMPLICATION; DISEASE MODEL; ENCEPHALITIS; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; MALE; METABOLISM; PATHOLOGY; PHYSIOLOGY; SURVIVAL;

ANIMALS; BEHAVIOR, ANIMAL; BLOOD-BRAIN BARRIER; BRAIN; CEREBRAL HEMORRHAGE; CYTOKINES; DISEASE MODELS, ANIMAL; ENCEPHALITIS; INTERFERON-GAMMA; MALE; MENINGITIS, PNEUMOCOCCAL; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; SURVIVAL ANALYSIS;

EID: 84904125465     PISSN: 08891591     EISSN: 10902139     Source Type: Journal    
DOI: 10.1016/j.bbi.2014.02.020     Document Type: Article

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