Excitotoxins in neuronal apoptosis and necrosis

Journal of Cerebral Blood Flow and Metabolism

Volumn 19, Issue 6, 1999, Pages 583-591

  Nicotera, Pierluigi ^a   Lipton, Stuart A ^b  

^a UNIVERSITY OF KONSTANZ   (Germany)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Apoptosis; Caspases; Excitotoxicity; Glutamate; Nitric oxide; NMDA receptor; Peroxynitrite; Superoxide

Indexed keywords

CALCIUM ION; CASPASE; EXCITOTOXIN; GLUTAMIC ACID; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; BRAIN MITOCHONDRION; CELL ULTRASTRUCTURE; CHROMATIN STRUCTURE; ENERGY METABOLISM; ENZYME ACTIVATION; HUMAN; NERVE CELL DEGENERATION; NERVE CELL NECROSIS; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

EID: 0033496016     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-199906000-00001     Document Type: Review

References (22)

1. Abate C, Patel N, Rauscher III FJ, Curran T (1990) Redox regulation of Fos and Jun DNA-binding activity in vitro. Science 249:1157-1161
2. Adle-Biassette H, Levy Y, Colombel M, Poron F, Natchev S, Keohane C, Gray F (1995) Neuronal apoptosis in HIV infection in adults. Neuropathol Appl Neurobiol 21:218-227
3. An SF, Giometto B, Scaravilli T, Tavolato B, Gray F, Scaravilli F (1996) Programmed cell death in brains of HIV-1 positive AIDS and jpre-AIDS patients. Acta Neuropathol 91:169-173
4. An SF, Gray F, Scaravilli F (1995) Programmed cell death in brain of HIV-1 positive pre-AIDS patients. Lancet 346:911-912
5. Ankarcrona M, Dypbukt JM, Bonfoco E, Zhivotovsky B, Orrenius S, Lipton SA, Nicotera P (1995) Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron 15:961-973
6. Ayata C, Ayata G, Hara H, Matthews RT, Beal MF, Ferrante RJ, Endres M, Kim A, Christie RH, Waeber C, Huang PL, Hyman BT, Moskowitz MA (1997) Mechanisms of reduced striatal NMDA excitotoxicity in type 1 nitric oxide synthase knock-out mice. J Neurosci 17:6908-6917
7. Beal MF (1992) Role of excitotoxicity in neurological diseases. Curr Opin Neurobiol 2:657-662
8. Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA (1990) Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 87:1620-1624
9. Behl C, Davis JB, Lesley R, Schubert D (1994) Hydrogen peroxide mediates amyloid b protein toxicity. Cell 77:817-827
10. Bonfoco E, Ankarcrona M, Krainc D, Nicotera P, Lipton SA (1997) Techniques for distinguishing apoptosis from necrosis in cerebrocortical and cerebellar neurons. In: Neuromethods: Apoptosis Techniques and Protocols (Poirier J, ed) Totowa, NJ, Humana Press, pp 237-253
11. Bonfoco E, Krainc D, Ankarcrona M, Nicotera P, Lipton SA (1995) Apoptosis and necrosis: two distinct events induced respectively by mild and intense insults with NMDA or nitric oxide/superoxide in cortical cell cultures. P roc Natl Acad Sci USA 92:7162-7166
12. Buttke TM, Sandstrom PA (1994) Oxidative stress as a mediator of apoptosis. Immunol Today 15:7-10
13. Cardone JH, Salvesen GS, Widmann C, Johnson G, Frisch SM (1997) The regulation of anoikis: MEKK-1 activation requires cleavage by caspases. Cell 90:315-323
14. Choi DW (1988) Glutamate neurotoxicity and diseases of the nervous system. Neuron 1:623-634
15. Coyle JT, Puttfarken P (1993) Oxidative stress, glutamate and neurodegenerative disorders. Science 262:689-695
16. Dawson VL, Dawson TM, London ED, Bredt DS, Snyder SH (1991) Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proc Natl Acad Sci USA 88:6368-6371
17. Dawson TM, Dawson VL, Snyder S (1992) A novel neuronal messenger molecule in brain: the free radical, nitric oxide. Ann Neurol 32:297-311
18. Deckwerth TL, Johnson Jr EM (1993) Neurotrophic factor deprivation-induced death. Ann NY Acad Sci 679:121-131
19. Dickson DW (1995) Apoptosis in the brain. Physiology and pathology. Am J Pathol 146:1040-1044
20. Dugan LL, Sensi SL, Canzoniero LMT, Handran SD, Rothman SM, Lin T-S, Goldberg MP, Choi DW (1995) Mitochondrial production of reactive oxygen species in cortical neurons following exposure to W-methyl-D-aspartate. J Neurosci 15:6377-6388
21. +: implications for neurodegeneration. J Neurochem 63:584-591
22. Dypbukt JM, Ankarcrona M, Burkitt M, Sjöholm Å, Ström K, Orrenius S, Nicotera P (1994) Different prooxidant levels stimulate growth, trigger apoptosis, or produce necrosis of insulin-secreting RINm5F cells: the role of intracellular polyamines. J Biol Chem 269:30553-30560