Immunohistochemical analysis of an equine model of synovitis-induced arthritis

American Journal of Veterinary Research

Volumn 57, Issue 7, 1996, Pages 1080-1093

  Todhunter, P G ^a,d   Kincaid, S A ^a   Todhunter, R J ^b   Kammermann, J R ^a   Johnstone, B ^c   Baird, A N ^a   Hanson, R R ^a   Wright, J M ^a   Lin, H C ^a   Purohit, R C ^a  

^a AUBURN UNIVERSITY   (United States)

^b Department of Obstetrics Gynecology   (United States)

^c CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d Canberra Veterinary Clinic   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; INTERLEUKIN 1; LEUKOCYTE ANTIGEN; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR 2;

ANIMAL; ARTICLE; ARTICULAR CARTILAGE; CARPAL BONE; CHEMICALLY INDUCED DISORDER; HORSE; HYPERTROPHY; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; JOINT; METHODOLOGY; PATHOLOGY; RHEUMATOID ARTHRITIS; SYNOVITIS; SYNOVIUM; WESTERN BLOTTING;

ANIMALS; ANTIGENS, CD; ARTHRITIS, RHEUMATOID; BLOTTING, WESTERN; CARPAL BONES; CARTILAGE, ARTICULAR; EPITOPES; HORSES; HYPERTROPHY; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-1; JOINTS; LIPOPOLYSACCHARIDES; RECEPTORS, TUMOR NECROSIS FACTOR; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE II; SYNOVIAL MEMBRANE; SYNOVITIS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0030184471     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (73)

1. Jeffcott LB, Rossdale P, Freestone J, et al. Assessment of wastage in Thoroughbred racing from conception to 4 years of age. Equine Vet J 1982;14:185-196.
2. Todhunter RJ, Lust G. Pathophysiology of synovitis: clinical signs and examination in horses. Compend Contin Educ Pract Vet 1990;12:980-992.
3. McIlraith CW. Diseases of joints, tendons, ligaments, and related structures. In: Stashak TS, ed. Adams' lameness in dorses. Philadelphia: Lea & Febiger, 1987;360-395.
4. Todhunter RJ, Lust G. Synovial joint anatomy, biology, and pathobiology. In: Auer J, ed. Equine surgery. Philadelphia: WB Saunders Co, 1992;844-866.
5. Burton-Wurster N, Todhunter RJ, Lust G. Animal models of osteoarthritis. In: Woessner JF, Howell DS, eds. Joint cartilage degradation: basic and clinical aspects. New York: Marcel Dekker Inc, 1993;347-384.
6. Poole AR. Enzymatic degradation: cartilage destruction. In: Brandt KD, ed. Cartilage changes in osteoarthritis. Indianapolis: Indiana University School of Medicine, 1990;63-72.
7. Morales TI. Polypeptide regulators of matrix homeostasis in articular cartilage. In: Kuettner K, ed. Articular cartilage and osteoarthritis. New York: Raven Press Ltd, 1992;265-279.
8. Maroudas A, Mizrahi J, Katz EP, et al. Physicochemical properties and functional behavior of normal and osteoarthritic human cartilage. In: Kuettner K, ed. Articular cartilage biochemistry. New York: Raven Press, 1986;311-329.
9. Palmer JL, Bertone AL. Joint structure, biochemistry and biochemical disequilibrium in synovitis and equine joint disease. Equine Vet J 1994;26:263-277.
10. Vilcek J, Lee TH. Tumor necrosis factor: new insights into the molecular mechanisms of its multiple actions. J Biol Chem 1991; 266:7313-7316.
11. Campbell IK, Piccoli DS, Roberts MJ, et al. Effects of tumor necrosis factor alpha and beta on resorption of human articular cartilage and production of plasminogen activator by human articular chondrocytes. Arthritis Rheum 1990;33:542-552.
12. Dinnarello CA. Role of interleukin-1 and tumor necrosis factor in systemic responses to infection and inflammation. In: Gallin JI, Goldstein IM, Snyderman R, et al, eds. Inflammation: basic principles and clinical correlates. 2nd ed. New York: Raven Press Ltd, 1992;211-232.
13. Pelletier J-P, Roughley PJ, DiBattista JA, et al. Are cytokines involved in osteoarthritic pathophysiology? Arthritis Rheum 1991;20: 12-25.
14. Arend WP, Dayer JM. Cytokines and cytokine inhibitors or antagonists in rheumatoid arthritis. Arthritis Rheum 1990;33:305-315.
15. Fell HB, Jubb RW. The effect of synovial tissue on the breakdown of articular cartilage in organ culture. Arthritis Rheum 1977;20:1359-1371.
16. Dingle JT, Saklatvala J, Hembry R, et al. A cartilage catabolic factor from synovium. Biochem J 1979;184:177-180.
17. MacDonald MH, Stover MS, Willits NH, et al. Regulation of matrix metabolism in equine cartilage explant cultures by interleukin 1. Am J Vet Res 1992;53:2278-2285.
18. Platt D, Bayliss MT. An investigation of the proteoglycan metabolism of mature equine articular cartilage and its regulation by interleukin-1. Equine Vet J 1994;26:297-303.
19. McGuire-Goldring MKB, Meats JE, Wood DD, et al. In vitro activation of human chondrocytes and synoviocytes by a human interleukin-1-like factor. Arthritis Rheum 1987;27:654-662.
20. Wood DD, Ihrie EJ, Dinnarello CA, et al. Isolation of interleukin-1-like factor from human joint effusion. Arthritis Rheum 1983;26:975-983.
21. Martell-Pelletier J, Pelletier J-P, Cloutier J-M, et al. Neutral proteases capable of proteoglycan digesting activity in osteoarthritic and normal human articular cartilage. Arthritis Rheum 1984;27:305-311.
22. 2 and stromelysin. Equine Vet J 1991;23:380-382.
23. Speirs S, May SA, Bennett D, et al. Cellular sources of proteolytic enzymes in equine joints. Equine Vet J 1994;26:43-47.
24. Speirs S, May SA, Harrison LJ, et al. Proteolytic enzymes in equine joints with infectious arthritis. Equine Vet J 1994;26:48-50.
25. Arner EC, Pratta MA. Independent effects of interleukin-1 on proteoglycan breakdown, proteoglycan synthesis, and prostaglandin E2 release from cartilage in organ culture. Arthritis Rheum 1989; 32:288-296.
26. Chandrasekhar S, Harvey AK, Hrubey PS. Intraarticular administration of interleukin-1 causes prolonged suppression of cartilage proteoglycan synthesis in rats. Matrix Biol 1992;11:1-10.
27. Woessner JF. Matrix metalloproteinases and their inhibitors in connective tissue remodelling. FASEB J 1991;5:2145-2154.
28. May SA, Hooke RE, Lees P. Equine chondrocyte activation by a variety of stimuli Br Vet J 1992;148:389-397.
29. Morris EA, McDonald BS, Webb AC, et al. Identification of interleukin-1 in equine osteoarthritis joint effusions. Am J Vet Res 1990;51:59-64.
30. Alwin WH, Carter SD, Dixon JB, et al. Interleukin-1 like activity in synovial fluid and sera of horses with arthritis. Res Vet Sci 1991;51:72-77.
31. 2 values in horses. Am J Vet Res 1993;54:379-386.
32. Dingle JT, Davies ME, Mativa BY, et al. Immunohistological identification of interleukin-1 activated chondrocytes. Ann Rheum Dis 1990;49:889-892.
33. Pelletier J-P, Faure M-P, DiBattista JA, et al. Coordinate synthesis of stromelysin, interleukin-1, and oncogene proteins in experimental osteoarthritis. Am J Pathol 1993;142:95-105.
34. Deleuran BW, Chu C-Q, Field M, et al. Localization of tumor necrosis factor receptors in the synovial tissue and cartilage-pannus junction in patients with rheumatoid arthritis. Arthritis Rheum 1992;35:1170-1178.
35. Von der Mark K, Kirsch T, Aigner T, et al. The fate of chondrocytes in osteoarthritic cartilage. In: Kuettner K, ed. Articular cartilage and osteoarthritis. New York: Raven Press Ltd, 1992;220-234.
36. Ratcliffe A, Shurety W, Caterson B. The quantitation of a native chondroitin sulfate epitope in synovial fluid lavages and articular cartilage from canine experimental osteoarthritis and disuse atrophy. Arthritis Rheum 1993;36:1-9.
37. Visco DM, Johnstone B, Hill MA, et al. Immunohistochemical analysis of 3-B-3(-) and 7-D-4 epitope expression in canine osteoarthritis. Arthritis Rheum 1993;36:1718-1725.
38. Caterson B, Christner JE, Baker JR, et al. Production and characterization of monoclonal antibodies directed against connective tissue proteoglycans. Fed Proc 1985;44:386-393.
39. Byers S, Caterson B, Hopwood JJ, et al. Immunolocalization analysis of glycosaminoglycans in the human growth plate. J Histochem Cytochem 1992;40:275-282.
40. Sorrel JM, Mahmoodian F, Caterson B. Immunolocalization characterization and ultrastructural localization of chondroitin sulfates and keratin sulfate in embryonic chick bone marrow. Cell Tissue Res 1988;252:523-531.
41. Caterson B, Mahmoodian F, Sorrell JM, et al. Modulation of native chondroitin sulfate structure in tissue development and in disease. J Cell Sci 1990;97:411-417.
42. Ostendorf RH, van de Stadt RJ, van Kampen GPJ. Intermittent loading induces the expression of 3-B-3(-) epitope in cultured bovine articular cartilage. J Rheumatol 1984;21:287-292.
43. Ratcliffe A, Billingham MEJ, Saed-Nejad F, et al. Increased release of matrix components from articular cartilage in experimental canine osteoarthritis. J Orthop Res Soc 1992;10:350-358.
44. Firth EC, Wensing TH, Seuren F. An induced synovitis disease model in ponies. Cornell Vet 1986;77:107-118.
45. Saez-Llorens X, Jafari HS, Olsen KD, et al. Induction of suppurative arthritis in rabbits by Haemophilus endotoxin, tumor necrosis factor alpha and interleukin-1 beta. J Infect Dis 1991;163: 1267-1272.
46. Ding AH, Sanchez E, Srimal S, et al. Macrophages rapidly internalize their tumor necrosis factor receptors in response to bacterial lipopolysaccharide. J Biol Chem 1989;264:3924-3929.
47. Morales TI, Wahl LM, Hascall VC. The effect of bacterial lipopolysaccharide on the biosynthesis and release of proteoglycans from calf articular cartilage cultures. J Biol Chem 1984;259:6720-6729.
48. Todhunter RJ, Yeh L-A, Sheldon A, et al. Effects of stromelysin on proteoglycan degradation of canine articular cartilage expiants. Am J Vet Res 1995;56:1241-1247.
49. Su X, Morris DD, McGraw RA. Cloning and characterization of gene TNFα encoding equine tumor necrosis factor alpha. Gene 1991;107:319-321.
50. Pauli U, Bertoni G, Duerr M, et al. A bioassay for the detection of tumor necrosis factor from eight different species: evaluation of neutralization rates of a monoclonal antibody against human TNF alpha. J Immunol Methods 1994;171:263-265.
51. May SA, Hooke RE, Lees P. The characterization of equine interleukin-1. Vet Immunol Immunopathol 1990;24:169-175.
52. Carrino DA, Arias JL, Caplan AI. A spectrophotometric modification of a sensitive safranin O assay for glycosaminoglycans. Biochem Int 1991;24:485-495.
53. 35S-labeled proteoglycans on polyacrylamide-agarose composite gels and their visualization by fluorography. Anal Biochem 1986;156:38-44.
54. Greiling H, Kleesiek K, Reinards R. Interaction of synovial cells and synovial fluid with cartilage. In: Kuettner K, ed. Articular cartilage biochemistry. New York: Raven Press, 1986:195-210.
55. Lowther DA, Sriratana A, Baker MS. Effects of inflammation on cartilage metabolism. In: Kuettner K, ed. Articular cartilage and ostecarthritis. New York: Raven Press, 1992;543-558.
56. Pelletier J-P, Martell-Pelletier J, Ghandhur-Mnaymni, et al. Role of synovial membrane inflammation in cartilage matrix breakdown in the Pond-Nuki model of osteoarthritis. Arthritis Rheum 1985;28:554-561.
57. Smith MM, Ghosh P, Numata Y, et al. The effects of orally administered calcium pentosan polysulfate on inflammation and cartilage degradation produced in rabbits by intraarticular injection of a hyaluronate-polylysine complex. Arthritis Rheum 1994;37:125-136.
58. Apte RN, Durum SK, Oppenheim JJ. Opioids modulate interleukin-1 production and secretion by bone-marrow macrophages. Immunol Lett 1990;24:141-148.
59. Eggli PS, Hunziker EB, Schenk RK. Quantitation of structural features characterizing weight- and less-weight bearing regions in articular cartilage: a stereological analysis of medial femoral condyles in young adult rabbits. Anat Rec 1988;222:217-227.
60. Kincaid SA, Van Sickle DC, Wilsman NJ. Histochemical evidence of a functional heterogeneity of the chondrocyte of adult canine articular cartilage. Histochem J 1972;4:237-243.
61. Trippel SB, Ehrlich MG, Lippiello L, et al. Characterization of chondrocytes from bovine articular cartilage. 1. Metabolic and morphological experimental studies. J Bone Joint Surg Am 1980;62: 816-819.
62. Kincaid SA, Van Sickle DC. Regional histochemical and thickness variation of adult canine articular cartilage. Am J Vet Res 1981;42:428-432.
63. Aydelotte MB, Schumacher BL, Kuettner KE. Heterogeneity of articular chondrocytes. In: Kuettner KE, Schkeyerbach R, Peyron JC, et al, eds. Articular cartilage and osteoarthritis. New York: Raven Press, 1992;237-239.
64. Weiss C, Rosenberg L, Helfet AJ. An ultrastructural study of normal young adult human articular cartilage. J Bone Joint Surg Am 1968;50:663-674.
65. Kempson GE, Muir H, Swanson SAV, et al. Correlations between stiffness and the chemical constituents of cartilage on the human femoral head. Biochem Biophys Acta 1970;215:70-77.
66. Ollivierre F, Gubler U, Towle CA, et al. Expression of IL-1 genes in human and bovine chondrocytes: a mechanism for autocrine control of cartilage matrix degradation. Biochem Biophys Res Commun 1986;141:904-911.
67. Cavaillon JM. Le participation des cytokines au cours des mecanismes inflammatoires. Pathol Biol 1993;41:799-811.
68. Cope AP, Aderka D, Doherty M, et al. Increased levels of soluble tumor necrosis factor receptors in the sera and synovial fluid of patients with rheumatic diseases. Arthritis Rheum 1992;35:1160-1169.
69. Schenk RK, Eggli PS, Hunziker EB. Articular cartilage morphology. In: Kuettner K, ed. Articular cartilage biochemistry. New York: Raven Press, 1986;3-22.
70. McIlwraith CW, Van Sickle DC. Experimentally induced arthritis of the equine carpus: histologic and histochemical changes in the articular cartilage. Am J Vet Res 1981;42:209-217.
71. Mankin HJ, Lipiello L. The glycosaminoglycans of normal and osteoarthritic cartilage. J Clin Invest 1971;50:1712-1719.
72. Cole AA, Chubinskaya S, Luchene LJ, et al. Doxycycline disrupts chondrocyte differentiation and inhibits cartilage matrix degradation. Arthritis Rheum 1994;37:1727-1734.
73. Yamashita F, Sakakida K, Kusuzaki K, et al. Immunohistochemical localization of interleukin 1 in human growth cartilage. J Jpn Orthop Assoc 1989;63:562-568.