Rasgrp1 mutation increases naïve T-cell CD44 expression and drives mTOR-dependent accumulation of Helios+ T cells and autoantibodies

eLife

Volumn 2013, Issue 2, 2013, Pages

  Daley, Stephen R ^a   Coakley, Kristen M ^b   Hu, Daniel Y ^a   Randall, Katrina L ^a,c   Jenne, Craig N ^d   Limnander, Andre ^b   Myers, Darienne R ^b   Polakos, Noelle K ^b   Enders, Anselm ^a   Roots, Carla ^a   Balakishnan, Bhavani ^a   Miosge, Lisa A ^a   Sjollema, Geoff ^a   Bertram, Edward M ^a   Field, Matthew A ^a   Shao, Yunli ^a   Daniel Andrews, T ^a   Whittle, Belinda ^a   Whitney Barnes, S ^e   Walker, John R ^e   Cyster, Jason G ^f   Goodnow, Christopher C ^a   Roose, Jeroen P ^b   more..

^a Biology and Environment   (Australia)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c The Australian National University   (Australia)

^d UNIVERSITY OF CALGARY   (Canada)

^e GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TUBULIN; ANTINUCLEAR ANTIBODY; AUTOANTIBODY; BROXURIDINE; CALMODULIN; DIACYLGLYCEROL; GAMMA INTERFERON; GUANINE NUCLEOTIDE EXCHANGE FACTOR; HELIOS; HERMES ANTIGEN; IKAROS TRANSCRIPTION FACTOR; INTERLEUKIN 17; INTERLEUKIN 2; INTERLEUKIN 4; IONOMYCIN; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; RAPAMYCIN; RAS PROTEIN; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG; CD44 PROTEIN, MOUSE; MTOR PROTEIN, MOUSE; RASGRP1 PROTEIN, MOUSE; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL PROLIFERATION ASSAY; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; GENE; GENE MAPPING; GENE MUTATION; GENE OVEREXPRESSION; GENETIC VARIABILITY; GENOTYPE; MALE; MISSENSE MUTATION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RASGRP1 GENE; SIGNAL TRANSDUCTION; SPLEEN CELL; T LYMPHOCYTE; THYMOCYTE; WESTERN BLOTTING; ANIMAL; GENETICS; IMMUNOLOGY; MUTATION; PHYSIOLOGY; PROTEIN MOTIF;

ANIMALS; ANTIGENS, CD44; AUTOANTIBODIES; EF HAND MOTIFS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; MICE; MUTATION; T-LYMPHOCYTES; TOR SERINE-THREONINE KINASES;

EID: 84890412893     PISSN: None     EISSN: 2050084X     Source Type: Journal    
DOI: 10.7554/eLife.01020     Document Type: Article

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