Natural products and transforming growth factor-beta (TGF-β) signaling in cancer development and progression

Current Cancer Drug Targets

Volumn 13, Issue 5, 2013, Pages 500-505

  Lee, Chung ^a,b   Zhang, Qiang ^a   Kozlowski, James ^a   Brendler, Charles ^c   Soares, Marcelo B ^d   Dash, Atrya ^b   Mcclelland, Michael ^b   Mercola, Dan ^b  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NORTHSHORE UNIVERSITY HEALTHSYSTEM   (United States)

^d Children's Memorial Research Center   (United States)

Author keywords

Dietary components; DNA methylation; Non smad pathways; Smad pathways; TGF signaling; Tumor development and progression

Indexed keywords

ANGELICA SINENSIS EXTRACT; BLACK TEA EXTRACT; CURCUMIN; DNA METHYLTRANSFERASE; EPIGALLOCATECHIN GALLATE; GENISTEIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LYCOPENE; NATURAL PRODUCT; POLYPODIUM LEUCOTOMOS EXTRACT; RESVERATROL; ROSMARINIC ACID; SALVIA MILTIORRHIZA EXTRACT; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

APOPTOSIS; ARTICLE; BENIGN TUMOR; CANCER CELL; CANCER GROWTH; CARCINOGENESIS; CELL PROLIFERATION; DIET; DNA METHYLATION; ENVIRONMENTAL FACTOR; EPIGENETICS; HUMAN; METASTASIS; PROTEIN EXPRESSION; RHUBARB; SIGNAL TRANSDUCTION;

EID: 84888091511     PISSN: 15680096     EISSN: 18735576     Source Type: Journal    
DOI: 10.2174/15680096113139990034     Document Type: Article

References (66)

1. Massagué, J. How Cells read TGF-β signals. Nature Rev. Mol. Cell. Biol. 2000, 1, 169-178.
2. Derynck, R.; Akhurst, R. J.; Balmain, A. TGF-beta signaling in tumor suppression and cancer progression. Nat. Genet. 2001, 29, 117-129.
3. Massague, J.; Cheifetz, S.; Laiho, M.; Ralph, D. A.; Weis, F.; Zentella A. TGF-β. Cancer Surv. 1992, 12, 81-103.
4. Dernyck, R.; Feng, X. TGF-β receptor signaling. Biochem. et Biophs. Acta. 1997, 333, F105-F150.
5. Mu, Y.; Gudey, S. K.; Landström, M. Non-Smad signaling pathways. Cell Tissue Res. 2012, 347 (1), 11-20.
6. Kretzschmar, M. Transforming growth factor-beta and breast cancer: Transforming growth factor-beta/SMAD signaling defects and cancer. Breast Cancer Res. 2000, 2 (2), 107-115.
7. Teicher, B. A. Malignant cells, directors of the malignant process: role of transforming growth factor-beta. Cancer Metastasis Rev. 2001, 20 (1-2), 133-143.
8. Yu, N.; Kozlowski, J. M.; Park, I. I.; Chen, L.; Zhang, Q.; Xu, D.; Doll, J. A.; Crawford, S. E.; Brendler, C. B.; Lee, C. Over-expression of transforming growth factor p1 in malignant prostate cells is partly caused by a runaway of TGF-β1 auto-induction mediated through a defective recruitment of protein phosphatase 2A by TGF-β type I receptor. Urology 2010, 76 (6), 1519.e8-13.
9. Link, A.; Balaguer, F.; Goel, A. Cancer chemoprevention by dietary polyphenols: promising role for epigenetics. Biochem. Pharmacol. 2010, 80 (12), 1771-92.
10. Cedar, H.; Bergman, Y. Programming of DNA Methylation Patterns. Annu. Rev. Biochem. 2012, 81, 97-117.
11. Chiam K, Ricciardelli C, Bianco-Miotto T. Epigenetic Biomarkers in Prostate Cancer: Current and Future Uses. Cancer Lett. 2012, [Epub ahead of print].
12. Sandoval, J.; Esteller, M. Cancer epigenomics: beyond genomics. Curr. Opin. Genet. Dev. 2012, 22 (1), 50-5.
13. Matsumura, N.; Huang, Z.; Mori, S.; Baba, T.; Fujii, S.; Konishi, I.; Iversen, E. S.; Berchuck, A.; Murphy, S. K.; Epigenetic suppression of the TGF-beta pathway revealed by transcriptome profiling in ovarian cancer. Genome Res. 2011, 21 (1), 74-82.
14. Zhang, Q.; Chen, L.; Helfand, B. T.; Zhu, L. J.; Kozlowski, J; Minn, A.; Jang, T.; Yang, X. J.; Javonovic, B.; Guo, Y.; Lonning, S.; Harper, J.; Teicher, B. A.; Yu, N.; Brendler, C; Wang, J; Catalona, W. J.; Lee, C. Transforming Growth Factor-beta-induced DNA methyltransferase contributes to aggressive prostate cancer phenotypes and predicts biochemical recurrence after radical prostatectomy PloS ONE 2011, 6, e25168.
15. Luo, X.; Zhang, Q.; Liu, V.; Xia, Z.; Pothoven, K. L.; Lee, C. Cutting Edge: TGF-β Induced expression of Foxp3 in T cells is mediated through inactivation of ERK. J. Immunol. 2008, 180, 2757-2761.
16. You, H.; Ding, W.; Rountree, C. B. Epigenetic regulation of cancer stem cell marker CD133 by transforming growth factor-beta. Hepatology 2010, 51 (5), 1635-44.
17. Zhang, Q.; Helfand, B. T.; Jang, T. L.; Zhu, L. J.; Chen, L.; Yang, X. J.; Kozlowski, J.; Smith, N.; Kundu, S. D.; Yang, G.; Raji, A. A.; Javonovic, B.; Pins, M.; Lindholm, P.; Guo, Y.; Catalona, W. J.; Lee, C. NF-kB-Mediated Transforming Growth Factor-?-Induced Expression of Vimentin is an Independent Predictor of Biochemical Recurrence After Radical Prostatectomy. Clinical Cancer Res. 2009, 15, 3557-3567.
18. Lim, U.; Song, M. A. Dietary and lifestyle factors of DNA methylation. Chapter 23. Methods Mol. Biol. 2012, 863, 359-376.
19. Funahashi, H.; Imai, T.; Tanaka, Y.; Tsukamura, K.; Hayakawa, Y.; Kikumori, T.; Mase, T.; Itoh, T.; Nishikawa, M.; Hayashi, H.; Shibata, A.; Hibi, Y.; Takahashi, M.; Narita, T. Wakame seaweed suppresses the proliferation of 7,12-dimethylbenz(a)-anthracene-induced mammary tumors in rats. Jpn. J. Cancer Res. 1999, 90 (9), 922-927.
20. Lu, R.; Serrero, G. Resveratrol, a natural product derived from grape, exhibits antiestrogenic activity and inhibits the growth of human breast cancer cells. J. Cell. Physiol. 1999, 179(3), 297-304.
21. Yamamoto, M.; Ogawa, K.; Morita, M.; Fukuda, K.; Komatsu, Y. The herbal medicine Inchin-ko-to inhibits liver cell apoptosis induced by transforming growth factor beta 1. Hepatology 1996, 23 (3), 552-559.
22. Chou, C. C; Pan, S. L.; Teng, C. M.; Guh, J. H. Pharmacological evaluation of several major ingredients of Chinese herbal medicines in human hepatoma Hep3B cells. Eur. J. Pharm. Sci. 2003, 19(5), 403-12.
23. Lee, C. Y.; Hsu, Y. C; Wang, J. Y.; Chen, C. C; Chiu, J. H. Chemopreventive effect of selenium and Chinese medicinal herbs on N-nitrosobis(2-oxopropyl)amine-induced hepatocellular carcinoma in Syrian hamsters. Liver Int. 2008, 28 (6), 841-855.
24. Lee, T. K.; Kim, D. I.; Han, J. Y.; Kim, C. H. Inhibitory effects of Scutellaria barbata D. Don. and Euonymus alatus Sieb. on aromatase activity of human leiomyomal cells. Immunopharmacol. Immunotoxicol. 2004, 26 (3), 315-327.
25. Lee, T. K.; Lee, J. Y.; Kim, D. I.; Lee, Y. C; Kim, C. H. Differential regulation of protein kinase C activity by modulating factors and Euonymus alatus (Thunb.) Sieb in human myometrial and uterine leiomyomal smooth muscle cells. Int. J. Gynecol. Cancer 2005, 15 (2), 349-58.
26. McCarty, M. F. Isoflavones made simple - genistein's agonist activity for the beta-type estrogen receptor mediates their health benefits. Med. Hypotheses. 2006, 66 (6), 1093-114.
27. Lin, H. H.; Tsai, C. W.; Chou, F. P.; Wang, C. J.; Hsuan, S. W.; Wang, C. K.; Chen, J. H. Andrographolide down-regulates hypoxia-inducible factor-1a in human non-small cell lung cancer A549 cells. Toxicol. Appl. Pharmacol. 2011, 250 (3), 336-345.
28. Roomi, M. W.; Roomi, N.; Ivanov, V.; Kalinovsky, T.; Niedzwiecki, A.; Rath, M. Inhibitory effect of a mixture containing ascorbic acid, lysine, proline and green tea extract on critical parameters in angiogenesis. Oncol. Rep. 2005, 14 (4), 807-815.
29. Mandal, D.; Bhattacharyya, S.; Lahiry, L.; Chattopadhyay, S.; Sa, G.; Das, T. Black tea-induced decrease in IL-10 and TGF-beta of tumor cells promotes Th1/Tc1 response in tumor bearer. Nutr. Cancer 2007, 58 (2), 213-221.
30. Han, G.; Zhou, Y. F.; Zhang, M. S.; Cao, Z.; Xie, C. H.; Zhou, F. X.; Peng, M.; Zhang, W. J. Angelica sinensis down-regulates hydroxyproline and Tgfb1 and provides protection in mice with radiation-induced pulmonary fibrosis. Radiat. Res. 2006, 165 (5), 546-552.
31. Park, E. Y.; Shin, S. M.; Ma, C. J.; Kim, Y. C; Kim, S. G. Meso-dihydroguaiaretic acid from Machilus thunbergii down-regulates TGF-beta1 gene expression in activated hepatic stellate cells via inhibition of AP-1 activity. Planta. Med. 2005, 71 (5), 393-398.
32. Shin, J. W.; Son, J. Y.; Oh, S. M.; Han, S. H.; Wang, J. H.; Cho, J. H.; Cho, C. K.; Yoo, H. S.; Lee, Y. W.; Lee, M.M.; Hu, X.P.; Son, C.G. An herbal formula, CGX, exerts hepatotherapeutic effects on dimethylnitrosamine-induced chronic liver injury model in rats. World J. Gastroenterol. 2006, 12 (38), 6142-6148.
33. Xiao, Z.; Su, Y.; Yang, S.; Yin, L.; Wang, W.; Yi, Y.; Fenton, B. M.; Zhang, L.; Okunieff, P. Protective effect of esculentoside A on radiation-induced dermatitis and fibrosis. Int. J. Radiat. Oncol. Biol. Phys. 2006, 65 (3), 882-889.
34. Yu, H. M.; Liu, Y. F.; Cheng, Y. F.; Hu, L. K.; Hou, M. Effects of rhubarb extract on radiation induced lung toxicity via decreasing transforming growth factor-beta-1 and interleukin-6 in lung cancer patients treated with radiotherapy. Lung Cancer 2008, 59 (2), 219-226.
35. Liu, X.; Yang, Y.; Zhang, X.; Xu, S.; He S.; Huang W, Roberts MS. Compound Astragalus and Salvia miltiorrhiza extract inhibits cell invasion by modulating transforming growth factor-beta/Smad in HepG2 cell. J. Gastroenterol. Hepatol. 2010, 25 (2), 420-426.
36. Pitchakarn, P.; Ogawa, K.; Suzuki, S.; Takahashi, S.; Asamoto, M.; Chewonarin T.; Limtrakul, P.; Shirai, T. Momordica charantia leaf extract suppresses rat prostate cancer progression in vitro and in vivo. Cancer Sci. 2010, 101 (10), 2234-2240.
37. Philips, N.; Dulaj, L.; Upadhya, T. Cancer cell growth and extracellular matrix remodeling mechanism of ascorbate; beneficial modulation by P. leucotomos. Anticancer Res. 2009, 29 (8), 3233-3238.
38. Philips, N.; Conte, J.; Chen, Y. J.; Natrajan, P.; Taw, M.; Keller, T.; Givant, J.; Tuason, M.; Dulaj, L.; Leonardi, D.; Gonzalez, S. Beneficial regulation of matrixmetalloproteinases and their inhibitors, fibrillar collagens and transforming growth factor-beta by Polypodium leucotomos, directly or in dermal fibroblasts, ultraviolet radiated fibroblasts, and melanoma cells. Arch. Dermatol. Res. 2009, 301 (7), 487-495.
39. Bajracharya, P.; Lee, E. J.; Lee, D. M.; Shim, S. H.; Kim, K. J.; Lee, S. H.; Bae, J. J.; Chun, S. S.; Lee, T. K.; Kwon, S. H.; Choi, I. Effect of different ingredients in traditional Korean medicine for human uterine leiomyoma on normal myometrial and leiomyomal smooth muscle cell proliferation. Arch. Pharm. Res. 2009, 32 (11), 1555-1563.
40. Lee, S.; Ra, J.; Song, J. Y.; Gwak, C; Kwon, H. J.; Yim, S. V.; Hong, S. P.; Kim, J.; Lee, K. H.; Cho, J. J.; Park, Y. S.; Park, C. S.; Ahn, H. J. Extracts from Citrus unshiu promote immune-mediated inhibition of tumor growth in a murine renal cell carcinoma model. J. Ethnopharmacol. 2011, 133 (3), 973-979.
41. Gunasekera, R. S.; Sewgobind, K.; Desai, S.; Dunn, L.; Black, H. S.; McKeehan, W. L.; Patil, B. Lycopene and lutein inhibit proliferation in rat prostate carcinoma cells. Nutr. Cancer 2007, 58 (2), 171-177.
42. Wertz, K.; Siler, U.; Goralczyk, R. Lycopene: modes of action to promote prostate health. Arch. Biochem. Biophys. 2004, 430 (1), 127-134.
43. Nantz, M. P.; Rowe, C. A.; Nieves, C. Jr.; Percival, S. S. Immunity and antioxidant capacity in humans is enhanced by consumption of a dried, encapsulated fruit and vegetable juice concentrate. J. Nutr. 2006, 136 (10), 2606-2610.
44. Jang M.; Pezzuto, J. M. Cancer chemopreventive activity of resveratrol. Drugs Exp. Clin. Res. 1999, 25 (2-3), 65-77.
45. Tamura, T.; Kobayashi, H.; Yamataka, A.; Lane, G. J.; Koga, H.; Miyano, T. Inchin-ko-to prevents medium-term liver fibrosis in postoperative biliary atresia patients. Pediatr. Surg. Int. 2007, 23 (4), 343-347.
46. Kitano, A.; Saika, S.; Yamanaka, O.; Reinach, P. S.; Ikeda, K.; Okada, Y.; Shirai, K.; Ohnishi, Y. Genipin suppression of fibrogenic behaviors of the alpha-TN4 lens epithelial cell line. J. Cataract Refract. Surg. 2006, 32 (10), 1727-1735.
47. Vittal, R.; Selvanayagam, Z. E.; Sun, Y.; Hong, J.; Liu, F.; Chin, K. V.; Yang, C. S. Gene expression changes induced by green tea polyphenol (-)-epigallocatechin-3-gallate in human bronchial epithelial 21BES cells analyzed by DNA microarray. Mol. Cancer Ther. 2004, 3 (9), 1091-1099.
48. Zhang, D.; Al-Hendy, M.; Richard-Davis, G.; Montgomery-Rice, V.; Rajaratnam, V.; Al-Hendy, A. Antiproliferative and proapoptotic effects of epigallocatechin gallate on human leiomyoma cells. Fertil. Steril. 2010, 94 (5), 1887-1893.
49. Manabe, M.; Takenaka, R.; Nakasa, T.; Okinaka, O. Induction of anti-inflammatory responses by dietary Momordica charantia L. (bitter gourd). Biosci. Biotechnol. Biochem. 2003, 67 (12), 2512-2517.
50. Pavese, J. M.; Farmer, R. L.; Bergan, R. C. Inhibition of cancer cell invasion and metastasis by genistein. Cancer Metastasis Rev. 2010, 29 (3), 465-482.
51. Ji, G.; Yang, Q.; Hao, J.; Guo, L.; Chen, X.; Hu, J.; Leng, L.; Jiang, Z. Anti-inflammatory effect of genistein on non-alcoholic steatohepatitis rats induced by high fat diet and its potential mechanisms. Int. Immunopharmacol. 2011, 11 (6), 762-768.
52. Whyte, L.; Huang, Y. Y.; Torres, K.; Mehta, R. G. Molecular mechanisms of resveratrol action in lung cancer cells using dual protein and microarray analyses. Cancer Res. 2007, 67 (24), 12007-12017.
53. Kwak, K. G.; Wang, J. H.; Shin, J. W.; Lee, D. S.; Son, C. G. A traditional formula, Chunggan extract, attenuates thioacetamide-induced hepatofibrosis via GSH system in rats. Hum. Exp. Toxicol. 2011, 30 (9), 1322-1332.
54. Fang, M.; Chen, D.; Yang, C. S. Dietary polyphenols may affect DNA methylation. J. Nutr. 2007, 137(1 Suppl), 223S-228S.
55. Li, Y.; Tollefsbol, T. O. Impact on DNA methylation in cancer prevention and therapy by bioactive dietary components. Curr. Med. Chem. 2010, 17 (20), 2141-2151.
56. Adjakly, M.; Bosviel, R.; Rabiau, N.; Boiteux, J. P.; Bignon, Y. J.; Guy, L.; Bernard-Gallon, D. DNA methylation and soy phytoestrogens, quantitative study in DU-145 and PC-3 human prostate cancer cell lines. Epigenomics 2011, 3 (6), 795-803.
57. Majid, S.; Dar, A.A.; Shahryari, V.; Hirata, H.; Ahmad, A.; Saini, S.; Tanaka, Y.; Dahiya, A. V.; Dahiya, R. Genistein reverses hypermethylation and induces active histone modifications in tumor suppressor gene B-Cell translocation gene 3 in prostate cancer. Cancer 2010, 116 (1), 66-76.
58. King-Batoon, A.; Leszczynska, J. M.; Klein, C. B. Modulation of gene methylation by genistein or lycopene in breast cancer cells. Environ. Mol. Mutagen 2008, 49 (1), 36-45.
59. Liu, A. G.; Erdman, J. W. Jr. Lycopene and apo-10'-lycopenal do not alter DNA methylation of GSTP1 in LNCaP cells. Biochem. Biophys. Res. Commun. 2011, 412 (3), 479-482.
60. Khor, T. O.; Huang, Y.; Wu, T. Y.; Shu, L.; Lee, J.; Kong, A. N. Pharmacodynamics of curcumin as DNA hypomethylation agent in restoring the expression of Nrf2 via promoter CpGs demethylation. Biochem. Pharmacol. 2011, 82(9), 1073-1078.
61. Liu, Y. L.; Yang, H. P.; Gong, L.; Tang, C. L.; Wang, HJ. Hypomethylation effects of curcumin, demethoxycurcumin and bisdemethoxycurcumin on WIF-1 promoter in non-small cell lung cancer cell lines. Mol. Med. Report 2011, 4 (4), 675-679.
62. Papoutsis, A. J.; Borg, J. L.; Selmin, O. I.; Romagnolo, D. F. BRCA-1 promoter hypermethylation and silencing induced by the aromatic hydrocarbon receptor-ligand TCDD are prevented by resveratrol in MCF-7 Cells. J. Nutr Biochem. 2011, 23 (10), 1324-1332.
63. Zhu, W.; Qin, W.; Zhang, K.; Rottinghaus, G. E.; Chen, Y. C; Kliethermes, B.; Sauter, E. R. Trans-resveratrol alters mammary promoter hypermethylation in women at Increased risk for breast cancer. Nutr. Cancer 2012, 64 (3), 393-400.
64. Ruiz-Torres, M. P.; Perez-Rivero, G.; Diez-Marques, M. L.; Griera, M.; Ortega, R.; Rodriguez-Puyol, M.; Rodríguez-Puyol, D. Role of activator protein-1 on the effect of arginine-glycine-aspartic acid containing peptides on transforming growth factor-beta1 promoter activity. Int. J. Biochem. Cell. Biol. 2007, 39 (1), 133-145.
65. Li, G.S., Jiang, W. L.; Tian, J. W.; Qu, G. W.; Zhu, H. B.; Fu, F. H. In vitro and in vivo antifibrotic effects of rosmarinic acid on experimental liver fibrosis. Phytomedicine 2010, 17 (3-4), 282-288.
66. Paluszczak, J.; Krajka-Kuzniak, V.; Baer-Dubowska, W. The effect of dietary polyphenols on the epigenetic regulation of gene expression in MCF7 breast cancer cells. Toxicol. Lett. 2010, 192 (2), 119-125.