메뉴 건너뛰기




Volumn 18, Issue 12, 2010, Pages 1552-1556

HIF-2α as a possible therapeutic target of osteoarthritis

Author keywords

HIF 2 ; Osteoarthritis; Transcription factor

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; ARYL HYDROCARBON NUCLEAR TRANSLOCATOR LIKE; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; BIOLOGICAL FACTOR; HYPOXIA INDUCIBLE FACTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 78649689772     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.joca.2010.10.006     Document Type: Review
Times cited : (68)

References (56)
  • 2
    • 0008184427 scopus 로고    scopus 로고
    • Epidemiology of osteoarthritis
    • Lippincott Williams and Wilkins, Philadelphia, R.W. Moskowitz, R.D. Altman, M.C. Hochberg, J.A. Buckwalter, V.M. Goldberg (Eds.)
    • Sharma L., Kapoor D. Epidemiology of osteoarthritis. Osteoarthritis, Diagnosis and Medical/Surgical Management 2007, 3-26. Lippincott Williams and Wilkins, Philadelphia. 4th edn. R.W. Moskowitz, R.D. Altman, M.C. Hochberg, J.A. Buckwalter, V.M. Goldberg (Eds.).
    • (2007) Osteoarthritis, Diagnosis and Medical/Surgical Management , pp. 3-26
    • Sharma, L.1    Kapoor, D.2
  • 3
    • 15844413814 scopus 로고    scopus 로고
    • Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis
    • Glasson S.S., Askew R., Sheppard B., Carito B., Blanchet T., Ma H.L., et al. Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis. Nature 2005, 434:644-648.
    • (2005) Nature , vol.434 , pp. 644-648
    • Glasson, S.S.1    Askew, R.2    Sheppard, B.3    Carito, B.4    Blanchet, T.5    Ma, H.L.6
  • 4
    • 73249137617 scopus 로고    scopus 로고
    • Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development
    • Little C.B., Barai A., Burkhardt D., Smith S.M., Fosang A.J., Werb Z., et al. Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development. Arthritis Rheum 2009, 60:3723-3733.
    • (2009) Arthritis Rheum , vol.60 , pp. 3723-3733
    • Little, C.B.1    Barai, A.2    Burkhardt, D.3    Smith, S.M.4    Fosang, A.J.5    Werb, Z.6
  • 5
    • 15844384854 scopus 로고    scopus 로고
    • ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro
    • Stanton H., Rogerson F.M., East C.J., Golub S.B., Lawlor K.E., Meeker C.T., et al. ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro. Nature 2005, 434:648-652.
    • (2005) Nature , vol.434 , pp. 648-652
    • Stanton, H.1    Rogerson, F.M.2    East, C.J.3    Golub, S.B.4    Lawlor, K.E.5    Meeker, C.T.6
  • 6
    • 33847183465 scopus 로고    scopus 로고
    • Molecular targets in osteoarthritis: metalloproteinases and their inhibitors
    • Burrage P.S., Brinckerhoff C.E. Molecular targets in osteoarthritis: metalloproteinases and their inhibitors. Curr Drug Targets 2007, 8:293-303.
    • (2007) Curr Drug Targets , vol.8 , pp. 293-303
    • Burrage, P.S.1    Brinckerhoff, C.E.2
  • 7
    • 77951035922 scopus 로고    scopus 로고
    • Novel therapies in OA
    • Flannery C.R. Novel therapies in OA. Curr Drug Targets 2010, 11:614-619.
    • (2010) Curr Drug Targets , vol.11 , pp. 614-619
    • Flannery, C.R.1
  • 8
    • 31344458952 scopus 로고    scopus 로고
    • Structure and function of matrix metalloproteinases and TIMPs
    • Nagase H., Visse R., Murphy G. Structure and function of matrix metalloproteinases and TIMPs. Cardiovasc Res 2006, 69:562-573.
    • (2006) Cardiovasc Res , vol.69 , pp. 562-573
    • Nagase, H.1    Visse, R.2    Murphy, G.3
  • 9
    • 0032818036 scopus 로고    scopus 로고
    • Immunohistochemical analysis of type-X-collagen expression in osteoarthritis of the hip joint
    • Boos N., Nerlich A.G., Wiest I., von der Mark K., Ganz R., Aebi M. Immunohistochemical analysis of type-X-collagen expression in osteoarthritis of the hip joint. J Orthop Res 1999, 17:495-502.
    • (1999) J Orthop Res , vol.17 , pp. 495-502
    • Boos, N.1    Nerlich, A.G.2    Wiest, I.3    von der Mark, K.4    Ganz, R.5    Aebi, M.6
  • 10
    • 65249136616 scopus 로고    scopus 로고
    • The pattern recognition receptor CD36 is a chondrocyte hypertrophy marker associated with suppression of catabolic responses and promotion of repair responses to inflammatory stimuli
    • Cecil D.L., Appleton C.T., Polewski M.D., Mort J.S., Schmidt A.M., Bendele A., et al. The pattern recognition receptor CD36 is a chondrocyte hypertrophy marker associated with suppression of catabolic responses and promotion of repair responses to inflammatory stimuli. J Immunol 2009, 182:5024-5031.
    • (2009) J Immunol , vol.182 , pp. 5024-5031
    • Cecil, D.L.1    Appleton, C.T.2    Polewski, M.D.3    Mort, J.S.4    Schmidt, A.M.5    Bendele, A.6
  • 11
    • 16244421736 scopus 로고    scopus 로고
    • Transcriptional regulation of chondrocyte maturation: potential involvement of transcription factors in OA pathogenesis
    • Drissi H., Zuscik M., Rosier R., O'Keefe R. Transcriptional regulation of chondrocyte maturation: potential involvement of transcription factors in OA pathogenesis. Mol Aspects Med 2005, 26:169-179.
    • (2005) Mol Aspects Med , vol.26 , pp. 169-179
    • Drissi, H.1    Zuscik, M.2    Rosier, R.3    O'Keefe, R.4
  • 12
    • 17644372415 scopus 로고    scopus 로고
    • External GTP-bound transglutaminase 2 is a molecular switch for chondrocyte hypertrophic differentiation and calcification
    • Johnson K.A., Terkeltaub R.A. External GTP-bound transglutaminase 2 is a molecular switch for chondrocyte hypertrophic differentiation and calcification. J Biol Chem 2005, 280:15004-15012.
    • (2005) J Biol Chem , vol.280 , pp. 15004-15012
    • Johnson, K.A.1    Terkeltaub, R.A.2
  • 13
    • 20944436579 scopus 로고    scopus 로고
    • Osteoarthritis development in novel experimental mouse models induced by knee joint instability
    • Kamekura S., Hoshi K., Shimoaka T., Chung U., Chikuda H., Yamada T., et al. Osteoarthritis development in novel experimental mouse models induced by knee joint instability. Osteoarthritis Cartilage 2005, 13:632-641.
    • (2005) Osteoarthritis Cartilage , vol.13 , pp. 632-641
    • Kamekura, S.1    Hoshi, K.2    Shimoaka, T.3    Chung, U.4    Chikuda, H.5    Yamada, T.6
  • 14
    • 33746938803 scopus 로고    scopus 로고
    • Contribution of runt-related transcription factor 2 to the pathogenesis of osteoarthritis in mice after induction of knee joint instability
    • Kamekura S., Kawasaki Y., Hoshi K., Shimoaka T., Chikuda H., Maruyama Z., et al. Contribution of runt-related transcription factor 2 to the pathogenesis of osteoarthritis in mice after induction of knee joint instability. Arthritis Rheum 2006, 54:2462-2470.
    • (2006) Arthritis Rheum , vol.54 , pp. 2462-2470
    • Kamekura, S.1    Kawasaki, Y.2    Hoshi, K.3    Shimoaka, T.4    Chikuda, H.5    Maruyama, Z.6
  • 15
    • 42949166679 scopus 로고    scopus 로고
    • Endochondral ossification signals in cartilage degradation during osteoarthritis progression in experimental mouse models
    • Kawaguchi H. Endochondral ossification signals in cartilage degradation during osteoarthritis progression in experimental mouse models. Mol Cells 2008, 25:1-6.
    • (2008) Mol Cells , vol.25 , pp. 1-6
    • Kawaguchi, H.1
  • 16
    • 58149087220 scopus 로고    scopus 로고
    • Regulation of osteoarthritis development by Wnt-beta-catenin signaling through the endochondral ossification process
    • Kawaguchi H. Regulation of osteoarthritis development by Wnt-beta-catenin signaling through the endochondral ossification process. J Bone Miner Res 2009, 24:8-11.
    • (2009) J Bone Miner Res , vol.24 , pp. 8-11
    • Kawaguchi, H.1
  • 18
    • 0026729099 scopus 로고
    • Type X collagen synthesis in human osteoarthritic cartilage. Indication of chondrocyte hypertrophy
    • von der Mark K., Kirsch T., Nerlich A., Kuss A., Weseloh G., Gluckert K., et al. Type X collagen synthesis in human osteoarthritic cartilage. Indication of chondrocyte hypertrophy. Arthritis Rheum 1992, 35:806-811.
    • (1992) Arthritis Rheum , vol.35 , pp. 806-811
    • von der Mark, K.1    Kirsch, T.2    Nerlich, A.3    Kuss, A.4    Weseloh, G.5    Gluckert, K.6
  • 19
    • 33744997890 scopus 로고    scopus 로고
    • Carminerin contributes to chondrocyte calcification during endochondral ossification
    • Yamada T., Kawano H., Koshizuka Y., Fukuda T., Yoshimura K., Kamekura S., et al. Carminerin contributes to chondrocyte calcification during endochondral ossification. Nat Med 2006, 12:665-670.
    • (2006) Nat Med , vol.12 , pp. 665-670
    • Yamada, T.1    Kawano, H.2    Koshizuka, Y.3    Fukuda, T.4    Yoshimura, K.5    Kamekura, S.6
  • 20
    • 0038687536 scopus 로고    scopus 로고
    • Developmental regulation of the growth plate
    • Kronenberg H.M. Developmental regulation of the growth plate. Nature 2003, 423:332-336.
    • (2003) Nature , vol.423 , pp. 332-336
    • Kronenberg, H.M.1
  • 21
    • 77953208836 scopus 로고    scopus 로고
    • Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development
    • Saito T., Fukai A., Mabuchi A., Ikeda T., Yano F., Ohba S., et al. Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development. Nat Med 2010, 16:678-686.
    • (2010) Nat Med , vol.16 , pp. 678-686
    • Saito, T.1    Fukai, A.2    Mabuchi, A.3    Ikeda, T.4    Yano, F.5    Ohba, S.6
  • 22
    • 0042368882 scopus 로고    scopus 로고
    • The hypoxia-inducible factors: key transcriptional regulators of hypoxic responses
    • Bracken C.P., Whitelaw M.L., Peet D.J. The hypoxia-inducible factors: key transcriptional regulators of hypoxic responses. Cell Mol Life Sci 2003, 60:1376-1393.
    • (2003) Cell Mol Life Sci , vol.60 , pp. 1376-1393
    • Bracken, C.P.1    Whitelaw, M.L.2    Peet, D.J.3
  • 23
    • 0034663989 scopus 로고    scopus 로고
    • HIF-1 and human disease: one highly involved factor
    • Semenza G.L. HIF-1 and human disease: one highly involved factor. Genes Dev 2000, 14:1983-1991.
    • (2000) Genes Dev , vol.14 , pp. 1983-1991
    • Semenza, G.L.1
  • 24
    • 0036469038 scopus 로고    scopus 로고
    • Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch
    • Lando D., Peet D.J., Whelan D.A., Gorman J.J., Whitelaw M.L. Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch. Science 2002, 295:858-861.
    • (2002) Science , vol.295 , pp. 858-861
    • Lando, D.1    Peet, D.J.2    Whelan, D.A.3    Gorman, J.J.4    Whitelaw, M.L.5
  • 26
    • 0031000736 scopus 로고    scopus 로고
    • A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development
    • Ema M., Taya S., Yokotani N., Sogawa K., Matsuda Y., Fujii-Kuriyama Y. A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development. Proc Natl Acad Sci U S A 1997, 94:4273-4278.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 4273-4278
    • Ema, M.1    Taya, S.2    Yokotani, N.3    Sogawa, K.4    Matsuda, Y.5    Fujii-Kuriyama, Y.6
  • 27
    • 40949088476 scopus 로고    scopus 로고
    • Biology of hypoxia-inducible factor-2alpha in development and disease
    • Patel S.A., Simon M.C. Biology of hypoxia-inducible factor-2alpha in development and disease. Cell Death Differ 2008, 15:628-634.
    • (2008) Cell Death Differ , vol.15 , pp. 628-634
    • Patel, S.A.1    Simon, M.C.2
  • 28
    • 0032213236 scopus 로고    scopus 로고
    • The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development
    • Tian H., Hammer R.E., Matsumoto A.M., Russell D.W., McKnight S.L. The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development. Genes Dev 1998, 12:3320-3324.
    • (1998) Genes Dev , vol.12 , pp. 3320-3324
    • Tian, H.1    Hammer, R.E.2    Matsumoto, A.M.3    Russell, D.W.4    McKnight, S.L.5
  • 29
    • 36549088609 scopus 로고    scopus 로고
    • HIF1alpha regulation of Sox9 is necessary to maintain differentiation of hypoxic prechondrogenic cells during early skeletogenesis
    • Amarilio R., Viukov S.V., Sharir A., Eshkar-Oren I., Johnson R.S., Zelzer E. HIF1alpha regulation of Sox9 is necessary to maintain differentiation of hypoxic prechondrogenic cells during early skeletogenesis. Development 2007, 134:3917-3928.
    • (2007) Development , vol.134 , pp. 3917-3928
    • Amarilio, R.1    Viukov, S.V.2    Sharir, A.3    Eshkar-Oren, I.4    Johnson, R.S.5    Zelzer, E.6
  • 30
    • 36549065233 scopus 로고    scopus 로고
    • Fetal growth plate: a developmental model of cellular adaptation to hypoxia
    • Provot S., Schipani E. Fetal growth plate: a developmental model of cellular adaptation to hypoxia. Ann N Y Acad Sci 2007, 1117:26-39.
    • (2007) Ann N Y Acad Sci , vol.1117 , pp. 26-39
    • Provot, S.1    Schipani, E.2
  • 31
    • 0035499204 scopus 로고    scopus 로고
    • Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival
    • Schipani E., Ryan H.E., Didrickson S., Kobayashi T., Knight M., Johnson R.S. Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival. Genes Dev 2001, 15:2865-2876.
    • (2001) Genes Dev , vol.15 , pp. 2865-2876
    • Schipani, E.1    Ryan, H.E.2    Didrickson, S.3    Kobayashi, T.4    Knight, M.5    Johnson, R.S.6
  • 32
    • 70349758284 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1alpha inhibits the fibroblast-like markers type I and type III collagen during hypoxia-induced chondrocyte redifferentiation: hypoxia not only induces type II collagen and aggrecan, but it also inhibits type I and type III collagen in the hypoxia-inducible factor 1alpha-dependent redifferentiation of chondrocytes
    • Duval E., Leclercq S., Elissalde J.M., Demoor M., Galera P., Boumediene K. Hypoxia-inducible factor 1alpha inhibits the fibroblast-like markers type I and type III collagen during hypoxia-induced chondrocyte redifferentiation: hypoxia not only induces type II collagen and aggrecan, but it also inhibits type I and type III collagen in the hypoxia-inducible factor 1alpha-dependent redifferentiation of chondrocytes. Arthritis Rheum 2009, 60:3038-3048.
    • (2009) Arthritis Rheum , vol.60 , pp. 3038-3048
    • Duval, E.1    Leclercq, S.2    Elissalde, J.M.3    Demoor, M.4    Galera, P.5    Boumediene, K.6
  • 33
    • 0038325620 scopus 로고    scopus 로고
    • HIF-1alpha controls extracellular matrix synthesis by epiphyseal chondrocytes
    • Pfander D., Cramer T., Schipani E., Johnson R.S. HIF-1alpha controls extracellular matrix synthesis by epiphyseal chondrocytes. J Cell Sci 2003, 116:1819-1826.
    • (2003) J Cell Sci , vol.116 , pp. 1819-1826
    • Pfander, D.1    Cramer, T.2    Schipani, E.3    Johnson, R.S.4
  • 34
    • 30344480826 scopus 로고    scopus 로고
    • Elevated expression of hypoxia inducible factor-2alpha in terminally differentiating growth plate chondrocytes
    • Stewart A.J., Houston B., Farquharson C. Elevated expression of hypoxia inducible factor-2alpha in terminally differentiating growth plate chondrocytes. J Cell Physiol 2006, 206:435-440.
    • (2006) J Cell Physiol , vol.206 , pp. 435-440
    • Stewart, A.J.1    Houston, B.2    Farquharson, C.3
  • 35
    • 77953183739 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-2alpha is a catabolic regulator of osteoarthritic cartilage destruction
    • Yang S., Kim J., Ryu J.H., Oh H., Chun C.H., Kim B.J., et al. Hypoxia-inducible factor-2alpha is a catabolic regulator of osteoarthritic cartilage destruction. Nat Med 2010, 16:687-693.
    • (2010) Nat Med , vol.16 , pp. 687-693
    • Yang, S.1    Kim, J.2    Ryu, J.H.3    Oh, H.4    Chun, C.H.5    Kim, B.J.6
  • 36
    • 0025906014 scopus 로고
    • Cloning of a factor required for activity of the Ah (dioxin) receptor
    • Hoffman E.C., Reyes H., Chu F.F., Sander F., Conley L.H., Brooks B.A., et al. Cloning of a factor required for activity of the Ah (dioxin) receptor. Science 1991, 252:954-958.
    • (1991) Science , vol.252 , pp. 954-958
    • Hoffman, E.C.1    Reyes, H.2    Chu, F.F.3    Sander, F.4    Conley, L.H.5    Brooks, B.A.6
  • 38
    • 0029928689 scopus 로고    scopus 로고
    • CDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS factor (Arnt2) with close sequence similarity to the aryl hydrocarbon receptor nuclear translocator (Arnt)
    • Hirose K., Morita M., Ema M., Mimura J., Hamada H., Fujii H., et al. cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS factor (Arnt2) with close sequence similarity to the aryl hydrocarbon receptor nuclear translocator (Arnt). Mol Cell Biol 1996, 16:1706-1713.
    • (1996) Mol Cell Biol , vol.16 , pp. 1706-1713
    • Hirose, K.1    Morita, M.2    Ema, M.3    Mimura, J.4    Hamada, H.5    Fujii, H.6
  • 39
    • 0034726707 scopus 로고    scopus 로고
    • CDNA cloning of a novel bHLH-PAS transcription factor superfamily gene, BMAL2: its mRNA expression, subcellular distribution, and chromosomal localization
    • Ikeda M., Yu W., Hirai M., Ebisawa T., Honma S., Yoshimura K., et al. cDNA cloning of a novel bHLH-PAS transcription factor superfamily gene, BMAL2: its mRNA expression, subcellular distribution, and chromosomal localization. Biochem Biophys Res Commun 2000, 275:493-502.
    • (2000) Biochem Biophys Res Commun , vol.275 , pp. 493-502
    • Ikeda, M.1    Yu, W.2    Hirai, M.3    Ebisawa, T.4    Honma, S.5    Yoshimura, K.6
  • 40
    • 0034711261 scopus 로고    scopus 로고
    • CLIF, a novel cycle-like factor, regulates the circadian oscillation of plasminogen activator inhibitor-1 gene expression
    • Maemura K., de la Monte S.M., Chin M.T., Layne M.D., Hsieh C.M., Yet S.F., et al. CLIF, a novel cycle-like factor, regulates the circadian oscillation of plasminogen activator inhibitor-1 gene expression. J Biol Chem 2000, 275:36847-36851.
    • (2000) J Biol Chem , vol.275 , pp. 36847-36851
    • Maemura, K.1    de la Monte, S.M.2    Chin, M.T.3    Layne, M.D.4    Hsieh, C.M.5    Yet, S.F.6
  • 41
    • 0030887045 scopus 로고    scopus 로고
    • Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway
    • Hogenesch J.B., Chan W.K., Jackiw V.H., Brown R.C., Gu Y.Z., Pray-Grant M., et al. Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway. J Biol Chem 1997, 272:8581-8593.
    • (1997) J Biol Chem , vol.272 , pp. 8581-8593
    • Hogenesch, J.B.1    Chan, W.K.2    Jackiw, V.H.3    Brown, R.C.4    Gu, Y.Z.5    Pray-Grant, M.6
  • 42
    • 0032510778 scopus 로고    scopus 로고
    • The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors
    • Hogenesch J.B., Gu Y.Z., Jain S., Bradfield C.A. The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors. Proc Natl Acad Sci U S A 1998, 95:5474-5479.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 5474-5479
    • Hogenesch, J.B.1    Gu, Y.Z.2    Jain, S.3    Bradfield, C.A.4
  • 43
    • 0037092008 scopus 로고    scopus 로고
    • Identification and functional characterization of hypoxia-inducible factor 2alpha from the estuarine teleost, Fundulus heteroclitus: interaction of HIF-2alpha with two ARNT2 splice variants
    • Powell W.H., Hahn M.E. Identification and functional characterization of hypoxia-inducible factor 2alpha from the estuarine teleost, Fundulus heteroclitus: interaction of HIF-2alpha with two ARNT2 splice variants. J Exp Zool 2002, 294:17-29.
    • (2002) J Exp Zool , vol.294 , pp. 17-29
    • Powell, W.H.1    Hahn, M.E.2
  • 44
  • 45
  • 46
    • 69949118870 scopus 로고    scopus 로고
    • Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis
    • Echtermeyer F., Bertrand J., Dreier R., Meinecke I., Neugebauer K., Fuerst M., et al. Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis. Nat Med 2009, 15:1072-1076.
    • (2009) Nat Med , vol.15 , pp. 1072-1076
    • Echtermeyer, F.1    Bertrand, J.2    Dreier, R.3    Meinecke, I.4    Neugebauer, K.5    Fuerst, M.6
  • 47
    • 71549136203 scopus 로고    scopus 로고
    • Modulating hedgehog signaling can attenuate the severity of osteoarthritis
    • Lin A.C., Seeto B.L., Bartoszko J.M., Khoury M.A., Whetstone H., Ho L., et al. Modulating hedgehog signaling can attenuate the severity of osteoarthritis. Nat Med 2009, 15:1421-1425.
    • (2009) Nat Med , vol.15 , pp. 1421-1425
    • Lin, A.C.1    Seeto, B.L.2    Bartoszko, J.M.3    Khoury, M.A.4    Whetstone, H.5    Ho, L.6
  • 48
    • 0029761644 scopus 로고    scopus 로고
    • Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
    • Forsythe J.A., Jiang B.H., Iyer N.V., Agani F., Leung S.W., Koos R.D., et al. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol 1996, 16:4604-4613.
    • (1996) Mol Cell Biol , vol.16 , pp. 4604-4613
    • Forsythe, J.A.1    Jiang, B.H.2    Iyer, N.V.3    Agani, F.4    Leung, S.W.5    Koos, R.D.6
  • 49
    • 77949266555 scopus 로고    scopus 로고
    • Dynamic compression alters NFkappaB activation and IkappaB-alpha expression in IL-1beta-stimulated chondrocyte/agarose constructs
    • Akanji O.O., Sakthithasan P., Salter D.M., Chowdhury T.T. Dynamic compression alters NFkappaB activation and IkappaB-alpha expression in IL-1beta-stimulated chondrocyte/agarose constructs. Inflamm Res 2009, 59:41-52.
    • (2009) Inflamm Res , vol.59 , pp. 41-52
    • Akanji, O.O.1    Sakthithasan, P.2    Salter, D.M.3    Chowdhury, T.T.4
  • 50
    • 65349083779 scopus 로고    scopus 로고
    • Biomechanical thresholds regulate inflammation through the NF-kappaB pathway: experiments and modeling
    • Nam J., Aguda B.D., Rath B., Agarwal S. Biomechanical thresholds regulate inflammation through the NF-kappaB pathway: experiments and modeling. PLoS One 2009, 4:e5262.
    • (2009) PLoS One , vol.4
    • Nam, J.1    Aguda, B.D.2    Rath, B.3    Agarwal, S.4
  • 52
    • 77953227861 scopus 로고    scopus 로고
    • Shifting HIFs in osteoarthritis
    • Husa M., Liu-Bryan R., Terkeltaub R. Shifting HIFs in osteoarthritis. Nat Med 2010, 16:641-644.
    • (2010) Nat Med , vol.16 , pp. 641-644
    • Husa, M.1    Liu-Bryan, R.2    Terkeltaub, R.3
  • 53
    • 66049155861 scopus 로고    scopus 로고
    • Regulation of autophagy in human and murine cartilage: hypoxia-inducible factor 2 suppresses chondrocyte autophagy
    • Bohensky J., Terkhorn S.P., Freeman T.A., Adams C.S., Garcia J.A., Shapiro I.M., et al. Regulation of autophagy in human and murine cartilage: hypoxia-inducible factor 2 suppresses chondrocyte autophagy. Arthritis Rheum 2009, 60:1406-1415.
    • (2009) Arthritis Rheum , vol.60 , pp. 1406-1415
    • Bohensky, J.1    Terkhorn, S.P.2    Freeman, T.A.3    Adams, C.S.4    Garcia, J.A.5    Shapiro, I.M.6
  • 54
    • 67650481882 scopus 로고    scopus 로고
    • Selective inhibition of hypoxia-inducible factor (HIF) prolyl-hydroxylase 1 mediates neuroprotection against normoxic oxidative death via HIF- and CREB-independent pathways
    • Siddiq A., Aminova L.R., Troy C.M., Suh K., Messer Z., Semenza G.L., et al. Selective inhibition of hypoxia-inducible factor (HIF) prolyl-hydroxylase 1 mediates neuroprotection against normoxic oxidative death via HIF- and CREB-independent pathways. J Neurosci 2009, 29:8828-8838.
    • (2009) J Neurosci , vol.29 , pp. 8828-8838
    • Siddiq, A.1    Aminova, L.R.2    Troy, C.M.3    Suh, K.4    Messer, Z.5    Semenza, G.L.6
  • 55
    • 56649084972 scopus 로고    scopus 로고
    • Integrative microRNA and proteomic approaches identify novel osteoarthritis genes and their collaborative metabolic and inflammatory networks
    • Iliopoulos D., Malizos K.N., Oikonomou P., Tsezou A. Integrative microRNA and proteomic approaches identify novel osteoarthritis genes and their collaborative metabolic and inflammatory networks. PLoS One 2008, 3:e3740.
    • (2008) PLoS One , vol.3
    • Iliopoulos, D.1    Malizos, K.N.2    Oikonomou, P.3    Tsezou, A.4
  • 56
    • 69449103973 scopus 로고    scopus 로고
    • MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates interleukin-1 responses
    • Miyaki S., Nakasa T., Otsuki S., Grogan S.P., Higashiyama R., Inoue A., et al. MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates interleukin-1 responses. Arthritis Rheum 2009, 60:2723-2730.
    • (2009) Arthritis Rheum , vol.60 , pp. 2723-2730
    • Miyaki, S.1    Nakasa, T.2    Otsuki, S.3    Grogan, S.P.4    Higashiyama, R.5    Inoue, A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.