RasGRP1 opposes proliferative EGFR-SOS1-Ras signals and restricts intestinal epithelial cell growth

Nature Cell Biology

Volumn 17, Issue 6, 2015, Pages 804-815

  Depeille, Philippe ^a,e   Henricks, Linda M ^a,d   Van De Ven, Robert A H ^a,e   Lemmens, Ed ^a,f   Wang, Chih Yang ^a,b   Matli, Mary ^a   Werb, Zena ^a   Haigis, Kevin M ^c   Donner, David ^a   Warren, Robert ^a   Roose, Jeroen P ^a,e  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d NETHERLANDS CANCER INSTITUTE   (Netherlands)

^e UTRECHT UNIVERSITY   (Netherlands)

^f Aduro BioTech Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; EPIDERMAL GROWTH FACTOR RECEPTOR; GUANINE NUCLEOTIDE EXCHANGE FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; RAS GUANINE NUCLEOTIDE RELEASING PROTEIN 1; RAS PROTEIN; SOS PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN; APC PROTEIN; EGFR PROTEIN, MOUSE; KRAS2 PROTEIN, MOUSE; PROTEIN P21; RASGRP1 PROTEIN, MOUSE; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER GROWTH; CANCER INHIBITION; CANCER SURVIVAL; CARCINOGENESIS; CELL EXPANSION; CELL GROWTH; CELL PROLIFERATION; CELL PROTECTION; COLITIS; COLORECTAL CANCER; CONTROLLED STUDY; DISEASE EXACERBATION; ENZYME ACTIVATION; GASTROINTESTINAL DYSPLASIA; GENE; GENE EXPRESSION; GOBLET CELL; GROWTH INHIBITION; HOMEOSTASIS; HUMAN; HUMAN TISSUE; INTESTINE EPITHELIUM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RASGRP1 GENE; SIGNAL TRANSDUCTION; SURVIVAL TIME; TUMOR VOLUME; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CANCER TRANSPLANTATION; CELL DIFFERENTIATION; COLORECTAL TUMOR; CYTOLOGY; EPITHELIUM CELL; GENETICS; INTESTINE MUCOSA; KNOCKOUT MOUSE; METABOLISM; RNA INTERFERENCE; TUMOR CELL LINE; WNT SIGNALING PATHWAY; XENOGRAFT;

MUS;

ADENOMATOUS POLYPOSIS COLI PROTEIN; ANIMALS; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL PROLIFERATION; COLORECTAL NEOPLASMS; EPITHELIAL CELLS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; INTESTINAL MUCOSA; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEOPLASM TRANSPLANTATION; PROTO-ONCOGENE PROTEINS P21(RAS); RECEPTOR, EPIDERMAL GROWTH FACTOR; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SOS1 PROTEIN; TRANSPLANTATION, HETEROLOGOUS; WNT PROTEINS; WNT SIGNALING PATHWAY;

EID: 84930180479     PISSN: 14657392     EISSN: 14764679     Source Type: Journal    
DOI: 10.1038/ncb3175     Document Type: Article

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