Effect of resveratrol on cartilage protection and apoptosis inhibition in experimental osteoarthritis of rabbit

Rheumatology International

Volumn 32, Issue 6, 2012, Pages 1541-1548

  Wang, Jing ^a   Gao, Jie Sheng ^a   Chen, Jin Wei ^a   Li, Fen ^a   Tian, Jing ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Apoptosis; Cartilage; Chondrocyte; Osteoarthritis; Resveratrol

Indexed keywords

DIMETHYL SULFOXIDE; NITRATE; NITRIC OXIDE; RESVERATROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARTILAGE CELL; CONTROLLED STUDY; DISEASE COURSE; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG MECHANISM; DRUG MEGADOSE; EXPERIMENTAL RABBIT; FEMALE; FEMUR CONDYLE; HISTOPATHOLOGY; LOW DRUG DOSE; MALE; NICK END LABELING; NONHUMAN; OSTEOARTHRITIS; PRIORITY JOURNAL; RAT; SYNOVIAL FLUID; TREATMENT DURATION;

ANIMALS; APOPTOSIS; CARTILAGE; CHONDROCYTES; CYTOPROTECTION; DISEASE MODELS, ANIMAL; FEMALE; IN SITU NICK-END LABELING; INJECTIONS, INTRA-ARTICULAR; KNEE JOINT; MALE; NITRIC OXIDE; OSTEOARTHRITIS, KNEE; RABBITS; STILBENES; SYNOVIAL FLUID; TIME FACTORS;

EID: 84863880436     PISSN: 01728172     EISSN: 1437160X     Source Type: Journal    
DOI: 10.1007/s00296-010-1720-y     Document Type: Article

References (23)

1. Hashimoto S, Ochs RL, Komiya S et al (1998) Linkage of chondrocyte apoptosis and cartilage degradation in human osteoarthritis. Arthritis Rheum 41(9):1632-1638
2. Chen MH, Wang JL, Wong CY et al (2005) Relationship of chondrocyte apoptosis to matrix degradation and swelling potential of osteoarthritic cartilage. J Formos Med Assoc 104(4): 264-272
3. Hashimoto S, Setareh M, Ochs RL et al (1997) Fas/Fas ligand expression and induction of apoptosis in chondrocytes. Arthritis Rheum 40(10):1749-1755
4. López-Armada M, Caramés B, Lires-Deán M et al (2006) Cytokines, tumor necrosis factor-a and interleukin-1b, differentially regulate apoptosis in osteoarthritis cultured human chondrocytes. Osteoarthr Cartil 14(7):660-669
5. Abramson SB (2008) Osteoarthritis and nitric oxide. Osteoarthr Cartil 16(Suppl 2):S15-S20
6. de la Lastra CA, Villegas I (2005) Resveratrol as an antiinflammatory and anti-aging agent: Mechanisms and clinical implications. Mol Nutr Food Res 49(5):405-430
7. Udenigwe CC, Ramprasath VR, Aluko RE et al (2008) Potential of resveratrol in anticancer and anti-inflammatory therapy. Nutr Rev 66(8):445-454
8. Manna SK, Mukhopadhyay A, Aggarwal BB (2000) Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-kappaB, activator protein-1 and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation. J Immunol 164(12):6509-6519
9. Holmes-McNary M, Baldwin AS Jr (2000) Chemopreventive properties of trans-resveratrol are associated with inhibition of activation of the IkappaB kinase. Cancer Res 60(13):3477-3483
10. Surh YJ, Chun KS, Cha HH et al (2001) Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation. Mutat Res 1(480-481): 243-268
11. Estrov Z, Shishodia S, Faderl S et al (2003) Resveratrol blocks interleukin-1beta-induced activation of the nuclear transcription factor NF-kappaB, inhibits proliferation, causes S-phase arrest, and induces apoptosis of acute myeloid leukemia cells. Blood 102(3):987-995
12. Kuhn K, Hashimoto S, Lotz M (2000) IL-1 beta protects human chondrocytes from CD95-induced apoptosis. J Immunol 164(4): 2233-2239
13. Kim SJ, Chun JS (2003) Protein kinase C alpha and zeta regulate nitric oxide-induced NF-kappa B activation that mediates cyclooxygenase-2 expression and apoptosis but not dedifferentiation in articular chondrocytes. Biochem Biophys Res Commun 303(1):206-211
14. Mendes AF, Carvalho AP, Caramona MM et al (2002) Role of nitric oxide in the activation of NF-kappaB, AP-1 and NOS II expression in articular chondrocytes. Inflamm Res 51(7):369-375
15. Martel-Pelletier J, Mineau F, Jovanovic D et al (1999) Mitogenactivated protein kinase and nuclear factor kappaB together regulate interleukin-17- induced nitric oxide production in human osteoarthritic chondrocytes: possible role of transactivating factor mitogen-activated protein kinase-activated protein kinase (MAPKAPK). Arthritis Rheum 42(11):2399-2409
16. Shalom-Barak T, Quach J, Lotz M (1998) Interleukin-17-induced gene expression in articular chondrocytes is associated with activation of mitogen-activated protein kinases and NF-kappaB. J Biol Chem 273(42):27467-27473
17. Shakibaei M, John T, Seifarth C et al (2007) Resveratrol inhibits IL-1beta-induced stimulation of caspase-3 and cleavage of PARP in human articular chondrocytes in vitro. Ann N Y Acad Sci 1095(1):554-563
18. Dave M, Attur M, Palmer G et al (2008) The antioxidant resveratrol protects against chondrocyte apoptosis via effects on mitochondrial polarization and ATP production. Arthritis Rheum 58(9):2786-2797
19. Elmali N, Esenkaya I, Harma A et al (2005) Effect of resveratrol in experimental osteoarthritis in rabbits. Inflamm Res 54(4): 158-162
20. Blanco FJ, Guitian R, Vazquez-Martul E et al (1998) Osteoarthritis chondrocytes die by apoptosis. A possible pathway for osteoarthritis pathology. Arthritis Rheum 41(2):284-289
21. D'Lima D, Hermida J, Hashimoto S et al (2006) Caspase inhibitors reduce severity of cartilage lesions in experimental osteoarthritis. Arthritis Rheum 54(6):1814-1821
22. Pelletier JP, Jovanovic DV, Lascau Coman V et al (2000) Selective inhibitor of inducible nitric oxide synthase reduces progression of experimental osteoarthritis in vivo: possible link with the reduction in chondrocyte apoptosis and caspase-3 level. Arthritis Rheum 43(6):1290-1299
23. Pelletier JP, Lascau-Coman V, Jovanovic D et al (1999) Selective inhibition of inducible nitric oxide synthase in experimental osteoarthritis is associated with reduction in tissue levels of catabolic factors. J Rheumatol 26(9):2002-2014