Mutant kras promotes hyperplasia and alters differentiation in the colon epithelium but does not expand the presumptive stem cell pool

Gastroenterology

Volumn 141, Issue 3, 2011, Pages

  Feng, Ying ^a   Bommer, Guido T ^a   Zhao, Jenny ^a   Green, Maranne ^a   Sands, Evan ^a   Zhai, Yali ^a   Brown, Kelly ^a   Burberry, Aaron ^a   Cho, Kathleen R ^a   Fearon, Eric R ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Colon Cancer; Oncogene; Transgenic Mice; Tumor Suppressor

Indexed keywords

APC PROTEIN; BETA CATENIN; CD133 ANTIGEN; CELL PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLIN DEPENDENT KINASE INHIBITOR 1C; CYCLIN E2 PROTEIN; K RAS PROTEIN; LGR5 PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MSI1 PROTEIN; MUTANT PROTEIN; NOTCH1 RECEPTOR; OLFM4 PROTEIN; PROTEIN P19ARF; TRANSCRIPTION FACTOR HES 1; TRANSCRIPTION FACTOR HEY1; UNCLASSIFIED DRUG;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANUS; APOPTOSIS; ARTICLE; CECUM DISEASE; CELL COUNT; CELL DIFFERENTIATION; CELL LOSS; CELL PROLIFERATION; COLON ADENOMA; COLON MUCOSA; COLON POLYP; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; EPITHELIUM CELL; GENE INACTIVATION; GOBLET CELL; HUMAN; HUMAN TISSUE; HYPERPLASIA; HYPERPLASTIC POLYP; ILEUM DISEASE; INTESTINE CRYPT; MOUSE; NONHUMAN; PANETH CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; WILD TYPE;

EID: 80052115426     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2011.05.007     Document Type: Article

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