Aggravation of ADAMTS and matrix metalloproteinase production and role of ERK1/2 pathway in the interaction of osteoarthritic subchondral bone osteoblasts and articular cartilage chondrocytes - Possible pathogenic role in osteoarthritis

Journal of Rheumatology

Volumn 39, Issue 3, 2012, Pages 621-634

  Prasadam, Indira ^a   Crawford, Ross ^a,b   Xiao, Yin ^a  

^a QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

^b THE PRINCE CHARLES HOSPITAL   (Australia)

Author keywords

Cell interactions; Chondrocytes; Matrix metalloproteinase; Mitogen activated protein kinase; Osteoarthritis; Osteoblasts; Signaling pathway

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ADAMTS PROTEIN; AGGRECANASE 1; AGGRECANASE 2; COLLAGENASE 3; GELATINASE B; INTERSTITIAL COLLAGENASE; MATRIX METALLOPROTEINASE; METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NEUTROPHIL COLLAGENASE; STROMELYSIN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; ARTICULAR CARTILAGE CHONDROCYTE; CARTILAGE CELL; COCULTURE; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; IN VIVO STUDY; KNEE OSTEOARTHRITIS; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SUBCHONDRAL BONE OSTEOBLAST; UPREGULATION;

ADAM PROTEINS; CARTILAGE, ARTICULAR; CELL COMMUNICATION; CELLS, CULTURED; CHONDROCYTES; COCULTURE TECHNIQUES; FLAVONOIDS; HUMANS; MAP KINASE SIGNALING SYSTEM; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 3; MATRIX METALLOPROTEINASE 9; MATRIX METALLOPROTEINASES; OSTEOARTHRITIS; OSTEOBLASTS; PHENOTYPE; PHOSPHORYLATION; PROCOLLAGEN N-ENDOPEPTIDASE;

EID: 84857863192     PISSN: 0315162X     EISSN: 14992752     Source Type: Journal    
DOI: 10.3899/jrheum.110777     Document Type: Article

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